Patents by Inventor Sang-Ho Ye
Sang-Ho Ye has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11904069Abstract: The invention relates to biomimetic, biodegradable composites including a magnesium (Mg) alloy mesh and a polymer/extracellular matrix (ECM). These hybrid composites, more particularly, are useful for the fabrication of medical implant devices, e.g., scaffolds, and are effective for bone regeneration. The fabrication process includes creating the Mg alloy mesh, and concurrently electrospinning the polymer and electrospraying the ECM onto the mesh.Type: GrantFiled: April 4, 2018Date of Patent: February 20, 2024Assignees: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, UNIVERSITY OF CINCINNATIInventors: William R. Wagner, Sang-Ho Ye, Yingqi Chen, Vesselin Shanov
-
Patent number: 11298452Abstract: A extracorporeal system for lung assist includes a housing, a blood flow inlet in fluid connection with the housing; a blood flow outlet in fluid connection with the housing; a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers, the plurality of hollow gas permeable fibers being positioned between the blood flow inlet and the blood flow outlet such that blood flows around the plurality of hollow gas permeable fibers when flowing from the blood flow inlet to the blood flow outlet; a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers; a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers; and at least one moving element to create velocity fields in blood flow contacting the plurality of hollow gas permeable fibers.Type: GrantFiled: September 22, 2018Date of Patent: April 12, 2022Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, Carnegie Mellon UniversityInventors: William J. Federspiel, Brian Joseph Frankowski, James F. Antaki, Christian Andres Bermudez, Richard Garrett Jeffries, William R. Wagner, Sang-Ho Ye
-
Publication number: 20220049098Abstract: A zwitterionic polysiloxane polymer (e.g., a polyurethane elastomer) composition having poly(dialkylsiloxane) blocks and a zwitterionic moiety is prepared by the copolymerization of a poly(dialkylsiloxane) diol, a diisocyanate, a tertiary amine alkyl diol, and a poly(dialkylsiloxane) diamine to form a poly(urethane urea) copolymer. A substituted saturated heterocylic compound is reacted with the tertiary amine of the poly(urethane urea) copolymer to introduce a zwitterionic group into the poly(urethane urea) copolymer backbone. A polysiloxane polymer having a zwitterionic moiety is prepared by reacting a diallyl tertiary amine compound and a substituted saturated heterocylic compound to form a diallyl zwitterionic macromer and cross-linking a vinyl terminated poly(dialkylsiloxane) and the diallyl zwitterionic macromer with a curing agent to introduce a zwitterionic group into the poly(dialkylsiloxane) polymer.Type: ApplicationFiled: August 10, 2021Publication date: February 17, 2022Inventors: William R. Wagner, Sang Ho Ye, Seungil Kim, Sung Kwon Cho
-
Publication number: 20210236700Abstract: The present invention relates to substrates and composites having dynamic, reversible micron-level luminal surface deformation including texture or geometric instabilities, e.g., surface wrinkling and folding. The surface deformation and its reversal to the original surface form or to another, different surface form, is effective to reduce or prevent surface fouling and, more particularly, in certain applications, to reduce or prevent unwanted platelet adhesion and thrombus formation. The substrates and composites include a wide variety of designs and, more particularly, biomedical-related designs, such as, synthetic vascular graft or patch designs.Type: ApplicationFiled: October 18, 2017Publication date: August 5, 2021Applicants: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, UPMC, UNIVERSIDAD DE SANTIAGO DE CHILEInventors: WILLIAM R. WAGNER, SACHIN SHANKAR VELANKAR, SANG HO YE, EDITH TZENG, LUKA POCIVAVSEK, ENRIQUE CERDA
-
Publication number: 20210187158Abstract: The invention relates to biomimetic, biodegradable composites including a magnesium (Mg) alloy mesh and a polymer/extracellular matrix (ECM). These hybrid composites, more particularly, are useful for the fabrication of medical implant devices, e.g., scaffolds, and are effective for bone regeneration. The fabrication process includes creating the Mg alloy mesh, and concurrently electrospinning the polymer and electrospraying the ECM onto the mesh.Type: ApplicationFiled: April 4, 2018Publication date: June 24, 2021Applicants: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, UNIVERSITY OF CINCINNATIInventors: WILLIAM R. WAGNER, SANG-HO YE, YINGQI CHEN
-
Publication number: 20190022300Abstract: A extracorporeal system for lung assist includes a housing, a blood flow inlet in fluid connection with the housing; a blood flow outlet in fluid connection with the housing; a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers, the plurality of hollow gas permeable fibers being positioned between the blood flow inlet and the blood flow outlet such that blood flows around the plurality of hollow gas permeable fibers when flowing from the blood flow inlet to the blood flow outlet; a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers; a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers; and at least one moving element to create velocity fields in blood flow contacting the plurality of hollow gas permeable fibers.Type: ApplicationFiled: September 22, 2018Publication date: January 24, 2019Inventors: William J. Federspiel, Brian Joseph Frankowski, James F. Antaki, Christian Andres Bermudez, Richard Garrett Jeffries, William R. Wagner, Sang-Ho Ye
-
Patent number: 10080834Abstract: A extracorporeal system for lung assist includes a housing, a blood flow inlet in fluid connection with the housing; a blood flow outlet in fluid connection with the housing; a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers, the plurality of hollow gas permeable fibers being positioned between the blood flow inlet and the blood flow outlet such that blood flows around the plurality of hollow gas permeable fibers when flowing from the blood flow inlet to the blood flow outlet; a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers; a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers; and at least one moving element to create velocity fields in blood flow contacting the plurality of hollow gas permeable fibers.Type: GrantFiled: November 27, 2013Date of Patent: September 25, 2018Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, CARNEGIE MELLON UNIVERSITYInventors: William J. Federspiel, Brian Joseph Frankowski, James F. Antaki, Christian Andres Bermudez, Richard Garrett Jeffries, William R. Wagner, Sang-Ho Ye
-
Patent number: 9808560Abstract: A method of forming an implantable article includes providing a biodegradable polymer including anti-thrombogenic groups along the length of the biodegradable polymer, biodegradable groups in the backbone of the biodegradable polymer and a plurality of functional groups adapted to react with reactive functional groups on a surface of the implantable article, and reacting at least a portion of the plurality of functional groups with the reactive functional groups on the surface of the implantable article.Type: GrantFiled: February 28, 2014Date of Patent: November 7, 2017Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Yi Hong, William R Wagner, Sang-Ho Ye
-
Publication number: 20170049941Abstract: Provided herein are methods or making and using whole or partial organ ECM structures comprising an anticoagulant. Also provided are organ structures prepared according to those methods.Type: ApplicationFiled: April 29, 2015Publication date: February 23, 2017Inventors: Alejandro SOTO-GUTIERREZ, Kentaro MATSUBARA, Ken FUKUMITSU, Kan HANDA, Jorge Guzman LEPE, William R. WAGNER, Sang Ho YE, Hiroshi YAGI, Yuko KITAGAWA
-
Publication number: 20140248232Abstract: A method of forming an implantable article includes providing a biodegradable polymer including anti-thrombogenic groups along the length of the biodegradable polymer, biodegradable groups in the backbone of the biodegradable polymer and a plurality of functional groups adapted to react with reactive functional groups on a surface of the implantable article, and reacting at least a portion of the plurality of functional groups with the reactive functional groups on the surface of the implantable article.Type: ApplicationFiled: February 28, 2014Publication date: September 4, 2014Applicant: University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Yi Hong, William R, Wagner, Sang-Ho Ye