Patents by Inventor Seiko Narushima

Seiko Narushima has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240325458
    Abstract: The present inventors have found that the content ratios of isoalloLCA, 3-oxoLCA, alloLCA, and 3-oxoalloLCA in the feces of centenarians are higher than those of younger ones, and have also identified gut microbiomes peculiar to centenarians involved in the production of these bile acids. Furthermore, it has been found that these bile acids, enzymes involved in the production thereof, and bacteria producing the enzymes reduce the risk of infection with pathogens, prostate cancer, and the like, and are involved in longevity.
    Type: Application
    Filed: January 18, 2021
    Publication date: October 3, 2024
    Applicants: KEIO UNIVERSITY, JSR CORPORATION
    Inventors: Nobuyoshi HIROSE, Kenya HONDA, Yuko SATO, Koji ATARASHI, Seiko NARUSHIMA, Yasumichi ARAI, Kozue TAKESHITA, Satoshi SASAJIMA
  • Patent number: 12036249
    Abstract: With the aim of proving an antibacterial composition against oral bacteria and the like capable of inducing Th1 cell proliferation or activation in an intestinal tract, the present inventors have found out that bacteria that suppress colonization and the like of the oral bacteria and the like in the intestinal tract are present in an intestinal microbiota. Moreover, the present inventors have succeeded in isolating intestinal bacteria that suppress intestinal colonization and the like of oral bacteria and the like.
    Type: Grant
    Filed: November 21, 2022
    Date of Patent: July 16, 2024
    Assignee: KEIO UNIVERSITY
    Inventors: Kenya Honda, Koji Atarashi, Seiko Narushima, Wataru Suda, Masahira Hattori, Munehiro Furuichi, Takaaki Kawaguchi, Keiko Mitobe
  • Publication number: 20230293656
    Abstract: The result of orally administering saliva derived from a Crohn’s disease patient or an ulcerative colitis patient to germ-free mice has revealed that Th1 cells markedly increased in the colons. Further, from the bacterial microbiota in the intestines of the mice in which such an increase in Th1 cells were observed, bacteria have been successfully isolated which caused strong Th1 cell induction in the colon upon intestinal colonization.
    Type: Application
    Filed: November 1, 2017
    Publication date: September 21, 2023
    Applicant: KEIO UNIVERSITY
    Inventors: Kenya HONDA, Koji ATARASHI, Seiko NARUSHIMA, Wataru SUDA, Masahira HATTORI
  • Publication number: 20230263839
    Abstract: A composition for suppressing trypsin activity is disclosed. The composition contains a bacterium belonging to a genus Paraprevotella as an active ingredient.
    Type: Application
    Filed: March 15, 2023
    Publication date: August 24, 2023
    Applicant: RIKEN
    Inventors: Kenya HONDA, Seiko NARUSHIMA, Eiichiro WATANABE, Osamu OHARA, Yusuke KAWASHIMA, Youxian LI
  • Publication number: 20230190827
    Abstract: With the aim of proving an antibacterial composition against oral bacteria and the like capable of inducing Th1 cell proliferation or activation in an intestinal tract, the present inventors have found out that bacteria that suppress colonization and the like of the oral bacteria and the like in the intestinal tract are present in an intestinal microbiota. Moreover, the present inventors have succeeded in isolating intestinal bacteria that suppress intestinal colonization and the like of oral bacteria and the like.
    Type: Application
    Filed: November 21, 2022
    Publication date: June 22, 2023
    Applicant: KEIO UNIVERSITY
    Inventors: Kenya HONDA, Koji Atarashi, Seiko Narushima, Wataru Suda, Masahira Hattori, Munehiro Furuichi, Takaaki Kawaguchi, Keiko Mitobe
  • Patent number: 11633433
    Abstract: With the aim of proving an antibacterial composition against oral bacteria and the like capable of inducing Th1 cell proliferation or activation in an intestinal tract, the present inventors have found out that bacteria that suppress colonization and the like of the oral bacteria and the like in the intestinal tract are present in an intestinal microbiota. Moreover, the present inventors have succeeded in isolating intestinal bacteria that suppress intestinal colonization and the like of oral bacteria and the like.
    Type: Grant
    Filed: July 18, 2018
    Date of Patent: April 25, 2023
    Assignee: KEIO UNIVERSITY
    Inventors: Kenya Honda, Koji Atarashi, Seiko Narushima, Wataru Suda, Masahira Hattori, Munehiro Furuichi, Takaaki Kawaguchi, Keiko Mitobe
  • Publication number: 20220152132
    Abstract: Disclosed herein are bacteriophage compositions and therapeutic uses thereof. The disclosure also relates to bacteriophage that are capable of lysing Klebsiella bacterial strains, e.g., strains that are associated with inflammatory bowel disease, and thereby capable of modulating disease.
    Type: Application
    Filed: March 6, 2020
    Publication date: May 19, 2022
    Applicants: Keio University, Biomx Ltd.
    Inventors: Kenya HONDA, Koji ATARASHI, Seiko NARUSHIMA, Efrat KHABRA, Hava BEN DAVID, Eyal WEINSTOCK, Yulia MATIUHIN, Naomi Bluma ZAK
  • Publication number: 20220125858
    Abstract: The present invention provides an antibacterial composition against drug-resistant bacteria or pro-inflammatory bacteria containing an intestinal bacterium as an active ingredient, or a pharmaceutical composition for treating, ameliorating, or preventing an infectious disease or an inflammatory disease.
    Type: Application
    Filed: March 5, 2020
    Publication date: April 28, 2022
    Applicant: KEIO UNIVERSITY
    Inventors: Kenya HONDA, Keiko YASUMA, Koji ATARASHI, Seiko NARUSHIMA, Munehiro FURUICHI, Takaaki KAWAGUCHI
  • Publication number: 20220047647
    Abstract: The present invention provides a composition for suppressing trypsin activity, comprising: a bacterium belonging to a genus Paraprevotella as an active ingredient.
    Type: Application
    Filed: September 10, 2019
    Publication date: February 17, 2022
    Applicant: RIKEN
    Inventors: Kenya HONDA, Seiko NARUSHIMA, Eiichiro WATANABE, Osamu OHARA, Yusuke KAWASHIMA, Youxian LI
  • Publication number: 20220031776
    Abstract: Disclosed herein are bacteriophage compositions and therapeutic uses thereof. The disclosure also relates to bacteriophage that are capable of lysing Klebsiella bacterial strains, e.g., strains that are associated with inflammatory bowel disease, and thereby capable of modulating disease.
    Type: Application
    Filed: September 7, 2018
    Publication date: February 3, 2022
    Inventors: Kenya Honda, Koji Atarashi, Seiko Narushima, Eran Elinav, Rotem Sorek, Efrat Khabra, Hava Ben David, Eyal Weinstock, Sarah Pollock, Yulia Matiuhin, Naomi Zak
  • Publication number: 20200171099
    Abstract: With the aim of proving an antibacterial composition against oral bacteria and the like capable of inducing Th1 cell proliferation or activation in an intestinal tract, the present inventors have found out that bacteria that suppress colonization and the like of the oral bacteria and the like in the intestinal tract are present in an intestinal microbiota. Moreover, the present inventors have succeeded in isolating intestinal bacteria that suppress intestinal colonization and the like of oral bacteria and the like.
    Type: Application
    Filed: July 18, 2018
    Publication date: June 4, 2020
    Applicant: KEIO UNIVERSITY
    Inventors: Kenya HONDA, Koji ATARASHI, Seiko NARUSHIMA, Wataru SUDA, Masahira HATTORI, Munehiro FURUICHI, Takaaki KAWAGUCHI, Keiko MITOBE
  • Patent number: 9314041
    Abstract: A probiotic lactobacillus was discovered from lactobacilli of the Lactobacillus genus independently isolated from human adult feces.
    Type: Grant
    Filed: February 23, 2006
    Date of Patent: April 19, 2016
    Assignee: MEIJI CO., LTD.
    Inventors: Toshihiro Sashihara, Makoto Yamaguchi, Yoshitaka Nakamura, Shuji Ikegami, Seiko Narushima, Katsunori Kimura, Shinya Nagafuchi, Masaki Terahara
  • Patent number: 8241684
    Abstract: The present invention relates to a preventive and/or a therapeutic agent for inflammatory bowel diseases containing a fermentation product of a propionic acid bacterium as an active ingredient.
    Type: Grant
    Filed: June 28, 2011
    Date of Patent: August 14, 2012
    Assignee: Meiji Co., Ltd.
    Inventors: Masayuki Uchida, Seiko Narushima, Keiko Morikubo
  • Publication number: 20110257269
    Abstract: The present invention relates to a preventive and/or a therapeutic agent for inflammatory bowel diseases containing a fermentation product of a propionic acid bacterium as an active ingredient.
    Type: Application
    Filed: June 28, 2011
    Publication date: October 20, 2011
    Applicant: MEIJI DAIRIES CORPORATION
    Inventors: Masayuki Uchida, Seiko Narushima, Keiko Morikubo
  • Patent number: 8025911
    Abstract: The present invention relates to a preventive and/or a therapeutic agent for inflammatory bowel diseases containing a fermentation product of a propionic acid bacterium as an active ingredient.
    Type: Grant
    Filed: April 13, 2005
    Date of Patent: September 27, 2011
    Assignee: Meiji Dairies Corporation
    Inventors: Masayuki Uchida, Seiko Narushima, Keiko Morikubo
  • Publication number: 20090269321
    Abstract: A probiotic lactobacillus was discovered from lactobacilli of the Lactobacillus genus independently isolated from human adult feces.
    Type: Application
    Filed: February 23, 2006
    Publication date: October 29, 2009
    Inventors: Toshihiro Sashihara, Makoto Yamaguchi, Yoshitaka Nakamura, Shuji Ikegami, Seiko Narushima, Katsunori Kimura, Shinya Nagafuchi, Masaki Terahara
  • Publication number: 20070196341
    Abstract: The present invention relates to a preventive and/or a therapeutic agent for inflammatory bowel diseases containing a fermentation product of a propionic acid bacterium as an active ingredient.
    Type: Application
    Filed: April 13, 2005
    Publication date: August 23, 2007
    Applicant: MEIJI DAIRIES CORPORATION
    Inventors: Masayuki Uchida, Seiko Narushima, Keiko Morikubo