Patents by Inventor Samantha Cooper

Samantha Cooper has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200270677
    Abstract: System, including methods, apparatus, and compositions, for performing amplification assays with an amplification reporter including a first oligomer and a second oligomer capable of base-pairing with one another below a melting temperature of the reporter. The reporter may have a detectable photoluminescence that is affected, such as reduced, by base-pairing of the first and second oligomers with one another. A target, such as a nucleic acid target sequence, may be amplified in at least one volume, such as a plurality of partitions, above the melting temperature, and photoluminescence of the reporter may be detected from the at least one volume below the melting temperature. A property of the target, such as a concentration of the target, may be determined based on the photoluminescence detected.
    Type: Application
    Filed: March 30, 2020
    Publication date: August 27, 2020
    Applicant: Bio-Rad Laboratories, Inc.
    Inventors: John F. REGAN, Dianna MAAR, Dawne N. SHELTON, Tina C. LEGLER, Samantha COOPER, Wei YANG, Eli A. HEFNER, Niels KLITGORD
  • Patent number: 10718008
    Abstract: Methods of detecting or quantifying short RNA or DNA molecules using split cycle amplification are provided.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: July 21, 2020
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Dianna Maar, Samantha Cooper, Wei Yang
  • Patent number: 10604789
    Abstract: System, including methods, apparatus, and compositions, for performing amplification assays with an amplification reporter including a first oligomer and a second oligomer capable of base-pairing with one another below a melting temperature of the reporter. The reporter may have a detectable photoluminescence that is affected, such as reduced, by base-pairing of the first and second oligomers with one another. A target, such as a nucleic acid target sequence, may be amplified in at least one volume, such as a plurality of partitions, above the melting temperature, and photoluminescence of the reporter may be detected from the at least one volume below the melting temperature. A property of the target, such as a concentration of the target, may be determined based on the photoluminescence detected.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: March 31, 2020
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: John F. Regan, Dianna Maar, Dawne N. Shelton, Tina C. Legler, Samantha Cooper, Wei Yang, Eli A. Hefner, Niels Klitgord
  • Publication number: 20190203274
    Abstract: Methods, compositions, and kits are provided for quantification of genome editing.
    Type: Application
    Filed: March 13, 2019
    Publication date: July 4, 2019
    Inventors: Jennifer BERMAN, Samantha COOPER, George KARLIN-NEUMANN, Yuichiro MIYAOKA, Bruce CONKLIN, Josh SHINOFF
  • Publication number: 20190161793
    Abstract: Methods of detecting or quantifying short RNA or DNA molecules using split cycle amplification are provided.
    Type: Application
    Filed: December 21, 2018
    Publication date: May 30, 2019
    Inventors: Dianna MAAR, Samantha COOPER, Wei YANG
  • Patent number: 10280451
    Abstract: Methods, compositions, and kits are provided for quantification of genome editing.
    Type: Grant
    Filed: January 8, 2016
    Date of Patent: May 7, 2019
    Assignees: Bio-Rad Laboratories, Inc., J. David Gladstone Institutes
    Inventors: Jennifer Berman, Samantha Cooper, George Karlin-Neumann, Yuichiro Miyaoka, Bruce Conklin, Josh Shinoff
  • Patent number: 10066256
    Abstract: Methods, compositions, and kits are provided for quantifying a number or frequency of double stranded breaks in the genome of a cell or in the genomes of a population of cells.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: September 4, 2018
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Yann Jouvenot, Nick Heredia, Viresh Patel, Samantha Cooper, Jen Berman, Eli Hefner
  • Patent number: 9868981
    Abstract: Methods and compositions for detecting an allelic form of a target. In an exemplary method, partitions may be created that collectively contain at least one first allelic form and a second allelic form of a target. Each partition may contain (i) a same probe capable of binding specifically to each of the first and second allelic forms of the target and (ii) a competitor configured to bind selectively to the second allelic form relative to the first allelic form and to block binding of the probe to the second allelic form. The first allelic form of the target may be amplified in the partitions. A signal may be detected from a label of the probe while the label is contained by the partitions. A number of partitions that are positive (or negative) for the at least one first allelic form may be determined based on the signal.
    Type: Grant
    Filed: June 13, 2016
    Date of Patent: January 16, 2018
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Samantha Cooper, Wei Yang, Jennifer Berman
  • Publication number: 20170166957
    Abstract: System, including methods, apparatus, and compositions, for performing amplification assays with an amplification reporter including a first oligomer and a second oligomer capable of base-pairing with one another below a melting temperature of the reporter. The reporter may have a detectable photoluminescence that is affected, such as reduced, by base-pairing of the first and second oligomers with one another. A target, such as a nucleic acid target sequence, may be amplified in at least one volume, such as a plurality of partitions, above the melting temperature, and photoluminescence of the reporter may be detected from the at least one volume below the melting temperature. A property of the target, such as a concentration of the target, may be determined based on the photoluminescence detected.
    Type: Application
    Filed: January 20, 2017
    Publication date: June 15, 2017
    Inventors: John F. Regan, Dianna Maar, Dawne N. Shelton, Tina C. Legler, Samantha Cooper, Wei Yang, Eli A. Hefner, Niels Klitgord
  • Patent number: 9556475
    Abstract: System, including methods, apparatus, and compositions, for performing amplification assays with an amplification reporter including a first oligomer and a second oligomer capable of base-pairing with one another below a melting temperature of the reporter. The reporter may have a detectable photoluminescence that is affected, such as reduced, by base-pairing of the first and second oligomers with one another. A target, such as a nucleic acid target sequence, may be amplified in at least one volume, such as a plurality of partitions, above the melting temperature, and photoluminescence of the reporter may be detected from the at least one volume below the melting temperature. A property of the target, such as a concentration of the target, may be determined based on the photoluminescence detected.
    Type: Grant
    Filed: August 12, 2014
    Date of Patent: January 31, 2017
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: John F. Regan, Dianna Maar, Dawne N. Shelton, Tina C. Legler, Samantha Cooper, Wei Yang, Eli A. Hefner, Niels Klitgord
  • Publication number: 20160362731
    Abstract: Methods and compositions for detecting an allelic form of a target. In an exemplary method, partitions may be created that collectively contain at least one first allelic form and a second allelic form of a target. Each partition may contain (i) a same probe capable of binding specifically to each of the first and second allelic forms of the target and (ii) a competitor configured to bind selectively to the second allelic form relative to the first allelic form and to block binding of the probe to the second allelic form. The first allelic form of the target may be amplified in the partitions. A signal may be detected from a label of the probe while the label is contained by the partitions. A number of partitions that are positive (or negative) for the at least one first allelic form may be determined based on the signal.
    Type: Application
    Filed: June 13, 2016
    Publication date: December 15, 2016
    Inventors: Samantha Cooper, Wei Yang, Jennifer Berman
  • Publication number: 20160273023
    Abstract: Methods, compositions, and kits are provided for quantifying a number or frequency of double stranded breaks in the genome of a cell or in the genomes of a population of cells.
    Type: Application
    Filed: March 17, 2016
    Publication date: September 22, 2016
    Inventors: Yann Jouvenot, Nick Heredia, Viresh Patel, Samantha Cooper, Jen Berman, Eli Hefner
  • Publication number: 20160265041
    Abstract: Methods of detecting or quantifying short RNA or DNA molecules using split cycle amplification are provided.
    Type: Application
    Filed: February 17, 2016
    Publication date: September 15, 2016
    Inventors: Dianna MAAR, Samantha COOPER, Wei YANG
  • Publication number: 20160208319
    Abstract: Methods, compositions, and kits are provided for quantification of genome editing.
    Type: Application
    Filed: January 8, 2016
    Publication date: July 21, 2016
    Inventors: Jennifer Berman, Samantha Cooper, George Karlin-Neumann, Yuichiro Miyaoka, Bruce Conklin, Josh Shinoff
  • Patent number: 9347095
    Abstract: Provided herein are methods, compositions, and kits for detecting alleles using a single probe or a single primer set. Also, provided herein are methods, compositions, and kits for detecting allelic variants using a single probe or a single primer set. Also, provided herein are methods, compositions, and kits for determining a polymerization error rate.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: May 24, 2016
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: John Regan, Samantha Cooper, Austin So, Ryan Koehler, Luz Montesclaros
  • Publication number: 20160060621
    Abstract: Methods, compositions, and kits are provided for nucleic acid analysis, including single cell analysis.
    Type: Application
    Filed: June 24, 2015
    Publication date: March 3, 2016
    Inventors: Jeremy Agresti, Samantha Cooper, George Karlin-Neumann, Nick Heredia, Ronald Lebofsky
  • Publication number: 20150148250
    Abstract: System, including methods, apparatus, and compositions, for performing amplification assays with an amplification reporter including a first oligomer and a second oligomer capable of base-pairing with one another below a melting temperature of the reporter. The reporter may have a detectable photoluminescence that is affected, such as reduced, by base-pairing of the first and second oligomers with one another. A target, such as a nucleic acid target sequence, may be amplified in at least one volume, such as a plurality of partitions, above the melting temperature, and photoluminescence of the reporter may be detected from the at least one volume below the melting temperature. A property of the target, such as a concentration of the target, may be determined based on the photoluminescence detected.
    Type: Application
    Filed: August 12, 2014
    Publication date: May 28, 2015
    Inventors: John F. Regan, Dianna Maar, Dawne N. Shelton, Tina C. Legler, Samantha Cooper, Wei Yang, Eli A. Hefner, Niels Klitgord
  • Publication number: 20140309128
    Abstract: Provided herein are methods, compositions, and kits for detecting alleles using a single probe or a single primer set. Also, provided herein are methods, compositions, and kits for detecting allelic variants using a single probe or a single primer set. Also, provided herein are methods, compositions, and kits for determining a polymerization error rate.
    Type: Application
    Filed: March 13, 2014
    Publication date: October 16, 2014
    Applicant: Bio-Rad Laboratories, Inc.
    Inventors: John Regan, Samantha Cooper, Austin So, Ryan Koehler, Luz Montesclaros