Patents by Inventor Saul J. Priceman

Saul J. Priceman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Membrane-bound IL-12 for cellular immunotherapy
    Patent number: 12129286
    Abstract: This disclosure relates to, inter alia, cells expressing both a chimeric antigen receptor (CAR) and membrane bound IL-12 and the use of these cells to target and treat cancers (e.g., solid tumors and cancers expressing CD19, CD22, BCMA, PSCA, HER2, TAG-72, and PSCA). The disclosure also relates to cells expressing a membrane bound IL-12.
    Type: Grant
    Filed: March 21, 2024
    Date of Patent: October 29, 2024
    Assignee: City of Hope
    Inventors: Saul J. Priceman, John P. Murad, Eric Lee
  • MEMBRANE-BOUND IL-12 FOR CELLULAR IMMUNOTHERAPY
    Publication number: 20240254183
    Abstract: This disclosure relates to, inter alia, cells expressing both a chimeric antigen receptor (CAR) and membrane bound IL-12 and the use of these cells to target and treat cancers (e.g., solid tumors and cancers expressing CD19, CD22, BCMA, PSCA, HER2, TAG-72, and PSCA). The disclosure also relates to cells expressing a membrane bound IL-12.
    Type: Application
    Filed: March 21, 2024
    Publication date: August 1, 2024
    Inventors: Saul J. Priceman, John P. MURAD, Eric LEE
  • CHIMERIC ANTIGEN RECEPTORS TARGETED TO PSCA
    Publication number: 20230348617
    Abstract: Chimeric transmembrane immunoreceptors (CAR) targeted to PSCA are described.
    Type: Application
    Filed: August 17, 2022
    Publication date: November 2, 2023
    Inventors: Saul J. Priceman, Christine E. Brown, Stephen J. Forman
  • COMPOSITION AND METHOD FOR REDUCING EXPRESSION OF CHECKPOINT INHIBITORS IN T CELLS EXPRESSING A CAR OR CTL
    Publication number: 20230065784
    Abstract: Described herein is an approach for targeting multiple critical checkpoint genes involved in T cell exhaustion, for example, PD-1, TIM3, and LAG-3 in a manner that allows knock-down of their expression in T cells that also express a T cell receptor targeted to cancer cells, e.g., a CAR targeted to a cancer antigen or a T cell receptor (TCR).
    Type: Application
    Filed: March 20, 2020
    Publication date: March 2, 2023
    Inventors: Saul J. Priceman, John C. Burnett, Yukiko Yamaguchi, Elizabeth Epps
  • Chimeric antigen receptors targeted to PSCA
    Patent number: 11466097
    Abstract: Chimeric transmembrane immunoreceptors (CAR) targeted to PSCA are described.
    Type: Grant
    Filed: October 6, 2016
    Date of Patent: October 11, 2022
    Assignee: City of Hope
    Inventors: Saul J. Priceman, Christine E. Brown, Stephen J. Forman
  • CHIMERIC ANTIGEN RECEPTORS TARGETING HER2
    Publication number: 20220265796
    Abstract: Chimeric transmembrane immunoreceptors (CAR) which include an extracellular domain targeted to HER2, a transmembrane region, a costimulatory domain and an intracellular signaling domain are described.
    Type: Application
    Filed: December 6, 2021
    Publication date: August 25, 2022
    Inventors: Saul J. Priceman, Stephen J. Forman, Christine E. Brown
  • Chimeric antigen receptors targeting HER2
    Patent number: 11197919
    Abstract: Chimeric transmembrane immunoreceptors (CAR) which include an extracellular domain targeted to HER2, a transmembrane region, a costimulatory domain and an intracellular signaling domain are described.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: December 14, 2021
    Assignee: City of Hope
    Inventors: Saul J. Priceman, Stephen J. Forman, Christine E. Brown
  • TAG72 TARGETED CHIMERIC ANTIGEN RECEPTOR MODIFIED T CELLS FOR TREATMENT OF TAG72-POSITIVE TUMORS
    Publication number: 20210308184
    Abstract: Chimeric antigen receptors targeted to TAG72 and the use thereof to treat ovarian cancer and other cancers are described
    Type: Application
    Filed: August 1, 2019
    Publication date: October 7, 2021
    Inventors: Saul J. Priceman, John P. Murad, Stephen J. Forman, Jack Shively, Paul Yazaki, David Colcher, Anna Kozlowska, Hee Jun Lee
  • Administration of Engineered T Cells for Treatment of Cancers in the Central Nervous System
    Publication number: 20210244761
    Abstract: An improved method of treating cancers with engineered T cells is described.
    Type: Application
    Filed: September 18, 2020
    Publication date: August 12, 2021
    Inventors: Behnam Badie, Christine E. Brown, Stephen J. Forman, Saul J. Priceman
  • CHIMERIC ANTIGEN RECEPTORS TARGETED TO PSCA
    Publication number: 20200308300
    Abstract: Chimeric transmembrane immunoreceptors (CAR) targeted to PSCA are described.
    Type: Application
    Filed: October 6, 2016
    Publication date: October 1, 2020
    Inventors: Saul J. Priceman, Christine E. Brown, Stephen J. Forman
  • ONCOLYTIC VIRUS EXPRESSING A CAR T CELL TARGET AND USES THEREOF
    Publication number: 20200215132
    Abstract: An oncolytic poxvirus encoding a truncated human CD19 is used in conjunction with a chimeric antigen receptor to treat solid tumors.
    Type: Application
    Filed: August 10, 2018
    Publication date: July 9, 2020
    Inventors: Yuman Fong, Saul J. Priceman, Stephen J. Forman, Nanhai Chen, Anthony K. Park
  • CHIMERIC ANTIGEN RECEPTORS TARGETING HER2
    Publication number: 20180326032
    Abstract: Chimeric transmembrane immunoreceptors (CAR) which include an extracellular domain targeted to HER2, a transmembrane region, a costimulatory domain and an intracellular signaling domain are described.
    Type: Application
    Filed: November 4, 2016
    Publication date: November 15, 2018
    Inventors: Saul J. Priceman, Stephen J. Forman, Christine E. Brown
  • Administration of Engineered T Cells for Treatment of Cancers in the Central Nervous System
    Publication number: 20170224733
    Abstract: An improved method of treating cancers with engineered T cells is described.
    Type: Application
    Filed: February 6, 2017
    Publication date: August 10, 2017
    Inventors: Behnam Badie, Christine E. Brown, Stephen J. Forman, Saul J. Priceman