Abstract: Devices which are used for performing multiple modes of electro, vacuum and ultrasound therapy are disclosed as well as methods of using those devices. One device for providing a constant current and/or a constant voltage to regions of a patient's body includes a housing, at least one microprocessor for generating at least one signal, at least one amplifier circuit for amplifying the one or more signals, at least one feedback circuit for delivering at least one constant current to a patient's body, at least one lead wire socket located on the exterior of the housing, at least one pair of electrodes connected to the one or more lead wire sockets, wherein the electrodes are placed in communication with at least one region of the patient's body so that an output current and or voltage is delivered to one or more of the skin regions of the patient's body.