Patents by Inventor Sesha I. Natarajan

Sesha I. Natarajan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified plasminogen related peptide fragments and their use as angiogenesis inhibitors
    Publication number: 20030054988
    Abstract: Modified peptide fragments of plasminogen domain are provided which exhibit anti-angiogenic activity. Compositions containing these peptide fragments and methods of using these compositions to treat angiogenic dependent and associated disorders are also provided.
    Type: Application
    Filed: October 31, 2001
    Publication date: March 20, 2003
    Inventors: Weidong-Richard Ji, Chester A. Meyers, Sesha I. Natarajan, Pamela A. Trail
  • Ureido renin inhibitors
    Patent number: 4757050
    Abstract: Compounds of the formula ##STR1## are disclosed. These compounds intervene in the conversion of angiotensinogen to angiotensin II by inhibiting renin and thus are useful as antihypertensive agents.
    Type: Grant
    Filed: August 28, 1987
    Date of Patent: July 12, 1988
    Assignee: E. R. Squibb Sons, Inc.
    Inventors: Sesha I. Natarajan, Denis E. Ryono, Edward W. Petrillo, Jr.
  • Diamino ketones and alcohols as analgesic agents
    Patent number: 4749792
    Abstract: Analgesic activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein R.sub.1, R.sub.2 and R.sub.4 are each independently hydrogen, alkyl, carboxyalkyl, halosubstituted alkyl, hydroxyalkyl, aminoalkyl, mercaptoalkyl, alkylthioalkyl, (cycloalkyl)alkyl, (heteroaryl)alkyl, arylalkyl, carbamoylalkyl, guanidinylalkyl, or heteroaryl, and R.sub.3 is hydroxymethylene or carbonyl.
    Type: Grant
    Filed: September 26, 1984
    Date of Patent: June 7, 1988
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Sesha I. Natarajan, Eric M. Gordon
  • Acylalkylaminocarbonyl substituted amino and imino acid compounds
    Patent number: 4742067
    Abstract: Compounds of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.
    Type: Grant
    Filed: July 30, 1986
    Date of Patent: May 3, 1988
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Sesha I. Natarajan, Eric M. Gordon
  • Intermediate for substituted peptide compounds
    Patent number: 4736066
    Abstract: Intermediates of the formula ##STR1## are disclosed. These compounds are useful in preparing substituted peptide compounds which possess hypotensive and analgesic activity.
    Type: Grant
    Filed: May 25, 1984
    Date of Patent: April 5, 1988
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Sesha I. Natarajan, Eric M. Gordon
  • Acylalkylaminocarbonyl substituted amino and imino acid compounds
    Patent number: 4623729
    Abstract: Compounds of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.
    Type: Grant
    Filed: July 22, 1982
    Date of Patent: November 18, 1986
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Sesha I. Natarajan, Eric M. Gordon
  • Substituted proline compounds, composition and method of use
    Patent number: 4621092
    Abstract: Compounds of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.
    Type: Grant
    Filed: July 14, 1983
    Date of Patent: November 4, 1986
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Sesha I. Natarajan, Eric M. Gordon
  • Hydroxy substituted ureido amino and imino acids
    Patent number: 4604402
    Abstract: Compounds of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.
    Type: Grant
    Filed: March 30, 1984
    Date of Patent: August 5, 1986
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Jollie D. Godfrey, Jr., Eric M. Gordon, Sesha I. Natarajan
  • Intermediates for substituted peptide compounds
    Patent number: 4535176
    Abstract: Intermediates of the formula ##STR1## are disclosed. These compounds are useful in preparing substituted peptide compounds which possess hypotensive and analgesic activity.
    Type: Grant
    Filed: May 29, 1984
    Date of Patent: August 13, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Sesha I. Natarajan, Eric M. Gordon
  • Hydroxy substituted peptide compounds
    Patent number: 4514391
    Abstract: Hydroxy substituted peptide compounds of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.
    Type: Grant
    Filed: July 21, 1983
    Date of Patent: April 30, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Eric M. Gordon, Jollie D. Godfrey, Jr., Sesha I. Natarajan
  • Substituted peptide compounds
    Patent number: 4470973
    Abstract: Substituted peptide compounds of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.
    Type: Grant
    Filed: June 2, 1983
    Date of Patent: September 11, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Sesha I. Natarajan, Eric M. Gordon
  • 4-Methylene-1-[[(alranoyl or arylcarbonyl)mercapto]acyl]proline and pipecolic acid
    Patent number: 4377701
    Abstract: Compounds having the formula ##STR1## and salts thereof, wherein R.sub.1 is a readily hydrolyzable acyl protecting group;R.sub.2 is hydrogen or alkyl;R.sub.3 is hydrogen, alkyl or arylalkyl;n is 1 or 2; andp is 1 or 2inhibit the action of angiotensin converting enzyme.
    Type: Grant
    Filed: September 21, 1981
    Date of Patent: March 22, 1983
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Sesha I. Natarajan, Miguel A. Ondetti
  • Mixed disulfides
    Patent number: 4325944
    Abstract: This invention is directed to compounds of the formula ##STR1## wherein A and A.sub.1 are amino acid residues, X is an .alpha.-imino acid residue, and R.sub.1 is hydrogen, lower alkyl, or halo substituted lower alkyl. These compounds are useful as hypotensive agents.
    Type: Grant
    Filed: December 22, 1980
    Date of Patent: April 20, 1982
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Sesha I. Natarajan, Miguel A. Ondetti, Shih-jung Lan, Keith K. Wong
  • Mixed disulfides
    Patent number: 4325943
    Abstract: This invention is directed to compounds of the formula ##STR1## wherein A and A.sub.1 are amino acid residues, X is an .alpha.-imino acid residue, and R.sub.1 is hydrogen, lower alkyl, or halo substituted lower alkyl. These compounds are useful as hypotensive agents.
    Type: Grant
    Filed: December 22, 1980
    Date of Patent: April 20, 1982
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Sesha I. Natarajan, Miguel A. Ondetti, Shih-jung Lan, Keith K. Wong
  • Mixed disulfides
    Patent number: 4325945
    Abstract: This invention is directed to compounds of the formula ##STR1## wherein A and A.sub.1 are amino acid residues, X is an .alpha.-imino acid residue, and R.sub.1 is hydrogen, lower alkyl, or halo substituted lower alkyl. These compounds are useful as hypotensive agents.
    Type: Grant
    Filed: December 22, 1980
    Date of Patent: April 20, 1982
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Sesha I. Natarajan, Miguel A. Ondetti, Shih-jung Lan, Keith K. Wong
  • Mixed disulfides
    Patent number: 4284624
    Abstract: This invention is directed to compounds of the formula ##STR1## wherein A and A.sub.1 are amino acid residues, X is and .alpha.-imino acid residue, and R.sub.1 is hydrogen, lower alkyl, or halo substituted lower alkyl. These compounds are useful as hypotensive agents.
    Type: Grant
    Filed: May 2, 1980
    Date of Patent: August 18, 1981
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Sesha I. Natarajan, Miguel A. Ondetti, Shih-jung Lan, Keith K. Wong
  • Derivatives of pyrrolidinecarboxaldehyde and piperidinecarboxaldehyde and intermediates therefor
    Patent number: 4206122
    Abstract: Derivatives of pyrrolidinecarboxaldehyde and piperidinecarboxaldehyde, and intermediates therefor, which have the general formula ##STR1## wherein R is hydrogen, lower alkanoyl or ##STR2## R.sub.1 is hydrogen or lower alkyl; R.sub.2 is hydrogen or hydroxy;R.sub.3 is hydroxymethyl, di(lower alkoxy)methyl or formyl;n is 1 or 2;and their bisulfite addition products, are useful as hypotensive agents.
    Type: Grant
    Filed: April 14, 1978
    Date of Patent: June 3, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Sesha I. Natarajan, Miguel A. Ondetti
  • Certain dimers of tetrahydropyridine-2-carboxylic acids or pyrroline-2-carboxylic acids and derivatives thereof
    Patent number: 4156084
    Abstract: New compounds which have the general formula ##STR1## are useful as hypotensive agents.
    Type: Grant
    Filed: August 15, 1978
    Date of Patent: May 22, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, Sesha I. Natarajan