Abstract: An object of the present invention is to provide an echinomycin derivative that has anti-cancer activity equal to or greater than that of echinomycin, and a production method therefor based on a chemical procedure. Provided are an echinomycin derivative represented by formula (I), and a production method therefor based on a chemical procedure.

Abstract: This invention provides a method for stably producing type II alveolar epithelial cells from pluripotent stem cells. Specifically, the invention relates to a method for producing type II alveolar epithelial cells from pluripotent stem cells comprising steps of: (1) culturing pluripotent stem cells in a medium containing activin A and a GSK3? inhibitor; (2) culturing the cells obtained in Step (1) in a medium containing a BMP inhibitor and a TGF? inhibitor; (3) culturing the cells obtained in Step (2) in a medium containing BMP4, retinoic acid, and a GSK3? inhibitor; (4) culturing the ventral anterior foregut cells obtained in Step (3) in a medium containing a GSK3? inhibitor, FGF10, KGF, and a NOTCH signal inhibitor; and (5) subjecting the alveolar epithelial progenitor cells obtained in Step (4) to three-dimensional culture in a medium containing a steroid drug, a cAMP derivative, a phosphodiesterase inhibitor, and KGF.

Abstract: This invention provides a method for stably producing type II alveolar epithelial cells from pluripotent stem cells. Specifically, the invention relates to a method for producing type II alveolar epithelial cells from pluripotent stem cells comprising steps of: (1) culturing pluripotent stem cells in a medium containing activin A and a GSK3? inhibitor; (2) culturing the cells obtained in Step (1) in a medium containing a BMP inhibitor and a TGF? inhibitor; (3) culturing the cells obtained in Step (2) in a medium containing BMP4, retinoic acid, and a GSK3? inhibitor; (4) culturing the ventral anterior foregut cells obtained in Step (3) in a medium containing a GSK3? inhibitor, FGF10, KGF, and a NOTCH signal inhibitor; and (5) subjecting the alveolar epithelial progenitor cells obtained in Step (4) to three-dimensional culture in a medium containing a steroid drug, a cAMP derivative, a phosphodiesterase inhibitor, and KGF.

Abstract: A terminal device is configured to establish a communication link with communication equipment through a base station device such that, upon establishing the communication link, part of the communication link is left for a certain base station while another part of the communication link is established with the terminal device through the other base station device according to a plurality of architectures, wherein the terminal device includes a wireless communication part configured to transmit support architecture information representing an architecture supported by the terminal device among a plurality of architectures to the base station device.

Abstract: Provided are an oiliness/fattiness enhancer for foods in which oiliness/fattiness of a food can be enhanced, and a food in which oiliness/fattiness has been enhanced. Provided is an oiliness/fattiness enhancer for foods characterized by containing, as an active component, an oxidized oil/fat having a peroxide value of 20 or more to 400 or less and including milk fat in an amount of 10% by mass or more to 100% by mass or less. The oiliness/fattiness enhancer for foods preferably contains the oxidized oil/fat in an amount of 0.001% by mass or more to 100% by mass or less, preferably has anhydrous milk fat as the milk fat, preferably includes a pulverulent oil/fat containing the oxidized oil/fat and an excipient, and is preferably applied to a food having an oil/fat content of 0.1% by mass or more to 70% by mass or more. The food is preferably any one food selected from the group consisting of a dressing, a roux, and a soup.

Abstract: [Problem] To provide a method for producing an oil and fat composition in which it is possible to enhance the flavor of a flavor oil. [Solution] This method for producing a powder oil and fat composition includes a step for heating an oil mixture including a vegetable ingredient and an edible oil or fat at a temperature that is at least 45° C. and less than 100° C., and a step for obtaining the powder oil composition from a raw-ingredient mixture including the flavor oil and a diluent.

Abstract: A terminal device is configured to establish a communication link with communication equipment through a base station device such that, upon establishing the communication link, part of the communication link is left for a certain base station while another part of the communication link is established with the terminal device through the other base station device according to a plurality of architectures, wherein the terminal device includes a wireless communication part configured to transmit support architecture information representing an architecture supported by the terminal device among a plurality of architectures to the base station device.

Abstract: A terminal device is configured to establish a communication link with communication equipment through a base station device such that, upon establishing the communication link, part of the communication link is left for a certain base station while another part of the communication link is established with the terminal device through the other base station device according to a plurality of architectures, wherein the terminal device includes a wireless communication part configured to transmit support architecture information representing an architecture supported by the terminal device among a plurality of architectures to the base station device.

Abstract: This invention provides a method for stably producing airway epithelial cells from pluripotent stem cells. Specifically, the invention relates to a method for producing airway epithelial cells from pluripotent stem cells comprising steps: (1) culturing pluripotent stem cells in a medium containing activin A and a GSK3? inhibitor; (2) culturing the cells obtained in Step (1) in a medium containing a BMP inhibitor and a TGF? inhibitor; (3) culturing the cells obtained in Step (2) in a medium containing BMP4, retinoic acid, and a GSK3? inhibitor; (5) subjecting the cells obtained after Step (3) to three-dimensional culture in a medium containing a GSK3? inhibitor, FGF10, and a ROCK inhibitor; and (6) subjecting the proximal airway epithelial progenitor cells obtained in Step (5) to three-dimensional culture in a medium containing a ROCK inhibitor.

Abstract: The object of the present invention is to provide a combination weighing device in which supply of articles at an article conveyance part is controlled with good precision. A combination weighing device (100) is provided with article conveyance parts (10, 20) having loading parts (11, 21) of articles and driving parts (12, 22) for driving the loading parts, the article conveyance parts (10, 20) driving the driving parts and thereby causing the articles to be conveyed to hoppers (30) arranged downstream in a conveyance direction, a sensing part (60) for sensing, in non-contact manner, a state of the articles on the loading parts, and a supply control part (82c) for controlling supply of the articles by controlling driving of the article conveyance parts based on a sensing result of the sensing part. The sensing part sense, for a plurality of regions along the conveyance direction, the state of the articles for each of the regions.

Abstract: A terminal device includes a wireless communication part configured to wirelessly communicate with base station devices; a link controller configured to establish a link with a primary base station device (PCell) so as to enable a wireless communication via the wireless communication part while establishing a link with a secondary base station device (SCell) so as to enable a wireless communication via the wireless communication part; a primary base station link failure detector configured to detect a radio link failure in the wireless communication with the primary base station device based on the predetermined condition; and a primary base station link failure information transmitter configured to wirelessly transmit the information, concerning the radio link failure with the primary base station device, to the secondary base station device when the primary base station link failure detector detects the radio link failure status.

Abstract: Provided is a cell culture apparatus capable of constructing cultured cells under an environment closer to that in a living body. The cell culture apparatus includes: a culture substrate (11) having a culture surface (11a) on which cells S are cultured; and a drive unit (12) configured to allow opening and closing of the culture substrate (11) between a closed form and an open form. The closed form is a form in which the culture substrate (11) forms a flow path having an internal volume with the culture surface (11) being an internal surface of the flow path. The open form is a form in which the culture surface (11a) of the culture substrate (11) is opened outward more than the culture surface (11a) of the culture substrate (11) in the closed form.

Abstract: A communication apparatus performs communication in a manner such that communication with a first base station apparatus using a first frequency band and communication with a second base station apparatus using a second frequency band are switched on a per-subframe basis, obtains, from the first base station apparatus, specification information that specifies a subframe in which the first frequency band should be used and a subframe in which the second frequency band should be used among a plurality of subframes included in one or more frames, and performs control on the basis of the specification information to communicate with the first base station apparatus in the subframe in which the first frequency band should be used and with the second base station apparatus in the subframe in which the second frequency band should be used.

Abstract: A wireless communication terminal includes a base station communication part which communicates with a base station; an interterminal communication part which communicates with another wireless communication part; a communication failure detector which detects a communication failure with a first connected base station serving as a base station connected thereto; and a communication resume processor which carries out an interterminal communication with another wireless communication terminal so as to communicate with a second connected base station, connected to another wireless communication terminal, via another wireless communication terminal when a communication failure is detected with the first connected base station, thus carrying out a process of resuming a communication upon detecting the communication failure.

Abstract: A terminal device includes a wireless communication unit performing wireless communication; a connection control unit connecting to a first base station device to wirelessly communicate with the first base station device via the wireless communication unit, the first base station serving as a primary, the connection control unit connecting to a second base station device to wirelessly communicate with the second base station device via the wireless communication unit, the second base station device serving as a secondary; a detection unit determining whether quality of wireless communication between the terminal device and the first base station device is in a low state based on a predetermined condition; and a signal transmission control unit wirelessly transmitting via the wireless communication unit, a predetermined signal toward at least either the first or second base station device when the quality is determined to be in the low state by the detection unit.

Abstract: This invention provides a method for stably producing airway epithelial cells from pluripotent stem cells. Specifically, the invention relates to a method for producing airway epithelial cells from pluripotent stem cells comprising steps: (1) culturing pluripotent stem cells in a medium containing activin A and a GSK3? inhibitor; (2) culturing the cells obtained in Step (1) in a medium containing a BMP inhibitor and a TGF? inhibitor; (3) culturing the cells obtained in Step (2) in a medium containing BMP4, retinoic acid, and a GSK3? inhibitor; (5) subjecting the cells obtained after Step (3) to three-dimensional culture in a medium containing a GSK3? inhibitor, FGF10, and a ROCK inhibitor; and (6) subjecting the proximal airway epithelial progenitor cells obtained in Step (5) to three-dimensional culture in a medium containing a ROCK inhibitor.

Abstract: This invention provides a method for stably producing type II alveolar epithelial cells from pluripotent stem cells. Specifically, the invention relates to a method for producing type II alveolar epithelial cells from pluripotent stem cells comprising steps of: (1) culturing pluripotent stem cells in a medium containing activin A and a GSK3? inhibitor; (2) culturing the cells obtained in Step (1) in a medium containing a BMP inhibitor and a TGF? inhibitor; (3) culturing the cells obtained in Step (2) in a medium containing BMP4, retinoic acid, and a GSK3? inhibitor; (4) culturing the ventral anterior foregut cells obtained in Step (3) in a medium containing a GSK3? inhibitor, FGF10, KGF, and a NOTCH signal inhibitor; and (5) subjecting the alveolar epithelial progenitor cells obtained in Step (4) to three-dimensional culture in a medium containing a steroid drug, a cAMP derivative, a phosphodiesterase inhibitor, and KGF.

Abstract: The present invention provides such pumping apparatuses that have very little deviation and high stability in pumping flow. A pumping apparatus comprises two members that are set along a longitudinal direction of a tube made of an elastic material with a relation that the space formed by grooves made in the two members holds the tube. The two members have reciprocal motion such that at least one of the two opposing members shuttles in parallel with the other opposing member and has a move-in motion such that at least one of the two opposing members vertically moves to the opposing surfaces of the other opposing member so that surrounding part of the groove thereof moves into an inner space of the groove of the other opposing member, by which motion the liquid in the tube is discharged from the tube by the deformation of tube cross sectional shape.

Abstract: The position of blood vessels can be more appropriately specified by means of appropriately selecting, on the basis of the conditions and components utilized, and angle between a light emitting unit optical axis of a near-infrared light emitting unit and a normal light of an irradiated surface, and angle between an optical axis of a light receiving side lens and the normal line of the irradiated surface, and an angle between a light receiving surface of a photo diode array and the light receiving unit optical axis. Thus, the subcutaneous blood vessel depth in the direction of the normal line from the irradiated surface can be specified based on changes in illumination intensity in a photodiode array. Consequently, the position of subcutaneous blood vessels can be easily specified.

Abstract: A communication control apparatus, in a wireless communication system having an area in which coverage areas of a macro cell base station and a small cell base station using different frequency bands overlap, includes a storage unit and a control unit. The storage unit stores small cell base station information indicating whether the small cell base station is present within a coverage area of a macro cell base station. The control unit instructs a radio terminal apparatus present within the coverage area of the macro cell base station to perform quality measurement in a frequency band of the small cell base station when the small cell base station is present within the coverage area of the macro cell base station based on the small cell base station information.