Abstract: This invention is directed to processes for the preparation of a compound of the formula I or salt thereof, that is useful as a tryptase inhibitor, to intermediates useful in the preparation of such a compound, to processes for the preparation of such intermediates, and to the use of such intermediates for the preparation of such a compound.

Abstract: A method and system for priming a drug delivery device. The drug delivery device includes a dose dial sleeve and an internal housing portion. The dose dial sleeve is coupled to the internal housing. The dose dial sleeve rotates on a substantially circumferential rotational path during priming of the drug delivery device. Further, the dose dial sleeve rotates on a helical path during dose setting of the drug delivery device.

Abstract: An assembly for a drug delivery device comprises a housing, a rotation member, a drive member and at least one correction member. The rotation member is adapted to be rotated with respect to the housing in a first rotational direction for delivering a dose of a drug. The drive member is coupleable to the rotation member for delivering the dose. In a delivery mode, the drive member and the rotation member are coupled such that the drive member follows rotational movement of the rotation member in the first rotational direction due to mechanical interaction of the rotation member and the drive member.

Abstract: A resettable drive mechanism for a medication delivery device comprising a housing, a drive member rotatable with respect to the housing in a second direction for delivering a dose of a medication, and a piston rod by the drive member, when drive member rotates in the second direction, a stop member adapted to prevent rotation of drive member in a first direction, when the stop member engages the drive member, a clutch member movable between a delivery position and a reset position. When clutch member is in the delivery position, stop member and drive member are engaged and drive member is prevented from rotation in the first direction, and when the cutch member is in the reset position, the drive member and the stop member are disengaged, the drive member is rotatable in the first direction.

Abstract: A dose setting mechanism for a drug delivery device is provided comprising first maximum dose stop features (1) on a first component part (2) of the drug delivery device and corresponding second maximum dose stop features (3) on a second component part (4) of the drug delivery device, with the first and second maximum dose stop features (1, 3) being designed to limit a relative movement between the first and second component parts (2, 4). To limit the maximum dose which can be chosen, a maximum dose limiting device (5, 10, 10?, 10?, 10?') is provided interposed on the first component part (2) between the first and second maximum dose stop features (1, 3).

Abstract: An agent injection device is provided that is capable of injecting an agent to a known predetermined tissue depth. An injection member has an elongate injection shaft with an outlet port configured to dispense an agent at a controllable time. A controllable driver is coupled to the elongate injection shaft and is configured to drive the injection member into target tissue. A velocity control system is in communication with the controllable driver and is configured to control the velocity of the elongate injection shaft.