Patents by Inventor Sarah Braford-Goldberg

Sarah Braford-Goldberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Interleukin-3 (IL-3) multiple mutation polypeptides
    Publication number: 20050244372
    Abstract: The present invention relates to recombinant human interleukin-3 (hIL-3) variant or mutant proteins (muteins). These hIL-3 muteins contain amino acid substitutions and may also have amino acid deletions at both the N- and C-termini. The invention also relates to pharmaceutical compositions containing the hIL-3 muteins and methods for using them. Additionally, the present invention relates to recombinant expression vectors comprising nucleotide sequences encoding the hIL-3 muteins, related microbial expression systems, and processes for making the hIL-3 muteins using the microbial expression systems. Included in the present invention are deletion mutants of hIL-3 in which from 1 to 14 amino acids have been deleted from the N-terminus, and from 1 to 15 amino acids 119 to 133 have been deleted from the C-terminus, and which also contain amino acid substitutions in the polypeptide.
    Type: Application
    Filed: May 13, 2004
    Publication date: November 3, 2005
    Inventors: S. Bauer, Mark Abrams, Sarah Braford-Goldberg, Maire Caparon, Alan Easton, Barbara Klein, John McKearn, Peter Olins, Kumnan Paik, John Thomas
  • Methods of ex-vivo expansion of hematopoeitic cells using multivariant IL-3 hematopoiesis chimera proteins
    Publication number: 20050059149
    Abstract: The present invention relates to methods of ex-vivo expansion of hematopoietic cells by culturing hematopoietic cells in a growth medium comprising a chimera protein which comprises a variant of human interleukin-3 (hIL-3) which contains multiple amino acid substitutions and which may have portions of the native hIL-3 molecule deleted and a hematopoietic growth factor. The present invention also relates to the ex-vivo expansion of hematopoietic cells for gene therapy. Additionally, the present invention relates to the use of the expanded hematopoietic cells for treating patients having a hematopoietic disorder.
    Type: Application
    Filed: September 22, 2004
    Publication date: March 17, 2005
    Inventors: S. Bauer, Mark Abrams, Sarah Braford-Goldberg, Maire Caparon, Alan Easton, Barbara Klein, John McKearn, Peter Olins, Kumnan Paik, John Thomas
  • Co-administration of interleukin-3 mutant polypeptides with CSF's for multi-lineage hematopoietic cell production
    Publication number: 20030194783
    Abstract: The present invention relates to human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally co-administered with a other colony stimulating factors (CSF), cytokines, lymphokines, interleukins, hematopoietic growth factors or IL-3 variants.
    Type: Application
    Filed: February 8, 2002
    Publication date: October 16, 2003
    Inventors: John P. McKearn, Peter Olins, John Thomas, Maire Caparon, Alan Easton, Barbara Klein, S. Christopher Bauer, Mark Abrams, Kumnan Paik, Sarah Braford-Goldberg
  • Co-administration of interleukin-3 mutant polypeptides with CSF's for multi-lineage hematopoietic cell production
    Patent number: 6379662
    Abstract: The present invention relates to human interleukin-3 (hIL-3) variant or mutant proteins (muteins) functionally co-administered with a other colony stimulating factors (CSF), cytokines, lymphokines, interleukins, hematopoietic growth factors or IL-3 variants.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: April 30, 2002
    Inventors: John P. McKearn, Peter Olins, John Thomas, Maire Caparon, Alan Easton, Barbara Klein, S. Christopher Bauer, Mark Abrams, Kumnan Paik, Sarah Braford-Goldberg
  • G-CSF receptor agonists
    Patent number: 6358505
    Abstract: Disclosed are novel G-CSF receptor agonist proteins, DNAs which encode the multi-functional hematopoietic receptor agonists proteins, methods of making the multi-functional hematopoietic receptor agonists proteins and methods of using the multi-functional hematopoietic receptor agonists proteins.
    Type: Grant
    Filed: June 25, 1999
    Date of Patent: March 19, 2002
    Inventors: Linda Zurfluh, Barbara Klein, Charles McWherter, Yiping Feng, John McKearn, Sarah Braford-Goldberg