Patents by Inventor Sarah M. Gruba
Sarah M. Gruba has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220296881Abstract: The present disclosure relates generally to electroporation systems and utilizing algorithms for electroporation pulse delivery including a patient's EKG/EGM monitoring. In some embodiments, an electroporation delivery system may include an electrocardiogram operatively connected to a processing device and a memory. One or more sensors may be operatively connected to the electrocardiogram for measuring electrical activity QRS complex of a patient's heart. One or more electrodes for treatment may be disposed in, at, or near the patient's heart, the one or more electrodes operatively connected to a pulse delivery mechanism. The electroporation delivery system may be configured to determine whether an electroporation pulse is deliverable to a patient based on the electrocardiogram.Type: ApplicationFiled: June 6, 2022Publication date: September 22, 2022Inventors: Samuel J. Asirvatham, Suraj Kapa, Sarah M. Gruba, Douglas D. Pagoria, James P. Rohl, Chance M. Witt, Ammar M. Killu, Niyada Naksuk
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Patent number: 11426233Abstract: Embodiments of the present disclosure relate to treating diseased tissue with ablation therapy. In an embodiment, an apparatus comprises a catheter having an elongate body extending between a proximal end and a distal end. The apparatus further includes a balloon structure arranged proximal to the distal end of the catheter, wherein the balloon structure has a first portion with a first permeability and a second portion with a second permeability such that the first permeability is different than the second permeability. In addition, the apparatus includes a first electrode arranged on or within the balloon structure and configured to: transmit current through the first portion, receive current transmitted through the first portion or both.Type: GrantFiled: June 5, 2018Date of Patent: August 30, 2022Assignees: Cardiac Pacemakers, Inc., Mayo Foundation for Medical Education and ResearchInventors: Sarah M. Gruba, James P. Rohl, Samuel J. Asirvatham, Suraj Kapa, Chance M. Witt, Deepak Padmanabhan, Christopher V. DeSimone
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Patent number: 11389642Abstract: The present disclosure relates generally to electroporation systems and utilizing algorithms for electroporation pulse delivery including a patient's EKG/EGM monitoring. In some embodiments, an electroporation delivery system may include an electrocardiogram operatively connected to a processing device and a memory. One or more sensors may be operatively connected to the electrocardiogram for measuring electrical activity QRS complex of a patient's heart. One or more electrodes for treatment may be disposed in, at, or near the patient's heart, the one or more electrodes operatively connected to a pulse delivery mechanism. The electroporation delivery system may be configured to determine whether an electroporation pulse is deliverable to a patient based on the electrocardiogram.Type: GrantFiled: August 21, 2018Date of Patent: July 19, 2022Assignees: Cardiac Pacemakers, Inc., Mayo Foundation for Medical Education and ResearchInventors: Samuel J. Asirvatham, Suraj Kapa, Sarah M. Gruba, Douglas D. Pagoria, James P. Rohl, Chance M. Witt, Ammar M. Killu, Niyada Naksuk
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Publication number: 20220062632Abstract: A medical system includes a shaft having a proximal end and a distal end, a balloon attached to the distal end of the shaft, the balloon movable between an expanded state and a deflated state where a maximum diameter of the balloon is greater in the expanded state than in the deflated state, and an electrode is attached to the shaft where a portion of the balloon includes a plurality of apertures fluidly connecting an interior of the balloon to an exterior of the balloon.Type: ApplicationFiled: August 27, 2021Publication date: March 3, 2022Applicant: Boston Scientific Scimed, Inc.Inventors: Sarah M. GRUBA, James A. KLOS, James P. ROHL, Sandra L. WEEDA, Troy A. GIESE
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Patent number: 11123078Abstract: The present disclosure relates generally to apparatuses and methods for delivering an occlusion device to a paravalvular leak. In some embodiments, a paravalvular occlusion apparatus includes a catheter having main body including a proximal end and a distal end, a visualization element disposed in the distal end of the main body, and a working channel extending from the distal end of the main body. The catheter further includes an elongate shaft extendable from the working channel, wherein an occlusion device is coupled to the elongate shaft. In some embodiments, an occlusion device includes a leading end including a first section, and a trailing end opposite the leading end, the trailing end including a second section. The first section and the second section of the occlusion device are operable to be positioned along a perimeter of a prosthetic valve for blocking the paravalvular leak.Type: GrantFiled: September 5, 2018Date of Patent: September 21, 2021Assignee: Boston Scientific Scimed, Inc.Inventors: Sarah M. Gruba, Katherine L. Baldwin, James P. Rohl, Todd College, Charanjit S. Rihal
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Patent number: 10850073Abstract: The present disclosure relates generally to medical devices and methods for medical devices to be placed within a lumen of a patient, wherein the devices comprise one or more radiopaque filaments arranged with the devices and viewable to assist in placement and orientation of the devices with respect to the lumen.Type: GrantFiled: May 21, 2018Date of Patent: December 1, 2020Assignee: Boston Scientific Scimed, Inc.Inventors: Douglas D. Pagoria, Joel T. Eggert, James P. Rohl, Douglas Pennington, Katherine L. Baldwin, James K. Cawthra, Jr., Sarah M. Gruba, Daniel Shuey
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Patent number: 10842912Abstract: A coating for a metal surface, the coating including poly(ethylene glycol) disposed on and covalently bonded directly to at least a portion of the metal surface, and a functional group grafted to at least a portion of the poly(ethylene glycol). The functional group is one of a bioactive functional group and an antimicrobial functional group.Type: GrantFiled: August 9, 2017Date of Patent: November 24, 2020Assignee: Cardiac Pacemakers, Inc.Inventors: Danielle Frankson, Joseph T. Delaney, Jr., David R. Wulfman, Adam McGraw, Sarah M. Gruba
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Patent number: 10716621Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems, and methods for applying ablation therapy to a tissue region. The apparatuses, systems, and methods may include a balloon structure and one or more electrodes arranged on or within the balloon structure and configured to deliver energy to the tissue region.Type: GrantFiled: October 25, 2017Date of Patent: July 21, 2020Assignees: Boston Scientific Scimed, Inc., Mayo Foundation for Medical Education and ResearchInventors: James P. Rohl, Douglas Pennington, David R. Wulfman, Joel T. Eggert, Douglas D. Pagoria, Samuel J. Asirvatham, Adeniyi O. Aremu, James A. Klos, Todd College, Suraj Kapa, Sarah M. Gruba, David R. Holmes
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Patent number: 10465318Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems and methods that include a porous coating on a medical device. The porous coating may be formed by forming a scaffold along an exterior surface of the medical device to support the porous coating during application thereof and electrospinning a polymer to apply the porous coating on the scaffold.Type: GrantFiled: December 26, 2017Date of Patent: November 5, 2019Assignees: Boston Scientific Scimed Inc, Mayo Foundation for Medical Education and researchInventors: Sarah M. Gruba, James P. Rohl, James A. Klos, Joseph B. Fitzgerald
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Patent number: 10342899Abstract: A coating for an implantable medical device includes a poly(monochloro-p-xylylene) coating formed on at least a portion of the implantable medical device, and a layer including at least one of poly(ethylene glycol) and a poly(ethylene glycol) derivative linked to the poly(monochloro-p-xylylene) coating by covalent bonds.Type: GrantFiled: December 18, 2016Date of Patent: July 9, 2019Assignee: Cardiac Pacemakers, Inc.Inventors: Joseph T. Delaney, Jr., David R. Wulfman, Sarah M. Gruba, Michael J. Kane
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Publication number: 20190159785Abstract: The present disclosure relates generally to apparatuses and methods for delivering an occlusion device to a paravalvular leak. In some embodiments, a paravalvular occlusion apparatus includes a catheter having main body including a proximal end and a distal end, a visualization element disposed in the distal end of the main body, and a working channel extending from the distal end of the main body. The catheter further includes an elongate shaft extendable from the working channel, wherein an occlusion device is coupled to the elongate shaft. In some embodiments, an occlusion device includes a leading end including a first section, and a trailing end opposite the leading end, the trailing end including a second section. The first section and the second section of the occlusion device are operable to be positioned along a perimeter of a prosthetic valve for blocking the paravalvular leak.Type: ApplicationFiled: September 5, 2018Publication date: May 30, 2019Inventors: Sarah M. Gruba, Katherine L. Baldwin, James P. Rohl, Todd College, Charanjit S. Rihal
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Publication number: 20190125788Abstract: In various aspects, the present disclosure provides methods for applying ablation therapy to a target tissue region within a patient, which methods include: (a) navigating a catheter to a target tissue region within the patient, the catheter including an elongate body having a proximal portion and a distal portion and a balloon structure positioned at the distal portion of the elongate body, which balloon structure may be permeable to a calcium-ion-containing solution that comprises one or more calcium salts; (b) positioning the balloon structure at the target tissue region; (c) delivering energy to the target tissue region; and (d) eluting the calcium-ion-containing solution from the balloon structure before, during, and/or after delivering the energy to the target tissue region. In various other aspects, the present disclosure provides apparatuses that can be used for performing such methods, among others.Type: ApplicationFiled: October 26, 2018Publication date: May 2, 2019Inventors: Sarah M. Gruba, Douglas D. Pagoria, James P. Rohl, Stephen J. Hahn, Suraj Kapa, Chance M. Witt
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Publication number: 20190125439Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems, and methods for assessing electroporation therapy applied to a tissue region of a patient. In certain instances, the apparatuses, systems, and methods may include one or more sensors configured to sense an application of electroporation energy by an electroporation device to determine a location of the electroporation device within the patient.Type: ApplicationFiled: October 25, 2018Publication date: May 2, 2019Inventors: James P. Rohl, Sarah M. Gruba, Douglas D. Pagoria, Matthew Hein, Samuel J. Asirvatham, Chance M. Witt, Suraj Kapa
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Publication number: 20190060632Abstract: The present disclosure relates generally to electroporation systems and utilizing algorithms for electroporation pulse delivery including a patient's EKG/EGM monitoring. In some embodiments, an electroporation delivery system may include an electrocardiogram operatively connected to a processing device and a memory. One or more sensors may be operatively connected to the electrocardiogram for measuring electrical activity QRS complex of a patient's heart. One or more electrodes for treatment may be disposed in, at, or near the patient's heart, the one or more electrodes operatively connected to a pulse delivery mechanism. The electroporation delivery system may be configured to determine whether an electroporation pulse is deliverable to a patient based on the electrocardiogram.Type: ApplicationFiled: August 21, 2018Publication date: February 28, 2019Inventors: Samuel J. Asirvatham, Suraj Kapa, Sarah M. Gruba, Douglas D. Pagoria, James P. Rohl, Chance M. Witt, Ammar M. Killu, Niyada Naksuk
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Publication number: 20190015638Abstract: The present disclosure relates to medical devices that comprise (a) a balloon structure having a proximal end, a distal end, a porous region, a non-porous region and an interior chamber, and (b) one or more radiopaque markers disposed on the balloon structure, the radiopaque markers including a polymeric material and a radiopaque material. The present disclosure also relates to methods of forming such medical devices, systems that include such medical devices, and methods of using such medical devices and systems.Type: ApplicationFiled: July 16, 2018Publication date: January 17, 2019Inventors: Sarah M. Gruba, James A. Klos, James P. Rohl, Samuel J. Asirvatham, Suraj Kapa, Douglas Pennington
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Publication number: 20180344393Abstract: Embodiments of the present disclosure relate to treating diseased tissue with ablation therapy. In an embodiment, an apparatus comprises a catheter having an elongate body extending between a proximal end and a distal end. The apparatus further includes a balloon structure arranged proximal to the distal end of the catheter, wherein the balloon structure has a first portion with a first permeability and a second portion with a second permeability such that the first permeability is different than the second permeability. In addition, the apparatus includes a first electrode arranged on or within the balloon structure and configured to: transmit current through the first portion, receive current transmitted through the first portion or both.Type: ApplicationFiled: June 5, 2018Publication date: December 6, 2018Inventors: Sarah M. Gruba, James P. Rohl, Samuel J. Asirvatham, Suraj Kapa, Chance M. Witt, Deepak Padmanabhan, Christopher V. DeSimone
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Publication number: 20180333562Abstract: The present disclosure relates generally to medical devices and methods for medical devices to be placed within a lumen of a patient, wherein the devices comprise one or more radiopaque filaments arranged with the devices and viewable to assist in placement and orientation of the devices with respect to the lumen.Type: ApplicationFiled: May 21, 2018Publication date: November 22, 2018Inventors: Douglas D. Pagoria, Joel T. Eggert, James P. Rohl, Douglas Pennington, Katherine L. Baldwin, James K. Cawthra, JR., Sarah M. Gruba, Daniel Shuey
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Publication number: 20180179680Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems and methods that include a porous coating on a medical device. The porous coating may be formed by forming a scaffold along an exterior surface of the medical device to support the porous coating during application thereof and electrospinning a polymer to apply the porous coating on the scaffold.Type: ApplicationFiled: December 26, 2017Publication date: June 28, 2018Inventors: Sarah M. Gruba, James P. Rohl, James A. Klos, Joseph B. Fitzgerald
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Publication number: 20180110563Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems, and methods for applying ablation therapy to a tissue region. The apparatuses, systems, and methods may include a balloon structure and one or more electrodes arranged on or within the balloon structure and configured to deliver energy to the tissue region.Type: ApplicationFiled: October 25, 2017Publication date: April 26, 2018Inventors: James P. Rohl, Douglas Pennington, David R. Wulfman, Joel T. Eggert, Douglas D. Pagoria, Samuel J. Asirvatham, Adeniyi O. Aremu, James A. Klos, Todd College, Suraj Kapa, Sarah M. Gruba, David R. Holmes
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Publication number: 20180043056Abstract: A coating for a metal surface, the coating including poly(ethylene glycol) disposed on and covalently bonded directly to at least a portion of the metal surface, and a functional group grafted to at least a portion of the poly(ethylene glycol). The functional group is one of a bioactive functional group and an antimicrobial functional group.Type: ApplicationFiled: August 9, 2017Publication date: February 15, 2018Inventors: Danielle Frankson, Joseph T. Delaney, JR., David R. Wulfman, Adam McGraw, Sarah M. Gruba