Patents by Inventor Sean M. Baker

Sean M. Baker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods relating to DNA mismatch repair genes
    Publication number: 20030224463
    Abstract: Genomic sequences of human mismatch repair genes and gene products are described, as are methods of detecting mutations and/or polymorphisms in those genes. Also described are methods of diagnosing cancer susceptibility in a subject, and methods of identifying and classifying mismatch-repair-defective tumors. In particular, sequences and methods relating to human mutL homologs, hMLH1 and hPMS1 genes and gene products are provided.
    Type: Application
    Filed: January 22, 2003
    Publication date: December 4, 2003
    Inventors: Robert M. Liskay, C. Eric Bronner, Sean M. Baker, Roni J. Bollag, Richard D. Kolodner
  • Compositions and methods relating to DNA mismatch repair genes
    Patent number: 6538108
    Abstract: Genomic sequences of human mismatch repair genes and gene products are described, as are methods of detecting mutations and/or polymorphisms in those genes. Also described are methods of diagnosing cancer susceptibility in a subject, and methods of identifying and classifying mismatch-repair-defective tumors. In particular, sequences and methods relating to human mutL homologs, hMLH1 and hPMS1 genes and gene products are provided.
    Type: Grant
    Filed: March 10, 1999
    Date of Patent: March 25, 2003
    Assignees: Dana-Farber Cancer Institute, Oregon Health Sciences University
    Inventors: Robert M. Liskay, C. Eric Bronner, Sean M. Baker, Roni J. Bollag, Richard D. Kolodner
  • Compositions and methods relating to DNA mismatch repair genes
    Patent number: 6191268
    Abstract: Genomic sequences of human mismatch repair genes are described, as are methods of detecting mutations and/or polymorphisms in those genes. Also described are methods of diagnosing cancer susceptibility in a subject, and methods of identifying and classifying mismatch-repair-defective tumors. In particular, sequences and methods relating to human mutL homologs, hMLH1 and hPMS1 genes are provided.
    Type: Grant
    Filed: December 9, 1994
    Date of Patent: February 20, 2001
    Assignees: Dana-Farber Cancer Institute, Oregon Health Sciences University
    Inventors: Robert M. Liskay, C. Eric Bronner, Sean M. Baker, Roni J. Bollag, Richard D. Kolodner
  • Composition and methods relating to DNA mismatch repair genes
    Patent number: 6165713
    Abstract: Genomic sequences of human mismatch repair genes are described, as are methods of detecting mutations and/or polymorphisms in those genes. Also described are methods of diagnosing cancer susceptibility in a subject, and methods of identifying and classifying mismatch-repair-defective tumors. In particular, sequences and methods relating to human mutL homologs, hMLH1 and hPMS1 genes are provided.
    Type: Grant
    Filed: October 31, 1997
    Date of Patent: December 26, 2000
    Assignees: Oregon Health Sciences University, Dana-Farber Cancer Institute
    Inventors: Robert M. Liskay, C. Eric Bronner, Sean M. Baker, Roni J. Bollag, Richard D. Kolodner
  • Mammalian DNA mismatch repair genes MLH1 and PMS1
    Patent number: 5922855
    Abstract: We have discovered two human genes, hMLH1 and hPMS1, each of which apparently encodes for a protein involved in DNA mismatch repair. The hMLH1 gene encodes for a protein which is homologous to the bacterial DNA mismatch repair protein MutL, and is located on human chromosome 3p21.3-23. We believe that mutations in the hMLH1 gene cause hereditary non-polyposis colon cancer (HNPCC) in some individuals based upon the similarity of the hMLH1 gene product to the yeast DNA mismatch repair protein MLH1, the coincident location of the hMLH1 gene and the HNPCC locus on chromosome 3, and hMLH1 missense mutations in affected individuals from a chromosome 3-linked HNPCC family. The human hPMS1 gene is homologous to the yeast DNA mismatch repair gene PMS1, and is located on human chromosome 7q.
    Type: Grant
    Filed: March 8, 1994
    Date of Patent: July 13, 1999
    Assignees: Oregon Health Sciences University, Dana-Farber Cancer Institute
    Inventors: Robert M. Liskay, C. Eric Bronner, Sean M. Baker, Roni J. Bollag, Richard D. Kolodner