Patents by Inventor Sarah M. Cheal

Sarah M. Cheal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11413354
    Abstract: The present disclosure provides compositions and methods for the treatment of cancer. Specifically, the compositions of the present technology include novel clearing agents that may be used in pretargeted radioimmunotherapy.
    Type: Grant
    Filed: July 10, 2019
    Date of Patent: August 16, 2022
    Assignee: MEMORIAL SLOAN KETTERING CANCER CENTER
    Inventors: Ouathek Ouerfelli, Guangbin Yang, Sarah M. Cheal, Steve Larson
  • Publication number: 20210330805
    Abstract: The present disclosure provides compositions and methods for the treatment of cancer. Specifically, the compositions of the present technology include novel clearing agents that may be used in pretargeted radioimmunotherapy.
    Type: Application
    Filed: July 10, 2019
    Publication date: October 28, 2021
    Inventors: Ouathek OUERFELLI, Guangbin YANG, Sarah M. CHEAL, Steve LARSON
  • Publication number: 20210145988
    Abstract: The present disclosure provides compositions and methods for the detection and treatment of cancer. Specifically, the compositions of the present technology include novel DOTA-haptens that may be complexed with a radioisotope (e.g., 225Ac). Also disclosed herein are methods of the using the DOTA-haptens of the present technology in diagnostic imaging as well as pretargeted radioimmunotherapy.
    Type: Application
    Filed: July 5, 2018
    Publication date: May 20, 2021
    Applicant: MEMORIAL SLOAN KETTERING CANCER CENTER
    Inventors: Sarah M. CHEAL, Michael MCDEVITT, Ouathek OUERFELLI, Steven M. LARSON, Guangbin YANG
  • Publication number: 20210047436
    Abstract: The present disclosure relates generally to immunoglobulin-related compositions (e.g., antibodies or antigen binding fragments thereof) that can bind to and neutralize the activity of polysialic acid. The antibodies of the present technology are useful in methods for detecting and treating a polysialic acid-associated cancer in a subject in need thereof.
    Type: Application
    Filed: March 13, 2019
    Publication date: February 18, 2021
    Inventors: Linlin WANG, Zhihao WU, Mahiuddin AHMED, Sarah M. CHEAL, Steven M. LARSON, Nai-Kong V. CHEUNG
  • Patent number: 10806808
    Abstract: The present disclosure describes a non-linear compartmental model using PET-derived data to predict, on a patient-specific basis, the optimal therapeutic dose of cargo carrying antibody (e.g., huA33) such as radiolabeled antibody, the antigen occupancy, residency times in normal and malignant tissues, and the cancer-to-normal tissue (e.g., colorectal cancer-to-normal colon tissue) therapeutic index. In addition, the non-linear compartmental model can be readily applied to the development of strategies such as multi-step targeting (MST) designed to further improve the therapeutic indices of RIT.
    Type: Grant
    Filed: May 19, 2016
    Date of Patent: October 20, 2020
    Assignee: Memorial Sloan Kettering Cancer Center
    Inventors: Pat B. Zanzonico, Sarah M. Cheal, Steven M. Larson, Joseph Reginald Osborne, Edward Komin Fung, David Ulmert
  • Publication number: 20180133350
    Abstract: The present disclosure describes a non-linear compartmental model using PET-derived data to predict, on a patient-specific basis, the optimal therapeutic dose of cargo carrying antibody (e.g., huA33) such as radiolabeled antibody, the antigen occupancy, residency times in normal and malignant tissues, and the cancer-to-normal tissue (e.g., colorectal cancer-to-normal colon tissue) therapeutic index. In addition, the non-linear compartmental model can be readily applied to the development of strategies such as multi-step targeting (MST) designed to further improve the therapeutic indices of RIT.
    Type: Application
    Filed: May 19, 2016
    Publication date: May 17, 2018
    Inventors: Pat B. Zanzonico, Sarah M. Cheal, Steven M. Larson, Joseph Reginald Osborne, Edward Komin Fung, David Ulmert
  • Patent number: 7267994
    Abstract: The present invention provides compositions and methods for detecting, analyzing, and identifying biomolecules. More particularly, the invention provides Element Coded Affinity Tags comprising a metal chelate and a metal ion and methods of using the tags to detect, analyze, and identify biomolecules including polypeptides, nucleic acids, lipids, and polysaccharides.
    Type: Grant
    Filed: May 24, 2004
    Date of Patent: September 11, 2007
    Assignee: Regents of the University of California
    Inventors: Claude F. Meares, Carlito B. Lebrilla, Nathaniel G. Butlin, Sarah M. Cheal, Todd M. Corneillie, Susan Lee, Paul A. Whetstone, Nicolas L. Young