Patents by Inventor Santipharp Panmai

Santipharp Panmai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10842751
    Abstract: The instant invention relates to pharmaceutical compositions comprising doravirine, tenofovir disoproxil fumarate and lamivudine. These compositions are useful for the treatment of HIV infection. Also disclosed are processes for making said pharmaceutical compositions.
    Type: Grant
    Filed: February 14, 2020
    Date of Patent: November 24, 2020
    Assignee: MERCK SHARP & DOHME CORP.
    Inventors: Santipharp Panmai, Aditya Tatavarti, Andrew M. Farrington, Varsha Biyyala, Leonardo R. Allain, Marcela Nefliu, Gerard R. Klinzing, Jie Ren, Matthew Lamm
  • Publication number: 20200179291
    Abstract: The instant invention relates to pharmaceutical compositions comprising doravirine, tenofovir disoproxil fumarate and lamivudine. These compositions are useful for the treatment of HIV infection. Also disclosed are processes for making said pharmaceutical compositions.
    Type: Application
    Filed: February 14, 2020
    Publication date: June 11, 2020
    Applicant: MERCK SHARP & DOHME CORP.
    Inventors: Santipharp Panmai, Aditya Tatavarti, Andrew M. Farrington, Varsha Biyyala, Leonardo R. Allain, Marcela Nefliu, Gerard R. Klinzing, Jie Ren, Matthew Lamm
  • Patent number: 10603282
    Abstract: The instant invention relates to pharmaceutical compositions comprising doravirine, tenofovir disoproxil fumarate and lamivudine. These compositions are useful for the treatment of HIV infection. Also disclosed are processes for making said pharmaceutical compositions.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: March 31, 2020
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Santipharp Panmai, Aditya Tatavarti, Andrew M. Farrington, Varsha Biyyala, Leonardo R. Allain, Marcela Nefliu, Gerard R. Klinzing, Jie Ren, Matthew Lamm
  • Publication number: 20190254977
    Abstract: The instant invention relates to pharmaceutical compositions comprising doravirine, tenofovir disoproxil fumarate and lamivudine. These compositions are useful for the treatment of HIV infection. Also disclosed are processes for making said pharmaceutical compositions.
    Type: Application
    Filed: November 29, 2016
    Publication date: August 22, 2019
    Applicant: MERCK SHARP & DOHME CORP.
    Inventors: Santipharp Panmai, Aditya Tatavarti, Andrew M. Farrington, Varsha Biyyala, Leonardo R. Allain, Marcela Nefliu, Gerard R. Klinzing, Jie Ren, Matthew Lamm
  • Publication number: 20110053927
    Abstract: The invention encompasses a method for making nano-sized particles of water-insoluble pharmaceuticals comprising: (1) dissolving the water-insoluble pharmaceutical in a water-miscible solvent, optionally with water and inactive pharmaceutical ingredients, to make a solution; (2) rapidly mixing the solution with an anti-solvent which creates a high level of supersaturation, wherein the anti-solvent is water with optional inactive pharmaceutical ingredients; (3) simultaneously applying energy to the resulting mixture during the mixing of solution and anti-solvent as nano-sized drug particles precipitate out and form a slurry mixture under supersaturation; and (4) optionally isolating the nano-sized particles of water-insoluble pharmaceuticals from the slurry mixture.
    Type: Application
    Filed: April 20, 2009
    Publication date: March 3, 2011
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Hsien-Hsin Tung, Lei Wang, Santipharp Panmai, Michael Riebe
  • Publication number: 20080145430
    Abstract: The present invention is directed to a novel pharmaceutical composition suitable for ophthalmic use comprising nanoparticles dispersed in a liquid dispersion medium, wherein said nanoparticles comprise a cyclooxygenase-2 selective inhibitor having adsorbed on the surface thereof at least one surface stabilizer. The ophthalmic formulation of the present invention is stable, non-irritating and sufficiently bioavailable. The invention also encompasses a process for making as well as a kit for preparing the novel ophthalmic formulation.
    Type: Application
    Filed: December 5, 2005
    Publication date: June 19, 2008
    Inventors: Santipharp Panmai, Laman L. Alani
  • Publication number: 20070298099
    Abstract: N-[1S,2S]-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-trifluoromethyl]pyridine-2-yl}oxy}propanamide (Compound I) has surprisingly improved solubility and bioavailability in a lipophilic vehicle comprising a pharmaceutically acceptable digestible oil, a surfactant, or a cosolvent, or a mixture of any two or more thereof. In one embodiment of the present invention are self-emulsifying or self-microemulsifying composition comprising 1) Compound I; 2) a surfactant having an HLB of 1 to 8; and 3) a surfactant having an HLB of over 8 to 20; and optionally, 4) a digestible oil and/or cosolvent and/or antioxidant or preservative.
    Type: Application
    Filed: November 18, 2005
    Publication date: December 27, 2007
    Inventors: Andrey Peresypkin, Eleni Dokou, Craig McKelvey, Charles DeLuca, Laman Alani, Todd Gibson, Danielle Euler, Santipharp Panmai, W. Wuelfing, Thomas Gandek, Drazen Ostovic, Timothy Rhodes, Brian Hamilton
  • Publication number: 20050165000
    Abstract: Pharmaceutical compositions comprise a therapeutically effective amount of an 8-hydroxy-1,6-naphthyridine-7-carboxamide of Formula (I), or a pharmaceutically acceptable salt thereof: and a nonionic surfactant; wherein R1, R2, R3 and Q1 are defined herein. Compounds of Formula (I) are HIV integrase inhibitors, and the pharmaceutical compositions are useful for preventing or treating HIV infection or for preventing, treating, or delaying the onset of AIDS. The pharmaceutical compositions are typically administered orally, for example, in the form of capsules or tablets, and can provide good oral bioavailability. Methods for preparing encapsulated and tabletted forms of the pharmaceutical compositions are described.
    Type: Application
    Filed: March 13, 2003
    Publication date: July 28, 2005
    Inventors: Sandra Robertson, Maria Cruanes, Sami karaborni, Drazen Ostovic, Xi-Yong Fu, Ashkan Kamali, Santipharp Panmai