Patents by Inventor Sangku Lee

Sangku Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8299049
    Abstract: The present invention relates to an anoikis-inducing agent comprising a Tiarella polyphylla extract, a tiarellic acid compound isolated therefrom or a pharmaceutically acceptable salt thereof, which is specific to cancer cells expressing a tumor-associated antigen L6 or a homolog thereof. The Tiarella polyphylla extract, the tiarellic acid compound isolated therefrom or pharmaceutically acceptable salt thereof of the present invention leads to loss of cell adhesion to reduce cancer cell proliferation and exhibits the effect of inducing cell death in cancer cells expressing a tumor-associated antigen L6 or a homolog thereof, thereby being used for preventing and treating cancer diseases due to a tumor-associated antigen L6 or a homolog thereof.
    Type: Grant
    Filed: November 25, 2009
    Date of Patent: October 30, 2012
    Assignee: Korea Institute of Bioscience and Biotechnology
    Inventors: Hyeong-Kyu Lee, Sei-Ryang Oh, Kyungseop Ahn, Joongku Lee, Sangku Lee, Ho-Jae Lee, Doo-Young Kim, Jung-Hee Kim, Eun-Ah Kim, Soon-Ja Choi, Soo Hyun Kim, Jung Weon Lee, Su-Yong Choi
  • Patent number: 7838047
    Abstract: The present invention relates to a pharmaceutical composition and health food comprising Phellinus sp. PL3 extract or phellinsin A isolated from the same as an effective component. More particularly, the present invention relates to a pharmaceutical composition and health food comprising Phellinus sp. PL3 extract or phellinsin A isolated from the same as an effective component, wherein the Phellinus sp. PL3 extract and its phellinsin A inhibit the oxidation of low density lipoprotein (LDL), and further, they can be used as a component for medicine and food to effectively prevent and treat cardiovascular diseases such as hyperlipemia and arteriosclerosis.
    Type: Grant
    Filed: September 5, 2008
    Date of Patent: November 23, 2010
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Sung Uk Kim, Eui Il Hwang, Ju Ryoung Kim, Tae Sook Jeong, Sangku Lee, Sang Han Lee, Jae Sun Moon, Mun-Chual Rho
  • Publication number: 20100081638
    Abstract: The present invention relates to an anoikis-inducing agent comprising a Tiarella polyphylla extract, a tiarellic acid compound isolated therefrom or a pharmaceutically acceptable salt thereof, which is specific to cancer cells expressing a tumor-associated antigen L6 or a homolog thereof. The Tiarella polyphylla extract, the tiarellic acid compound isolated therefrom or pharmaceutically acceptable salt thereof of the present invention leads to loss of cell adhesion to reduce cancer cell proliferation and exhibits the effect of inducing cell death in cancer cells expressing a tumor-associated antigen L6 or a homolog thereof, thereby being used for preventing and treating cancer diseases due to a tumor-associated antigen L6 or a homolog thereof.
    Type: Application
    Filed: November 25, 2009
    Publication date: April 1, 2010
    Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Hyeong-Kyu Lee, Sei-Ryang Oh, Kyungseop Ahn, Joongku Lee, Sangku Lee, Ho-Jae Lee, Doo-Young Kim, Jung-Hee Kim, Eun-Ah Kim, Soon-Ja Choi, Soo Hyun Kim, Jung Weon Lee, Su-Yong Choi
  • Publication number: 20090005440
    Abstract: The present invention relates to a pharmaceutical composition and health food comprising Phellinus sp. PL3 extract or phellinsin A isolated from the same as an effective component. More particularly, the present invention relates to a pharmaceutical composition and health food comprising Phellinus sp. PL3 extract or phellinsin A isolated from the same as an effective component, wherein the Phellinus sp. PL3 extract and its phellinsin A inhibit the oxidation of low density lipoprotein (LDL), and further, they can be used as a component for medicine and food to effectively prevent and treat cardiovascular diseases such as hyperlipemia and arteriosclerosis.
    Type: Application
    Filed: September 5, 2008
    Publication date: January 1, 2009
    Inventors: Sung Uk KIM, Eui Il Hwang, Ju Ryoung Kim, Tae Sook Jeong, Sangku Lee, Sang Han Lee, Jae Sun Moon, Mun-Chual Rho
  • Publication number: 20070128136
    Abstract: The present invention relates to a melanin biosynthesis inhibitor containing terrein compound as an effective ingredient. The terrein compound can be easily separated from Penicillium sp KCTC 26245, a fungal strain inhabited in domestic soil. It does not directly inhibit tyrosinase but inhibits the expression of MITF (microphthalmia-associated transcription factor) by activating ERK (extracellular signal-regulated kinase) in melanin chromatocytes to give whitening effect. So, the melanin biosynthesis inhibiting effect of the compound is much greater than that of any other conventional inhibitors, and further the effect can be raised when the compound is used together with other inhibitors, owing to their different mechanisms. Thus, the compound of the present invention can be effectively used as a skin trouble treating agent, a skin whitening agent and a browning inhibitor.
    Type: Application
    Filed: October 19, 2004
    Publication date: June 7, 2007
    Inventors: Ick-Dong Yoo, Won-Gon Kim, In-Ja Ryoo, Jong-Pyung Kim, Sangku Lee, Seo-Hyoung Park, Dong-Seok Kim, Kyoung-Chan Park
  • Patent number: 7223793
    Abstract: The present invention relates to phenolic acid derivatives of the formula I and compositions for the preventing and the treating blood lipid level-related diseases comprising the phenolic acid derivatives. The compounds have excellent effects of reducing blood lipid level, inhibiting cholesterol metabolism-related enzymes and preventing and treating blood lipid level-related diseases.
    Type: Grant
    Filed: December 4, 2002
    Date of Patent: May 29, 2007
    Assignee: Bionutrigen Co., Ltd.
    Inventors: Songhae Bok, Sangku Lee, Taesook Jeong, Euneai Kim, Surksik Moon, Myungsook Choi, Byunghwa Hyun, Chulho Lee, Yangkyu Choi, Gootaeg Oh
  • Publication number: 20060115492
    Abstract: The present invention relates to a pharmaceutical composition and health food comprising Phellinus sp. PL3 extract or phellinsin A isolated from the same as an effective component. More particularly, the present invention relates to a pharmaceutical composition and health food comprising Phellinus sp. PL3 extract or phellinsin A isolated from the same as an effective component, wherein the Phellinus sp. PL3 extract and its phellinsin A inhibit the oxidation of low density lipoprotein (LDL), and further, they can be used as a component for medicine and food to effectively prevent and treat cardiovascular diseases such as hyperlipemia and arteriosclerosis.
    Type: Application
    Filed: November 30, 2005
    Publication date: June 1, 2006
    Inventors: Sung Kim, Eui Hwang, Ju Kim, Tae Jeong, Sangku Lee, Sang Lee, Jae Moon, Mun-Chual Rho
  • Patent number: 6949682
    Abstract: The present invention relates to cinnamaldehyde derivatives inhibiting growth of tumor cell and regulating cell cycle, the method for preparation and the pharmaceutical composition thereof. The cinnamaldehyde derivatives of the present invention can be effectively used as a cell cycle regulator or a cancer cell growth inhibitor, since it has an ability to regulate cell cycle by holding the cells in G2/M stage of the cell division and has activity to inhibit cancer cell growth.
    Type: Grant
    Filed: May 28, 2004
    Date of Patent: September 27, 2005
    Assignee: Korea Research Institute of Bioscience and Biotechnology
    Inventors: Byoung-Mog Kwon, Kwang-Hee Son, Dong Cho Han, Sangku Lee, Jong Han Kim, Sung-Gyu Choi, Mi-Young Lee, Sun Bok Jeon
  • Publication number: 20040254196
    Abstract: The present invention relates to cinnamaldehyde derivatives inhibiting growth of tumor cell and regulating cell cycle, the method for preparation and the pharmaceutical composition thereof. The cinnamaldehyde derivatives of the present invention can be effectively used as a cell cycle regulator or a cancer cell growth inhibitor, since it has an ability to regulate cell cycle by holding the cells in G2/M stage of the cell division and has activity to inhibit cancer cell growth.
    Type: Application
    Filed: May 28, 2004
    Publication date: December 16, 2004
    Inventors: Byoung-Mog Kwon, Kwang-Hee Son, Dong Cho Han, Sangku Lee, Jong Han Kim, Sung-Gyu Choi, Mi-Young Lee, Sun Bok Jeon
  • Publication number: 20030199566
    Abstract: The present invention relates to phenolic acid derivatives of the formula I and compositions for the preventing and the treating blood lipid level-related diseases comprising the phenolic acid derivatives. The compounds have excellent effects of reducing blood lipid level, inhibiting cholesterol metabolism-related enzymes and preventing and treating blood lipid level-related diseases.
    Type: Application
    Filed: December 4, 2002
    Publication date: October 23, 2003
    Inventors: Songhae Bok, Sangku Lee, Taesook Jeong, Euneai Kim, Surksik Moon, Myungsook Choi, Byunghwa Hyun, Chulho Lee, Yangkyu Choi, Gootaeg Oh