Patents by Inventor Saverio LaFrancesca

Saverio LaFrancesca has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PRODUCTION OF A BIOENGINEERED LUNG
    Publication number: 20210155904
    Abstract: The present invention provides processes for producing a bioengineered lung (BEL) from an acellular lung matrix that has been treated with growth hormones, seeded with primary lung cells, and cultured in a bioreactor. Also provided are BELs and methods of transplanting the BEL into a subject in need of a lung transplant, and methods for using BELs for the study of the lung microbiome and its role in lung development and remodeling.
    Type: Application
    Filed: April 18, 2019
    Publication date: May 27, 2021
    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Joaquin CORTIELLA, Joan E. NICHOLS, Jean NILES, Saverio LAFRANCESCA, Jason SAKAMOTO
  • ORGANS FOR TRANSPLANTATION
    Publication number: 20180325945
    Abstract: The invention provides methods and compositions that improve the success of organ transplantation. The methods and compositions are directed to exposing a desired organ to stem cells prior to, during, and/or after transplantation. In one embodiment, the stem cells reduce the deleterious effects of ischemia on an organ designated to be harvested for transplantation or that has been harvested for transplantation. In another embodiment in which an organ designated for transplantation is perfused ex vivo, the method involves reducing ischemic reperfusion injury by perfusing the organ with a medium that contains stem cells.
    Type: Application
    Filed: January 8, 2018
    Publication date: November 15, 2018
    Inventors: Saverio LaFrancesca, Anthony E. Ting, Robert J. Deans
  • Organs for transplantation
    Patent number: 9861660
    Abstract: The invention provides methods and compositions that improve the success of organ transplantation. The methods and compositions are directed to exposing a desired organ to stem cells prior to, during, and/or after transplantation. In one embodiment, the stem cells reduce the deleterious effects of ischemia on an organ designated to be harvested for transplantation or that has been harvested for transplantation. In another embodiment in which an organ designated for transplantation is perfused ex vivo, the method involves reducing ischemic reperfusion injury by perfusing the organ with a medium that contains stem cells.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: January 9, 2018
    Inventors: Saverio LaFrancesca, Anthony P. Ting, Robert J. Deans
  • Organs for Transplantation
    Publication number: 20140308252
    Abstract: The invention provides methods and compositions that improve the success of organ transplantation. The methods and compositions are directed to exposing a desired organ to stem cells prior to, during, and/or after transplantation. In one embodiment, the stem cells reduce the deleterious effects of ischemia on an organ designated to be harvested for transplantation or that has been harvested for transplantation. In another embodiment in which an organ designated for transplantation is perfused ex vivo, the method involves reducing ischemic reperfusion injury by perfusing the organ with a medium that contains stem cells.
    Type: Application
    Filed: April 14, 2014
    Publication date: October 16, 2014
    Inventors: Saverio LaFrancesca, Anthony P. Ting, Robert J. Deans