Patents by Inventor Samuel Nochumson

Samuel Nochumson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8802448
    Abstract: Substrates comprising a solid support, a ligand, and a linker comprising at least one C, O, N, or S atom covalently connecting the solid support to the ligand, are disclosed, along with methods of using and making the substrates, and devices including the substrates.
    Type: Grant
    Filed: July 23, 2012
    Date of Patent: August 12, 2014
    Assignee: Pall Corporation
    Inventors: Hassan Ait-Haddou, Frank Onyemauwa, Jonathan Haigh, Samuel Nochumson
  • Publication number: 20130030154
    Abstract: Substrates comprising a solid support, a ligand, and a linker comprising at least one C, O, N, or S atom covalently connecting the solid support to the ligand, are disclosed, along with methods of using and making the substrates, and devices including the substrates.
    Type: Application
    Filed: July 23, 2012
    Publication date: January 31, 2013
    Applicant: PALL CORPORATION
    Inventors: Hassan AIT-HADDOU, Frank ONYEMAUWA, Jonathan HAIGH, Samuel NOCHUMSON
  • Patent number: 8236495
    Abstract: A scalable alkaline lysis process, including procedures and devices for the isolation of large quantities (grams and kilograms) of plasmid DNA from recombinant E. coli cells. Effective, controllable, and economical operation, and consistent low level of host chromosomal DNA in the final plasmid product. Involves a series of new unit operations and devices for cell resuspension, cell lysis, and neutralization.
    Type: Grant
    Filed: January 9, 2006
    Date of Patent: August 7, 2012
    Inventors: Samuel Nochumson, Ross Durland, Audrey Yu-Speight, John Welp, Kuowei Wu, Rexford Hayes
  • Patent number: 7732216
    Abstract: Methods for testing the chromatography type and/or the integrity of a chromatography membrane or monolith, preferably, for testing the chromatography type and integrity of a chromatography device comprising a chromatography membrane or chromatography monolith while the membrane or monolith is sealed in a housing, are disclosed.
    Type: Grant
    Filed: November 17, 2006
    Date of Patent: June 8, 2010
    Assignee: Pall Corporation
    Inventors: Samuel Nochumson, Peter Levison
  • Publication number: 20080299672
    Abstract: Methods for testing the chromatography type and/or the integrity of a chromatography membrane or monolith, preferably, for testing the chromatography type and integrity of a chromatography device comprising a chromatography membrane or chromatography monolith while the membrane or monolith is sealed in a housing, are disclosed.
    Type: Application
    Filed: November 17, 2006
    Publication date: December 4, 2008
    Applicant: PALL CORPORATION
    Inventors: Samuel Nochumson, Peter Levison
  • Publication number: 20060106208
    Abstract: A scalable alkaline lysis process, including procedures and devices for the isolation of large quantities (grams and kilograms) of plasmid DNA from recombinant E. coli cells. Effective, controllable, and economical operation, and consistent low level of host chromosomal DNA in the final plasmid product. Involves a series of new unit operations and devices for cell resuspension, cell lysis, and neutralization.
    Type: Application
    Filed: January 9, 2006
    Publication date: May 18, 2006
    Applicant: Valentis, Inc
    Inventors: Samuel Nochumson, Ross Durland, Audrey Yu-Speight, John Welp, Kuoewi Wu, Rexford Hayes
  • Patent number: 7026468
    Abstract: A scalable alkaline lysis process, including procedures and devices for the isolation of large quantities (grams and kilograms) of plasmid DNA from recombinant E. coli cell. Effective, contgrollable, and economical operation, and consistent low level of host chromosomal DNA in the final plasmid product. Involves a series of new unit operations and devices for cell resuspension, cell lysis, and nuetralization.
    Type: Grant
    Filed: January 29, 2001
    Date of Patent: April 11, 2006
    Assignee: Valentis, Inc.
    Inventors: Samuel Nochumson, Ross Durland, Audrey Yu-Speight, John Welp, Kuoewi Wu, Rexford Hayes
  • Publication number: 20030211970
    Abstract: Disclosed is a method for processing a plasmid-containing fluid comprising contacting the plasmid-containing fluid with two charged membranes and obtaining a plasmid-enriched fluid such as a purified plasmid. In an embodiment, the first charged membrane is positively charged, and the second charged membranes is positively or negatively charged membrane. In a preferred embodiment, both first and second charged membranes are positively charged. In another embodiment, the plasmid-containing fluid is contacted with two positively charged membranes and a third charged membrane. The present invention further provides a system and a kit for processing plasmid-containing fluids.
    Type: Application
    Filed: November 19, 2002
    Publication date: November 13, 2003
    Inventors: Samuel Nochumson, Yujing Yang, Joe L. Kinsey Jr
  • Publication number: 20010034435
    Abstract: A scalable alkaline lysis process, including procedures and devices for the isolation of large quantities (grams and kilograms) of plasmid DNA from recombinant E. coli cells. Effective, controllable, and economical operation, and consistent low level of host chromosomal DNA in the final plasmid product. Involves a series of new unit operations and devices for cell resuspension, cell lysis, and neutralization.
    Type: Application
    Filed: January 29, 2001
    Publication date: October 25, 2001
    Applicant: Valentis, Inc.
    Inventors: Samuel Nochumson, Ross Durland, Audrey Yu-Speight, John Welp, Kuoewi Wu, Rexford Hayes
  • Patent number: 5552325
    Abstract: Disclosed is a centrifuge tube containing a porous selection means for selectively separating and recovering biological substances from gels, broths, or solutions containing the same, and thus concentrating them, the tube comprising separate upper and lower containers and means for joining the two containers to form a unitary device, the bottom of the upper container comprising a porous selection means, preferably a membrane containing a particulate substance which will selectively bind the biological substances while allowing unbound substances to pass through from the upper to lower container while being centrifuged.
    Type: Grant
    Filed: July 17, 1992
    Date of Patent: September 3, 1996
    Assignee: FMC Corporation
    Inventors: Samuel Nochumson, Bruce S. Goldberg
  • Patent number: 5455344
    Abstract: A nucleic acid sequencing gel comprising 2 to 10% of a gelling polysaccharide, preferably agarose; a denaturing agent, a non-gelling additive, preferably glycerol, and electrophoretic buffers. This composition is capable of resolving nucleic acid fragments having at least 50 bases and which differ from each other by at least one base.
    Type: Grant
    Filed: September 3, 1993
    Date of Patent: October 3, 1995
    Assignee: FMC Corporation
    Inventors: David L. Harper, Jonathan H. Morgan, Samuel Nochumson, Mikhail V. Ostrovsky, Donald W. Renn, William C. Snow
  • Patent number: 5143646
    Abstract: Electrophoretic resolving gel compositions, discontinuous stacking gel systems containing these and other resolving gel compositions, and kits for preparing such gel systems, comprising one or more polysaccharide hydrogels of which agarose is typical wherein at least one of the gels in the resolving gel composition has been derivatized and at least one of the gels in the resolving gel composition has been depolymerized sufficiently to reduce its casting-effective viscosity.
    Type: Grant
    Filed: June 20, 1991
    Date of Patent: September 1, 1992
    Assignee: FMC Corporation
    Inventors: Samuel Nochumson, Foner P. Curtis, Jonathan H. Morgan, Francis H. Kirkpatrick
  • Patent number: 5053332
    Abstract: A method for forming agarose beads, which may incorporate biological material at least partially labile at above 40.degree. C., in which an aqueous agarose solution is formed into bead-size portions which are gelled by contacting the portions with a cooled atmosphere, gas, and/or smooth hydrophobic surface, and then collected.
    Type: Grant
    Filed: July 24, 1989
    Date of Patent: October 1, 1991
    Inventors: Richard B. Cook, Richard B. Provonchee, Samuel Nochumson
  • Patent number: 4983268
    Abstract: Purified agarose suitable for rapid electrophoresis, characterized by a sulfate content of less than 0.2 wt % but greater than zero, a pyruvate content of 0-0.1 wt %, and a nitrogen content of 0-0.02 wt %. Gels prepared from the agarose exhibit a gel strength at 1.0 wt % concentration of at least 1200 g/cm.sup.2, substantial absence of DNA binding in 0.07 M or less tris acetate buffer, and an electroendosmosis (EEO) at 1.0 wt % concentration of 0.05 or less. Agaroses are purified to provide the low EEO material by dissolving agarose or alkali-modified agar in an aqueous medium buffered at a pH of 6.0 to 8.0 and containing no more than 2.0 nM salt as chloride, and precipitating the agarose by contact with a lower alkanol.
    Type: Grant
    Filed: August 3, 1989
    Date of Patent: January 8, 1991
    Assignee: FMC Corporation
    Inventors: Francis H. Kirkpatrick, Kenneth Guiseley, Richard Provonchee, Samuel Nochumson
  • Patent number: 4542200
    Abstract: An electrophoresis medium, comprising a copolymer of acrylamide and an ethylenically unsaturated resin formed by replacing at least some of the hydroxyl hydrogens in a polysaccharide with an ethylenically unsaturated group, is described.
    Type: Grant
    Filed: November 30, 1984
    Date of Patent: September 17, 1985
    Assignee: FMC Corporation
    Inventor: Samuel Nochumson
  • Patent number: 4504641
    Abstract: An electrophoresis medium, comprising a copolymer of acrylamide and an ethylenically unsaturated resin formed by replacing at least some of the hydroxyl hydrogens in a polysaccharide with an ethylenically unsaturated group, is described.
    Type: Grant
    Filed: October 17, 1983
    Date of Patent: March 12, 1985
    Assignee: FMC Corporation
    Inventor: Samuel Nochumson
  • Patent number: 4415428
    Abstract: An electrophoretic support comprising a base plate having on at least one side thereof, a layer of an adherent resin containing ethylenically unsaturated groups capable of undergoing copolymerization with acrylamide. The support provides excellent adhesion for polyacrylamide gels and other electrophoretic media such as agarose.
    Type: Grant
    Filed: January 27, 1982
    Date of Patent: November 15, 1983
    Assignee: FMC Corporation
    Inventors: Samuel Nochumson, Henry J. Witt