Patents by Inventor Seiji Shimazaki

Seiji Shimazaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200155764
    Abstract: A dual chamber prefillable syringe (100) includes: a cylinder (10) which has a bypass portion (11); a hub luer-lock (20); a front stopper (30); a middle stopper (40) which seals a preparation (S) together with the front stopper (30); an end stopper (50) which seals a solvent (L) together with the middle stopper (40); a finger grip (60); and a plunger rod (70) which is connected to the end stopper from the rear end side. A female screw portion (64) which is screwed around the axis line is formed on an inner circumferential surface of the finger grip (60), and a male screw portion (73) which is able to be screwed to the female screw portion is formed on an outer circumferential surface of the plunger rod (70).
    Type: Application
    Filed: November 15, 2019
    Publication date: May 21, 2020
    Applicants: ARTE CORPORATION, OTSUKA PHARMACEUTICAL CO. LTD.
    Inventors: Makoto KAKIUCHI, Seiji SHIMAZAKI, Yasuhiko TAKESHIMA, Shogo HIRAOKA, Tadayoshi MAESAKA
  • Patent number: 9919094
    Abstract: A cartridge set including: a plurality of cartridges; a plurality of holders, each of which has an upper end externally fitted to the outer peripheral surface of each of the cartridges, and has a lower end face whose outer diameter is greater than the outer diameter of the outer peripheral surface of the cartridge; a supporting plate that has a plurality of through-holes, each of which has an inner diameter greater than the outer diameter of the outer peripheral surface of the cartridge and has each of the plurality of cartridges inserted therethrough; a storage box that stores the supporting plate therein; and a lid member that blocks an upper end opening of the storage box.
    Type: Grant
    Filed: June 18, 2013
    Date of Patent: March 20, 2018
    Assignee: ARTE CORPORATION
    Inventors: Seiji Shimazaki, Makoto Kakiuchi, Teruo Matsuda
  • Patent number: 9801999
    Abstract: A manufacturing method of two-chamber type combined container-syringe including: a vacuum plugging process (S2) of eliminating air bubbles from the dissolving solution of the dissolving solution-filled cartridge and sealing the dissolving solution with a middle stopper after the dissolving solution filling process (S1); a vacuum plugging process (S2) has a first cooling processing (S21) of cooling the inside of a vacuum plugging equipment in which a dissolving solution-filled cartridge is disposed to a cooling temperature that does not freeze the dissolving solution, a first decompression processing (S23) of decreasing a pressure inside the vacuum plugging equipment while the vacuum plugging equipment maintains the cooling temperature after the first cooling processing (S21), and a middle stopper pushing processing (S24) of pushing the middle stopper downward and bringing the middle stopper into contact with the dissolving solution after the first decompression processing (S23).
    Type: Grant
    Filed: May 7, 2014
    Date of Patent: October 31, 2017
    Assignee: ARTE CORPORATION
    Inventors: Kiyoshi Okajima, Seiji Shimazaki
  • Patent number: 9636463
    Abstract: A combination container/syringe (1) provided with an outer cylinder (10) that forms a cylindrical shape centered on an axial line (O); a front stopper that is inserted into a distal end side of the outer cylinder (10); and a cylindrical tip (50) that is fitted to an outer periphery of the distal end of the outer cylinder via a fitting hole (61) at a base end side, and that has a bypass chamber (71) that houses the front stopper at a front side of the fitting hole, in which an inner diameter of the bypass chamber is formed larger than an outer diameter of the front stopper, and a plurality of ribs (74) that protrude toward an inside in a radial direction and extend in the direction of the axial line to make close contact with the outer peripheral surface of the front stopper that has moved to the inside of the bypass chamber are provided spaced apart in a circumferential direction on the inner peripheral surface (73) of the bypass chamber.
    Type: Grant
    Filed: February 2, 2012
    Date of Patent: May 2, 2017
    Assignee: ARTE CORPORATION
    Inventors: Makoto Kakiuchi, Harumi Kakiuchi, Seiji Shimazaki
  • Patent number: 9333147
    Abstract: A device for sealing a vessel, in particular a cartridge (7) or a test-tube for accommodating a freeze-dried pharmaceutical product (S), wherein the vessel (1) comprises at its opening end (3) an opening edge (4) and an adjoining longitudinal portion (5) with an evenly formed inner cross section, including a front plunger (2) to be positioned inside the vessel (1) at the longitudinal portion (5), is characterized in that the front plunger (2) is configured to be positioned in the vessel (1) in a sealing state, in which the front plunger (2) is fully inserted in the vessel (1), or in an exchange state, in which the front plunger (2) is inserted partly in the vessel (1) and partly protrudes over the opening edge (4) of the vessel (1), wherein the front plunger (2) comprises sealing means that are configured to seal the inside of the vessel (1) against the outside when the front plunger (2) is positioned in the sealing state, and one or more communicating grooves (2i) that are configured to place the inside and
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: May 10, 2016
    Assignee: ARTE CORPORATION
    Inventors: Andreas Schuetz, Makoto Kakiuchi, Seiji Shimazaki, Teruo Matsuda
  • Patent number: 9333299
    Abstract: A two-chamber type combined container-syringe includes an outer tube (10) formed in a tubular shape having a uniform inner diameter about an axis (O) thereof throughout the axis direction and provided with a bypass groove (11a) concaved from an inner circumferential surface in a portion in the axis direction, wherein the inner diameter of the outer tube (10) is 6.0 mm or more and 10.0 mm or less, the plurality of bypass grooves are formed in the circumferential direction of the axis at intervals, a cross-sectional area of the bypass groove perpendicular to the axis is 0.13% or more and 0.24% or less of an inner circumferential cross-sectional area of the outer tube perpendicular to the axis, and a depth of the bypass groove concaved from the inner circumferential surface is 2.7% or more and 3.8% or less of the inner diameter of the outer tube. As a result, solution can smoothly flow through the bypass groove, and an amount of solution remaining in the bypass groove can be reduced.
    Type: Grant
    Filed: February 13, 2014
    Date of Patent: May 10, 2016
    Assignee: ARTE CORPORATION
    Inventors: Atsushi Kanazawa, Katsuyoshi Tuchida, Junichi Komuro, Seiji Shimazaki
  • Publication number: 20150041498
    Abstract: A device for accommodating a freeze-dried pharmaceutical product (S) for reconstitution, comprising: a vessel (1) having at its opening end (3) an opening edge (4) and an adjoining longitudinal portion (5) with an evenly formed inner cross section, a front plunger (2) to be positioned inside the vessel (1) at the longitudinal portion (5), wherein the front plunger (2) is configured to be positioned inside the vessel (1) in a sealing state, in which the front plunger (2) is fully inserted in the vessel (1), or in an exchange state, in which the front plunger (2) is inserted partly in the vessel (1) and partly protrudes over the opening edge (4) of the vessel (1), and wherein the front plunger (2) comprises sealing means that are configured to seal the inside of the vessel (1) against the outside when the front plunger (2) is positioned in the sealing state, and one or more communicating grooves (2i) that are configured to place the inside and outside of the vessel (1) in communication with each other when the
    Type: Application
    Filed: February 11, 2013
    Publication date: February 12, 2015
    Inventors: Makoto Kakiuchi, Seiji Shimazaki, Teruo Matsuda, Andreas Schuetz
  • Publication number: 20150013276
    Abstract: A manufacturing method of two-chamber type combined container-syringe including: a vacuum plugging process (S2) of eliminating air bubbles from the dissolving solution of the dissolving solution-filled cartridge and sealing the dissolving solution with a middle stopper after the dissolving solution filling process (S1); a vacuum plugging process (S2) has a first cooling processing (S21) of cooling the inside of a vacuum plugging equipment in which a dissolving solution-filled cartridge is disposed to a cooling temperature that does not freeze the dissolving solution, a first decompression processing (S23) of decreasing a pressure inside the vacuum plugging equipment while the vacuum plugging equipment maintains the cooling temperature after the first cooling processing (S21), and a middle stopper pushing processing (S24) of pushing the middle stopper downward and bringing the middle stopper into contact with the dissolving solution after the first decompression processing (S23).
    Type: Application
    Filed: May 7, 2014
    Publication date: January 15, 2015
    Inventors: Kiyoshi OKAJIMA, Seiji SHIMAZAKI
  • Publication number: 20140316342
    Abstract: A two-chamber type combined container-syringe includes an outer tube (10) formed in a tubular shape having a uniform inner diameter about an axis (O) thereof throughout the axis direction and provided with a bypass groove (11a) concaved from an inner circumferential surface in a portion in the axis direction, wherein the inner diameter of the outer tube (10) is 6.0 mm or more and 10.0 mm or less, the plurality of bypass grooves are formed in the circumferential direction of the axis at intervals, a cross-sectional area of the bypass groove perpendicular to the axis is 0.13% or more and 0.24% or less of an inner circumferential cross-sectional area of the outer tube perpendicular to the axis, and a depth of the bypass groove concaved from the inner circumferential surface is 2.7% or more and 3.8% or less of the inner diameter of the outer tube. As a result, solution can smoothly flow through the bypass groove, and an amount of solution remaining in the bypass groove can be reduced.
    Type: Application
    Filed: February 13, 2014
    Publication date: October 23, 2014
    Inventors: Atsushi KANAZAWA, Katsuyoshi Tuchida, Junichi Komuro, Seiji Shimazaki
  • Publication number: 20140048432
    Abstract: A combination container/syringe (1) provided with an outer cylinder (10) that forms a cylindrical shape centered on an axial line (O); a front stopper that is inserted into a distal end side of the outer cylinder (10); and a cylindrical tip (50) that is fitted to an outer periphery of the distal end of the outer cylinder via a fitting hole (61) at a base end side, and that has a bypass chamber (71) that houses the front stopper at a front side of the fitting hole, in which an inner diameter of the bypass chamber is formed larger than an outer diameter of the front stopper, and a plurality of ribs (74) that protrude toward an inside in a radial direction and extend in the direction of the axial line to make close contact with the outer peripheral surface of the front stopper that has moved to the inside of the bypass chamber are provided spaced apart in a circumferential direction on the inner peripheral surface (73) of the bypass chamber.
    Type: Application
    Filed: February 2, 2012
    Publication date: February 20, 2014
    Applicant: Arte Corporation
    Inventors: Makoto Kakiuchi, Seiji Shimazaki
  • Publication number: 20130341849
    Abstract: A cartridge set including: a plurality of cartridges; a plurality of holders, each of which has an upper end externally fitted to the outer peripheral surface of each of the cartridges, and has a lower end face whose outer diameter is greater than the outer diameter of the outer peripheral surface of the cartridge; a supporting plate that has a plurality of through-holes, each of which has an inner diameter greater than the outer diameter of the outer peripheral surface of the cartridge and has each of the plurality of cartridges inserted therethrough; a storage box that stores the supporting plate therein; and a lid member that blocks an upper end opening of the storage box.
    Type: Application
    Filed: June 18, 2013
    Publication date: December 26, 2013
    Inventors: Seiji SHIMAZAKI, Makoto Kakiuchi, Teruo Matsuda
  • Patent number: 8517983
    Abstract: A dual chamber combined container-syringe includes: an outer casing having a bypass portion; a hub lure lock; a front stopper; a middle stopper that seals a pharmaceutical preparation together with the front stopper; an end stopper that seals a liquid medicine together with the middle stopper; a finger grip; and a plunger rod that is connected to the end stopper from the rear end side, wherein a female screw portion twisted around an axis is formed on an inner peripheral surface of the finger grip, and a first male screw portion, a tip of which comes into contact with a rear end of the female screw portion and can be screwed into the female portion, and a first guide plate are formed on an outer peripheral surface of the plunger rod when a part of the middle stopper enters the bypass portion.
    Type: Grant
    Filed: October 18, 2011
    Date of Patent: August 27, 2013
    Assignee: Arte Corporation
    Inventors: Makoto Kakiuchi, Seiji Shimazaki, Teruo Matsuda
  • Publication number: 20130197467
    Abstract: A device for sealing a vessel, in particular a cartridge (7) or a test-tube for accommodating a freeze-dried pharmaceutical product (S), wherein the vessel (1) comprises at its opening end (3) an opening edge (4) and an adjoining longitudinal portion (5) with an evenly formed inner cross section, including a front plunger (2) to be positioned inside the vessel (1) at the longitudinal portion (5), is characterized in that the front plunger (2) is configured to be positioned in the vessel (1) in a sealing state, in which the front plunger (2) is fully inserted in the vessel (1), or in an exchange state, in which the front plunger (2) is inserted partly in the vessel (1) and partly protrudes over the opening edge (4) of the vessel (1), wherein the front plunger (2) comprises sealing means that are configured to seal the inside of the vessel (1) against the outside when the front plunger (2) is positioned in the sealing state, and one or more communicating grooves (2i) that are configured to place the inside and
    Type: Application
    Filed: August 8, 2011
    Publication date: August 1, 2013
    Applicant: ARTE CORPORATION
    Inventors: Andreas Schuetz, Makoto Kakiuchi, Seiji Shimazaki, Teruo Matsuda
  • Publication number: 20120118777
    Abstract: A packaging plate that supports a plurality of syringe bodies in an arranged state, including a first plate in which a plurality of support hole portions into which the syringe bodies are respectively inserted and each having a rectangular shape in plan view are formed, and an extension portion on which a flange portion of the syringe body is mounted is formed in each of these support hole portions; and a second plate that is stacked on and fixed to the upper surface of the first plate and in which through-holes through which the flange portion cannot pass are formed at locations corresponding to the support hole portions.
    Type: Application
    Filed: September 28, 2011
    Publication date: May 17, 2012
    Applicant: ARTE CORPORATION
    Inventors: Makoto KAKIUCHI, Seiji SHIMAZAKI
  • Publication number: 20120095394
    Abstract: A dual chamber combined container-syringe includes: an outer casing having a bypass portion; a hub lure lock; a front stopper; a middle stopper that seals a pharmaceutical preparation together with the front stopper; an end stopper that seals a liquid medicine together with the middle stopper; a finger grip; and a plunger rod that is connected to the end stopper from the rear end side, wherein a female screw portion twisted around an axis is formed on an inner peripheral surface of the finger grip, and a first male screw portion, a tip of which comes into contact with a rear end of the female screw portion and can be screwed into the female portion, and a first guide plate are formed on an outer peripheral surface of the plunger rod when a part of the middle stopper enters the bypass portion.
    Type: Application
    Filed: October 18, 2011
    Publication date: April 19, 2012
    Applicant: ARTE CORPORATION
    Inventors: Makoto KAKIUCHI, Seiji SHIMAZAKI, Teruo MATSUDA
  • Publication number: 20110174647
    Abstract: In a combined container-syringe, a rubber packing that covers the distal end opening of a cylinder at a fitting hole of a cylindrical tip in an air tight and liquid tight manner, and in which is formed a through hole that brings a communication hole formed in a lure tip and the inside of the cylinder into communication, and a rubber member that is inserted from the distal end side of the communication hole and blocks the through hole are provided, and the rubber packing is formed with an elastic body that is corrosion resistant to the liquid medicament. With this combined container-syringe, in addition to being able to store it for a long period without deteriorating the liquid medicament, it is possible to observe well the liquid medicament or blood that flows to the cylindrical tip, and moreover preventing leftover liquid medicament after injection becomes possible.
    Type: Application
    Filed: February 19, 2009
    Publication date: July 21, 2011
    Applicant: Arte Corporation
    Inventors: Seiji Shimazaki, Makoto Kakiuchi
  • Patent number: 7727203
    Abstract: This combined container-syringe comprising a glass cylinder which can be pre-filled with a drug, an cylindrical tip provided at an exterior portion of an anterior end of the syringe, and a finger grip provided at an exterior portion of an posterior end of the syringe, and a drug is pre-filled therein and sealed by a stopper. Furthermore, an impact absorption part is provided around the exterior portion of the cylindrical tip and a diameter of the impact absorption part is greater than an outer diameter of a fitting part to the cylinder of the cylindrical tip.
    Type: Grant
    Filed: January 19, 2006
    Date of Patent: June 1, 2010
    Assignee: Arte Corporation
    Inventors: Seiji Shimazaki, Makoto Kakiuchi
  • Publication number: 20080188816
    Abstract: A luer-lock type cylindrical tip of a syringe has a luer tip of which a center portion is fitted with an injection needle and a luer-lock portion which is disposed outside the luer tip with a gap therebetween and which has a lock screw disposed therein. The lock screw is formed as a trapezoid screw having a root diameter set to the range of 8.0 mm±0.1 mm, an inner diameter set to the range greater than or equal to 6.6 mm and smaller than 6.8 mm, and a pitch set to the range greater than 2.5 mm and smaller than or equal to 2.8 mm. Accordingly, it is possible to reliably prevent the injection needle from being loosened or pulled out in the handling process. It is also possible to easily replace the syringe needle with another one having different size at the time of use.
    Type: Application
    Filed: November 13, 2007
    Publication date: August 7, 2008
    Inventors: Seiji Shimazaki, Yasuhiko Takeshima
  • Publication number: 20080091148
    Abstract: A combined container-syringe is provided. A bypass chamber and front chamber is provided at a cylindrical tip. The bypass chamber has an inner diameter greater than the outer diameters of front and rear stoppers. The front stopper is inserted into the bypass chamber. The front chamber has an inner diameter equal to the inner diameter of a cylinder or not greater than the outer diameters of the front and rear stoppers and has a volume greater than the volume of a drug solution. A bypass groove is formed in the inner wall of the bypass chamber and allows the cylinder to communicate with the front chamber while bypassing the front stopper. Accordingly, it is possible to provide a combined container-syringe enabling observation of the condition of a drug solution filled therein before making an injection and thus to make an injection in a secure manner.
    Type: Application
    Filed: October 16, 2007
    Publication date: April 17, 2008
    Inventors: Seiji Shimazaki, Makoto Kakiuchi
  • Publication number: 20060184138
    Abstract: This combined container-syringe comprising a glass cylinder which can be pre-filled with a drug, an cylindrical tip provided at an exterior portion of an anterior end of the syringe, and a finger grip provided at an exterior portion of an posterior end of the syringe, and a drug is pre-filled therein and sealed by a stopper. Furthermore, an impact absorption part is provided around the exterior portion of the cylindrical tip and a diameter of the impact absorption part is greater than an outer diameter of a fitting part to the cylinder of the cylindrical tip.
    Type: Application
    Filed: January 19, 2006
    Publication date: August 17, 2006
    Inventors: Seiji Shimazaki, Makoto Kakiuchi