Patents by Inventor Sergiu M. Gorun
Sergiu M. Gorun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210277279Abstract: Photoactive polymer coatings and methods of making the same are disclosed herein. In some embodiments, a polymer coating having a porous structure extending throughout the polymer coating, wherein the porous structure is present at an exposed surface of the polymer coating creating a roughened surface, wherein the polymer of the polymer coating is a siloxane based polymer; and a modified support particle disposed within the polymer coating, wherein the modified support particle includes a substituted phthalocyanine and a support particle. In some embodiments, the substituted phthalocyanine is a halogenated phthalocyanine.Type: ApplicationFiled: May 24, 2021Publication date: September 9, 2021Applicant: Seton Hall UniversityInventors: James E. Hanson, Abdul Azeez, Sergiu M. Gorun
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Patent number: 11015032Abstract: Photoactive polymer coatings and methods of making the same are disclosed herein. In some embodiments, a polymer coating comprises a polymer matrix having a porous structure extending throughout the polymer matrix, wherein the porous structure is present at an exposed surface of the polymer coating creating a roughened surface, and a modified support particle disposed within the polymer matrix, wherein the modified support particle includes a substituted phthalocyanine and a support particle. In some embodiments, the substituted phthalocyanine is a halogenated phthalocyanine.Type: GrantFiled: February 28, 2019Date of Patent: May 25, 2021Assignee: Seton Hall UniversityInventors: James E. Hanson, Abdul Azeez, Sergiu M. Gorun
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Patent number: 10942142Abstract: Methods and apparatus for detecting an analyte using fluorinated phthalocyanines is disclosed herein. A method for detecting an analyte includes illuminating an analyte solution which contacts an electrode comprising a conductive material having a photosensitizer coupled thereto to generate a reactive oxygen species, wherein the photosensitizer is a fluorinated pthalocyanine having a metal or a non-metal center, oxidizing an analyte present in the analyte solution with the reactive oxygen species to form an oxidized analyte, and detecting a current resulting from the reduction of the oxidized analyte at the electrode.Type: GrantFiled: July 13, 2018Date of Patent: March 9, 2021Assignees: Seton Hall UniversityInventors: Karolien De Wael, Sergiu M. Gorun, Stanislav Trashin, Erik N. Carrión
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Publication number: 20190270858Abstract: Photoactive polymer coatings and methods of making the same are disclosed herein. In some embodiments, a polymer coating comprises a polymer matrix having a porous structure extending throughout the polymer matrix, wherein the porous structure is present at an exposed surface of the polymer coating creating a roughened surface, and a modified support particle disposed within the polymer matrix, wherein the modified support particle includes a substituted phthalocyanine and a support particle. In some embodiments, the substituted phthalocyanine is a halogenated phthalocyanine.Type: ApplicationFiled: February 28, 2019Publication date: September 5, 2019Applicant: Seton Hall UniversityInventors: James E. Hanson, Abdul Azeez, Sergiu M. Gorun
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Publication number: 20190017955Abstract: Methods and apparatus for detecting an analyte using fluorinated phthalocyanines is disclosed herein. A method for detecting an analyte includes illuminating an analyte solution which contacts an electrode comprising a conductive material having a photosensitizer coupled thereto to generate a reactive oxygen species, wherein the photosensitizer is a fluorinated pthalocyanine having a metal or a non-metal center, oxidizing an analyte present in the analyte solution with the reactive oxygen species to form an oxidized analyte, and detecting a current resulting from the reduction of the oxidized analyte at the electrode.Type: ApplicationFiled: July 13, 2018Publication date: January 17, 2019Applicants: Seton Hall University, AXES Research Group, Department of Chemistry, University of Antwerp,Inventors: Karolien De Wael, Sergiu M. Gorun, Stanislav Trashin, Erik N. Carrión
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Patent number: 9956549Abstract: A new class of organic-inorganic hybrid composite materials, composites of a fluoroalkyl fluorophthalocyanine and a solid-state support containing an imidazole group. The new class of composite materials can be used as a heterogeneous catalyst for the heterogeneous oxidation organic molecules in aqueous and some organic solvents systems is claimed.Type: GrantFiled: February 26, 2016Date of Patent: May 1, 2018Assignee: Seton Hall UniversityInventors: Hemantbhai Patel, Sergiu M. Gorun
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Patent number: 9731284Abstract: A process for use of composite catalysts for oxidation of amines during synthesis of energetic compounds. This method overcomes the safety concerns associated with dangerous reaction conditions for these energetic materials. The process requires exposing phthalocyanine conjugated to an inorganic substrate to the precursor reactant and activating the composite material to light and oxygen to covert amine groups into oxidized nitrogen species.Type: GrantFiled: February 24, 2016Date of Patent: August 15, 2017Assignees: The United States of America as Represented by the Secretary of the Army, Seton Hall UniversityInventors: Peggy A. Sanchez, Kimberly Griswold, Sergiu M. Gorun, Hemantbhai H. Patel
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Patent number: 9572898Abstract: Functionalized fluorine containing phthalocyanine molecules, methods of making, and methods of use in diagnostic applications and disease treatment are disclosed herein. In some embodiments, the fluorine containing phthalocyanine molecules are functionalized with a reactive functional group or at least one cancer-targeting ligand (CTL). The CTL can facilitate more efficient binding and/or internalization to a cancer cell than to a healthy cell. The CTL can inhibit expression of oncoprotein in some embodiments. The pthalocyanine moiety can be used in diagnostic applications, such as fluorescence labeling of a cancer cell, and/or treatment applications, such as catalyzing formation of a reactive oxygen species (ROS) which can contribute to cell death of a cancer cell.Type: GrantFiled: September 9, 2014Date of Patent: February 21, 2017Assignee: Seton Hall UniversityInventors: David Sabatino, Sergiu M. Gorun, Emily Borland, Hemantbhai Patel, Pradeepkumar Patel, Erik Nathaniel Carrión
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Patent number: 9260630Abstract: Coating compositions that include a halopigment dispersed within a silicon-containing polymeric matrix (e.g., a polysiloxane polymer) are provided. The halopigment comprises a halogenated phthalocyanine (e.g., a fluorinated phthalocyanine) attached to a support particle (e.g., a metal oxide, a non-metal oxide, and/or an inert material). The halogenated phthalocyanine can have the formula: (16R-Pc)nMLo, where each R is, independently, a halogen or a perhaloalkyl group, with each R group being independent from the other groups; Pc is a phthalocyanine compound; 1?n?2; L is a ligand or ligands and M is a cation; and 0?o?8. Methods are also provided for forming such a coating composition and for coating a substrate with the coating composition.Type: GrantFiled: April 2, 2015Date of Patent: February 16, 2016Inventors: Sergiu M. Gorun, James Sullivan, Karpagavalli Ramji
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Publication number: 20150368194Abstract: Organo-metallic materials with reduced steric hindrance and the ability to aggregate are disclosed. The metal remains capable of binding additional molecules. As an example, Zn complexes that prove aggregation are provided. Such aggregation may help improve or trigger new surface properties of the materials, alone or in combination with others. In a further implementation of the present disclosure, a robust molecule that resists degradation via nucleophilic, electrophilic and radical attacks is provided. Coordinated O2 is reduced catalytically, producing efficiently thyil radicals in spite of the extreme electronic deficiency of the catalyst.Type: ApplicationFiled: August 31, 2015Publication date: December 24, 2015Inventors: Sergiu M. Gorun, Andrei Ioan Loas, Kimberly Griswold, Lukasz Lapok, Hemantbhai Hasmukhbhai Patel, Robert Gerdes
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Publication number: 20150315137Abstract: Organo-metallic materials with reduced steric hindrance and the ability to aggregate are disclosed. The metal remains capable of binding additional molecules. As an example, Zn complexes that prove aggregation are provided. Such aggregation may help improve or trigger new surface properties of the materials, alone or in combination with others. In a further implementation of the present disclosure, a robust molecule that resists degradation via nucleophilic, electrophilic and radical attacks is provided. Coordinated O2 is reduced catalytically, producing efficiently thyil radicals in spite of the extreme electronic deficiency of the catalyst.Type: ApplicationFiled: July 17, 2014Publication date: November 5, 2015Applicant: NEW JERSEY INSTITUTE OF TECHNOLOGYInventors: Sergiu M. Gorun, Andrei Ioan Loas, Kimberly Griswold, Lukasz Lapok, Hemantbhai Hasmukhbhai Patel, Robert Gerdes
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Publication number: 20150284592Abstract: Coating compositions that include a halopigment dispersed within a silicon-containing polymeric matrix (e.g., a polysiloxane polymer) are provided. The halopigment comprises a halogenated phthalocyanine (e.g., a fluorinated phthalocyanine) attached to a support particle (e.g., a metal oxide, a non-metal oxide, and/or an inert material). The halogenated phthalocyanine can have the formula: (16R-Pc)nMLo, where each R is, independently, a halogen or a perhaloalkyl group, with each R group being independent from the other groups; Pc is a phthalocyanine compound; 1?n?2; L is a ligand or ligands and M is a cation; and 0?o?8. Methods are also provided for forming such a coating composition and for coating a substrate with the coating composition.Type: ApplicationFiled: April 2, 2015Publication date: October 8, 2015Inventors: Sergiu M. Gorun, James Sullivan, Karpagavalli Ramji
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Patent number: 9150431Abstract: A method of purifying or sanitizing contaminated water to be potable, by exposing the water in the presence of light, to an electrically neutral metal complex of a perfluoroalkylated fluorinated phthalocyanine photosensitizer, having only external R groups with C—F bonds, preferably F64PcZn; whereby, a sufficient quantity of singlet oxygen is provided by the chemical reaction of the light and the photosensitizer to destroy the pollutants or pathogens present in the contaminated water.Type: GrantFiled: November 29, 2012Date of Patent: October 6, 2015Assignee: The United States of America as Represented by the Secretary of the ArmyInventors: Sergiu M. Gorun, Kimberly Ann Griswold
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Publication number: 20150266011Abstract: A new class of hybrid composite materials, composites of a perfluoroalkyl fluoro phthalocyanine and a solid-state support—useful as heterogeneous catalysts for the degradation of organic molecules in aqueous systems via the photocatalytic generation of reactive oxygen species.Type: ApplicationFiled: March 24, 2014Publication date: September 24, 2015Inventors: Kimberly A. Griswold, Sergiu M. Gorun
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Publication number: 20150071862Abstract: Functionalized fluorine containing phthalocyanine molecules, methods of making, and methods of use in diagnostic applications and disease treatment are disclosed herein. In some embodiments, the fluorine containing phthalocyanine molecules are functionalized with a reactive functional group or at least one cancer-targeting ligand (CTL). The CTL can facilitate more efficient binding and/or internalization to a cancer cell than to a healthy cell. The CTL can inhibit expression of oncoprotein in some embodiments. The pthalocyanine moiety can be used in diagnostic applications, such as fluorescence labeling of a cancer cell, and/or treatment applications, such as catalyzing formation of a reactive oxygen species (ROS) which can contribute to cell death of a cancer cell.Type: ApplicationFiled: September 9, 2014Publication date: March 12, 2015Inventors: David Sabatino, Sergiu M. Gorun, Emily Borland, Hemantbhai Patel, Pradeepkumar Patel
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Publication number: 20130064712Abstract: The present invention relates to a composite comprising at least one type of perfluoroalkyl-perfluoro-phthalocyanine, and to a method of producing such composite. The present invention also relates to a method of generating singlet oxygen, a method of killing eukaryotic or prokaryotic cells and a method of sterilization, cleaning and/or decontamination. Moreover, the present invention relates to a composite or a device for use in a method of sterilization, cleaning and/or decontamination.Type: ApplicationFiled: October 12, 2010Publication date: March 14, 2013Inventors: Beate Roder, Sergiu M. Gorun, Robert Gerdes, Christian Litwinski
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Patent number: 8349457Abstract: Perfluoroisopropyl-substituted perfluorophtalocyanines, including zinc (II), copper (II) and oxo-vanadium (IV) complexes of 29H,31H,1,4,8,11,15,18,22,25-octakis-fluoro-2,3,9,10,16,17,23,24-octakis-perfluoro(isopropyl)phthalocyanine (F64Pc), may be sublimed under high vacuum conditions. The compounds/molecules produce advantageous thin films (20-100 nm) on glass substrates by physical vapor deposition. Many potential applications of the disclosed compounds/molecules are disclosed, e.g., as semiconductor materials. In situ electrical conduction and optical transmission measurements during the deposition process reveal the formation of conducting pathways and potential microscopic intermolecular electronic couplings.Type: GrantFiled: December 1, 2009Date of Patent: January 8, 2013Assignee: New Jersey Institute of TechnologyInventors: Sergiu M. Gorun, Olga Tsaryova, Lukasz Lapok
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Publication number: 20120283430Abstract: Organo-metallic materials with reduced steric hindrance and the ability to aggregate ar disclosed. The metal remains capable of binding additional molecules. As an example, Zn complexes that prove aggregation are provided. Such aggregation may help improve or trigger new surface properties of the materials, alone or in combination with others. In a further implementation of the present disclosure, a robust molecule that resists degradation via nucleophilic, electrophilic and radical attacks is provided. Coordinated O2 is reduced catalytically, producing efficiently thyil radicals in spite of the extreme electronic deficiency of the catalyst.Type: ApplicationFiled: November 1, 2011Publication date: November 8, 2012Applicant: NEW JERSEY INSTITUTE OF TECHNOLOGYInventors: Sergiu M. Gorun, Andrei Ioan Loas, Kimberly Griswold, Lukasz Lapok, Hemantbhai Hasmukhbhai Patel, Robert Gerdes
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Publication number: 20110168543Abstract: Advantageous microwave-assisted methods for synthesis of fluorinated phthalocyanines are provided. The microwave-assisted methods offer enhanced yields, substantially eliminate reaction solvents, and facilitate purification relative to conventional synthesis techniques. Typical implementation involve a reaction mixture that includes perfluoro-phthalonitrile that is reacted in a vessel with application of microwave energy for a reaction period sufficient to yield a fluorinated phthalocyanine. The fluorinated phthalocyanines synthesized according to the disclosed microwave-assisted methods have wide ranging applications, e.g., corrosion-related applications, coating-related applications, catalysis, and the production of optical and electronic materials.Type: ApplicationFiled: April 1, 2009Publication date: July 14, 2011Applicants: NEW JERSEY INSTITUTE OF TECHNOLOGY, FRAUNHOFER-GESELLSCHAFTInventors: Sergiu M. Gorun, Guenter Schnurpfeil, Olaf Hild, Dieter Woehrle, Olga Gerdes, Robert Gerdes
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Publication number: 20110172437Abstract: Advantageous methods for synthesis of fluorinated phthalocyanines are provided. Typical implementation involves a reaction mixture that includes perfluoro compound that is reacted for a reaction period sufficient to yield a fluorinated phthalocyanine of formula F64PcM, wherein “Pc” is any phthalocyanine macrocycle and “M” is hydrogen. Novel fluorinated phthalocyanine molecules/compounds are also provided herein, including specifically compounds that include fluorinated phthalocyanines wherein “M” is Cu or V?O. The fluorinated phthalocyanines have wide ranging applications, e.g., corrosion-related applications, coating-related applications, catalysis, and the production of optical and electronic materials.Type: ApplicationFiled: April 1, 2009Publication date: July 14, 2011Applicant: NEW JERSEY INSTITUTE OF TECHNOLOGYInventors: Sergiu M. Gorun, Robert Gerdes, Olga Gerdes, Lukasz Lapok