Patents by Inventor Sendurai A. Mani

Sendurai A. Mani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9846160
    Abstract: Methods for determining the presence of cancer stem cells by detecting GD2 expression. Also provided are methods for reducing proliferation of cancer stem cells by contacting the cells with a GD2 targeting agent, such as an anti-GD2 antibody or a GD3 synthase inhibitor. GD3 synthase inhibitor compounds are also provided.
    Type: Grant
    Filed: February 27, 2013
    Date of Patent: December 19, 2017
    Assignee: Board of Regents, The University of Texas Systems
    Inventors: Venkata Battula, Michael Andreeff, Sendurai A. Mani, Tapasree Roy Sarkar
  • Patent number: 9212347
    Abstract: Methods for preparing progenitor cells are described where epithelial cells are induced to undergo epithelial-mesenchymal transition as a result of exposure to an inducing agent or introduction of a gene therein that induces epithelial-mesenchymal transition. Progenitor cells resulting therefrom have use in cell-based therapies, among other utilities.
    Type: Grant
    Filed: June 18, 2012
    Date of Patent: December 15, 2015
    Assignee: WHITEHEAD INSTITUTE
    Inventors: Robert A. Weinberg, Sendurai A. Mani, Mai-Jing Liao
  • Publication number: 20150044233
    Abstract: Methods for determining the presence of cancer stem cells by detecting GD2 expression. Also provided are methods for reducing proliferation of cancer stem cells by contacting the cells with a GD2 targeting agent, such as an anti-GD2 antibody or a GD3 synthase inhibitor. GD3 synthase inhibitor compounds are also provided.
    Type: Application
    Filed: February 27, 2013
    Publication date: February 12, 2015
    Inventors: Venkata Battula, Michael Andreeff, Sendurai A. Mani, Tapasree Roy Sarkar
  • Publication number: 20140294729
    Abstract: The invention relates to methods for identifying compounds and compositions that target cancer stem cells. In some aspects, the invention relates to treatment methods that use compounds and compositions that specifically target cancer stem cells for inhibiting the growth and/or survival of cancer stem cells in a subject in need thereof. Other aspects of the invention relate to the use of cancer stem cell biomarkers in the selection of a treatment for inhibiting the growth and/or survival of cancer stem cells in a subject in need thereof.
    Type: Application
    Filed: October 28, 2013
    Publication date: October 2, 2014
    Applicants: Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: PIYUSH GUPTA, TAMER T. ONDER, ERIC S. LANDER, ROBERT A. WEINBERG, SENDURAI MANI, MAI-JING LIOA
  • Publication number: 20140275201
    Abstract: The present invention provides biomarkers of cancer stem cells, as well as cells that have undergone EMT. In addition, the present invention provides methods of treating patients determined to comprise cancer stem cells with PDGFR-? inhibitors to eliminate the cancer stem cells. Methods of predicting sensitivity to PDGFR-? inhibitors, monitoring efficacy of treatment, and determining a prognosis are also provided.
    Type: Application
    Filed: March 12, 2014
    Publication date: September 18, 2014
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Sendurai A. MANI, Brett G. HOLLIER, Kurt W. EVANS, Steven J. WERDEN, Tapasree Roy SARKAR, Agata TINNIRELLO
  • Patent number: 8568998
    Abstract: The invention relates to methods and compositions for inhibiting metastasis, such as by inhibiting FOXC2 expression or activity. The invention further relates to methods of prognosticating, diagnosing, and assisting in the diagnosis of metastasis in an individual, or of determining the metastatic potential of a tumor. The invention further relates to methods of identifying agents which inhibit metastasis.
    Type: Grant
    Filed: December 1, 2011
    Date of Patent: October 29, 2013
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: Sendurai Mani, Jing Yang, Robert A. Weinberg
  • Publication number: 20130260376
    Abstract: The invention utilizes gene expression profiles in methods of predicting the likelihood that a patient's cancer will respond to standard-of-care therapy. Also provided are methods of identifying therapeutic agents that target cancer stem cells or epithelial cancers that have undergone an epithelial to mesenchymal transition using such gene expression profiles.
    Type: Application
    Filed: August 2, 2011
    Publication date: October 3, 2013
    Applicants: WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH, THE BROAD INSTITUTE, INC.
    Inventors: Piyush Gupta, Tamer T. Onder, Eric S. Lander, Robert Weinberg, Sendurai Mani
  • Publication number: 20120329061
    Abstract: An assay and associated methodologies for detection of breast cancer are described. Circulating tumor cells (“CTCs”) undergo epithelial mesenchymal transition (“EMT”) prior to entering circulation, resulting in the loss of epithelial markers. These CTCs and EMT-related gene transcripts in the peripheral blood of patients are tested by quantitative RT-PCR to detect and diagnose breast cancer.
    Type: Application
    Filed: March 11, 2011
    Publication date: December 27, 2012
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Michal Mego, Sendurai Mani, Massimo Cristofanilli, Naoto T. Ueno, James M. Reuben
  • Publication number: 20120258084
    Abstract: Methods for preparing progenitor cells are described where epithelial cells are induced to undergo epithelial-mesenchymal transition as a result of exposure to an inducing agent or introduction of a gene therein that induces epithelial-mesenchymal transition. Progenitor cells resulting therefrom have use in cell-based therapies, among other utilities.
    Type: Application
    Filed: June 18, 2012
    Publication date: October 11, 2012
    Inventors: Robert A. WEINBERG, Sendurai A. MANI, Mai-Jing LIAO
  • Publication number: 20120164074
    Abstract: The invention relates to methods and compositions for inhibiting metastasis, such as by inhibiting FOXC2 expression or activity. The invention further relates to methods of prognosticating, diagnosing, and assisting in the diagnosis of metastasis in an individual, or of determining the metastatic potential of a tumor. The invention further relates to methods of identifying agents which inhibit metastasis.
    Type: Application
    Filed: December 1, 2011
    Publication date: June 28, 2012
    Inventors: Sendurai Mani, Jing Yang, Robert A. Weinberg
  • Patent number: 8088590
    Abstract: The invention relates to methods and compositions for inhibiting metastasis, such as by inhibiting FOXC2 expression or activity. The invention further relates to methods of prognosticating, diagnosing, and assisting in the diagnosis of metastasis in an individual, or of determining the metastatic potential of a tumor. The invention further relates to methods of identifying agents which inhibit metastasis.
    Type: Grant
    Filed: December 28, 2006
    Date of Patent: January 3, 2012
    Assignee: Whiteland Institute for Biomedical Research
    Inventors: Sendurai Mani, Jing Yang, Robert A. Weinberg
  • Publication number: 20110191868
    Abstract: The invention relates to methods for identifying compounds and compositions that target cancer stem cells. In some aspects, the invention relates to treatment methods that use compounds and compositions that specifically target cancer stem cells for inhibiting the growth and/or survival of cancer stem cells in a subject in need thereof. Other aspects of the invention relate to the use of cancer stem cell biomarkers in the selection of a treatment for inhibiting the growth and/or survival of cancer stem cells in a subject in need thereof.
    Type: Application
    Filed: April 10, 2009
    Publication date: August 4, 2011
    Applicants: Massachusetts Institute of Technology, Whitehead Institute for Biomedical Research Nine Cambrideg Center
    Inventors: Piyush Gupta, Tamer T. Onder, Eric S. Lander, Robert Weinberg, Sendurai Mani, Mai-Jing Liao
  • Publication number: 20100260827
    Abstract: The invention relates to methods and compositions for inhibiting metastasis, such as by inhibiting FOXC2 expression or activity. The invention further relates to methods of prognosticating, diagnosing, and assisting in the diagnosis of metastasis in an individual, or of determining the metastatic potential of a tumor. The invention further relates to methods of identifying agents which inhibit metastasis.
    Type: Application
    Filed: December 28, 2006
    Publication date: October 14, 2010
    Applicant: Whitehead Institute for Biomedical Research
    Inventors: Sendurai Mani, Jing Yang, Robert A. Weinberg
  • Publication number: 20090214483
    Abstract: Methods for preparing progenitor cells are described where epithelial cells are induced to undergo epithelial-mesenchymal transition as a result of exposure to an inducing agent or introduction of a gene therein that induces epithelial-mesenchymal transition. Progenitor cells resulting therefrom have use in cell-based therapies, among other utilities.
    Type: Application
    Filed: June 30, 2006
    Publication date: August 27, 2009
    Inventors: Robert A. Weinberg, Sendurai A. Mani, Mai-Jing Liao