Patents by Inventor Sadato Hongo

Sadato Hongo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200086323
    Abstract: According to one embodiment, an apparatus for maintaining a liquid membrane includes a liquid supply mechanism which supplies a liquid to the liquid membrane for wetting a biological substance and a liquid discharge mechanism which discharges the liquid in the liquid membrane.
    Type: Application
    Filed: March 11, 2019
    Publication date: March 19, 2020
    Applicant: KABUSHIKI KAISHA TOSHIBA
    Inventors: Sadato HONGO, Atsunobu Isobayashi, Yoshiaki Sugizaki, Kei Matsuoka
  • Publication number: 20200080977
    Abstract: A chemical sensor for detecting a target substance in a gas sample, including a membrane; and an olfactory receptor fragment which is fixed to the membrane. The chemical sensor optionally includes a source electrode connected to one end of the membrane; and a drain electrode connected to the other end of the membrane, in which the membrane is a graphene.
    Type: Application
    Filed: March 13, 2019
    Publication date: March 12, 2020
    Applicant: KABUSHIKI KAISHA TOSHIBA
    Inventors: Atsunobu Isobayashi, Yoshiaki Sugizaki, Sadato Hongo
  • Publication number: 20190064157
    Abstract: According to one embodiment, a detection device is disclosed. The detection device includes a first region, a first electrode on the first region, a second region, a second electrode on the second region, a partition partitioning the first region and the second region and including a through hole, thereby communicating the first region with the second region. The device further includes a probe which binds specifically to the detection target, and is detachably connected to the first electrode, a detacher to detach the probe from the first electrode, a determination unit to determine whether the first liquid contains a detection target based on a change of electrical condition between the first electrode and the second electrode in a state where the first region and the second region are supplied with the first liquid and the second liquid, respectively.
    Type: Application
    Filed: February 28, 2018
    Publication date: February 28, 2019
    Applicant: KABUSHIKI KAISHA TOSHIBA
    Inventors: Takuya MIYAGAWA, Sadato HONGO, Hiroko MIKI, Hiroshi HAMASAKI, Kentaro KOBAYASHI, Ping WANG, Naofumi NAKAMURA
  • Patent number: 9804116
    Abstract: According to one embodiment, a method for detecting a sample includes preparing a device for detecting a sample, the device including a measurement cassette, a first chamber formed by partitioning the cassette with a partition wall, a through-hole provided in the partition wall, a first electrode provided in the cassette, and a second electrode provided in the cassette, introducing a reagent and a sample containing a measuring object substance into the first chamber, introducing a conductive liquid into the second chamber, supplying current to the through-hole, allowing the measuring object substance whose surface is bound to and is covered by the tag particles via the capture substance in the first chamber to pass through the through-hole, and detecting presence of the measuring object substance.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: October 31, 2017
    Assignee: KABUSHIKI KAISHA TOSHIBA
    Inventors: Sadato Hongo, Hirohisa Miyamoto
  • Patent number: 9726636
    Abstract: According to one embodiment, provided is a single particle analyzing device including a measuring vessel, first and second chambers in the vessel defined by an insulating membrane, a pore opening in the membrane to connect the chambers, and first and second electrodes in the chambers. Electric current flows between the electrodes through the pore. Electrical characteristics are measured during migration of the target from the first chamber to the second chamber to measure the size and shape of the target. (a) t<a <d?100a or (b) s<L, s<d?100s, t<L and t<d, wherein a, L and s are the diameter, length and width of the target, d is the diameter of the pore, and t is the thickness of the membrane in the proximity to the pore.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: August 8, 2017
    Assignees: KABUSHIKI KAISHA TOSHIBA, OSAKA UNIVERSITY
    Inventors: Sadato Hongo, Tomoji Kawai, Makusu Tsutsui, Masateru Taniguchi, Soh Ryuzaki
  • Publication number: 20160187335
    Abstract: According to one embodiment, a method for detecting a sample includes preparing a device for detecting a sample, the device including a measurement cassette, a first chamber formed by partitioning the cassette with a partition wall, a through-hole provided in the partition wall, a first electrode provided in the cassette, and a second electrode provided in the cassette, introducing a reagent and a sample containing a measuring object substance into the first chamber, introducing a conductive liquid into the second chamber, supplying current to the through-hole, allowing the measuring object substance whose surface is bound to and is covered by the tag particles via the capture substance in the first chamber to pass through the through-hole, and detecting presence of the measuring object substance.
    Type: Application
    Filed: December 4, 2015
    Publication date: June 30, 2016
    Applicant: Kabushiki Kaisha Toshiba
    Inventors: Sadato HONGO, Hirohisa MIYAMOTO
  • Patent number: 9316576
    Abstract: According to one embodiment, a sample detection apparatus including an insulating partition to divide a first and a second region, a pore formed in the partition, a first electrode arranged in the first region, a second electrode arranged in the second region, a power source configured to apply electrical current between the first and second electrode in a state in which a reagent containing a capture substance to be bound to a target and a tag particle bound to the capture substance is introduced into the first region together with a sample, and an electrolyte solution is introduced into the second region, a measurement unit configured to observe a change in a conductive state, and a detection unit to detect presence/absence of the target in the sample based on an observation result.
    Type: Grant
    Filed: August 27, 2013
    Date of Patent: April 19, 2016
    Assignee: KABUSHIKI KAISHA TOSHIBA
    Inventors: Sadato Hongo, Kentaro Kobayashi, Hideto Furuyama
  • Publication number: 20140374255
    Abstract: According to one embodiment, provided is a single particle analyzing device including a measuring vessel, first and second chambers in the vessel defined by an insulating membrane, a pore opening in the membrane to connect the chambers, and first and second electrodes in the chambers. Electric current flows between the electrodes through the pore. Electrical characteristics are measured during migration of the target from the first chamber to the second chamber to measure the size and shape of the target. (a) t<a <d?100a or (b) s<L, s<d?100s, t<L and t<d, wherein a, L and s are the diameter, length and width of the target, d is the diameter of the pore, and t is the thickness of the membrane in the proximity to the pore.
    Type: Application
    Filed: September 12, 2014
    Publication date: December 25, 2014
    Applicants: KABUSHIKI KAISHA TOSHIBA, OSAKA UNIVERSITY
    Inventors: Sadato HONGO, Tomoji KAWAI, Makusu TSUTSUI, Masateru TANIGUCHI, Soh RYUZAKI
  • Publication number: 20140255911
    Abstract: According to one embodiment, a sample detection apparatus including an insulating partition to divide a first and a second region, a pore formed in the partition, a first electrode arranged in the first region, a second electrode arranged in the second region, a power source configured to apply electrical current between the first and second electrode in a state in which a reagent containing a capture substance to be bound to a target and a tag particle bound to the capture substance is introduced into the first region together with a sample, and an electrolyte solution is introduced into the second region, a measurement unit configured to observe a change in a conductive state, and a detection unit to detect presence/absence of the target in the sample based on an observation result.
    Type: Application
    Filed: August 27, 2013
    Publication date: September 11, 2014
    Applicant: KABUSHIKI KAISHA TOSHIBA
    Inventors: Sadato HONGO, Kentaro KOBAYASHI, Hideto FURUYAMA
  • Patent number: 8150635
    Abstract: A method for determining nucleotide sequence encompasses: injecting a solution containing a sample DNA into a chip cartridge provided with a detecting electrode, to which a probe DNA is immobilized; introducing an intercalator solution in the chip cartridge; obtaining a current-voltage characteristic curve by measuring a current in the solution due to an electrochemical reaction of the intercalator through the detecting electrode; obtaining a baseline by linearly approximating the current-voltage characteristic curve; obtaining a net current value by subtracting, from a peak current value of the current-voltage characteristic curve, a baseline current value obtained from the baseline at a peak voltage value defining the peak current value; and identifying a nucleotide sequence in the sample DNA, using the net current value.
    Type: Grant
    Filed: November 18, 2010
    Date of Patent: April 3, 2012
    Assignee: Kabushiki Kaisha Toshiba
    Inventors: Sadato Hongo, Shinji Yanaga
  • Publication number: 20110127171
    Abstract: A method for determining nucleotide sequence encompasses: injecting a solution containing a sample DNA into a chip cartridge provided with a detecting electrode, to which a probe DNA is immobilized; introducing an intercalator solution in the chip cartridge; obtaining a current-voltage characteristic curve by measuring a current in the solution due to an electrochemical reaction of the intercalator through the detecting electrode; obtaining a baseline by linearly approximating the current-voltage characteristic curve; obtaining a net current value by subtracting, from a peak current value of the current-voltage characteristic curve, a baseline current value obtained from the baseline at a peak voltage value defining the peak current value; and identifying a nucleotide sequence in the sample DNA, using the net current value.
    Type: Application
    Filed: November 18, 2010
    Publication date: June 2, 2011
    Applicant: KABUSHIKI KAISHA TOSHIBA
    Inventors: Sadato HONGO, Shinji YANAGA
  • Patent number: 7851206
    Abstract: A nucleic acid detection device includes a flow channel through which a solution containing a nucleic acid recognition body flows, probe electrodes having immobilized nucleic acid probes, and a counter electrode used to measure an electrochemical response of the nucleic acid recognition body. The flow channel includes a curved portion and a straight portion continued from and located downstream of the curved portion. The probe electrodes are arranged at intervals along the straight portion, avoiding an upstream end of the straight portion that is located within a distance L from the curved portion. The distance L is given by L=0.065×Re×D, Re=?uD/?, and D=4S/Lp where ?, u, and ? are a concentration, a flow velocity, and a viscosity of the solution, and S and Lp are a sectional area and a wall peripheral perimeter of the flow channel, respectively.
    Type: Grant
    Filed: March 6, 2007
    Date of Patent: December 14, 2010
    Assignee: Kabushiki Kaisha Toshiba
    Inventors: Jun Okada, Sadato Hongo, Nobuhiro Gemma
  • Publication number: 20100280758
    Abstract: A method for determining nucleotide sequence encompasses (a) injecting a solution containing a sample nucleic acid into a chip cartridge, (b) detecting first detection, second detection, and control signals through electrodes on the chip cartridge, (c) calculating a first difference between a mean value of the control signals and a mean value of the first detection signals, and dividing the first difference by the mean value of the control signals to define X, (c) calculating a second difference between the mean value of the control signals and a mean value of the second detection signals, and dividing the second difference by the mean value of the control signals to define Y, (d) calculating an angle between a positive X-axis and a vector from origin to a point (X, Y), and (d) comparing the angle with angle judgment criteria so as to identify a genotype of the sample nucleic acid.
    Type: Application
    Filed: September 26, 2008
    Publication date: November 4, 2010
    Applicant: KABUSHIKI KAISHA TOSHIBA
    Inventor: Sadato Hongo
  • Patent number: 7745203
    Abstract: A base sequence detection apparatus is provided with a channel formed on a base sequence detection chip. Working electrodes are formed along the channel and include a probe immobilized thereon, counter electrodes are formed on the inner surface of the channel and, reference electrodes are formed on the inner surface of the channel. An introduction port introduces solution or air from the upstream side of the channel, a delivery port delivers the solution or air in the channel, and the sample is injected into the channel through a sample injection port.
    Type: Grant
    Filed: January 31, 2005
    Date of Patent: June 29, 2010
    Assignee: Kabushiki Kaisha Toshiba
    Inventors: Sadato Hongo, Minoru Ishikawa, Takiji Ishimura, Shigeru Wakayama, Shinji Yanaga, Kenji Oki, Jun Okada
  • Publication number: 20100121490
    Abstract: A base sequence detection apparatus is provided with a channel formed on a base sequence detection chip. Working electrodes are formed along the channel and include a probe immobilized thereon, counter electrodes are formed on the inner surface of the channel and, reference electrodes are formed on the inner surface of the channel. An introduction port introduces solution or air from the upstream side of the channel, a delivery port delivers the solution or air in the channel, and the sample is injected into the channel through a sample injection port.
    Type: Application
    Filed: January 19, 2010
    Publication date: May 13, 2010
    Inventors: Sadato HONGO, Minoru ISHIKAWA, Takiji ISHIMURA, Shigeru WAKAYAMA, Shinji YANAGA, Kenji OKI, Jun OKADA
  • Publication number: 20100032319
    Abstract: A diagnostic cassette for diagnosing an electrochemical measuring apparatus is disclosed. The electrochemical measuring apparatus is to perform electrochemical measurement on a sample in a sample cassette, which is attachable to and detachable from the electrochemical measuring apparatus, and includes a first working electrode interface, a first counter electrode interface, and a first reference electrode interface.
    Type: Application
    Filed: March 23, 2009
    Publication date: February 11, 2010
    Inventors: Jun Okada, Nobuhiro Gemma, Sadato Hongo, Tetsuya Kuwabara
  • Patent number: 7482153
    Abstract: A nucleic acid detection cassette includes a cassette body, a nucleic acid detection region disposed in the cassette body, a first channel disposed in the cassette body, a second channel disposed in the cassette body. The nucleic acid detection region, in which a nucleic acid probe is immobilized, has a reagent inflow port, to which the first channel is connected, and a reagent outflow port, to which the second channel is connected. The nucleic acid detection cassette further includes a reagent injection portion which injects a reagent into the first channel, and a nucleic acid pretreatment region which is disposed in the first channel and which performs pretreatment for the detection of a nucleic acid. The first channel, the second channel, the nucleic acid detection region, the nucleic acid pretreatment region, and the reagent injection portion are sealed.
    Type: Grant
    Filed: March 21, 2006
    Date of Patent: January 27, 2009
    Assignee: Kabushiki Kaisha Toshiba
    Inventors: Jun Okada, Sadato Hongo, Kenji Ooki
  • Publication number: 20090023201
    Abstract: In a nucleic acid detecting cassette in which a heating treatment chamber and a liquid delivery channel are constituted of a stationary member and flexible members, the heating treatment chamber is held by convex heating sections from both sides, whereby the heat treatment chamber and the liquid delivery channel are spatially separated from each other. Thus, it is possible to automatically execute a consistent process including nucleic acid amplification and other required treatments of the object sample as well as detection of a target nucleic acid.
    Type: Application
    Filed: July 18, 2008
    Publication date: January 22, 2009
    Inventors: Sadato Hongo, Takahiro Kokubo, Hideki Horiuchi, Koji Hashimoto, Jun Okada
  • Publication number: 20080233634
    Abstract: A nucleic acid detection device is provided with a closed channel formed of a first channel portion, through which a washing reagent storage section for storing a washing reagent for washing a detection section for nucleic acid detection communicates with the detection section, and a second channel portion through which a pretreatment section for nucleic acid treatment communicates with the detection section. The closed channel is connected with a gas inlet/outlet path for communication with the outside. The gas inlet/outlet path is blocked by a sealing mechanism before nucleic acid detection. In storing a pretreatment reagent and the washing reagent frozen, the gas inlet/outlet path is kept open and connected to the channel. Thus, there is provided a nucleic acid detection device having a structure for preventing leakage of nucleic acid samples to the outside and which can be stored for a long period of time with the reagents therein.
    Type: Application
    Filed: March 14, 2008
    Publication date: September 25, 2008
    Inventors: Jun OKADA, Sadato Hongo, Keiko Ito, Kenji Ooki, Nobuhiro Gemma
  • Publication number: 20080153714
    Abstract: A nucleic acid cassette includes a main body in which first and second channels are formed. A sample containing a target nucleic acid is input in a sample chamber of the second channel via an injection port. In the cassette, a detecting part includes a detection chamber communicated to the first and second channels and a nucleic detection unit. The first channel has a first reagent reservoir storing a first reagent and a second reagent reservoir storing a second reagent. The first and second reagents reservoirs are separated by a gaseous body in the channel. The sample and the first and second reagents are supplied to the detecting part due to an action of a pump part communicated to the first and second channels.
    Type: Application
    Filed: August 31, 2007
    Publication date: June 26, 2008
    Inventors: Sadato HONGO, Jun Okada, Kenji Ooki, Nobuhiro Gemma