Patents by Inventor Seiji Tokumoto

Seiji Tokumoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10537723
    Abstract: The present invention provides a microneedle device comprising: a substrate; a microneedle disposed on the substrate; and a coating layer formed on the microneedle; wherein the coating layer comprises a physiologically active substance, arginine, and glycerin.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: January 21, 2020
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Shinpei Nishimura, Seiji Tokumoto
  • Publication number: 20190388668
    Abstract: An applicator of one embodiment is for applying a sheet member to skin. The applicator includes: a body including a bottom plate configured to face the skin and a bending portion provided to the bottom plate; a cap being movable along a slide direction substantially orthogonal to the bottom plate; and an elastic member configured to extend along the slide direction between the body and the cap. The elastic member applies, to the cap, elastic force that acts in a direction away from the bottom plate, the cap being movable toward the bottom plate against the elastic force. The bending portion bends the sheet member that has advanced thereto in a pressed state in which the cap has been moved toward the bottom plate, thereby applying the sheet member to the skin.
    Type: Application
    Filed: December 15, 2017
    Publication date: December 26, 2019
    Inventors: Takuya TAJIMA, Naoki YAMAMOTO, Seiji TOKUMOTO
  • Publication number: 20190381300
    Abstract: A method for producing a microneedle device having a coating on the microneedles comprises a step A of drying a precursor composition containing a biologically active substance and a first solvent to obtain -a freeze-dried composition, a step B of mixing the freeze-dried composition with a second solvent to obtain a coating composition, and a step C of applying the coating composition to the microneedles and drying the same, wherein the precursor composition further contains a thickener, or a thickener is added when the freeze-dried composition and the second solvent are mixed.
    Type: Application
    Filed: February 20, 2018
    Publication date: December 19, 2019
    Inventors: Toru KOBAYASHI, Toshiyuki MATSUDO, Shinpei NISHIMURA, Seiji TOKUMOTO, Tetsuji KUWAHARA
  • Publication number: 20190374761
    Abstract: A microneedle device of the present invention comprises a substrate, microneedles disposed on the substrate, and a coating layer formed on the microneedles, wherein a length of the microneedles is 300 to 500 ?m, the microneedles are disposed on the substrate at a density of 28 to 80 needles/cm2, and the coating layer comprises a biologically active substance. The microneedle device allows the skin irritation caused by administration of an agent to be reduced.
    Type: Application
    Filed: February 20, 2018
    Publication date: December 12, 2019
    Inventors: Kazuya MACHIDA, Shinpei NISHIMURA, Seiji TOKUMOTO
  • Publication number: 20190350840
    Abstract: A microneedle device of the present invention comprises a substrate, microneedles disposed on the substrate, and a coating formed on the microneedles, wherein the coating comprising dexmedetomidine or a pharmaceutically acceptable salt thereof and isoproterenol or a pharmaceutically acceptable salt thereof. Using said microneedle device, a fast increase rate of dexmedetomidine concentration in plasma after application of the microneedle device is achieved.
    Type: Application
    Filed: December 25, 2017
    Publication date: November 21, 2019
    Inventors: Ryota HORI, Toshihiro KOGURE, Seiji TOKUMOTO, Shinpei NISHIMURA
  • Publication number: 20190201676
    Abstract: A microneedle sheet is disclosed that comprises a plurality of microneedles formed on a sheet generally along a principal surface of the sheet, wherein the microneedles contain a water-soluble polysaccharide and water, the water content is 1 mass % or more and less than 19 mass % based on the total mass of the microneedles, and the microneedles are raised from the principal surface by bending the sheet.
    Type: Application
    Filed: August 30, 2017
    Publication date: July 4, 2019
    Inventors: Naoki YAMAMOTO, Seiji TOKUMOTO
  • Publication number: 20190117512
    Abstract: A liquid bag according to one embodiment stores liquid containing an active ingredient to be transdermally administered. This liquid bag includes a bag body configured to store the liquid and feed the liquid toward an injection needle. The bag body includes a tubular portion. At least part of the tubular portion is bent with respect to the axial direction of the tubular portion with the liquid being stored in the tubular portion.
    Type: Application
    Filed: December 1, 2016
    Publication date: April 25, 2019
    Inventors: Yusuke SHIROTANI, Kazuki KURIYAMA, Seiji TOKUMOTO
  • Publication number: 20190083770
    Abstract: An applicator according to one embodiment includes a housing having a tubular shape with one closed end, and configured to house an elastic member and a piston plate for transmitting biasing force of the elastic member to the microneedles, and release means configured to release the piston plate engaged in a manner resisting against the biasing force of the elastic member in the housing, to cause the piston plate to move toward an opening of the housing along an axial direction of the housing. The release means is configured, when the release means releases the engagement of the piston plate by moving toward the housing in the axial direction, to transmit force in a direction toward the opening to the housing.
    Type: Application
    Filed: August 19, 2016
    Publication date: March 21, 2019
    Inventors: Shinpei NISHIMURA, Seiji TOKUMOTO, Masafumi ONO
  • Publication number: 20190046779
    Abstract: An applicator according to one embodiment is an applicator for applying a sheet member to skin, and includes: a bottom plate facing the skin; a top plate facing the bottom plate and configured to be pressed toward the bottom plate; and a bending portion configured to apply the sheet member to the skin by bending the sheet member having advanced thereto in a pressed state in which the top plate has been moved toward the bottom plate.
    Type: Application
    Filed: February 15, 2017
    Publication date: February 14, 2019
    Inventors: Takuya TAJIMA, Naoki YAMAMOTO, Kazuki KURIYAMA, Seiji TOKUMOTO
  • Publication number: 20190015652
    Abstract: A microneedle sheet according to an embodiment comprises a plurality of microneedles formed on a sheet substantially along a principal surface of the sheet. The sheet is bent to raise the microneedles from the principal surface, and the raised microneedles pierce a skin.
    Type: Application
    Filed: September 18, 2018
    Publication date: January 17, 2019
    Inventors: Kazuya KOMINAMI, Shinpei NISHIMURA, Seiji TOKUMOTO, Makoto OGURA, Toshiyuki MATSUDO, Naoki YAMAMOTO
  • Patent number: 10086183
    Abstract: An applicator is configured to transfer an active ingredient into a body through skin by a puncture in the skin with microneedles. The applicator includes a piston plate that is provided with a first protrusion part and second protrusion parts on a lower surface side of a main body of the piston plate. The microneedles are provided on a surface of the first protrusion part. The second protrusion parts are provided in a periphery of the first protrusion part while spaced apart from the first protrusion part.
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: October 2, 2018
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Shunsuke Arami, Shinpei Nishimura, Seiji Tokumoto, Makoto Ogura
  • Patent number: 9993549
    Abstract: An adjuvant composition of the present invention contains lauryl alcohol and propylene glycol. Contents of the lauryl alcohol and the propylene glycol are 0.5 to 25% by mass and 8.0 to 99.5% by mass, relative to the total mass of the adjuvant composition, respectively. The lauryl alcohol is dissolved, and the adjuvant composition is used for transdermal or transmucosal administration.
    Type: Grant
    Filed: October 30, 2014
    Date of Patent: June 12, 2018
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Seiji Tokumoto, Kazuya Machida, Nao Kurokawa, Rie Namiki
  • Patent number: 9913970
    Abstract: An applicator includes a piston plate, a non-linear coil spring, a casing, a lock means and a release means. The casing includes a tubular main body part that houses therein the piston plate and the non-linear coil spring, and a cover part that is arranged on one end side of the main body part. The cover part and the piston plate sandwich the non-linear coil spring there between. The lock means locks the piston plate with the casing such that the piston plate is held at a retraction position thereof on the cover part side in a state where the cover part and the piston plate compress the non-linear coil spring. The release means releases a locked state where the piston plate is locked with the casing by the lock means and where the cover part and the piston plate compress the non-linear coil spring.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: March 13, 2018
    Assignee: HISAMITSU PHARMACEUTICAL CO., LTD.
    Inventors: Shunsuke Arami, Makoto Ogura, Seiji Tokumoto
  • Patent number: 9849170
    Abstract: Disclosed is a microneedle coating composition comprising a Japanese encephalitis vaccine antigen, a basic amino acid, and an acid, wherein the mole number of the acid for one mole of the basic amino acid is larger than 1/(N+1) and less than 2, where N represents the valence of the acid.
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: December 26, 2017
    Assignees: HISAMITSU PHARMACEUTICAL CO., INC., THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE
    Inventors: Kazuya Machida, Seiji Tokumoto, Kazuyoshi Kaminaka, Yuji Ishikawa
  • Publication number: 20170348228
    Abstract: The present invention provides a microneedle device comprising: a substrate; a microneedle disposed on the substrate; and a coating layer formed on the microneedle; in which the coating layer comprises a recombinant follicle-stimulating hormone, arginine, and glycerin, in the coating layer, the mass of arginine is 0.07 to 0.75-fold of the mass of the recombinant follicle-stimulating hormone and the mass of glycerin is 0.1 to 2.75-fold of the mass of the recombinant follicle-stimulating hormone.
    Type: Application
    Filed: October 19, 2015
    Publication date: December 7, 2017
    Inventors: Shinpei NISHIMURA, Seiji TOKUMOTO, Takeshi ITO, Hajime ASADA
  • Publication number: 20170266427
    Abstract: The present invention provides a microneedle device comprising: a substrate; a microneedle disposed on the substrate; and a coating layer formed on the microneedle; wherein the coating layer comprises a physiologically active substance, arginine, and glycerin.
    Type: Application
    Filed: September 10, 2015
    Publication date: September 21, 2017
    Inventors: Shinpei NISHIMURA, Seiji TOKUMOTO
  • Patent number: 9498611
    Abstract: An active agent is effectively administered without giving fear to the user when the microneedles are applied. An applicator 10 includes a transmission member that transmits biasing force of a biasing member to a microneedle array including micro projections (microneedles) with a needle density of 500 needles/cm2 or more. The transmission member has a mass of 1.5 g or less, and the transmission member activated by the biasing force of the biasing member has a momentum of from 0.0083 (N·s) to 0.015 (N·s).
    Type: Grant
    Filed: October 2, 2012
    Date of Patent: November 22, 2016
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Seiji Tokumoto, Makoto Ogura
  • Publication number: 20160263215
    Abstract: An adjuvant composition of the present invention contains lauryl alcohol and propylene glycol. Contents of the lauryl alcohol and the propylene glycol are 0.5 to 25% by mass and 8.0 to 99.5% by mass, relative to the total mass of the adjuvant composition, respectively. The lauryl alcohol is dissolved, and the adjuvant composition is used for transdermal or transmucosal administration.
    Type: Application
    Filed: October 30, 2014
    Publication date: September 15, 2016
    Inventors: Seiji TOKUMOTO, Kazuya MACHIDA, Nao KUROKAWA, Rie NAMIKI
  • Publication number: 20160263363
    Abstract: An applicator is configured to transfer an active ingredient into a body through skin by a puncture in the skin with microneedles. The applicator includes a piston plate that is provided with a first protrusion part and second protrusion parts on a lower surface side of a main body of the piston plate. The microneedles are provided on a surface of the first protrusion part. The second protrusion parts are provided in a periphery of the first protrusion part while spaced apart from the first protrusion part.
    Type: Application
    Filed: November 4, 2014
    Publication date: September 15, 2016
    Inventors: Shunsuke ARAMI, Shinpei NISHIMURA, Seiji TOKUMOTO, Makoto OGURA
  • Publication number: 20160107189
    Abstract: The present invention provides a system for manufacturing a therapeutic microneedle configured to regulate an air environment within a coating chamber for manufacturing a therapeutic microneedle by coating a microneedle with a coating liquid containing a drug, the system for manufacturing a therapeutic microneedle comprising an air compressor, a humidity regulator configured to regulate humidity of air supplied from the air compressor, and an air filter configured to eliminate microorganisms from air to be supplied to the inside of the coating chamber.
    Type: Application
    Filed: May 29, 2014
    Publication date: April 21, 2016
    Inventors: Eiji HASHIMOTO, Toshiyuki MATSUDO, Shinpei NISHIMURA, Seiji TOKUMOTO