Patents by Inventor Sachiko Kuno
Sachiko Kuno has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150099802Abstract: A method for treating a tumor with a decreased level of the 15-hydroxy-prostaglandin dehydrogenase (15-PGDH) in a mammalian subject, which comprises administering to the subject in need thereof an effective amount of a fatty acid derivative, a method for suppressing the growth of a tumor cell with a decreased level of the 15-hydroxy-prostaglandin dehydrogenase (15-PGDH), which comprises contacting said tumor cell with an effective amount of a fatty acid derivative, and a method for identifying a subject who would be responsive to a fatty acid derivative, comprising, (i) obtaining a biological sample from said subject; and (ii) measuring 15-hydroxyprostaglandin dehydrogenase (15-PGDH) level are provided.Type: ApplicationFiled: October 1, 2014Publication date: April 9, 2015Applicant: SUCAMPO AGInventors: Ryuji UENO, Sachiko KUNO
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Publication number: 20150005381Abstract: In one embodiment, provided is a composition including a prostaglandin compound for modulating stem cell proliferation and/or differentiation in a mammalian subject. In another embodiment, the instant application is directed to a composition which includes a prostaglandin compound for modulating proliferation and/or differentiation of stem cells of a mammalian subject, in which the stem cells are contacted directly or indirectly with the composition of the invention.Type: ApplicationFiled: September 16, 2014Publication date: January 1, 2015Applicant: SUCAMPO AGInventors: Ryuji UENO, Sachiko KUNO
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Publication number: 20140371304Abstract: A method for suppressing tumorigenicity of stem cells in a mammalian subject, which comprises administering an effective amount of a fatty acid derivative and a method for suppressing tumorigenicity of stem cells of a mammalian subject, which comprises contacting said stem cell with an effective amount of a fatty acid derivative, are provided.Type: ApplicationFiled: June 11, 2014Publication date: December 18, 2014Applicant: SUCAMPO AGInventors: Ryuji UENO, Sachiko KUNO, John CUPPOLETTI
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Patent number: 8871752Abstract: In one embodiment, provided is a composition including a prostaglandin compound for modulating stem cell proliferation and/or differentiation in a mammalian subject. In another embodiment, the instant application is directed to a composition which includes a prostaglandin compound for modulating proliferation and/or differentiation of stem cells of a mammalian subject, in which the stem cells are contacted directly or indirectly with the composition of the invention.Type: GrantFiled: February 18, 2009Date of Patent: October 28, 2014Assignee: Sucampo AGInventors: Ryuji Ueno, Sachiko Kuno
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Publication number: 20100298424Abstract: Disclosed is a novel use of a chloride channel opener, especially a prostaglandin compound for the treatment of abdominal discomfort. Further disclosed is a novel use of a chloride channel opener, especially a prostaglandin compound for the treatment of functional gastrointestinal disorders.Type: ApplicationFiled: August 2, 2010Publication date: November 25, 2010Applicant: SUCAMPO AGInventors: Ryuji UENO, Sachiko KUNO
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Patent number: 7795312Abstract: A method for treating irritable bowel syndrome in a mammalian subject includes administering an effective amount of 13,14-dihydro-15-keto-16,16-difluoro-18-methyl-prostaglandin E1 or 13,14-dihydro-15-keto-16,16-difluoro-prostaglandin E1, or a salt, ether, ester or amide thereof, to the subject. A method for treating abdominal discomfort associated with irritable bowel syndrome in a mammalian subject includes administering an effective amount of 13,14-dihydro-15-keto-16,16-difluoro-18-methyl-prostaglandin E1 or 13,14-dihydro-15-keto-16,16-difluoro-prostaglandin E1, or a salt, ether, ester or amide thereof, to the subject.Type: GrantFiled: December 29, 2003Date of Patent: September 14, 2010Assignee: Sucampo AGInventors: Ryuji Ueno, Sachiko Kuno
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Publication number: 20090254449Abstract: The invention achieves certain advantages in pharmaceutical development over large multinational companies by forming a multilateral alliance of independent entities, each with their own geographical focus. In accordance with the invention, a method is provided whereby multiple entities, within the coverage of a common patent portfolio, undertake their own research and development in their own territory. Under a second feature of the invention, the entities may each utilize the information obtained by the others in order to advance their own development program.Type: ApplicationFiled: June 12, 2009Publication date: October 8, 2009Applicant: RUSK Intellectual Reserve AGInventor: Sachiko KUNO
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Publication number: 20090209643Abstract: In one embodiment, provided is a composition comprising a prostaglandin compound for modulating stem cell proliferation and/or differentiation in a mammalian subject. In another embodiment, the instant application is a composition comprising a prostaglandin compound for, which comprises a prostaglandin compound for modulating proliferation and/or differentiation of stem cells of a mammalian subject, in which the stem cells are contacted directly or indirectly with the composition of the invention.Type: ApplicationFiled: February 18, 2009Publication date: August 20, 2009Applicant: SUCAMPO AGInventors: Ryuji Ueno, Sachiko Kuno
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Publication number: 20080207759Abstract: The present invention relates to a method for protecting mitochondria from damage in a mammalian subject, which comprises administering an effective amount of a prostaglandin compound to a subject in need thereof. Also provided is a method for treating mitochondrial dysfunction as well as a condition associated with mitochondrial dysfunction in a mammalian subject, which comprises administering an effective amount of a prostaglandin compound to a subject in need thereof.Type: ApplicationFiled: February 26, 2008Publication date: August 28, 2008Applicant: SUCAMPO AGInventors: Ryuji UENO, Sachiko Kuno, John Cuppoletti
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Publication number: 20070203228Abstract: The present invention relates to a method for treating chronic obstructive pulmonary disease in a mammalian subject, which comprises administering an effective amount of a specific bicyclic compound of formula (I): and/or a tautomer thereof to a subject in need thereof.Type: ApplicationFiled: February 27, 2007Publication date: August 30, 2007Inventors: Ryuji Ueno, Sachiko Kuno
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Publication number: 20060281818Abstract: Provided is a method for treating mucosal disorders using a specific prostaglandin compound. The prostaglandin compound induces a conformational change in the tight junction that results in recovery of mucosal barrier function. Accordingly, the prostaglandin compound used herein is useful for the treatment of mucosal disorders.Type: ApplicationFiled: March 21, 2006Publication date: December 14, 2006Inventors: Ryuji Ueno, Sachiko Kuno, Anthony Blikslager, Adam Moeser
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Publication number: 20040138308Abstract: Disclosed is a novel use of a chloride channel opener, especially a prostaglandin compound for the treatment of abdominal discomfort. Further disclosed is a novel use of a chloride channel opener, especially a prostaglandin compound for the treatment of functional gastrointestinal disorders.Type: ApplicationFiled: December 29, 2003Publication date: July 15, 2004Applicant: SUCAMPO AGInventors: Ryuji Ueno, Sachiko Kuno
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Publication number: 20040128220Abstract: The invention achieves certain advantages in pharmaceutical development over large multinational companies by forming a multilateral alliance of independent entities, each with their own geographical focus. In accordance with the invention, a method is provided whereby multiple entities, within the coverage of a common patent portfolio, undertake their own research and development in their own territory. Under a second feature of the invention, the entities may each utilize the information obtained by the others in order to advance their own development program.Type: ApplicationFiled: November 20, 2003Publication date: July 1, 2004Inventor: Sachiko Kuno
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Patent number: 5432174Abstract: A method for the treatment of ocular hypertension which comprises administering, to a subject in need of such treatment,(a) a .beta.-adrenergic blocker at the enhancement phase of aqueous humor production, and(b) a prostanoic acid compound at the suppression phase of aqueous humor production, andin an amount effective in treatment of ocular hypertension.Type: GrantFiled: December 7, 1993Date of Patent: July 11, 1995Assignee: R-Tech Ueno, Ltd.Inventors: Ryuji Ueno, Sachiko Kuno
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Patent number: 5317032Abstract: The present invention relates to cathartics comprising 15-keto-16-halogen-PGs as an essential ingredient without substantive side-effects; the catharic effect is thought mainly caused by an enteropooling effect.Type: GrantFiled: December 30, 1992Date of Patent: May 31, 1994Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo KenkyujoInventors: Ryuzo Ueno, Ryuji Ueno, Sachiko Kuno, Tomio Oda
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Patent number: 5100879Abstract: A method of disinfection for retroviruses which comprises contacting inanimate object in need of such treatment with a natural or synthetic oligo- or polysaccharide having at least one S-oxoacid group attached to the saccharic carbon atom through a linking group of low molecular weight.Type: GrantFiled: August 24, 1989Date of Patent: March 31, 1992Assignee: K.K. Ueno Seiyaku Oyo KenkyujoInventors: Ryuzo Ueno, Ryuji Ueno, Sachiko Kuno, Akihiko Tabata
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Patent number: 5026692Abstract: Method of treatment of immunodeficiency disease which comprises administering therapeutically effective amount of sex hormone to a subject in need of such treatment.Type: GrantFiled: June 5, 1989Date of Patent: June 25, 1991Assignees: Research Development Corporation of Japan, Ueno Seiyaku KabushikikaishaInventors: Sachiko Kuno, Ryuji Ueno, Osamu Hayaishi
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Patent number: 4880742Abstract: A method of treatment of the diseases caused by AIDS virus which comprises administering an effective amount of prostaglandin biosynthesis inhibitor to a subject in need of such treatment.Type: GrantFiled: February 3, 1987Date of Patent: November 14, 1989Assignees: Research Development Corporation of Japan, Ueno Seiyaku KabushikikaishaInventors: Osamu Hayaishi, Ryuji Ueno, Sachiko Kuno
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Patent number: 4840941Abstract: Method of treatment of diseases caused by retroviruses which comprises administering therapeutically effective amount of a natural or synthetic oligo- or polysaccharide having at least one S-oxoacid group attached to the saccharic carbon atom through a linking group of lower molecular weight or a pharmaceutically acceptable salt thereof to a subject in need of such treatment.Type: GrantFiled: January 15, 1988Date of Patent: June 20, 1989Assignee: Kabushiki Kaisha Ueno Seiyaku Oyo KenkyujoInventors: Ryuzo Ueno, Ryuji Ueno, Sachiko Kuno, Akihiko Tabata