Patents by Inventor Seokheon HONG

Seokheon HONG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of preparing three-dimensional cell spheroid including adipose-derived stem cells and hepatocytes
    Patent number: 12138283
    Abstract: Provided is a method of preparing a three-dimensional cell spheroid, the method including forming the cell spheroid by co-culturing adipose-derived stem cells or mesenchymal stem cells with hepatocytes. According to the cell spheroid prepared by the method, the secretome secreted by the adipose-derived stem cells affects hepatocyte maturation, and therefore, hepatic functions of the finally formed three-dimensional cell spheroid, i.e., organoid, may be enhanced. Further, a composition including a culture medium of the adipose-derived stem cells may prevent or treat liver diseases including hepatitis, hepatotoxicity, cholestasis, fatty liver, etc., and may enhance hepatic functions.
    Type: Grant
    Filed: May 15, 2019
    Date of Patent: November 12, 2024
    Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Sang-Heon Kim, Seokheon Hong, Seung Ja Oh, Kwi Deok Park
  • METHOD OF PREPARING THREE-DIMENSIONAL CELL SPHEROID INCLUDING ADIPOSE-DERIVED STEM CELLS AND HEPATOCYTES
    Publication number: 20190374580
    Abstract: Provided is a method of preparing a three-dimensional cell spheroid, the method including forming the cell spheroid by co-culturing adipose-derived stem cells or mesenchymal stem cells with hepatocytes. According to the cell spheroid prepared by the method, the secretome secreted by the adipose-derived stem cells affects hepatocyte maturation, and therefore, hepatic functions of the finally formed three-dimensional cell spheroid, i.e., organoid, may be enhanced. Further, a composition including a culture medium of the adipose-derived stem cells may prevent or treat liver diseases including hepatitis, hepatotoxicity, cholestasis, fatty liver, etc., and may enhance hepatic functions.
    Type: Application
    Filed: May 15, 2019
    Publication date: December 12, 2019
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Sang-Heon KIM, Seokheon HONG, Seung Ja OH, Kwi Deok PARK