Abstract: A method of detecting a contrast agent for photoacoustic imaging provides a high signal intensity. In a contrast agent for photoacoustic imaging, each particle containing an inorganic material supports at least an organic dye having an absorption coefficient in the near infrared region by means of chemical bonding.

Abstract: It is intended to provide a novel contrast agent for photoacoustic imaging that is highly capable of binding to a target molecule and generates high photoacoustic signals. The present invention provides a contrast agent for photoacoustic imaging represented by Formula 1: MNP-((L)l-(P)m)n??(Formula 1) (wherein MNP represents a particle containing an iron oxide particle; L represents a linker molecule; P represents a ligand molecule; l represents 0 or 1; and m and n represent an integer of 1 or larger), the contrast agent for photoacoustic imaging including: a particle containing an iron oxide particle that absorbs light in a near-infrared region; and at least one or more ligand molecule(s) immobilized on the particle containing an iron oxide particle, wherein the immobilization density of the ligand molecule is equal to or higher than the cell surface density of a target molecule.

Abstract: The present invention provides a composite particle having a high molar absorption coefficient for detection with higher detection sensitivity in photoacoustic imaging. In the present invention, a composite particle having a particle, a single-chain antibody which includes an antigen recognition region and a region other than the antigen recognition region and which is conjugated with the particle, and an organic dye conjugated with the single-chain antibody, in which the region other than the antigen recognition region of the single-chain antibody has thiol group, and a functional group of the particle is bound to the thiol group, is provided.

Abstract: A user inhales medicine ejected from the medicine ejecting section of an inhaler into the air flow duct of an air flow duct forming member through a hole. As the air flow duct forming member is taken off from the inhaler body, the medicine ejecting section is covered by a cap for protection. As the air flow duct forming member is fitted to the inhaler body, the cap is opened and a sensor recognizes the open state of the cap so that the air flow duct forming member is prohibited from being fitted to and taken off from the inhaler body by a claw that is secured to the air flow duct forming member. In this way, the medicine ejecting section is prevented from being damaged when the air flow duct is fitted to and taken away from the inhaler.

Abstract: A compound represented by Formula (1) below, where n is 2 or 3; a is an integer of 1 to 4 and b is an integer of 3 and 5 to 10, or a is 5 and b is an integer of 1 to 10; R1 to R8 each independently represent a hydrogen atom or a sulfonate that is any one of sodium sulfonate, potassium sulfonate, ammonium sulfonate, triethylammonium sulfonate, pyridinium sulfonate, lysine sulfonate, and arginine sulfonate; and R9 to R12 each independently represent a substituted or unsubstituted C1-C3 alkyl group.

Abstract: A content transfer service manager node of a computer network manages the transfer of content over the network from a content provider node to a user node. The characteristics of the configuration of the user node are determined, including the user nodes capabilities with respect to downloading content and processing downloaded content. The service manager arranges a content transfer that is particularly suited for the hardware, software, and communication capabilities of the user node.

Abstract: Regarding a composite particle in the related art, an antibody and a dye are bound to the surface of the particle. Therefore, it is not possible to bind both the antibody and the dye high in number. Accordingly, the present invention provides a composite particle, wherein a large acoustic wave can be emitted and both the antibody and the dye can be bound high in number. A composite particle including a core particle, a dye bound to the above described core particle, and an antibody, wherein the above described antibody is bound to the above described dye, is suitable for use.

Abstract: It is intended to provide a novel contrast agent for photoacoustic imaging that is highly capable of binding to a target molecule and generates high photoacoustic signals. The present invention provides a contrast agent for photoacoustic imaging represented by Formula 1: MNP?((L)l?(P)m)n ??(Formula 1) (wherein MNP represents a particle containing an iron oxide particle; L represents a linker molecule; P represents a ligand molecule; l represents 0 or 1; and m and n represent an integer of 1 or larger), the contrast agent for photoacoustic imaging including: a particle containing an iron oxide particle that absorbs light in a near-infrared region; and at least one or more ligand molecule(s) immobilized on the particle containing an iron oxide particle, wherein the immobilization density of the ligand molecule is equal to or higher than the cell surface density of a target molecule.

Abstract: The present invention provides a composite particle having a high molar absorption coefficient for detection with higher detection sensitivity in photoacoustic imaging. In the present invention, a composite particle having a particle, a single-chain antibody which includes an antigen recognition region and a region other than the antigen recognition region and which is conjugated with the particle, and an organic dye conjugated with the single-chain antibody, in which the region other than the antigen recognition region of the single-chain antibody has thiol group, and a functional group of the particle is bound to the thiol group, is provided.

Abstract: It is intended to provide a novel contrast agent for photoacoustic imaging that is highly capable of binding to a target molecule and generates high photoacoustic signals. The present invention provides a contrast agent for photoacoustic imaging represented by Formula 1: MNP-((L)l-(P)m)n??(Formula 1) (wherein MNP represents a particle containing an iron oxide particle; L represents a linker molecule; P represents a ligand molecule; l represents 0 or 1; and m and n represent an integer of 1 or larger), the contrast agent for photoacoustic imaging including: a particle containing an iron oxide particle that absorbs light in a near-infrared region; and at least one or more ligand molecule(s) immobilized on the particle containing an iron oxide particle, wherein the immobilization density of the ligand molecule is equal to or higher than the cell surface density of a target molecule.

Abstract: A method of detecting a contrast agent for photoacoustic imaging provides a high signal intensity. In a contrast agent for photoacoustic imaging, each particle containing an inorganic material supports at least an organic dye having an absorption coefficient in the near infrared region by means of chemical bonding.

Abstract: A compound represented by Formula (1) below, where n is 2 or 3; a is an integer of 1 to 4 and b is an integer of 3 and 5 to 10, or a is 5 and b is an integer of 1 to 10; R1 to R8 each independently represent a hydrogen atom or a sulfonate that is any one of sodium sulfonate, potassium sulfonate, ammonium sulfonate, triethylammonium sulfonate, pyridinium sulfonate, lysine sulfonate, and arginine sulfonate; and R9 to R12 each independently represent a substituted or unsubstituted C1-C3 alkyl group.

Abstract: A user inhales medicine ejected from the medicine ejecting section of an inhaler into the air flow duct of an air flow duct forming member through a hole. As the air flow duct forming member is taken off from the inhaler body, the medicine ejecting section is covered by a cap for protection. As the air flow duct forming member is fitted to the inhaler body, the cap is opened and a sensor recognizes the open state of the cap so that the air flow duct forming member is prohibited from being fitted to and taken off from the inhaler body by a claw that is secured to the air flow duct forming member. In this way, the medicine ejecting section is prevented from being damaged when the air flow duct is fitted to and taken away from the inhaler.

Abstract: A content transfer service manager node of a computer network manages the transfer of content over the network from a content provider node to a user node. The characteristics of the configuration of the user node are determined, including the user nodes capabilities with respect to downloading content and processing downloaded content. The service manager arranges a content transfer that is particularly suited for the hardware, software, and communication capabilities of the user node.

Abstract: A content transfer service manager node of a computer network manages the transfer of content over the network from a content provider node to a user node. The characteristics of the configuration of the user node are determined, including the user nodes capabilities with respect to downloading content and processing downloaded content. The service manager arranges a content transfer that is particularly suited for the hardware, software, and communication capabilities of the user node.

Abstract: A disk device is provided with a disk tray having a detachable guide member, which guides an optical disk between a depression and claws provided thereon. When an optical disk is to be mounted within a disk device in the vertical orientation, the optical disk can automatically be guided between depression and claws by moving the disk along the guide member. In addition, because the guide member is detachable, it can be attached if the disk device is to be used in vertical orientation and removed if it is to be used in horizontal orientation.

Abstract: A hybrid exchange which exchanges the STM data to be transmitted periodically to realize an exchange in unit of the ATM data to be transmitted asynchronously includes asynchronous transmission terminal interface as the interface with an STM terminal, an synchronous transmission terminal interface as the interface with an ATM terminal, an ATM exchange interface as the interface with an ATM exchange, a transmitting unit for transmitting the STM time slot and ATM time slot, and a control unit for controlling the interfaces. The synchronous transmission terminal interface assigns the STM data to be transmitted periodically to the STM time slot, while the asynchronous transmission terminal interface assigns the ATM data to be transmitted asynchronously to the ATM time slot. The STM time slot and ATM time slot are identified by the STM/ATM identifier. The STM time slot is stored by multiplexing a plurality of STM data.

Abstract: A content transfer service manager node of a computer network manages the transfer of content over the network from a content provider node to a user node. The characteristics of the configuration of the user node are determined, including the user nodes capabilities with respect to downloading content and processing downloaded content. The service manager arranges a content transfer that is particularly suited for the hardware, software, and communication capabilities of the user node.

Abstract: A hydroquinone compound is represented by the following formula or a pharmacologically acceptable salt thereof with W, R, R1-4, and B1-2 defined herein.

Abstract: Urocanic acid derivatives useful as antiallergic agents represented by the following formula (I) or a pharmacologically acceptable salt thereof: wherein R2 denotes hydrogen or lower alkyl, R3 denotes nitro, amino, cyano or COOR2, wherein R2 in said COOR2 is as defined above, and Q denotes carbon or nitrogen.