Patents by Inventor Samantha Byrnes
Samantha Byrnes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230149932Abstract: An embodiment of a system includes a compartment-generating device, a compartment detector, and electronic computing circuitry. The device is configured to generate compartments of a digital assay, at least one of the compartments having a respective volume that is different from a respective volume of each of at least another one of the compartments. The detector is configured to determine a number of the compartments each having a respective number of a target that is greater than a threshold number of the target. And the electronic circuitry is configured to determine a bulk concentration of the target in a source of the sample in response to the determined number of compartments. Because such a system can be configured to estimate a bulk concentration of a target in a source from a polydisperse digital assay, the system can be portable, and lower-cost and faster, than conventional systems.Type: ApplicationFiled: January 6, 2023Publication date: May 18, 2023Applicant: Tokitae LLCInventors: Toan Huynh, Bernhard Hans Weigl, Samantha A. Byrnes, Kevin Paul Flood Nichols
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Publication number: 20230062787Abstract: Described herein are systems and methods for multiplexed analysis of two or more targets in a test sample including a first set of particles including a first set of target-specific reagents and a first optically detectable identifier capable of emitting a first wavelength indicative of a first target, and at least one second set of particles including a second set of target-specific reagents and a second optically detectable identifier capable of emitting a second wavelength indicative of a second target; and at least one optically detectable reporter probe capable of constitutively emitting a third wavelength in response to reaction of the first set of target-specific reagents with the first target in the test sample and/or reaction of the second set of target-specific reagents with the second target in the test sample, wherein the first wavelength, the second wavelength, and the third wavelength are optically discernable from one another.Type: ApplicationFiled: October 21, 2022Publication date: March 2, 2023Applicant: TOKITAE LLCInventors: Samantha A. Byrnes, Kevin Paul Flood Nichols, Bernhard Hans Weigl
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Patent number: 11577247Abstract: An embodiment of a system includes a compartment-generating device, a compartment detector, and electronic computing circuitry. The device is configured to generate compartments of a digital assay, at least one of the compartments having a respective volume that is different from a respective volume of each of at least another one of the compartments. The detector is configured to determine a number of the compartments each having a respective number of a target that is greater than a threshold number of the target. And the electronic circuitry is configured to determine a bulk concentration of the target in a source of the sample in response to the determined number of compartments. Because such a system can be configured to estimate a bulk concentration of a target in a source from a polydisperse digital assay, the system can be portable, and lower-cost and faster, than conventional systems.Type: GrantFiled: March 8, 2022Date of Patent: February 14, 2023Assignee: Tokitae LLCInventors: Toan Huynh, Bernhard Hans Weigl, Samantha A. Byrnes, Kevin Paul Flood Nichols
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Patent number: 11512356Abstract: Described herein are systems and methods for multiplexed analysis of two or more targets in a test sample including a first set of particles including a first set of target-specific reagents and a first optically detectable identifier capable of emitting a first wavelength indicative of a first target, and at least one second set of particles including a second set of target-specific reagents and a second optically detectable identifier capable of emitting a second wavelength indicative of a second target; and at least one optically detectable reporter probe capable of constitutively emitting a third wavelength in response to reaction of the first set of target-specific reagents with the first target in the test sample and/or reaction of the second set of target-specific reagents with the second target in the test sample, wherein the first wavelength, the second wavelength, and the third wavelength are optically discernable from one another.Type: GrantFiled: November 8, 2018Date of Patent: November 29, 2022Assignee: Tokitae LLCInventors: Samantha A. Byrnes, Kevin Paul Flood Nichols, Bernhard Hans Weigl
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Publication number: 20220193661Abstract: An embodiment of a system includes a compartment-generating device, a compartment detector, and electronic computing circuitry. The device is configured to generate compartments of a digital assay, at least one of the compartments having a respective volume that is different from a respective volume of each of at least another one of the compartments. The detector is configured to determine a number of the compartments each having a respective number of a target that is greater than a threshold number of the target. And the electronic circuitry is configured to determine a bulk concentration of the target in a source of the sample in response to the determined number of compartments. Because such a system can be configured to estimate a bulk concentration of a target in a source from a polydisperse digital assay, the system can be portable, and lower-cost and faster, than conventional systems.Type: ApplicationFiled: March 8, 2022Publication date: June 23, 2022Applicant: Tokitae LLCInventors: Toan Huynh, Bernhard Hans Weigl, Samantha A. Byrnes, Kevin Paul Flood Nichols
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Patent number: 11305284Abstract: An embodiment of a system includes a compartment-generating device, a compartment detector, and electronic computing circuitry. The device is configured to generate compartments of a digital assay, at least one of the compartments having a respective volume that is different from a respective volume of each of at least another one of the compartments. The detector is configured to determine a number of the compartments each having a respective number of a target that is greater than a threshold number of the target. And the electronic circuitry is configured to determine a bulk concentration of the target in a source of the sample in response to the determined number of compartments. Because such a system can be configured to estimate a bulk concentration of a target in a source from a polydisperse digital assay, the system can be portable, and lower-cost and faster, than conventional systems.Type: GrantFiled: November 26, 2018Date of Patent: April 19, 2022Assignee: Tokitae, LLCInventors: Toan Huynh, Bernhard Hans Weigl, Samantha A. Byrnes, Kevin Paul Flood Nichols
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Publication number: 20210349087Abstract: The present technology generally relates to stopped-flow microfluidic devices. Select embodiments of the present technology include microfluidic devices having a first porous element configured to receive a first fluid and a second porous element configured to receive a second fluid. The second porous element can have one or more legs overlapping with the first porous element. The device can be configured such that (a) delivery of the first fluid to the first porous element causes the first fluid to flow along the length of the first porous element without substantially wetting the one or more legs, and (b) delivery of the second fluid to the second porous element causes the second fluid to flow into the overlapping regions of the first porous element, thereby substantially stopping flow of the first fluid along at least a portion of the first porous element.Type: ApplicationFiled: October 1, 2019Publication date: November 11, 2021Applicant: University of WashingtonInventors: Joshua BUSER, Joshua BISHOP, Dylan GUELIG, Arielle HOWELL, Sujatha KUMAR, Paul YAGER, Koji ABE, Erin HEINIGER, Samantha BYRNES, Caitlin ANDERSON, Peter C. KAUFFMAN, Maxwell WHEELER
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Patent number: 11098346Abstract: The present technology is directed to capillarity-based devices for performing chemical processes and associated system and methods. In one embodiment, for example, a device can include a porous receiving element having an input region and a receiving region, a first fluid source and a second fluid source positioned within the input region of the receiving element; wherein the first fluid source is positioned between the second fluid source and the receiving region, and wherein, when both the first and second fluid sources are in fluid connection with the input region, the device is configured to sequentially deliver the first fluid and the second fluid to the receiving region without leakage.Type: GrantFiled: August 9, 2018Date of Patent: August 24, 2021Assignee: University of WashingtonInventors: Joshua Bishop, Joshua Buser, Samantha Byrnes, Shivani Dharmaraja, Elain S. Fu, Jared Houghtaling, Peter C. Kauffman, Sujatha Kumar, Lisa Lafleur, Tinny Liang, Barry Lutz, Bhushan Toley, Maxwell Wheeler, Paul Yager, Xiaohong Zhang
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Publication number: 20200164364Abstract: An embodiment of a system includes a compartment-generating device, a compartment detector, and electronic computing circuitry. The device is configured to generate compartments of a digital assay, at least one of the compartments having a respective volume that is different from a respective volume of each of at least another one of the compartments. The detector is configured to determine a number of the compartments each having a respective number of a target that is greater than a threshold number of the target. And the electronic circuitry is configured to determine a bulk concentration of the target in a source of the sample in response to the determined number of compartments. Because such a system can be configured to estimate a bulk concentration of a target in a source from a polydisperse digital assay, the system can be portable, and lower-cost and faster, than conventional systems.Type: ApplicationFiled: November 26, 2018Publication date: May 28, 2020Applicant: Tokitae LLCInventors: Toan Huynh, Bernhard Hans Weigl, Samantha A. Byrnes, Kevin Paul Flood Nichols
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Publication number: 20200149092Abstract: Described herein are systems and methods for multiplexed analysis of two or more targets in a test sample including a first set of particles including a first set of target-specific reagents and a first optically detectable identifier capable of emitting a first wavelength indicative of a first target, and at least one second set of particles including a second set of target-specific reagents and a second optically detectable identifier capable of emitting a second wavelength indicative of a second target; and at least one optically detectable reporter probe capable of constitutively emitting a third wavelength in response to reaction of the first set of target-specific reagents with the first target in the test sample and/or reaction of the second set of target-specific reagents with the second target in the test sample, wherein the first wavelength, the second wavelength, and the third wavelength are optically discernable from one another.Type: ApplicationFiled: November 8, 2018Publication date: May 14, 2020Inventors: Samantha A. Byrnes, Kevin Paul Flood Nichols, Bernhard Hans Weigl
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Publication number: 20190134637Abstract: The present technology is directed to capillarity-based devices for performing chemical processes and associated system and methods. In one embodiment, for example, a device can include a porous receiving element having an input region and a receiving region, a first fluid source and a second fluid source positioned within the input region of the receiving element; wherein the first fluid source is positioned between the second fluid source and the receiving region, and wherein, when both the first and second fluid sources are in fluid connection with the input region, the device is configured to sequentially deliver the first fluid and the second fluid to the receiving region without leakage.Type: ApplicationFiled: August 9, 2018Publication date: May 9, 2019Inventors: Joshua Bishop, Joshua Buser, Samantha Byrnes, Shivani Dharmaraja, Elain S. Fu, Jared Houghtaling, Peter C. Kauffman, Sujatha Kumar, Lisa Lafleur, Tinny Liang, Barry Lutz, Bhushan Toley, Maxwell Wheeler, Paul Yager, Xiaohong Zhang
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Publication number: 20160310942Abstract: The present technology is directed to capillarity-based devices for performing chemical processes and associated system and methods. In one embodiment, for example, a device can include a first porous element having a first pore size and configured to receive a fluid at its proximal portion, and a second porous element having a second pore size greater than the first pore size and configured to receive a fluid at its proximal portion. The first porous element can be positioned across the second porous element such that an overlapping region exists between the porous elements where the porous elements are in fluid communication. Before delivery of the fluid to the second porous element, the fluid pressure at the overlapping region is greater than the capillary pressure of the second porous element such that a fluid delivered to the first porous element wicks through its overlapping portion without wetting the second porous element.Type: ApplicationFiled: April 21, 2016Publication date: October 27, 2016Inventors: Paul Yager, Joshua Buser, Samantha Byrnes, Erin K. Heiniger, Peter C. Kauffman, Paula Ladd
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Publication number: 20150361487Abstract: The present technology is directed to capillarity-based devices for performing chemical processes and associated system and methods. In one embodiment, for example, a device can include a porous receiving element having an input region and a receiving region, a first fluid source and a second fluid source positioned within the input region of the receiving element; wherein the first fluid source is positioned between the second fluid source and the receiving region, and wherein, when both the first and second fluid sources are in fluid connection with the input region, the device is configured to sequentially deliver the first fluid and the second fluid to the receiving region without leakage.Type: ApplicationFiled: January 22, 2014Publication date: December 17, 2015Inventors: Joshua Bishop, Joshua Buser, Samantha Byrnes, Shivani Dharmaraja, Elain S. Fu, Jared Houghtaling, Peter C. Kauffman, Sujatha Kumar, Lisa Lafleur, Tinny Liang, Barry Lutz, Bhushan Toley, Maxwell Wheeler, Paul Yager, Xiaohong Zhang
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Publication number: 20150203806Abstract: The present technology relates generally to systems for disrupting biological samples and associated devices and methods. In some embodiments, system includes a vessel configured to receive the biological sample, a permanent magnet configured to be positioned within the vessel, an electromagnet configured to be positioned proximate the vessel, and a current source operably coupled to the electromagnet and configured to transmit an alternating current. In some embodiments, when the biological sample is placed within the vessel and the alternating current is transmitted to the electromagnet, the electromagnet produces an alternating magnetic field that causes the permanent magnet to rotate within the vessel, thereby lysing at least one of the cells of the biological sample.Type: ApplicationFiled: January 21, 2015Publication date: July 23, 2015Inventors: Paul Yager, Peter C. Kauffman, Joshua Buser, Samantha Byrnes, Alec K. Wollen, Erin Heiniger