Patents by Inventor Sarkiz D. Issakani

Sarkiz D. Issakani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7915293
    Abstract: This invention describes compounds useful as ubiquitin ligase inhibitors. The compounds of the invention are useful as inhibitors of the biochemical pathways of organisms in which ubiquitination is involved. The invention also provides for pharmaceutical compositions comprising the compounds described in the invention for the treatment of conditions that require inhibition of ubiquitin ligases. Furthermore, the invention provides for methods of inhibiting ubiquitination in a cell comprising contacting a cell in which inhibition of ubiquitination is desired with a compound according to the invention.
    Type: Grant
    Filed: June 1, 2004
    Date of Patent: March 29, 2011
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Usha V. Ramesh, Gary Charles Look, Rajinder Singh, Sarkiz D. Issakani
  • Patent number: 7781182
    Abstract: The invention relates to assays for measuring ubiquitin ligase activity and for identifying modulators of ubiquitin ligase enzymes.
    Type: Grant
    Filed: January 9, 2006
    Date of Patent: August 24, 2010
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Sarkiz D. Issakani, Jianing Huang, Julie Sheung, Todd R. Pray
  • Publication number: 20090263831
    Abstract: The invention relates to assays for measuring ubiquitin ligase activity and for identifying modulators of ubiquitin ligase enzymes.
    Type: Application
    Filed: October 4, 2006
    Publication date: October 22, 2009
    Inventors: Sarkiz D. Issakani, Jianing Huang, Julie Sheung, Todd R. Pray
  • Patent number: 7566732
    Abstract: This invention describes compounds and pharmaceutical compositions useful as inhibitors of ubiquitination. The compounds and compositions of the invention are useful as inhibitors of the biochemical pathways of organisms in which ubiquitination is involved. In particular, the compounds and compositions are useful for treating diseases caused by viruses such as poxviruses and retroviruses. The invention further provides for methods of treating smallpox, Herpes virus and HIV infection in patients using the compounds and compositions of the invention.
    Type: Grant
    Filed: October 28, 2004
    Date of Patent: July 28, 2009
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Rajinder Singh, Usha Ramesh, Sarkiz D. Issakani, Gary Charles Look
  • Publication number: 20090137644
    Abstract: This invention describes compounds and pharmaceutical compositions useful as inhibitors of ubiquitination. The compounds and compositions of the invention are useful as inhibitors of the biochemical pathways of organisms in which ubiquitination is involved. In particular, the compounds and compositions are useful for treating diseases caused by viruses such as poxviruses and retroviruses. The invention further provides for methods of treating smallpox, Herpes virus and HIV infection in patients using the compounds and compositions of the invention.
    Type: Application
    Filed: October 28, 2004
    Publication date: May 28, 2009
    Applicant: Rigel Pharmaceuticals, Inc.
    Inventors: Rajinder Singh, Usha Ramesh, Sarkiz D. Issakani, Gary Charles Look
  • Patent number: 7524642
    Abstract: Provided are methods and compositions for assaying for ubiquitin agents that are enzymatic components of ubiquitin-mediated proteolysis and, more particularly, methods and compositions for assaying for agents that modulate the activity of such ubiquitin agents.
    Type: Grant
    Filed: October 2, 2006
    Date of Patent: April 28, 2009
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Sarkiz D. Issakani, Jianing Huang, Julie Sheung, Todd R. Pray
  • Publication number: 20080064117
    Abstract: Provided are methods and compositions for assaying for ubiquitin agents that are enzymatic components of ubiquitin-mediated proteolysis and, more particularly, methods and compositions for assaying for agents that modulate the activity of such ubiquitin agents.
    Type: Application
    Filed: October 2, 2006
    Publication date: March 13, 2008
    Applicant: Rigel Pharmaceuticals, Inc.
    Inventors: Sarkiz D. Issakani, Jianing Huang, Julie Sheung, Todd R. Pray
  • Patent number: 7153880
    Abstract: The present invention relates to substituted diphenyl heterocycle compounds and pharmaceutical compositions thereof that inhibit replication of HCV virus. The present invention also relates to the use of the compounds and/or compositions to inhibit HCV replication and/or proliferation and to treat or prevent HCV infections.
    Type: Grant
    Filed: June 22, 2004
    Date of Patent: December 26, 2006
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Rajinder Singh, Dane Goff, Henry Lu, Sarkiz D. Issakani, Thomas Sun
  • Patent number: 7022493
    Abstract: The invention relates to assays for measuring ubiquitin ligase activity and for identifying modulators of ubiquitin ligase enzymes.
    Type: Grant
    Filed: April 28, 2004
    Date of Patent: April 4, 2006
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Sarkiz D. Issakani, Jianing Huang, Julie Sheung, Todd R. Pray
  • Patent number: 6979551
    Abstract: Provided are methods and compositions for assaying for ubiquitin agents that are enzymatic components of ubiquitin-mediated proteolysis and, more particularly, methods and compositions for assaying for agents that modulate the activity of such ubiquitin agents.
    Type: Grant
    Filed: May 20, 2002
    Date of Patent: December 27, 2005
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Sarkiz D. Issakani, Jianing Huang, Julie Sheung, Todd R. Pray
  • Patent number: 6919184
    Abstract: Provided are methods and compositions for assaying for ubiquitin agents that are enzymatic components of ubiquitin-mediated proteolysis and, more particularly, methods and compositions for assaying for agents that modulate the activity of such ubiquitin agents.
    Type: Grant
    Filed: March 26, 2002
    Date of Patent: July 19, 2005
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Sarkiz D. Issakani, Jianing Huang, Julie Sheung, Todd R. Pray
  • Publication number: 20040236112
    Abstract: The present invention relates to substituted diphenyl heterocycle compounds and pharmaceutical compositions thereof that inhibit replication of HCV virus. The present invention also relates to the use of the compounds and/or compositions to inhibit HCV replication and/or proliferation and to treat or prevent HCV infections.
    Type: Application
    Filed: June 22, 2004
    Publication date: November 25, 2004
    Inventors: Rajinder Singh, Dane Goff, Henry Lu, Sarkiz D. Issakani, Thomas Sun
  • Patent number: 6740495
    Abstract: The invention relates to assays for measuring ubiquitin ligase activity and for identifying modulators of ubiquitin ligase enzymes.
    Type: Grant
    Filed: April 3, 2000
    Date of Patent: May 25, 2004
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Sarkiz D. Issakani, Jianing Huang, Julie Sheung
  • Patent number: 6737244
    Abstract: The invention relates to assays for measuring ubiquitin ligase activity and for identifying modulators of ubiquitin ligase enzymes.
    Type: Grant
    Filed: April 3, 2001
    Date of Patent: May 18, 2004
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Sarkiz D. Issakani, Jianing Huang, Julie Sheung, Todd R. Pray
  • Publication number: 20030165561
    Abstract: The present invention relates to substituted diphenyl heterocycle compounds and pharmaceutical compositions thereof that inhibit replication of HCV virus. The present invention also relates to the use of the compounds and/or compositions to inhibit HCV replication and/or proliferation and to treat or prevent HCV infections.
    Type: Application
    Filed: November 1, 2002
    Publication date: September 4, 2003
    Inventors: Rajinder Singh, Dane Goff, Henry Lu, Sarkiz D. Issakani, Thomas Sun
  • Publication number: 20030108947
    Abstract: Provided are methods and compositions for assaying for ubiquitin agents that are enzymatic components of ubiquitin-mediated proteolysis and, more particularly, methods and compositions for assaying for agents that modulate the activity of such ubiquitin agents.
    Type: Application
    Filed: May 20, 2002
    Publication date: June 12, 2003
    Inventors: Sarkiz D. Issakani, Jianing Huang, Julie Sheung, Todd R. Pray
  • Publication number: 20030104474
    Abstract: Provided are methods and compositions for assaying for ubiquitin agents that are enzymatic components of ubiquitin-mediated proteolysis and, more particularly, methods and compositions for assaying for agents that modulate the activity of such ubiquitin agents.
    Type: Application
    Filed: March 26, 2002
    Publication date: June 5, 2003
    Inventors: Sarkiz D. Issakani, Jianing Huang, Julie Sheung, Todd R. Pray
  • Publication number: 20020042083
    Abstract: The invention relates to assays for measuring ubiquitin ligase activity and for identifying modulators of ubiquitin ligase enzymes.
    Type: Application
    Filed: April 3, 2001
    Publication date: April 11, 2002
    Applicant: RIGEL PHARMACEUTICALS, INC.
    Inventors: Sarkiz D. Issakani, Jianing Huang, Julie Sheung, Todd R. Pray