Patents by Inventor Saeed IZADI

Saeed IZADI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220208309
    Abstract: The present disclosure relates to polypeptide therapeutics, and in particular to techniques for predicting side-chain degradation in polymers through physics based simulations. Particularly, aspects of the present disclosure are directed to generating a representation of a polymer having one or more side chains, performing a molecular-dynamics simulation using the representation to obtain a set of polymer conformations, determining, for each polymer conformation, one or more spatial characteristics of the polymer while in the polymer conformation, identifying, based on the one or more spatial characteristics, an incomplete subset of the set of polymer conformations estimated to undergo one or more reactions of a particular type, and estimating, based on a size of the incomplete subset, a probability of a reaction in which the polymer is a reactant and a particular other molecule is a product.
    Type: Application
    Filed: January 28, 2022
    Publication date: June 30, 2022
    Applicant: Genentech, Inc.
    Inventors: Saeed Izadi, Flaviyan Jerome Irudayanathan
  • Publication number: 20220148676
    Abstract: The present disclosure relates to polypeptide therapeutics, and in particular to techniques for prediction of polypeptide properties that may make for suitable polypeptide therapeutics using a model representative of electrostatics of a polypeptide. Particularly, aspects of the present disclosure are directed to ascertaining molecular multipole moments of an antibody molecule, creating a model of the antibody molecule by selecting sites within a representation of the antibody molecule, calculating a charge for each of the sites, where a combination of calculated charges for the sites approximates the molecular multipole moments of the antibody molecule, and simulating interactions of molecules in a solution. At least one molecule of the molecules in the solution is an instance of the model of the antibody molecule and the interactions are simulated based on the charges calculated for each of the sites within the representation of the antibody molecule.
    Type: Application
    Filed: January 28, 2022
    Publication date: May 12, 2022
    Applicant: GENENTECH, INC.
    Inventors: Saeed IZADI, Thomas W. PATAPOFF, Benjamin T. WALTERS