Patents by Inventor Sarina Grinberg

Sarina Grinberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190381137
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2-L1-HG1?? I where HG1, HG2 and L1 are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering siRNA into animal or human cell.
    Type: Application
    Filed: June 27, 2019
    Publication date: December 19, 2019
    Inventors: Charles LINDER, Eliahu HELDMAN, Sarina GRINBERG
  • Publication number: 20190216895
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2—L1—HG1 ??I where HG1, HG2 and L1 are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering GDNF or NGF into animal or human brain.
    Type: Application
    Filed: November 12, 2018
    Publication date: July 18, 2019
    Inventors: Charles LINDER, Eliahu HELDMAN, Sarina GRINBERG
  • Publication number: 20190076533
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2-L1-HG1??I where HG1, HG2 and L1 are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering imaging agents into animal or human brain.
    Type: Application
    Filed: July 25, 2018
    Publication date: March 14, 2019
    Inventors: Charles LINDER, Eliahu Heldman, Sarina Grinberg
  • Publication number: 20180036376
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2-L1-HG1??I where HG1, HG2 and L1 are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering siRNA into animal or human cell.
    Type: Application
    Filed: July 20, 2017
    Publication date: February 8, 2018
    Inventors: Charles LINDER, Eliahu HELDMAN, Sarina GRINBERG
  • Publication number: 20180021368
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2-L1-HG1?? I where HG1, HG2 and L1 are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering biologically active drugs into animal or human brain.
    Type: Application
    Filed: June 30, 2017
    Publication date: January 25, 2018
    Inventors: Charles LINDER, Eliahu HELDMAN, Sarina GRINBERG
  • Publication number: 20170367980
    Abstract: Nano-sized particles are provided comprising at least one multi-headed amphiphilic compound, in which at least one headgroup of said multi-headed amphiphilic compound is selectively cleavable or contains a selectively cleavable group, and at least one biologically active agent, which is both encapsulated within the nano-particle and non-covalently associated thereto.
    Type: Application
    Filed: May 9, 2017
    Publication date: December 28, 2017
    Inventors: Charles LINDER, Sarina GRINBERG, Eliahu HELDMAN
  • Patent number: 9642803
    Abstract: Nano-sized particles are provided comprising at least one multi-headed amphiphilic compound, in which at least one headgroup of said multi-headed amphiphilic compound is selectively cleavable or contains a selectively cleavable group, and at least one biologically active agent, which is both encapsulated within the nano-particle and non-covalently associated thereto.
    Type: Grant
    Filed: May 4, 2010
    Date of Patent: May 9, 2017
    Assignee: Ben-Gurion University Of The Negev Research And Development Authority
    Inventors: Charles Linder, Sarina Grinberg, Eliahu Heldman
  • Publication number: 20160367678
    Abstract: Bolaamphiphilic compounds are provided according to formula I: where HG1, HG2 and L1 are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering GDNF or NGF into animal or human brain.
    Type: Application
    Filed: April 15, 2016
    Publication date: December 22, 2016
    Inventors: Charles LINDER, Eliahu HELDMAN, Sarina GRINBERG
  • Publication number: 20150306236
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2-L1-HG1 ??I where HG1, HG2 and L1 are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering biologically active drugs into animal or human brain.
    Type: Application
    Filed: March 4, 2015
    Publication date: October 29, 2015
    Inventors: Charles LINDER, Eliahu HELDMAN, Sarina GRINBERG
  • Publication number: 20150246138
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2 -L1-HG1 ??I where HG1, HG2 and L1 are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering siRNA into animal or human cell.
    Type: Application
    Filed: March 4, 2015
    Publication date: September 3, 2015
    Inventors: Charles LINDER, Eliahu HELDMAN, Sarina GRINBERG
  • Publication number: 20150238611
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2-L1-HG1??I where HG1, HG2 and L1 are as defined herein. Provided bolaamphiphilic compounds and the pharmaceutical compositions thereof are useful for delivering imaging agents into animal or human brain.
    Type: Application
    Filed: March 4, 2015
    Publication date: August 27, 2015
    Inventors: Charles LINDER, Eliahu HELDMAN, Sarina GRINBERG
  • Publication number: 20150110875
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2-L1-HG1??I where HG1, HG2 and L1 are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering GDNF or NGF into animal or human brain.
    Type: Application
    Filed: July 10, 2014
    Publication date: April 23, 2015
    Inventors: Charles LINDER, Sarina GRINBERG, Eliahu HELDMAN
  • Publication number: 20150104502
    Abstract: Bolaamphiphilic compounds are provided according to formula I: HG2-L1-HG1??I where HG1, HG2 and L1 are as defined herein. Provided bolaamphiphilic compounds and the pharmaceutical compositions thereof are useful for delivering HIV active drugs into animal or human brain.
    Type: Application
    Filed: July 10, 2014
    Publication date: April 16, 2015
    Inventors: Charles LINDER, Sarina GRINBERG, Eliahu HELDMAN
  • Patent number: 8377469
    Abstract: Method for the preparation of nano- and mesosized particles consisting of a lipid layer comprising at least one amphiphile and a core of an inorganic compound and/or a metal, comprising: (i) dissolving in a common solvent at least one self-aggregating amphiphile with at least one inorganic, organometallic or metallorganic precursor of said inorganic compound or metal; and (ii) either injecting the resulting solution into an aqueous solution or drying the resulting solution and re-hydrating it, so as to form particles in which the precursor is encapsulated by the amphiphile(s) and is converted therein to said inorganic compound and/or metallic solid form.
    Type: Grant
    Filed: January 2, 2006
    Date of Patent: February 19, 2013
    Assignee: Ben-Gurion University of the Negev Research and Development Authority
    Inventors: Jacob Zabicky, Charles Linder, Sarina Grinberg, Eliahu Heldman
  • Publication number: 20120164072
    Abstract: Nano-sized particles are provided comprising at least one multi-headed amphiphilic compound, in which at least one headgroup of said multi-headed amphiphilic compound is selectively cleavable or contains a selectively cleavable group, and at least one biologically active agent, which is both encapsulated within the nano-particle and non-covalently associated thereto.
    Type: Application
    Filed: May 4, 2010
    Publication date: June 28, 2012
    Inventors: Charles Linder, Sarina Grinberg, Eliahu Heldman
  • Patent number: 7939562
    Abstract: Amphiphilic derivatives composed of at least one fatty acid chain are derived from natural vegetable oils such as vernonia oil, lesquerella oil and castor oil, in which the several reactive groups such as epoxy, hydroxy and double bonds can be modified to polar and ionic groups. The head group of the amphiphilic derivative may be in the main fatty acid chain or in a side chain. The amphiphiles are useful for the formation of vesicles and micelles and for use as complexants and surfactants.
    Type: Grant
    Filed: January 16, 2002
    Date of Patent: May 10, 2011
    Assignee: Ben-Gurion University of The Negev Research and Development Authority
    Inventors: Sarina Grinberg, Charles Linder, Zeev Wiesman, Eliahu Heldman, Victoria Kolot
  • Patent number: 7887833
    Abstract: An amphiphilic compound is provided capable of forming vesicles or liposomes, said amphiphilic compound having at least one headgroup containing a selectively cleavable group or moiety such as a residue of a choline or phenylalanine derivative, and at least one hydrogen-bonding group located either within said headgroup and/or in close proximity thereto. The cleavable group or moiety is cleaved under selective conditions including change of chemical, physical or biological environment and is preferably cleaved enzymatically in a biological environment such as the brain or the blood. Vesicles or liposomes made from said amphiphilic compounds are suitable for delivery of a therapeutic substance or a diagnostic agent specifically to a target organ or tissue, or for delivery of a nucleic acid for gene therapy.
    Type: Grant
    Filed: December 4, 2002
    Date of Patent: February 15, 2011
    Assignee: Ben-Gurion University of the Negev Research and Development Authority
    Inventors: Eliahu Heldman, Charles Linder, Sarina Grinberg, Victoria Kolot, Eleonora Shaubi
  • Publication number: 20090011002
    Abstract: Method for the preparation of nano- and mesosized particles consisting of a lipid layer comprising at least one amphiphile and a core of an inorganic compound and/or a metal, comprising: (i) dissolving in a common solvent at least one self-aggregating amphiphile with at least one inorganic, organometallic or metallorganic precursor of said inorganic compound or metal; and (ii) either injecting the resulting solution into an aqueous solution or drying the resulting solution and re-hydrating it, so as to form particles in which the precursor is encapsulated by the amphiphile(s) and is converted therein to said inorganic compound and/or metallic solid form.
    Type: Application
    Filed: January 2, 2006
    Publication date: January 8, 2009
    Applicant: Ben-Gurion University of the Negev Research and Development Authority
    Inventors: Jacob Zabicky, Charles Linder, Sarina Grinberg, Eliahu Heldman
  • Publication number: 20080271364
    Abstract: The invention provides methods for production of biodiesel from Balanites aegyptiaca oil or crushed nuts, and further relates to the biodiesel obtained. The Balanites aegyptiaca biodiesel obtained has a composition of triglycerides of mainly C16:0 and C18:0 saturated and unsaturated fatty acids, with a very high content of linoleic acid and of oleic acid, and it further contains Balanites saponins, acting as surfactants, which reduce the rate of corrosion and improve the performance of the engyne.
    Type: Application
    Filed: May 25, 2006
    Publication date: November 6, 2008
    Inventors: Zeev Wiesman, Mordechay Herskowitz, Sarina Grinberg
  • Patent number: 7217849
    Abstract: A method is described for producing n-propyl bromide of a high degree of purity, which contains isopropyl bromide in an amount lower than 0.1% w/w, and usually lower than 0.05%. The method is characterized in that n-propanol is reacted with HBr which is in gas form, preferably dry, and which is in excess over the stoichiometric amount, wherein the excess HBr is at the end of the reaction in an aqueous solution formed from the reaction water. The invention further relates to N-propyl bromide of high purity, containing typically less than 500 ppm of isopropyl bromide.
    Type: Grant
    Filed: November 11, 2002
    Date of Patent: May 15, 2007
    Assignee: Bromine Compounds Ltd.
    Inventors: Aharon Meirom, Arieh Kampf, Dmitri Grinberg, Sarina Grinberg, legal representative, Mark Grinberg, deceased