Patents by Inventor Satu Vainikka

Satu Vainikka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180273585
    Abstract: The invention provides a molecule that inhibits or prevents an interaction between a Src family kinase and an androgen or estradiol receptor, for use in preventing or treating a non-cancerous condition in which an activity of AR and/or ER is a contributory factor in a subject, or for use in preventing or treating a cancerous condition in which an activity of AR and/or ER is a contributory factor in a subject who wishes to preserve fertility, or for use in preventing or treating a gynaecological condition in which an activity of AR and/or ER is a contributory factor in a subject.
    Type: Application
    Filed: March 19, 2018
    Publication date: September 27, 2018
    Inventors: Mark Eccleston, Satu Vainikka, George Steven Morris
  • Patent number: 10023612
    Abstract: The invention provides a molecule that inhibits or prevents an interaction between a Src family kinase and an androgen or estradiol receptor, for use in preventing or treating a non-cancerous condition in which an activity of AR and/or ER is a contributory factor in a subject, or for use in preventing or treating a cancerous condition in which an activity of AR and/or ER is a contributory factor in a subject who wishes to preserve fertility, or for use in preventing or treating a gynecological condition in which an activity of AR and/or ER is a contributory factor in a subject.
    Type: Grant
    Filed: November 1, 2012
    Date of Patent: July 17, 2018
    Assignee: VALIRX PLC
    Inventors: Mark Eccleston, Satu Vainikka, George Steven Morris
  • Publication number: 20160068568
    Abstract: The invention provides a molecule that modulates an activity of a Src family kinase for use in preventing or treating a metastatic cancer a subject. Preferably, the molecule comprises or consists of the structure: Bj-[(Pro)n-Xr-His-Pro-His-Ala-Arg-Ile-Lys]m-Rp, or Bj-[lys-ile-arg-ala-his-pro-his-xr-(pro)n]m-Rp, or a derivative or fragment thereof, wherein B is a first chemical moiety, j is 0 or 1, n is an integer from 1-10, X is any amino acid, r is an integer from 0 to 2, m is an integer from 1 to 3, R is a second chemical moiety, p is 0 or 1, and [lys-ile-arg-ala-his-pro-his-xr-(pro)n] is the retro-inverso peptide of [(Pro)n-Xr-His-Pro-His-Ala-Arg-Ile-Lys].
    Type: Application
    Filed: April 30, 2014
    Publication date: March 10, 2016
    Inventors: Satu Vainikka, George Steven Morris, Samuel Ogunsalu, Gabriella Castoria, Antimo Migliaccio, Fernando Auricchio
  • Publication number: 20140322306
    Abstract: The invention provides a molecule that inhibits or prevents an interaction between a Src family kinase and an androgen or estradiol receptor, for use in preventing or treating a non-cancerous condition in which an activity of AR and/or ER is a contributory factor in a subject, or for use in preventing or treating a cancerous condition in which an activity of AR and/or ER is a contributory factor in a subject who wishes to preserve fertility, or for use in preventing or treating a gynaecological condition in which an activity of AR and/or ER is a contributory factor in a subject.
    Type: Application
    Filed: November 1, 2012
    Publication date: October 30, 2014
    Inventors: Mark Eccleston, Satu Vainikka, George Steven Morris
  • Publication number: 20120077270
    Abstract: A method for suppressing the expression of a selected gene in a cell, the method comprising introducing into the cell a molecule comprising (1) a nucleic acid binding portion which binds to a site or associated with the selected gene which site is present in a genome and (2) an expression repressor portion, wherein the nucleic acid binding portion comprises an oligonucleotide or oligonucleotide mimic or analogue, and wherein the repressor portion comprises a polypeptide or peptidomimetic. Molecules for use in the methods of the invention are provided. The repressor may be a portion of a histone deacetylase or DNA methylase or polypeptide capable of recruiting a histone deacetylase or DNA methylase.
    Type: Application
    Filed: October 3, 2011
    Publication date: March 29, 2012
    Applicant: IMPERIAL COLLEGE INNOVATIONS LIMITED
    Inventors: Stephen Hart, Simak Ali, Boris Tumi PuFong, Andrew C.G. Porter, Laki Buluwela, Satu Vainikka, John David Jenkinson, Patrick Kanda
  • Publication number: 20090082250
    Abstract: A method for suppressing the expression of a selected gene in a cell the method comprising introducing into the cell a molecule comprising (1) a nucleic acid binding portion which binds to a site or associated with the selected gene which site is present in a genome and (2) an expression repressor portion, wherein the nucleic acid binding portion comprises an oligonucleotide or oligonucleotide mimic or analogue, and wherein the repressor portion comprises a polypeptide or peptidomimetic. Molecules for use in the methods of the invention are provided. The repressor may be a portion of a histone deacetylase or DNA methylase or polypeptide capable of recruiting a histone deacetylase or DNA methylase.
    Type: Application
    Filed: May 13, 2008
    Publication date: March 26, 2009
    Applicant: IMPERIAL COLLEGEINNOVATIONS LIMITED
    Inventors: Stephen Hart, Simak Ali, Boris Tumi PuFong, Andrew C. G. Porter, Laki Buluwela, Satu Vainikka, John David Jenkinson, Patrick Kanda
  • Publication number: 20060247192
    Abstract: A method for suppressing the expression of a selected apoptosis-related gene in a cell the method comprising introducing into the cell a molecule comprising (1) a nucleic acid binding portion which binds to a site at or associated with the selected gene which site is present in a genome and (2) a modifying portion, wherein the nucleic acid binding portion comprises an oligonucleotide or oligonucleotide mimic or analogue, and wherein the repressor portion comprises a polypeptide or peptidomimetic. Molecules for use in the methods of the invention are provided. The repressor or modifying portion may be a portion of a histone deacetylase or DNA methylase or polypeptide capable of recruiting a histone deacetylase or DNA methylase. The nucleic acid binding portion may be a triplex forming oligonucleotide (TFO). The apoptosis-related gene may be Bcl-2.
    Type: Application
    Filed: December 5, 2003
    Publication date: November 2, 2006
    Inventors: John Jenkinson, Patrick Kanda, Satu Vainikka
  • Publication number: 20050136040
    Abstract: A method for suppressing the expression of a selected gene in a cell the method comprising introducing into the cell a molecule comprising (1) a nucleic acid binding portion which binds to a site or associated with the selected gene which site is present in a genome and (2) an expression repressor portion, wherein the nucleic acid binding portion comprises an oligonucleotide or oligonucleotide mimic or analogue, and wherein the repressor portion comprises a polypeptide or peptidomimetic. Molecules for use in the methods of the invention are provided. The repressor may be a portion of a histone deacetylase or DNA methylase or polypeptide capable of recruiting a histone deacetylase or DNA methylase.
    Type: Application
    Filed: April 8, 2004
    Publication date: June 23, 2005
    Applicant: Imperial College Innovations Limited
    Inventors: Stephen Hart, Simak Ali, Boris PuFong, Andrew Porter, Laki Buluwela, Satu Vainikka, John Jenkinson, Patrick Kanda