Patents by Inventor Shaheer H. Khan
Shaheer H. Khan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230194537Abstract: The invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins. The invention relates, in part, to glycan labeling with formulas/compounds enhancing their detection and/or analysis by methods such as capillary electrophoresis, liquid chromatography and mass spectrometry. These detection methods may be useful in studying glycosylation patterns of biological or medical samples, or for assessing protein production, protein quality/purity, for comparing innovator and biosimilar glycosylated proteins, or for selecting proteins with the desired glycosylation.Type: ApplicationFiled: March 16, 2018Publication date: June 22, 2023Inventors: Shaheer H. KHAN, Jonathan BONES, Csaba VARADI
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Patent number: 10724094Abstract: A method of conjugating a substrate includes exchanging a counter ion associated with a biomolecule with a lipophilic counter ion to form a biomolecule complex, dispersing the biomolecule complex in a nonaqueous solvent, and coupling the biomolecule complex to a substrate in the presence of the nonaqueous solvent.Type: GrantFiled: April 4, 2018Date of Patent: July 28, 2020Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Steven M. Menchen, Alan Blanchard, Luisa Andruzzi, Shaheer H. Khan, Dmitriy Gremyachinskiy, Alfred Lui, Craig Stolarczyk, Tanya Sokolsky, Prasanna Krishnan Thwar
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Patent number: 10309959Abstract: Methods, systems, compositions and kits are described for detecting cleaved glycans from a glycoconjugate. After labeling the glycan with a nucleic acid charged oligomer described herein, the labeled glycans can be separated under the influence of an electric field or based on their detectable tag and identified.Type: GrantFiled: December 3, 2015Date of Patent: June 4, 2019Assignee: Life Technologies CorporationInventors: James Stray, Shaheer H. Khan
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Publication number: 20180223359Abstract: A method of conjugating a substrate includes exchanging a counter ion associated with a biomolecule with a lipophilic counter ion to form a biomolecule complex, dispersing the biomolecule complex in a nonaqueous solvent, and coupling the biomolecule complex to a substrate in the presence of the nonaqueous solvent.Type: ApplicationFiled: April 4, 2018Publication date: August 9, 2018Inventors: Steven M. MENCHEN, Alan BLANCHARD, Luisa ANDRUZZI, Shaheer H. KHAN, Dmitriy GREMYACHINSKIY, Alfred LUI, Craig STOLARCZYK, Tanya SOKOLSKY, Prasanna Krishnan THWAR
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Patent number: 9938577Abstract: A method of conjugating a substrate includes exchanging a counter ion associated with a biomolecule with a lipophilic counter ion to form a biomolecule complex, dispersing the biomolecule complex in a nonaqueous solvent, and coupling the biomolecule complex to a substrate in the presence of the nonaqueous solvent.Type: GrantFiled: September 16, 2015Date of Patent: April 10, 2018Assignee: Life Technologies CorporationInventors: Steven M. Menchen, Alan Blanchard, Luisa Andruzzi, Shaheer H. Khan, Dmitriy Gremyachinskiy, Alfred Lui, Craig Stolarczyk, Tanya Sokolsky, Prasanna Krishnan Thwar
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Publication number: 20160002723Abstract: A method of conjugating a substrate includes exchanging a counter ion associated with a biomolecule with a lipophilic counter ion to form a biomolecule complex, dispersing the biomolecule complex in a nonaqueous solvent, and coupling the biomolecule complex to a substrate in the presence of the nonaqueous solvent.Type: ApplicationFiled: September 16, 2015Publication date: January 7, 2016Inventors: Steven M. MENCHEN, Alan Blanchard, Luisa Andruzzi, Shaheer H. Khan, Dmitriy Gremyachinskiy, Alfred Lui, Craig Stolarczyk, Tanya Sokolsky, Prasanna Krishnan Thwar
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Publication number: 20120309953Abstract: Disclosed, among other things, are compounds having the structure wherein X comprises a bond or a linker, LABEL comprises at least one detectable label, W1 taken alone is —H or —OH, W2 is —OH or a non-extendable moiety, W3 when taken alone is —H or when taken together with W1 is —CH2—O—, and W4 is OH, monophosphate, diphosphate, or triphosphate. Also disclosed are labeled polynucleotide compounds and methods of use thereof.Type: ApplicationFiled: May 11, 2012Publication date: December 6, 2012Applicant: Life Technologies CorporationInventors: Barnett B. ROSENBLUM, Geun-sook Jeon, Shaheer H. Khan
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Patent number: 7998706Abstract: Disclosed, among other things, are compounds having the structure wherein X comprises a bond or a linker, LABEL comprises at least one detectable label, W1 taken alone is —H or —OH, W2 is —OH or a non-extendable moiety, W3 when taken alone is —H or when taken together with W1 is —CH2—O—, and W4 is OH, monophosphate, diphosphate, or triphosphate. Also disclosed are labeled polynucleotide compounds and methods of use thereof.Type: GrantFiled: December 17, 2004Date of Patent: August 16, 2011Assignee: Applied Biosystems, LLCInventors: Barnett B. Rosenblum, Geun-sook Jeon, Shaheer H. Khan
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Publication number: 20100304381Abstract: Provided are nucleotide-dye conjugates and related compounds in which a dye is linked to a nucleobase directly or indirectly by an anionic linker. The anionic character of the linker is provided by one or more anionic moieties which are present in the linker, such as phosphate, phosphonate, sulfonate, and carboxylate groups. When the dye is a provided as a donor/acceptor dye pair, the anionic linker can be located between the donor and the acceptor, or between the nucleobase and either the donor or acceptor, or both. In one embodiment, conjugates of the invention provide enhanced electrophoretic mobility characteristics to sequencing fragments, e.g., for dideoxy sequencing using labeled terminators.Type: ApplicationFiled: February 5, 2010Publication date: December 2, 2010Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Meng Taing, Shaheer H. Khan, Steven M. Menchen, Barnett B. Rosenblum
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Publication number: 20100292457Abstract: The invention provides novel dye-labeled ribonucleotide analogs and methods for synthesizing those analogs. The compounds of the invention are especially useful for DNA sequencing by the polymerase chain reaction.Type: ApplicationFiled: January 25, 2010Publication date: November 18, 2010Applicant: Applied Biosystems, LLCInventors: Peter Virgil Fisher, Paolo Vatta, Shaheer H. Khan
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Publication number: 20100184074Abstract: The invention includes methods and kits for making and analyzing primer extension products incorporating one or more universal bases, including methods and kits for nucleic acid sequencing and microsatellite analysis.Type: ApplicationFiled: February 8, 2010Publication date: July 22, 2010Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Barnett B. ROSENBLUM, Geun-Sook Jeon, Shaheer H. Khan
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Publication number: 20100113759Abstract: The present teachings relate to nucleobase, nucleoside and nucleotide compounds, methods of synthesis, and uses thereof. The present teachings provide compounds, such as nucleobase, nucleoside and/or nucleotide compounds including a propargyl linker, and methods for making or using such compounds.Type: ApplicationFiled: December 29, 2009Publication date: May 6, 2010Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Barnett B. ROSENBLUM, Geun-sook Jeon, Shaheer H. Khan
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Patent number: 7687236Abstract: Provided are nucleotide-dye conjugates and related compounds in which a dye is linked to a nucleobase directly or indirectly by an anionic linker. The anionic character of the linker is provided by one or more anionic moieties which are present in the linker, such as phosphate, phosphonate, sulfonate, and carboxylate groups. When the dye is a provided as a donor/acceptor dye pair, the anionic linker can be located between the donor and the acceptor, or between the nucleobase and either the donor or acceptor, or both. In one embodiment, conjugates of the invention provide enhanced electrophoretic mobility characteristics to sequencing fragments, e.g., for dideoxy sequencing using labeled terminators.Type: GrantFiled: September 29, 2008Date of Patent: March 30, 2010Assignee: Applied Biosystems, LLCInventors: Meng C. Taing, Shaheer H. Khan, Steven M. Menchen, Barnett B. Rosenblum
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Patent number: 7678892Abstract: The invention provides novel dye-labeled ribonucleotide analogs and methods for synthesizing those analogs. The compounds of the invention are especially useful for DNA sequencing by the polymerase chain reaction.Type: GrantFiled: May 4, 2007Date of Patent: March 16, 2010Assignee: Applied Biosystems, LLCInventors: Peter Virgil Fisher, Paolo Vatta, Shaheer H. Khan
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Patent number: 7575902Abstract: Compounds, methods and kits for making and analyzing primer extension products incorporating one or more universal bases are described, including methods and kits for nucleic acid sequencing and microsatellite analysis.Type: GrantFiled: April 27, 2007Date of Patent: August 18, 2009Assignee: Applied Biosystems, LLCInventors: Geun-Sook Jeon, Shaheer H. Khan, Barnett B. Rosenbaum
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Publication number: 20090092986Abstract: Provided are nucleotide-dye conjugates and related compounds in which a dye is linked to a nucleobase directly or indirectly by an anionic linker. The anionic character of the linker is provided by one or more anionic moieties which are present in the linker, such as phosphate, phosphonate, sulfonate, and carboxylate groups. When the dye is a provided as a donor/acceptor dye pair, the anionic linker can be located between the donor and the acceptor, or between the nucleobase and either the donor or acceptor, or both. In one embodiment, conjugates of the invention provide enhanced electrophoretic mobility characteristics to sequencing fragments, e.g., for dideoxy sequencing using labeled terminators.Type: ApplicationFiled: September 29, 2008Publication date: April 9, 2009Applicant: APPLIED BIOSYSTEMS INC.Inventors: Meng TAING, Shaheer H. KHAN, Steven M. MENCHEN, Barnett B. ROSENBLUM
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Patent number: 7429651Abstract: Provided are nucleotide-dye conjugates and related compounds in which a dye is linked to a nucleobase directly or indirectly by an anionic linker. The anionic character of the linker is provided by one or more anionic moieties which are present in the linker, such as phosphate, phosphonate, sulfonate, and carboxylate groups. When the dye is a provided as a donor/acceptor dye pair, the anionic linker can be located between the donor and the acceptor, or between the nucleobase and either the donor or acceptor, or both. In one embodiment, conjugates of the invention provide enhanced electrophoretic mobility characteristics to sequencing fragments, e.g., for dideoxy sequencing using labeled terminators.Type: GrantFiled: October 28, 2004Date of Patent: September 30, 2008Assignee: Applera CorporationInventors: Meng Taing, Shaheer H. Khan, Steven M. Menchen, Barnett B. Rosenblum
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Patent number: 7262029Abstract: The invention provides novel dye-labeled ribonucleotide analogs and methods for synthesizing those analogs. The compounds of the invention are especially useful for DNA sequencing by the polymerase chain reaction.Type: GrantFiled: December 8, 2004Date of Patent: August 28, 2007Assignee: Applera CorporationInventors: Peter Virgil Fisher, Paolo Vatta, Shaheer H. Khan
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Patent number: 7169557Abstract: The invention includes methods and kits for making and analyzing primer extension products incorporating one or more universal bases, including methods and kits for nucleic acid sequencing and microsatellite analysis.Type: GrantFiled: November 7, 2002Date of Patent: January 30, 2007Assignee: Applera CorporationInventors: Barnett B. Rosenblum, Geun-Sook Jeon, Shaheer H. Khan
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Patent number: 7018431Abstract: Sulfonated diarylrhodamine compounds are useful as fluorescent labels of nucleosides, nucleotides, polynucleotides, and polypeptides. The compounds find particular application in the area of fluorescent nucleic acid analysis, e.g., automated DNA sequencing and fragment analysis, detection of probe hybridization in hybridization arrays, detection of nucleic acid amplification products, and the like.Type: GrantFiled: June 24, 2003Date of Patent: March 28, 2006Assignee: Applera CorporationInventors: Steven M. Menchen, Scott C. Benson, Joe Y. L. Lam, Weiguo Zhen, Daqing Sun, Barnett B. Rosenblum, Shaheer H. Khan, Meng Taing