Patents by Inventor Scott Alan Hilderbrand

Scott Alan Hilderbrand has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210299265
    Abstract: The present invention provides a novel method for preparing a cell-binding agent cytotoxic agent conjugate. The method comprises the step of reacting a cell-binding agent with a cytotoxic agent or a cytotoxic agent-linker compound having a reactive group capable of forming a covalent bond with the cell-binding agent at a pH between 4 to 9 in the presence of a buffer solution with high ionic strength, wherein the cell-binding agent comprises a lysine ?-NH2 group that forms a covalent bond with the cytotoxic agent or the cytotoxic agent-linker compound having an amine-reactive group. The cell-binding agent-cytotoxic agent conjugates prepared according to the methods described herein are also included in the present invention.
    Type: Application
    Filed: February 3, 2017
    Publication date: September 30, 2021
    Inventors: Katharine C. Lai, Robert W. Herbst, Scott Alan Hilderbrand
  • Publication number: 20190111147
    Abstract: The present invention generally relates to methods of preventing methionine oxidation in immunoconjugates. The present invention also relates to pharmaceutical compositions of immunoconjugates in which the amount of methionine oxidation is minimized.
    Type: Application
    Filed: September 21, 2018
    Publication date: April 18, 2019
    Inventors: Michael Fleming, Amit Gangar, Nicholas C. Yoder, Chen Bai, Scott Alan Hilderbrand, Benjamin M. Hutchins