Abstract: Needle-free injection devices having a delivery system to effect an injection and a body configured to house the delivery system. The delivery system includes an injectate assembly adapted to house a volume of liquid and a drive assembly adapted to expel the volume of liquid from the injectate assembly. In some embodiments, the drive assembly includes a pair of parallel springs configured to simultaneously deliver a drive force to the injectate assembly. The device further includes a priming system adapted to prepare the device for delivery of an injection. The priming system includes a force-preparation assembly adapted to selectively arrange the drive assembly to provide the drive force to the injectate assembly. In some embodiments, the priming system includes a locking assembly adapted to releasably retain the injectate assembly relative to the body. In some embodiments, the priming system includes a dosing assembly adapted to selectively draw a volume of liquid into the injectate assembly.

Abstract: A needle-free injection device is described. The injection device includes a user-grippable housing and a syringe assembly movably secured to the housing. The syringe assembly is configured to expel injectable fluid out of a nozzle upon application of pressurized gas to the syringe assembly. The injection device also includes a pressurized gas delivery mechanism disposed within the housing and configured to selectively apply pressurized gas to the syringe assembly. The pressurized gas delivery mechanism is at least partly actuated by pressing the nozzle onto an injection site so that the syringe assembly moves relative to the housing.

Abstract: A needle-free injection device is described. The injection device typically includes a system for providing directed and pre-selected pressure and a nozzle with an orifice for defining a stream of fluid that is directed toward the skin of a patient against which a front end of the nozzle is positioned. The device also normally includes an engagement system that can selectively engage the nozzle with the pressurizing system so that the nozzle can be mounted to the pressurizing system to receive pressure for injection and so that after injection the nozzle can be removed and replaced for each new use of the device.

Abstract: A needle-free injection device capable of delivering pressurized injections to an injection site. The device may include a barrier dispenser configured to provide a disposable piece of barrier material for each injection, so as to reduce risk of cross-contamination. The device may also include various sensors, a firing disable mechanism, a multiple use and/or disposable fluid path, and/or other mechanisms configured to enhance sterility and prevent contamination.

Abstract: A needle-free injector for injecting fluid from an injection cartridge that has a longitudinal axis, an injection orifice at a distal end and a displaceable plunger. The needle-free injector includes an injector body having a longitudinal axis and a side opening to receive the cartridge from a position laterally offset from the injector body longitudinal axis. The needle-free injector further includes a system disposed in the injector body for providing injection power and a ram for transferring power from the system to the plunger. The ram is disposed in the injector body and is axially aligned with the longitudinal axis of the cartridge when the cartridge is in position in the injector body. The needle-free injector further includes a closure mechanism for closing the side opening of the injector body after the cartridge is in position in the injector body to lock the cartridge in place in the injector body. The disclosure also includes other apparatus and methods as discussed in detail herein.

Abstract: The disclosure provides a filling cap for use in a needle-free injection system. The filling cap includes a vial-engagement portion and a needle-free syringe-engagement portion with a frangible portion extending therebetween. The vial-engagement portion is designed to removably engage a vial of fluid to be transferred into a needle-free syringe, and the needle-free syringe-engagement portion is designed to nonremovably engage a needle-free syringe.

Abstract: A needle-free injection system, including a spring-powered injection device and an arming mechanism. The arming mechanism is configured to be operatively engaged with the injection device so that a spring of the injection device is mechanically coupled with the arming mechanism, the coupling of the spring and arming mechanism being such that operation of an actuator of the arming mechanism causes the spring of the injection device to be compressed, thereby arming the injection device. The arming mechanism may be further configured to automatically engage and release the mechanical coupling used to compress the spring.

Abstract: A needle-free injection device in which a gas cartridge or other source of pressurized gas is used to advance a piston and forcibly expel injectable fluid out through an injection orifice. When a gas cartridge is used, the gas cartridge may be moveable from an initial position to an actuating position in which gas is released to drive the injection, and a recoil inhibiter may be employed to prevent the gas cartridge from moving back to the initial position. A gas cartridge seal may be disposed on the gas cartridge and moveable with the gas cartridge to seal the gas cartridge against an interior wall of a gas cartridge housing. The needle-free injection device may also be configured so that sealing is compromised upon full advancement of the piston, so as to de-pressurize the device after delivery of an injection.

Abstract: A needle-free injection system, including an injection device and a vial adapter. The injection device is configured to be loaded with a dose of injectable fluid and forcibly inject such dose into an injection site. The vial adapter is configured to secure to and selectively seal a vial containing an external supply of injectable fluid. The vial adapter also includes a flexible adapter structure biased into a blocking position. The injection device includes a filling adapter configured to move the flexible adapter structure out of the blocking position to thereby permit the vial adapter and injection device to be secured together in an engaged configuration. In this engaged configuration, a dose of injectable fluid may be drawn from the external supply of injectable fluid into the injection device.

Abstract: A needle-free injection system, including a nozzle having a fluid chamber and an injection orifice in fluid communication with the fluid chamber. The needle-free injection system also includes a filling adapter secured to the nozzle and configured to couple the nozzle with an external supply of injectable fluid to the nozzle to enable filling of the fluid chamber with injectable fluid. The filling adapter may be frangibly secured to the nozzle and/or the injection system may be configured to prevent delivery of an injection from the injection orifice into an injection site until the filling adapter's ability to enable filling of the fluid chamber has been disabled.

Abstract: A method and apparatus for providing high throughput injections is provided. The invention provides a filling device adapted to deliver injectate from a common reservoir to a plurality of disposable fluid injection assemblies and a reusable propulsion assembly adapted to receive a filled disposable fluid injection assembly and deliver an injection to a patient.

Abstract: A dispenser cap for combination with a standard flexible irrigation solution bottle to make a portable wound irrigation dispenser includes a collar threadably engageable with the irrigation bottle, and closed at one end by a wall defining a tubular neck. The tubular neck forms a flow path from the bottle to a splash shield including a nozzle for directing irrigation solution. A valve is disposed in the flow path for opening and closing this flow path. A combination apparatus includes the flexible irrigation solution bottle, which may be inverted and squeezed in order to direct a jet of cleansing liquid into a wound. A single use version of the apparatus includes a valve which is closed in a storage and shipping configuration of the apparatus, and an indicator which is freed within the transparent or translucent flexible bottle when the valve is opened, thus irreversibly indicating that the apparatus has been used.

Abstract: A needle-free injection device, including a plunger and a spring operatively coupled with the plunger. The plunger is slidably disposed within a fluid chamber, is retractable to draw injectable fluid into the fluid chamber through an injection orifice, and may be advanced within the fluid chamber to forcibly eject injection fluid out through the injection orifice. The spring is configured to be compressed during arming of the injection device, and decompressed during discharge to forcibly advance the plunger within the fluid chamber. The injection device further includes an actuator operable to cause the spring to be compressed during arming of the injection device, and selectively operable prior to decompression of the spring to cause the plunger to be moved to a desired position within the fluid chamber.

Abstract: A method of manufacture for a drug cartridge assembly. The method includes providing a drug cartridge, providing a nozzle sub-assembly, and sterilizing the drug cartridge and nozzle sub-assembly. The method further includes assembling the drug cartridge and nozzle sub-assembly together in a configuration that enables ejection of liquid out of the drug cartridge through the nozzle sub-assembly. The method further includes filling the drug cartridge with a liquid, such as an injectable drug. The method may include separate sterilization of the drug cartridge and nozzle sub-assembly, using different sterilization processes. Portions of the method may be performed prior to sterilization within a first cleanroom, with subsequent steps being performed in a second cleanroom having a substantially lower particulate-per-volume rating than the first cleanroom.

Abstract: A needle-free injection device capable of delivering pressurized injections to an injection site. The device may include a barrier dispenser configured to provide a disposable piece of barrier material for each injection, so as to reduce risk of cross-contamination. The device may also include various sensors, a firing disable mechanism, a multiple use and/or disposable fluid path, and/or other mechanisms configured to enhance sterility and prevent contamination.

Abstract: A needle-free injection device is described. The injection device includes a user-grippable housing and a syringe assembly movably secured to the housing. The syringe assembly is configured to expel injectable fluid out of a nozzle upon application of pressurized gas to the syringe assembly. The injection device also includes a pressurized gas delivery mechanism disposed within the housing and configured to selectively apply pressurized gas to the syringe assembly. The pressurized gas delivery mechanism is at least partly actuated by pressing the nozzle onto an injection site so that the syringe assembly moves relative to the housing.

Abstract: A needleless injector system including: a first injector assembly; a gas capsule disposed within the first injector assembly and containing pressurized gas, with a pierceable surface at the forward end thereof to provide an injection source; a gas capsule piercing member disposed within the first injector assembly, where the piercing member and the gas capsule are movable relative to each other; a second injector assembly containing a medical treatment fluid and having a forward facing injection orifice for injecting the medical treatment fluid into a patient; and a resilient seal mounted between the gas capsule and the first injector assembly to contain all pressurized gas within a forward end of the first injector assembly after pressurized gas is released from the gas capsule following piercing of the gas capsule, in order to cause an immediate increase in pressure in the medical treatment fluid contained within the second injector assembly.

Abstract: The present invention provides method and apparatus for providing high throughput injections. In one embodiment the invention provides a filling device adapted to deliver injectate from a common reservoir to a plurality of disposable fluid injection assemblies and a reusable propulsion assembly adapted to receive a filled disposable fluid injection assembly and deliver an injection to a patient.

Abstract: A gas-powered, durable, needle-less hypodermic jet injection device (10, 210) includes a hand-held injector (12, 212) which receives into an injection cylinder a volume of liquid medication to be injected in the form of a high velocity jet capable of penetrating the skin without the use of a hypodermic needle. The injection device provides an injection orifice, and an injection piston. Forceful movement of the injection piston causes a high velocity injection jet of liquid medication to be expelled from the injection cylinder via the injection orifice. The injection device includes features which improve its usability, particularly for users with hands that are possibly weak, feeble, or arthritic, for example; and also includes additional features which improve manufacturability, durability, and cost effectiveness of the device.

Abstract: A needle-free injection device is described. The injection device typically includes a system for providing directed and pre-selected pressure and a nozzle with an orifice for defining a stream of fluid that is directed toward the skin of a patient against which a front end of the nozzle is positioned. The device also normally includes an engagement system that can selectively engage the nozzle with the pressurizing system so that the nozzle can be mounted to the pressurizing system to receive pressure for injection and so that after injection the nozzle can be removed and replaced for each new use of the device.