Patents by Inventor Salvador Puig Torres

Salvador Puig Torres has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7807827
    Abstract: The invention relates to a procedure for preparing quetiapine by reaction between a compound of formula (II) and a compound of formula (III), in which X means a leaving group and P a protective group of alcohols resistant to alkaline conditions, in the presence of a base, followed by a step of deprotection and, optionally, obtaining a pharmaceutically acceptable salt thereof. Said procedure permits the obtaining of quetiapine with a high degree of purity under soft temperature conditions, with short reaction times and avoiding the use of toxic solvents.
    Type: Grant
    Filed: July 27, 2004
    Date of Patent: October 5, 2010
    Assignee: Inke, S.A.
    Inventors: Salvador Puig Torres, Reyes Herbera Espinal, Pere Dalmases Barjoan
  • Publication number: 20100029938
    Abstract: It comprises a process for the preparation of levofloxacin based on a cyclisation reaction of a compound of formula (IV), which has the alcohol group protected, followed by a deprotection reaction and the conversion of the compound obtained to levofloxacin by a process comprising a hydrolysis reaction and a second cyclisation reaction. It also comprises new intermediates compounds.
    Type: Application
    Filed: December 22, 2007
    Publication date: February 4, 2010
    Applicant: FARMAPROJECTS, S. A.
    Inventors: Salvador Puig Torres, Jordi Bessa Bellmunt
  • Patent number: 7071209
    Abstract: The invention relates to a process for preparing granisetron, or a pharmaceutically acceptable salt thereof, which comprises: a) cyclisation of a compound of formula (I) in an inert solvent and at a temperature between 0–100° C., in the presence of a strong acid, in order to yield the compound of formula (II); b) methylation of the compound of formula (II), with an alkylating agent, in the presence of a base, in an inert solvent and at a temperature between 0° C.–160° C., and with optional formation of a pharmaceutically acceptable salt. The process of the invention yields a granisetron of high purity, preventing impurities due to demethylation, by carrying out the methylation after rather than before cyclisation and with a higher yield.
    Type: Grant
    Filed: March 21, 2003
    Date of Patent: July 4, 2006
    Assignee: Laboratorios Vita, S.A.
    Inventors: Salvador Puig Torres, Pere Dalmases Barjoan
  • Publication number: 20050124650
    Abstract: The invention relates to a process for preparing granisetron, or a pharmaceutically acceptable salt thereof, which comprises: a) cyclisation of a compound of formula (I) in an inert solvent and at a temperature between 0-100° C., in the presence of a strong acid, in order to yield the compound of formula (II); b) methylation of the compound of formula (II), with an alkylating agent, in the presence of a base, in an inert solvent and at a temperature between 0° C.-160° C., and with optional formation of a pharmaceutically acceptable salt. The process of the invention yields a granisetron of high purity, preventing impurities due to demethylation, by carrying out the methylation after rather than before cyclisation and with a higher yield.
    Type: Application
    Filed: March 21, 2003
    Publication date: June 9, 2005
    Inventors: Salvador Puig Torres, Pere Dalmases Barjoan
  • Patent number: 6617457
    Abstract: The process for obtaining quinapril hydrochloride (I) comprises the stages of: a) hydrogenolysis of the benzyl ester of quinapril (II) by treatment in an alcoholic solvent, with concentrated hydrochloric acid or a solution of hydrogen chloride in isopropanol, and hydrogenation; b) removal of the solvent; c) addition of toluene to precipitate the quinapril hydrochloride as a toluene solvate; d) treatment of said solvate with a Class 3 solvent which forms a solvate of quinapril hydrochloride from which it can be removed by drying without degrading; and e) drying of the solvate from step d) to yield quinapril hydrochloride (I), an antihypertensive agent.
    Type: Grant
    Filed: June 17, 2002
    Date of Patent: September 9, 2003
    Assignee: Esteve Quimica, S.A.
    Inventors: Montserrat Monsalvatje Llagostera, Marti Bartra Sanmarti, Jaime Tomas Navarro, Salvador Puig Torres
  • Patent number: 5872125
    Abstract: It comprises the new polymorphs I and II of Lesopitron dihydrochloride, characterized by their infrared spectra and their X-ray diffraction patterns. They are obtained by crystallization of Lesopitron dihydrochloride. It also comprises the forms I-hydrate and II-hydrate, which are obtained from the corresponding polymorphs, which have a water content from 3 to 6% and from 1.5 to 2.5%, respectively. These products are used in human medicine mainly due to their pharmacological activity over the central nervous system.
    Type: Grant
    Filed: January 21, 1997
    Date of Patent: February 16, 1999
    Assignee: Laboratorios Del Dr. Esteve, S.A.
    Inventors: Pilar Lupon-Roses, Jaime Tomas-Navarro, Salvador Puig-Torres, Jordi Frigola-Constansa
  • Patent number: RE39888
    Abstract: The process for obtaining quinapril hydrochloride (I) comprises the stages of: a) hydrogenolysis of the benzyl ester of quinapril (II) by treatment in an alcoholic solvent, with concentrated hydrochloric acid or a solution of hydrogen chloride in isopropanol, and hydrogenation; b) removal of the solvent; c) addition of toluene to precipitate the quinapril hydrochloride as a toluene solvate; d) treatment of said solvate with a Class 3 solvent which forms a solvate of quinapril hydrochloride from which it can be removed by drying without degrading; and e) drying of the solvate from step d) to yield quinapril hydrochloride (I), an antihypertensive agent.
    Type: Grant
    Filed: May 25, 1998
    Date of Patent: October 16, 2007
    Assignee: Esteve Quimica, S.A.
    Inventors: Montserrant Monsalvatje Llagostera, Marti Bartra Sanmarti, Jaime Thomas Navarro, Salvador Puig Torres