Patents by Inventor Serge Martinez

Serge Martinez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1,3,5-triazine-2-amine derivatives, preparation thereof and diagnostic and therapeutic use thereof
    Patent number: 9115121
    Abstract: The present invention relates to compounds corresponding to formula (I) in which: —R1 represents a substituted phenyl; —R2 represents: —a substituted phenyl; —a heteroaromatic group, the said group being unsubstituted or substituted one or more times; —R3 represents a group Alk; —R4 represents a hydrogen atom or a (C1-C4)alkyl; —R5 represents a hydrogen atom, a (C3-C6)cycloalkyl or a (C1-C4)alkyl-O-Alk; —or alternatively R4 and R5, together with the nitrogen atom to which they are attached, constitute a heterocyclic radical chosen from: azetidin-1-yl, pyrrolidin-1-yl, piperid-1-yl, morpholin-4-yl; —R6 represents a group —COOAlk, a group —CONH2 or a group —NHSO2Alk; —Alk represents a (C1-C4)alkyl, which is unsubstituted or substituted one or more times with a halogen atom; in the form of the base or of an acid-addition salt. Preparation process and diagnostic and therapeutic use.
    Type: Grant
    Filed: December 11, 2012
    Date of Patent: August 25, 2015
    Assignee: Sanofi
    Inventors: Joelle Arnaud, Martine Artiaga, Francis Barth, Laurent Hortala, Serge Martinez, Pascale Roux
  • 1,3,5 -Triazine-2-Amine Derivatives, Preparation Thereof And Diagnostic And Therapeutic Use Thereof
    Publication number: 20140343061
    Abstract: The present invention relates to compounds corresponding to formula (I) in which: —R1 represents a substituted phenyl; —R2 represents: —a substituted phenyl; —a heteroaromatic group, the said group being unsubstituted or substituted one or more times; —R3 represents a group Alk; —R4 represents a hydrogen atom or a (C1-C4)alkyl; —R5 represents a hydrogen atom, a (C3-C6)cycloalkyl or a (C1-C4)alkyl-O-Alk; —or alternatively R4 and R5, together with the nitrogen atom to which they are attached, constitute a heterocyclic radical chosen from: azetidin-1-yl, pyrrolidin-1-yl, piperid-1-yl, morpholin-4-yl; —R6 represents a group —COOAlk, a group —CONH2 or a group —NHSO2Alk; —Alk represents a (C1-C4)alkyl, which is unsubstituted or substituted one or more times with a halogen atom; in the form of the base or of an acid-addition salt. Preparation process and diagnostic and therapeutic use.
    Type: Application
    Filed: December 11, 2012
    Publication date: November 20, 2014
    Inventors: Joelle Arnaud, Martine Artiaga, Francis Barth, Laurent Hortala, Serge Martinez, Pascale Roux
  • Substituted N-(4-cyano-1-pyrazol-3-yl)methylamine derivatives, preparation thereof and therapeutic use thereof
    Patent number: 8088797
    Abstract: The present invention relates to compounds corresponding to formula (I): Wherein X, R1, R2, R3 and R4 are as defined herein. The invention further relates to preparation and therapeutic use of these compounds.
    Type: Grant
    Filed: June 24, 2009
    Date of Patent: January 3, 2012
    Assignee: Sanofi-Aventis
    Inventors: Francis Barth, Christian Congy, Serge Martinez, Murielle Rinaldi-Carmona, Martine Vernhet
  • Derivatives of N-[(1,5-diphenyl-1H-pyrazol-3-yl)methyl] sulfonamide, their preparation and their application in therapeutics
    Patent number: 7875646
    Abstract: The present invention relates to compounds corresponding to the formula (I): In which R1, R2, R3, R4 and R5 are as described herein. The invention also relates to the method of preparation of said compounds and their application in therapeutics.
    Type: Grant
    Filed: September 21, 2007
    Date of Patent: January 25, 2011
    Assignee: Sanofi-Aventis
    Inventors: Francis Barth, Christian Congy, Serge Martinez, Philippe Pointeau, Murielle Rinaldi-Carmona
  • SUBSTITUTED N-(4-CYANO-1H-PYRAZOL-3-YL)METHYLAMINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
    Publication number: 20100041709
    Abstract: The present invention relates to compounds corresponding to formula (I): Wherein X, R1, R2, R3 and R4 are as defined herein. The invention further relates to preparation and therapeutic use of these compounds.
    Type: Application
    Filed: June 24, 2009
    Publication date: February 18, 2010
    Applicant: SANOFI-AVENTIS
    Inventors: Francis BARTH, Christian Congy, Serge Martinez, Murielle Rinaldi-Carmona, Martine Vernhet
  • 4-cyanopyrazole-3-carboxamide derivatives, preparation and application thereof
    Patent number: 7521471
    Abstract: The invention relates to 4-cyanopyrazole-3-carboxamide derivatives of formula (I): in which R1, R2, R3, R4, R5, R6, R7, R8 are as described herein. Also disclosed and claimed are the method of preparation and therapeutic application of compound of formula (I).
    Type: Grant
    Filed: August 1, 2007
    Date of Patent: April 21, 2009
    Assignee: Sanofi-Aventis
    Inventors: Francis Barth, Christian Congy, Serge Martinez, Murielle Rinaldi-Carmona
  • Terphenyl derivatives, preparation thereof, compositions containing same
    Patent number: 7390924
    Abstract: The invention relates to terphenyl derivatives of formula: and to their preparation and to the pharmaceutical compositions comprising them. These compounds exhibit an antagonist activity with respect to CB1 cannabinoid receptors.
    Type: Grant
    Filed: April 10, 2003
    Date of Patent: June 24, 2008
    Assignee: Sanofi-Aventis
    Inventors: Francis Barth, Serge Martinez, Murielle Rinaldi-Carmona
  • Pyrazolecarboxylic acid tricyclic derivatives, preparation and pharmaceutical compositions containing same
    Patent number: 7384960
    Abstract: The subject of the invention is tricyclic derivatives of pyrazolecarboxylic acid of formula: in which R1 represents a C3-C15 carboxyl radical or an NR2R3 group. The invention also relates to the method for preparing the compounds of formula (I), pharmaceutical compositions containing them. The compounds of formula (I) are active on cannabinoid CB1 receptors.
    Type: Grant
    Filed: April 29, 2005
    Date of Patent: June 10, 2008
    Assignee: Sanofi-Aventis
    Inventors: Francis Barth, Christian Congy, Serge Martinez, Murielle Rinaldi
  • DERIVATIVES OF N-[(1,5-DIPHENYL-1H-PYRAZOL-3-YL)METHYL] SULFONAMIDE, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS
    Publication number: 20080070962
    Abstract: The present invention relates to compounds corresponding to the formula (I): In which R1, R2, R3, R4 and R5 are as described herein. The invention also relates to the method of preparation of said compounds and their application in therapeutics.
    Type: Application
    Filed: September 21, 2007
    Publication date: March 20, 2008
    Applicant: SANOFI-AVENTIS
    Inventors: Francis Barth, Christian Congy, Serge Martinez, Philippe Pointeau, Murielle Rinaldi-Carmona
  • 4-CYANOPYRAZOLE-3-CARBOXAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF
    Publication number: 20070293541
    Abstract: The invention relates to 4-cyanopyrazole-3-carboxamide derivatives of formula (I): in which R1, R2, R3, R4, R5, R6, R7, R8 are as described herein. Also disclosed and claimed are the method of preparation and therapeutic application of compound of formula (I).
    Type: Application
    Filed: August 1, 2007
    Publication date: December 20, 2007
    Applicant: SANOFI-AVENTIS
    Inventors: Francis BARTH, Christian CONGY, Serge MARTINEZ, Murielle RINALDI-CARMONA
  • Derivatives of N-[(1,5-diphenyl-1H-pyrazol-3-yl)methyl]sulfonamide, their preparation and their application in therapeutics
    Patent number: 7297710
    Abstract: The present invention relates to compounds corresponding to the formula (I): In which R1, R2, R3, R4 and R5 are as described herein. The invention also relates to the method of preparation of said compounds and their application in therapeutics.
    Type: Grant
    Filed: July 12, 2006
    Date of Patent: November 20, 2007
    Assignee: Sanofi-Aventis
    Inventors: Francis Barth, Christian Congy, Serge Martinez, Philippe Pointeau, Murielle Rinaldi-Carmona
  • Derivatives of N?-(1,5-diphenyl-1H-pyrazol-3-yl) sulfonamide with CB1 receptor affinity
    Patent number: 7294645
    Abstract: The invention relates to compounds of formula (I): Wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 are as defined herein. The invention also relates to the preparation method thereof and to the use of same in therapeutics.
    Type: Grant
    Filed: July 6, 2006
    Date of Patent: November 13, 2007
    Assignee: Sanofi-Aventis
    Inventors: Francis Barth, Serge Martinez, Murielle Rinaldi-Carmona, Christian Congy
  • 4-cyanopyrazole-3-carboxamide derivatives, preparation, and application thereof
    Patent number: 7282516
    Abstract: The invention relates to 4-cyanopyrazole-3-carboxamide derivatives of formula (I): in which R1, R2, R3, R4, R5, R6, R7, R8 are as described herein. Also disclosed and claimed are the method of preparation and therapeutic application of compound of formula (I).
    Type: Grant
    Filed: December 22, 2005
    Date of Patent: October 16, 2007
    Assignee: Sanofi-Aventis
    Inventors: Francis Barth, Christian Congy, Serge Martinez, Murielle Rinaldi-Carmona
  • DERIVATIVES OF N-' (1,5-DIPHENYL-1H-PYRAZOL-3-YL) SULFONAMIDE WITH CB1 RECEPTOR AFFINITY
    Publication number: 20070021486
    Abstract: The invention relates to compounds of formula (I): Wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 are as defined herein. The invention also relates to the preparation method thereof and to the use of same in therapeutics.
    Type: Application
    Filed: July 6, 2006
    Publication date: January 25, 2007
    Applicant: SANOFI-AVENTIS
    Inventors: Francis BARTH, Serge MARTINEZ, Murielle RINALDI-CARMONA, Christian CONGY
  • Terphenly derivatives, preparation thereof, compositions containing same
    Publication number: 20060167049
    Abstract: The invention relates to terphenyl derivatives of formula: and to their preparation and to the pharmaceutical compositions comprising them. These compounds exhibit an antagonist activity with respect to CB1 cannabinoid receptors.
    Type: Application
    Filed: April 10, 2003
    Publication date: July 27, 2006
    Inventors: Francis Barth, Serge Martinez, Murielle Rinaldi-Carmona
  • 4-Cyanopyrazole-3-carboxamide derivatives, preparation, and application thereof
    Publication number: 20060135776
    Abstract: The invention relates to 4-cyanopyrazole-3-carboxamide derivatives of formula (I): in which R1, R2, R3, R4, R5, R6, R7, R8 are as described herein. Also disclosed and claimed are the method of preparation and therapeutic application of compound of formula (I).
    Type: Application
    Filed: December 22, 2005
    Publication date: June 22, 2006
    Applicant: sanofi-aventis
    Inventors: Francis Barth, Christian Congy, Serge Martinez, Murielle Rinaldi-Carmona
  • Pyrazolecarboxylic acid tricyclic derivatives, preparation and pharmaceutical compositions containing same
    Publication number: 20050192332
    Abstract: The subject of the invention is tricyclic derivatives of pyrazolecarboxylic acid of formula: in which R1 represents a C3-C15 carboxyl radical or an NR2R3 group. The invention also relates to the method for preparing the compounds of formula (I), pharmaceutical compositions containing them. The compounds of formula (I) are active on cannabinoid CB1 receptors.
    Type: Application
    Filed: April 29, 2005
    Publication date: September 1, 2005
    Applicant: Sanofi-Aventis
    Inventors: Francis Barth, Christian Congy, Serge Martinez, Murielle Rinaldi
  • Pyrazolecarboxylic acid tricyclic derivatives, preparation and pharmaceutical compositions containing same
    Patent number: 6906080
    Abstract: The subject of the invention is tricyclic derivatives of pyrazolecarboxylic acid of formula: in which R1 represents a C3-C15 carboxyl radical or an NR2R3 group. The invention also relates to the method for preparing the compounds of formula (I), pharmaceutical compositions containing them. The compounds of formula (I) are active on cannabinoid CB1 receptors.
    Type: Grant
    Filed: November 2, 2000
    Date of Patent: June 14, 2005
    Assignee: Sanofi-Aventis
    Inventors: Francis Barth, Christian Congy, Serge Martinez, Murielle Rinaldi
  • Pyrazolecarboxylic acid derivatives, their preparation and pharmaceutical compositions containing them
    Publication number: 20040039024
    Abstract: N-Piperidino-5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethylpyrazole-3-carboxamide and its salts and solvates are powerful antagonists of the CB1 cannabinoid receptors. They are prepared by reacting a functional derivative of 5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethylpyrazole-3-carboxylic acid with 1-aminopiperidine, optionally followed by salification.
    Type: Application
    Filed: June 5, 2003
    Publication date: February 26, 2004
    Inventors: Francis Barth, Philippe Camus, Serge Martinez, Murielle Rinaldi
  • Pyrazolecarboxylic acid derivatives, their preparation and pharmaceutical compositions containing them, and method of treating
    Patent number: 6645985
    Abstract: N-Piperidino-5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethylpyrazole -3-carboxamide and its salts and solvates are powerful antagonists of the CB1 cannabinoid receptors. They are prepared by reacting a functional derivative of 5-(4-bromophenyl)-1-(2,4-dichlorophenyl) -4-ethylpyrazole-3-carboxylic acid with 1-aminopiperidine, optionally followed by salification.
    Type: Grant
    Filed: June 7, 2002
    Date of Patent: November 11, 2003
    Inventors: Francis Barth, Philippe Camus, Serge Martinez, Murielle Rinaldi