Abstract: The present invention provides a medicament having a gentle but strong defecation-promoting action without causing diarrhea. That is, it provides a defecation-promoting agent comprising a compound having an adenosine A2 receptor antagonism, preferably an adenosine A2b receptor antagonism, or a salt thereof.

Abstract: The present invention provides a medicament having a gentle but strong defecation-promoting action without causing diarrhea. That is, it provides a defecation-promoting agent comprising a compound having an adenosine A2receptor antagonism, preferably an adenosine A2b receptor antagonism, or a salt thereof.

Abstract: A sulfur-containing compound has a structure represented by formula (1): (wherein R1 represents a hydrogen atom, a reactive terminal group, a straight, branched or cyclic alkyl group having 1 to 10 carbon atoms and a reactive terminal group or its thia derivative thereof, an aryl group, or an aralkyl group; Y represents an oxygen atom, a sulfur atom, a selenium atom, or a tellurium atom; R represents a substituted or unsubstituted bivalent hydrocarbon group having 1 to 10 carbon atoms, which may be thianated; n represents an integer of 0 to 3; X1 is substituted for any one of groups R2 to R7 of a partial structure represented by formula (2) in which the groups R2 to R7 other than the group substituted by X1 are independently a hydrogen atom or a substituted or unsubstituted monovalent hydrocarbon group having 1 to 10 carbon atoms; and R1 is not a group having a (meth)acryl group when Y is an oxygen atom.

Abstract: The invention provides an optical material being excellent in balance between the heat resistance, Abbe number and refractive index by providing a compound represented by the general formula (1): in the formula, k and n representing integers of 0 to 2 and 0 to 1, respectively, with the proviso that k and n are not simultaneously zero, and k=0 meaning that —(CH2)k- is not included in the formula.

Abstract: In a composite writing instrument having mounted therein a plurality of writing devices including at least one ball-point pen refill equipped with a tip of the ball-point pen at a top end and an ink reservoir section at a rear end so that writing tip portions may be alternately allowed to project and retreat from an front body top, a pumping type pressurization mechanism is provided behind the ball-point pen refill, and a rear end of ink is pressurized by way of knock operation in a situation where a tip end portion has projected from a body end, so as to help the ink flow towards the tip side.

Abstract: A writing implement includes a cylindrical shaft member, a pen tip member which is fixed to one end of the shaft member and from which colored ink seeps out, liquid for ink which is stored in the shaft member and which comprises a part of the colored ink seeping out from the end of the pen tip member, and colorant to be added to the above described liquid for ink to be the colored ink. Moreover, at least a part of a cylindrical side surface of the shaft member corresponding to the storing part of the liquid for ink is formed to be transparent. Between the liquid for ink and the colorant-storing part storing the colorant is provided a colorant-adsorbing core which introduces the liquid for ink into the colorant-storing part while capturing the colorant diffusing toward the storing part of the liquid for ink.

Abstract: A writing implement includes a cylindrical shaft member, a pen tip member which is fixed to one end of the shaft member and from which colored ink seeps out, liquid for ink which is stored in the shaft member and which comprises a major component of the colored ink seeping out from an end of the pen tip member, colorant to be added to the liquid for ink, and a valve member for isolating the colorant from the liquid for ink. In the writing implement, at least a part of a cylindrical side surface of the shaft member corresponding to a part where the liquid for ink is stored is formed to be transparent, the valve member is positioned between the storing part of the liquid for ink and the colorant, and the storing part of the liquid for ink is provided with a pressure-regulating part.

Abstract: A transmission apparatus includes a part which sets a resource management information path based on a given network management protocol onto PVC logically set traffic defined in ATM switching so that a customer network management agent process and a user network management system can communicate with each other.

Abstract: A sulfur-containing compound has a structure represented by formula (1): (wherein R1 represents a hydrogen atom, a reactive terminal group, a straight, branched or cyclic alkyl group having 1 to 10 carbon atoms and a reactive terminal group or its thia derivative thereof, an aryl group, or an aralkyl group; Y represents an oxygen atom, a sulfur atom, a selenium atom, or a tellurium atom; R represents a substituted or unsubstituted bivalent hydrocarbon group having 1 to 10 carbon atoms, which may be thianated; n represents an integer of 0 to 3; X1 is substituted for any one of groups R2 to R7 of a partial structure represented by formula (2) in which the groups R2 to R7 other than the group substituted by X1 are independently a hydrogen atom or a substituted or unsubstituted monovalent hydrocarbon group having 1 to 10 carbon atoms; and R1 is not a group having a (meth)acryl group when Y is an oxygen atom.

Abstract: A composition for making a high-refractive-index resin contains a polythiol compound and a compound containing at least two iso(thio)cyanato groups, the polythiol compound having a dithioacetal, dithioketal, orthotrithioformic ester, or orthotetrathiocarbonic ester skeleton. The molar ratio of the mercapto group to the iso(thio)cyanato group in the composition is greater than 1.0 but not more than 3.0. A method for making a resin by curing the composition, a resin prepared by curing the composition, an optical element made from the resin, and a lens made from the optical element are also provided.

Abstract: A polymerizable composition and a manufacturing method thereof are provided, in which the composition is capable of meeting requirements of overcoming decrease in production yield of a resin composed of a thioepoxy compound, the decrease being caused by variations in refractive index, hue, and optical strain. In a polymerizable composition containing a compound having at least one structure represented by the above formula (where R1 represents a hydrocarbon having 1 to 10 carbon atoms, R2, R3, and R4 each represent a hydrocarbon group having 1 to 10 carbon atoms or a hydrogen atom.), the total of a thioepoxy compound A, which has at least one structure represented by formula (2) and at least one structure represented by formula (3), and a thioepoxy compound B, which has at least one structure represented by formula (4) and at least one structure represented by formula (3), is 4 mass percent or less with respect to the total mass of the polymerizable composition.

Abstract: The present invention provides compounds having formula (I), wherein R1, R2, R3 and n are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of inflammatory or autoimmune and proliferative disorders and as inhibitors of cell adhesion molecule expression and inflammatory cytokine signal transduction generally.

Abstract: A laminated electronic component comprising: a plurality of parallel first conductive patterns, which are laminated via a magnetic layer to a plurality of parallel second conductive patterns, the first and second conductive patterns being alternately connected to each other via through-holes, thereby forming a spiral coil inside a laminated body, the axis of the spiral coil being parallel to a mount face; wherein the magnetic layer, provided between the plurality of first conductive patterns and the plurality of second conductive patterns, comprises non-magnetic sections which are provided at positions corresponding to ends of the conductive patterns and extend parallel to the axis of the coil, and a method for manufacturing the same.

Abstract: In a composite writing instrument having mounted therein a plurality of writing means including at least one ball-point pen refill equipped with a tip of the ball-point pen at a top end and an ink reservoir section at a rear end so that writing tip portions may be alternately allowed to project and retreat from an front body top, a pumping type pressurization mechanism is provided behind the ball-point pen refill, and a rear end of ink is pressurized by way of knock operation in a situation where a tip end portion has projected from a body end, so as to help the ink flow towards the tip side.

Abstract: The invention provides an optical material being excellent in balance between the heat resistance, Abbe number and refractive index by providing a compound represented by the general formula (1): in the formula, k and n representing integers of 0 to 2 and 0 to 1, respectively, with the proviso that k and n are not simultaneously zero, and k=0 meaning that —(CH2)k- is not included in the formula.

Abstract: The present invention provides a preventive or therapeutic agent for diabetes mellitus and diabetic complications, which is a new type based on an adenosine A2 receptor antagonist action. That is, it provides a novel condensed imidazole compound which has an adenosine A2 receptor antagonist action, is effective for preventing or treating diabetes mellitus and diabetic complications, and is represented by the formula (I); (wherein R1 represents e.g. an amino group which may be substituted with an alkyl group; R2 represents e.g. hydrogen atom, an alkyl group, a cycloalkyl group or an alkyl group, alkenyl group or alkynyl group which may be substituted with hydrox etc.; R3 represents e.g. an optionally substituted alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, pyridinone group, pyrimidinone group or piperadinone group; Ar represents e.g.

Abstract: The invention provides methods of treating and preventing heat shock protein-associated diseases and conditions.

Abstract: A writing implement includes a cylindrical shaft member, a pen tip member which is fixed to one end of the shaft member and from which colored ink seeps out, liquid for ink which is stored in the shaft member and which comprises a part of the colored ink seeping out from the end of the pen tip member, and colorant to be added to the above described liquid for ink to be the colored ink. Moreover, at least a part of a cylindrical side surface of the shaft member corresponding to the storing part of the liquid for ink is formed to be transparent. Between the liquid for ink and the colorant-storing part storing the colorant is provided a colorant-adsorbing core which introduces the liquid for ink into the colorant-storing part while capturing the colorant diffusing toward the storing part of the liquid for ink.

Abstract: A writing implement includes a cylindrical shaft member, a pen tip member which is fixed to one end of the shaft member and from which colored ink seeps out, liquid for ink which is stored in the shaft member and which comprises a major component of the colored ink seeping out from an end of the pen tip member, colorant to be added to the liquid for ink, and a valve member for isolating the colorant from the liquid for ink. In the writing implement, at least a part of a cylindrical side surface of the shaft member corresponding to a part where the liquid for ink is stored is formed to be transparent, the valve member is positioned between the storing part of the liquid for ink and the colorant, and the storing part of the liquid for ink is provided with a pressure-regulating part.

Abstract: The present invention provides a preventive or therapeutic agent of a new type for diabetes mellitus and diabetic complications on the basis of an adenosine A2 receptor antagonist action. A purine compound represented by the formula (I), its pharmacologically acceptable salt or hydrates thereof has an adenosine A2 receptor antagonistic action and is useful for prevention or therapy of diabetes mellitus and diabetic complications. In addition, adenosine A2 receptor antagonists having different structures from those of the compounds described above, for example KW6002, are also effective for prevention or therapy of diabetes mellitus and diabetic complications. In the formula, W is —CH2CH2—, or —CH?CH— or —C?C—; R1 is: (in the formula, X is hydrogen atom, hydroxyl group, a lower alkyl group, a lower alkoxy group, etc.; and R5 and R6 are the same as or different from each other and each represents hydrogen atom, a lower alkyl group, a cycloalkyl group, etc.) and the like; R2 is an amino group, etc.