Patents by Inventor Sarfaraz Niazi

Sarfaraz Niazi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9101857
    Abstract: Fine gas bubbles traveling at fast speed are employed to scrub a hard-surface filter for harvesting liquids from suspensions including those consisting of nutrient media and cell culture, on a continuous basis without clogging the filters.
    Type: Grant
    Filed: April 26, 2011
    Date of Patent: August 11, 2015
    Assignee: Therapeutic Proteins International, LLC
    Inventor: Sarfaraz Niazi
  • Patent number: 9005959
    Abstract: An exhaust system suitable for high volume exhaust from flexible disposable bags is described that prevents nutrient media volume loss and prevents cross-contamination without using any filters. The invention described here allows the use of disposable two-dimensional bioreactors for the cultivation of bacterial and other organisms and cells require high aeration.
    Type: Grant
    Filed: May 1, 2011
    Date of Patent: April 14, 2015
    Assignee: Therapeutic Proteins International, LLC
    Inventor: Sarfaraz Niazi
  • Patent number: 8932843
    Abstract: A buoyant device containing chromatography media performs the function of protein harvesting replacing the steps of cell separation and volume reduction; the device can be loaded into columns for further purification.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: January 13, 2015
    Assignee: Therapeutic Proteins International, LLC
    Inventor: Sarfaraz Niazi
  • Patent number: 8852435
    Abstract: An assembly capable of capturing and purifying expressed biological products during or at the end of a bioreaction cycle is disclosed wherein a binding resin is kept separated from the contents of the bioreactor allowing capturing, harvesting and purification of biological products in a bioreactor; the invention additionally provides means of removing undesirable metabolic products as well as provides for efficient loading of chromatography columns.
    Type: Grant
    Filed: November 29, 2011
    Date of Patent: October 7, 2014
    Assignee: Therapeutics Proteins International, LLC
    Inventor: Sarfaraz Niazi
  • Patent number: 8685245
    Abstract: A method and an apparatus for separating suspended matter from liquid includes a concentrator filter that draws the liquid out of the suspension while the filter kept unblocked by a sparging filter that allows scrubbing of the concentrator filter by gas bubbles. This invention can be used to replace cross-flow filtration and centrifugation in the bioprocess industry and to reduce the volume of suspensions to concentrate the yield of the end product in the chemical industry.
    Type: Grant
    Filed: May 31, 2011
    Date of Patent: April 1, 2014
    Assignee: Therapeutic Proteins International, LLC
    Inventor: Sarfaraz Niazi
  • Patent number: 8668886
    Abstract: A bioreactor that combines the steps of recombinant expression and separation of a biological product by binding the secreted biological product with a resin, discarding the nutrient medium and eluting the biological product as a concentrated solution, eliminating the steps of sterile filtration and volume reduction. The method also allows loading of resin for column-purification, eliminating all steps of perfusion process and maintaining a sink condition of a toxic product in nutrient medium to optimize productivity of host cells. The instant invention also allows harvesting of solubilized inclusion bodies after the cells have been lysed and refolding of proteins inside the bioreactor.
    Type: Grant
    Filed: April 24, 2011
    Date of Patent: March 11, 2014
    Assignee: Therapeutic Proteins International, LLC
    Inventor: Sarfaraz Niazi
  • Patent number: 8545759
    Abstract: A pair or receptacles capable of housing an emitter probe and a detector probe are installed inside a bioreactor to monitor the properties of the nutrient media without contacting the nutrient media.
    Type: Grant
    Filed: October 21, 2011
    Date of Patent: October 1, 2013
    Assignee: Therapeutic Proteins International, LLC
    Inventor: Sarfaraz Niazi
  • Patent number: 8183035
    Abstract: A method of manufacturing biological products in a single container from the growth of cells to purification of the product is performed in a flexible disposable bioreactor that uses only a compressed gas for mixing and gasification. A porous septum is used to create the gasification and mixing as well as to separate a chromatography media used to harvest and purify a biological product in the same container. The closed container can be used in any environment without the risk of contamination to the product or the risk of contamination of environment with the product. This allows large manufacturing of hazardous substances, drugs and vaccines anywhere at the lowest cost possible. Numerous applications can be found in counter-terrorism and biodefense operations as well in managing epidemic illnesses.
    Type: Grant
    Filed: September 7, 2011
    Date of Patent: May 22, 2012
    Assignee: Therapeutic Proteins International, LLC
    Inventor: Sarfaraz Niazi
  • Publication number: 20070142480
    Abstract: Methods of alleviating pain by the intra-articular application of perfluorodecalin are disclosed.
    Type: Application
    Filed: December 18, 2005
    Publication date: June 21, 2007
    Inventor: Sarfaraz Niazi
  • Publication number: 20070141182
    Abstract: This invention relates to pharmaceutical compositions for use in the treatment of pain and inflammation and the treatment of muscle spasms and associated pain, soreness and tightness of muscles in mammalian organism, said composition comprising: (i) an analgesically and anti-inflammatory effective amounts of five NSAIDs and (ii) an amount effective in the treatment of muscle spasms of at least one of the muscle relaxants, wherein (iii) the said preparation is applied locally to muscles and optionally contains absorption and blood flow enhancers.
    Type: Application
    Filed: December 20, 2005
    Publication date: June 21, 2007
    Inventor: Sarfaraz Niazi
  • Publication number: 20060177406
    Abstract: A formula, a system and a method is provided for treating urushiol induced contact dermatitis, chemical irritants and/or microbiological irritants on an affected area of skin of a user. The formula and/or the system is applied to an area of the skin of the user affected with urushiol, the chemical irritants and/or the microbiological irritants. The formula and/or the system have a cleansing agent, one or more surfactants and/or one or more abrasive agents for treating the urushiol induced contact dermatitis, the chemical irritants and/or the microbiological irritants. One or more abrasive agents separates the urushiol, the chemical irritants and/or the microbiological irritants from the skin of the user at the affected area. The cleansing agent bonds to the urushiol, the chemical irritants and/or the microbiological irritants at the affected area and withdraws the urushiol, the chemical irritants and/or the microbiological irritants from the tissue under the affected area of the skin of the user.
    Type: Application
    Filed: February 8, 2005
    Publication date: August 10, 2006
    Inventors: Sarfaraz Niazi, Nestor Tomasi
  • Publication number: 20050013871
    Abstract: Disclosed is a topical preparation for the treatment of topical itch in humans and animals. The said composition consists of Opuntia, Propolis, Stearic Acid, Beeswax, Vegetable Oil and ?-sitosterol. Itch includes scratch reaction itch, anal itch, or irritant itch due to plants (e.g.
    Type: Application
    Filed: July 20, 2003
    Publication date: January 20, 2005
    Inventors: Sarfaraz Niazi, Anjum Niazi
  • Publication number: 20030054020
    Abstract: This invention relates to reducing sebum production on the skin using methods and compositions containing a surfactant, a chylomicron disrupter, a skin penetration enhancer, and an anti-androgenic compound. In a preferred embodiment, the composition contains the surfactant as a mixture of polyoxyethylene compounds and the anti-androgenic agent as a mixture of saw palmetto extract and nettle extract.
    Type: Application
    Filed: September 7, 2001
    Publication date: March 20, 2003
    Inventor: Sarfaraz Niazi
  • Patent number: 4639368
    Abstract: A chewing gum composition adapted to supply a medicament to the oral cavity for local application thereto or for buccal absorption of said medicament which comprises a chewing gum base, an orally administrable medicament, a taste masking generator of carbon dioxide and optionally a taste bud desensitizing composition.
    Type: Grant
    Filed: June 6, 1985
    Date of Patent: January 27, 1987
    Assignee: Farmacon Research Corporation
    Inventors: Sarfaraz Niazi, Alvin Shemesh
  • Patent number: 4530936
    Abstract: A method of inhibiting the absorption of nutritional elements, principally food, from the gastrointesinal tract is disclosed which comprises ingesting perfluorodecalin in an amount sufficient to form a nutritional element-impermeable film thereof on at least a substantial part of the inner wall of the upper intestine and maintaining the film for a time long enough to inhibit the absorption from the gastrointestinal tract of a significant proportion of the ingested nutritional elements. An emulsion dosage form is preferred for carrying out this method, which emulsion contains perfluorodecalin, water, and a non-toxic emulsifier, preferably Pluronic F-68, and optionally flavoring and/or coloring agents.
    Type: Grant
    Filed: July 8, 1983
    Date of Patent: July 23, 1985
    Assignee: Farmacon Research Corporation
    Inventor: Sarfaraz Niazi