Patents by Inventor Sandrina Phipps

Sandrina Phipps has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20070212675
    Abstract: FEN1 transcriptional regulatory sequences (TREs) are provided. FEN1 TREs provide for transcriptional regulation dependent upon transcription factors that are only active in cancer cells. The FEN1 TREs may be used as a vehicle for introducing new genetic capability, particularly associated with cytotoxicity, for selective expression in cancer cells.
    Type: Application
    Filed: April 15, 2004
    Publication date: September 13, 2007
    Applicants: NOVARTIS AG, IRM LLC
    Inventors: Paul Hallenbeck, Garret Hampton, Carl Hay, Ying Huang, John Jakubczak, Sandrina Phipps
  • Patent number: 7109029
    Abstract: The present invention provides novel viral vectors and methods useful for the minimization of leaky gene expression, and, in particular, of nonspecific transcriptional read-through of genes. Such constructs may be obtained by the insertion of an insulating sequence into a vector construct, such as for example a termination signal sequence upstream of the transcription initiation site of the respective transcription unit.
    Type: Grant
    Filed: February 22, 2002
    Date of Patent: September 19, 2006
    Assignee: Cell Genesys, Inc.
    Inventors: Lori Clarke, Mario Gorziglia, Paul L. Hallenbeck, John Leonard Jakubczak, Michael Kaleko, Sandrina Phipps
  • Publication number: 20030104624
    Abstract: The present invention provides novel viral vectors and methods useful for the minimization of leaky gene expression, and, in particular, of nonspecific transcriptional read-through of genes. Such constructs may be obtained by the insertion of an insulating sequence into a vector construct, such as for example a termination signal sequence upstream of the transcription initiation site of the respective transcription unit.
    Type: Application
    Filed: February 22, 2002
    Publication date: June 5, 2003
    Inventors: Lori Clarke, Mario Gorziglia, Paul L. Hallenbeck, John Leonard Jakubczak, Michael Kaleko, Sandrina Phipps
  • Publication number: 20030104625
    Abstract: The present invention relates to oncolytic adenoviral vectors and their use in methods of gene therapy. Provided is a recombinant viral vector comprising an adenoviral nucleic acid backbone, wherein said nucleic acid backbone comprises in sequential order: A left ITR, a termination signal sequence, an E2F responsive promoter which is operably linked to a gene essential for replication of the recombinant viral vector, an adenoviral packaging signal, and a right ITR.
    Type: Application
    Filed: February 22, 2002
    Publication date: June 5, 2003
    Inventors: Cheng Cheng, Lori Clarke, Sheila Connelly, David Leonard Ennist, Suzanne Forry-Schaudies, Mario Gorziglia, Paul L. Hallenbeck, Carl M. Hay, John Leonard Jakubczak, Michael Kaleko, Sandrina Phipps, Seshidhar Reddy Police, Patricia Clare Ryan, David A. Stewart, Yuefeng Xie