Patents by Inventor Sergio Romagnani

Sergio Romagnani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation of conjugates comprising adenine derivatives and allergenic proteins and their use for specific immunotherapy of allengenic diseases
    Patent number: 8822407
    Abstract: The present invention refers to the preparation of adenine derivative active esters of formula (I) and use thereof for the preparation of stable conjugates between adenine derivative and allergenic proteins having general structure (II) for the modulation of TH2 response in allergic diseases. (I, II).
    Type: Grant
    Filed: August 4, 2011
    Date of Patent: September 2, 2014
    Assignee: Universita' Degli Studi di Firenze
    Inventors: Sergio Romagnani, Enrico Maggi, Paola Parronchi, Antonio Guarna, Ernesto Giovanni Occhiato
  • PREPARATION OF CONJUGATES COMPRISING ADENINE DERIVATIVES AND ALLERGENIC PROTEINS AND THEIR USE FOR SPECIFIC IMMUNOTHERAPY OF ALLENGENIC DISEASES
    Publication number: 20130136764
    Abstract: The present invention refers to the preparation of adenine derivative active esters of formula (I) and use thereof for the preparation of stable conjugates between adenine derivative and allergenic proteins having general structure (II) for the modulation of TH2 response in allergic diseases.(I, II).
    Type: Application
    Filed: August 4, 2011
    Publication date: May 30, 2013
    Applicant: UNIVERSITA ' DEGLI STUDI DI FIRENZE
    Inventors: Sergio Romagnani, Enrico Maggi, Paola Parronchi, Antonio Guarna, Ernesto Giovanni Occhiato
  • Kidney-Derived Stem Cell Population, Identification and Therapeutic Use
    Publication number: 20090196857
    Abstract: A novel population of kidney-derived cells is described that exhibits surface co-expression of CD133 and CD24 markers; said cells possess stem cell capacity and are capable of undergoing tubulogenic, adipogenic, osteogenic and neurogenic differentiation.
    Type: Application
    Filed: April 27, 2007
    Publication date: August 6, 2009
    Applicant: AZIENDA OSPEDALIERO-UNIVERSITARIA CAREGGI
    Inventors: Paola Romagnani, Enrico Maggi, Sergio Romagnani
  • Stem Cells, Method For Their Purification, Identification, and Use
    Publication number: 20080248000
    Abstract: Herein is described a new population of circulating CD14+cells, with a low density surface expression of CD34 and endowed with stem capacity, a method for their purification and identification, and their therapeutic use.
    Type: Application
    Filed: November 14, 2005
    Publication date: October 9, 2008
    Inventors: Paola Romagnani, Francesco Annunziato, Enrico Maggi, Sergio Romagnani
  • Methods for detecting, identifying, isolating, and selectively labelling and targeting TH1 lymphocyte by means of the LAG-3 protein
    Patent number: 6197524
    Abstract: The lymphocyte ativation gene (LAG-3) is a member of the immunoglobulin superfamily that is selectively transcribed in human activated T and NK cells. Surface LAG-3 expression correlated with IFN-&ggr; but not IL-4, production in antigen-stimulated T-cells and it was up-regulated by IL-12 and is preferentially associated with CD4+ T-cells producing Th1-type cytokines. The presence of LAG-3 on the surface of Th1 lymphocytes is used as a marker to detect and identify Th1 lymphocytes and differentiate them from Th2 lymphocytes. Monoclonal antibodies to LAG-3 are used in methods of detecting and isolating Th1 cells as well as methods of diagnosing Th1-mediated disease. The present invention also relates to methods of treating infectious diseases, cancer, and disorders assocated with Th1/Th2 imbalance.
    Type: Grant
    Filed: April 15, 1998
    Date of Patent: March 6, 2001
    Assignees: Institute National de la Sante et de la Recherche Medicale, Institut Gustave Roussy, Applied Research Systems, ARS Holding N.V.
    Inventor: Sergio Romagnani