Patents by Inventor Sejal Patel

Sejal Patel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE
    Publication number: 20220127247
    Abstract: The invention relates to heterocyclic compounds of the formula (I) in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.
    Type: Application
    Filed: February 4, 2020
    Publication date: April 28, 2022
    Inventors: Mihai AZIMIOARA, Bei CHEN, Robert EPPLE, James Paul LAJINESS, Casey Jacob Nelson MATHISON, Juliet NABAKKA, Victor Ivanovich NIKULIN, Sejal PATEL, Dean Paul PHILLIPS, Paul Vincent RUCKER, Andrew VALIERE, Baogen WU, Shanshan YAN, Xuefeng ZHU
  • MACROCYCLIC COMPOUNDS AND THEIR USE IN THE TREATMENT OF DISEASE
    Publication number: 20220071971
    Abstract: The invention relates to heterocyclic compounds of the formula (I), in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.
    Type: Application
    Filed: December 18, 2019
    Publication date: March 10, 2022
    Inventors: Mihai Azimioara, Badry Bursulaya, Songchun Jiang, Casey Jacob Nelson MATHISON, Victor Ivanovich NIKULIN, Truc Ngoc NGUYEN, Barun OKRAM, Sejal PATEL, Dean Paul PHILLIPS, Lewis WHITEHEAD, Baogen WU, Shanshan YAN, Xuefeng ZHU
  • N-(pyridin-2-ylsulfonyl)cyclopropanecarboxamide Derivatives and their Use in the Treatment of Disease
    Publication number: 20220033407
    Abstract: The invention relates to heterocyclic compounds of the formula (I), in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.
    Type: Application
    Filed: December 13, 2019
    Publication date: February 3, 2022
    Inventors: Mihai D. Azimioara, Bei Chen, Robert Epple, Declan Hardy, Ayako Honda, Philip Lam, Hasnain Ahmed Malik, Fabio Meier, Truc Ngoc Nguyen, Barun Okram, Sejal Patel, Rodrigo Rodriguez, Duncan Shaw, Yiping Shen, Baogen WU
  • N-(pyridin-2-yl)pyridine-sulfonamide derivatives and their use in the treatment of disease
    Patent number: 11066369
    Abstract: The invention relates to heterocyclic compounds of the formula (I) in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.
    Type: Grant
    Filed: September 10, 2019
    Date of Patent: July 20, 2021
    Assignee: Novartis AG
    Inventors: Mihai Azimioara, Bei Chen, Robert Epple, Ayako Honda, Philip Lam, Hasnain Ahmed Malik, Casey Jacob Nelson Mathison, True Ngoc Nguyen, Victor Ivanovich Nikulin, Sejal Patel, Dean Paul Phillips, Rodrigo A. Rodriguez, Baogen Wu, Xuefeng Zhu
  • N-(pyridin-2-yl)pyridine-sulfonamide Derivatives and their Use in the Treatment of Disease
    Publication number: 20200002281
    Abstract: The invention relates to heterocyclic compounds of the formula (I) in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.
    Type: Application
    Filed: September 10, 2019
    Publication date: January 2, 2020
    Inventors: Mihai Azimioara, Bei Chen, Robert Epple, Ayako Honda, Philip Lam, Hasnain Ahmed Malik, Casey Jacob Nelson Mathison, Truc Ngoc Nguyen, Victor Ivanovich Nikulin, Sejal Patel, Dean Paul Phillips, Rodrigo A. Rodriguez, Baogen Wu, Xuefeng Zhu
  • N-(pyridin-2-yl)pyridine-sulfonamide derivatives and their use in the treatment of disease
    Patent number: 10450273
    Abstract: The invention relates to heterocyclic compounds of the formula (I) in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.
    Type: Grant
    Filed: August 28, 2017
    Date of Patent: October 22, 2019
    Assignee: Novartis AG
    Inventors: Mihai Azimioara, Bei Chen, Robert Epple, Ayako Honda, Philip Lam, Hasnain Ahmed Malik, Casey Jacob Nelson Mathison, Truc Ngoc Nguyen, Victor Ivanovich Nikulin, Sejal Patel, Dean Paul Phillips, Rodrigo A. Rodriguez, Baogen Wu, Xuefeng Zhu
  • N-(pyridin-2-yl)pyridine-sulfonamide Derivatives and their Use in the Treatment of Disease
    Publication number: 20180072673
    Abstract: The invention relates to heterocyclic compounds of the formula (I) in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.
    Type: Application
    Filed: August 28, 2017
    Publication date: March 15, 2018
    Applicant: Novartis AG
    Inventors: Dean Paul Phillips, Mihai AZIMIOARA, Bei CHEN, Robert EPPLE, Victor Ivanovich NIKULIN, Rodrigo A. RODRIGUEZ, Sejal PATEL, Ayako HONDA
  • Cyclic ether DGAT1 inhibitorscyclic ether DGAT1 inhibitors
    Patent number: 9108956
    Abstract: The invention relates to compounds of formula (I): useful for treating disorders mediated by acyl coA-diacylglycerol acyl transferase 1 (DGAT1), e.g. metabolic disorders. The invention also provides methods of treating such disorders, and compounds and compositions etc. for their treatment.
    Type: Grant
    Filed: April 26, 2013
    Date of Patent: August 18, 2015
    Assignee: NOVARTIS AG
    Inventors: Sejal Patel, Justin Mao, Qian Liu, Tyler Harrison, Rohit Duvadie, Xin Chen, Frederic Zecri
  • CYCLIC BRIDGEHEAD ETHER DGAT1 INHIBITORS
    Publication number: 20150166563
    Abstract: The invention relates to compounds of formula (I): useful for treating disorders mediated by acyl coA-diacylglycerol acyl transferase 1 (DGAT1), e.g. metabolic disorders. The invention also provides methods of treating such disorders, and compounds and compositions etc. for their treatment.
    Type: Application
    Filed: February 20, 2015
    Publication date: June 18, 2015
    Applicant: NOVARTIS AG
    Inventors: Sejal Patel, Justin Mao, Qian Liu, Rui Zheng, Tyler Harrison, Rohit Duvadie, Xin Chen, Frederic Zecri, Jay Larrow, Xuchun Zheng, Yizong Zhou, Jiong Ye, Yiping Ding, Yu Gai
  • CYCLIC ETHER DGAT1 INHIBITORSCYCLIC ETHER DGAT1 INHIBITORS
    Publication number: 20150141474
    Abstract: The invention relates to compounds of formula (I): useful for treating disorders mediated by acyl coA-diacylglycerol acyl transferase 1 (DGAT1), e.g. metabolic disorders. The invention also provides methods of treating such disorders, and compounds and compositions etc. for their treatment.
    Type: Application
    Filed: April 26, 2013
    Publication date: May 21, 2015
    Applicant: NOVARTIS AG
    Inventors: Sejal Patel, Justin Mao, Qian Liu, Tyler Harrison, Rohit Duvadie, Xin Chen, Frederic Zecri
  • Cyclic bridgehead ether DGAT1 inhibitors
    Patent number: 8993619
    Abstract: The invention relates to compounds of formula (I): useful for treating disorders mediated by acyl coA-diacylglycerol acyl transferase 1 (DGAT1), e.g. metabolic disorders. The invention also provides methods of treating such disorders, and compounds and compositions etc. for their treatment.
    Type: Grant
    Filed: April 26, 2013
    Date of Patent: March 31, 2015
    Assignee: Novartis AG
    Inventors: Sejal Patel, Justin Mao, Qian Liu, Rui Zheng, Tyler Harrison, Rohit Duvadie, Xin Chen, Frederic Zecri, Jay Larrow, Xuchun Zheng, Yizong Zhou, Jiong Ye, Yiping Ding, Yu Gai
  • CYCLIC BRIDGEHEAD ETHER DGAT1 INHIBITORS
    Publication number: 20130289058
    Abstract: The invention relates to compounds of formula (I): useful for treating disorders mediated by acyl coA-diacylglycerol acyl transferase 1 (DGAT1), e.g. metabolic disorders. The invention also provides methods of treating such disorders, and compounds and compositions etc. for their treatment.
    Type: Application
    Filed: April 26, 2013
    Publication date: October 31, 2013
    Inventors: Sejal Patel, Justin Mao, Qian Lui, Rui Zheng, Tyler Harrison, Rohit Duvadie, Xin Chen, Frederic Zecri, Jay Larrow, Xuchun Zheng, Yizong Zhou, Jiong Ye, Yiping Ding, Yu Gai
  • Nitroimidazole Compounds
    Publication number: 20080275035
    Abstract: The present invention relates to certain nitroimidazole compounds, which have interesting pharmaceutical properties. In particular, the compounds are useful in the treatment and/or prevention of infections such as those caused by Mycobacterium tuberculosis, Trypanosoma cruzi or Leishmania donovani. The invention also relates to pharmaceutical compositions containing the compounds, as well as processes for their preparation.
    Type: Application
    Filed: December 22, 2006
    Publication date: November 6, 2008
    Inventors: Jan Jiricek, Sejal Patel, Thomas Hugo Keller, Clifton E. Barry, Cynthia S. Dowd
  • Method for selecting a resource to provide a requested service in a multicasting environment
    Patent number: 7444426
    Abstract: A method is provided for selecting a resource from a plurality of potential resources in order to provide a service in response to a service request. The method comprises the following steps. Aging services are determined by estimating which of the resources are likely to become available. One of the aging services is disconnected from its resource. The resource is then used for providing the service in the service request. In accordance with a further aspect of the present invention, an oldest service is determined. The oldest service is defined as the service that is most likely to be disconnected from its resource. The oldest service is disconnected from its resource, which is then used for providing the service in the service request.
    Type: Grant
    Filed: February 4, 2004
    Date of Patent: October 28, 2008
    Assignee: Ciena Corporation
    Inventors: Tim Jenkins, Sejal Patel
  • Method for selecting a resource to provide a requested service in a multicasting environment
    Publication number: 20040221029
    Abstract: A method is provided for selecting a resource from a plurality of potential resources in order to provide a service in response to a service request. The method comprises the following steps. Aging services are determined by estimating which of the resources are likely to become available. One of the aging services is disconnected from its resource. The resource is then used for providing the service in the service request. In accordance with a further aspect of the present invention, an oldest service is determined. The oldest service is defined as the service that is most likely to be disconnected from its resource. The oldest service is disconnected from its resource, which is then used for providing the service in the service request.
    Type: Application
    Filed: February 4, 2004
    Publication date: November 4, 2004
    Applicant: Catena Networks, Inc.
    Inventors: Tim Jenkins, Sejal Patel
  • Monodispersed polydimethylsiloxane-.alpha.,.omega.-diol fluids and .alpha.,.omega.-substituted polydimethylsiloxanes and polydimethylcyclosiloxanes prepared therefrom
    Patent number: 5254654
    Abstract: The molecular weight distribution of polydimethylsiloxane-.alpha., .omega.-diol fluids is reduced by contacting the fluid with an alkaline earth metal hydride or hydroxide. Molecular weight distributions lower than Poisson distributions may be obtained. The resulting monodispersed polydimethylsiloxane.alpha., .omega.-diol fluids may be substituted by reaction with common silanating reagents to prepare telechelic polydimethylsiloxanes which are nearly monodispersed.
    Type: Grant
    Filed: July 10, 1992
    Date of Patent: October 19, 1993
    Assignee: Temple University of the Commonwealth System of Higher Education
    Inventors: Mark A. Buese, Sejal Patel