Patents by Inventor Shaheer H. Khan

Shaheer H. Khan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230194537
    Abstract: The invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins. The invention relates, in part, to glycan labeling with formulas/compounds enhancing their detection and/or analysis by methods such as capillary electrophoresis, liquid chromatography and mass spectrometry. These detection methods may be useful in studying glycosylation patterns of biological or medical samples, or for assessing protein production, protein quality/purity, for comparing innovator and biosimilar glycosylated proteins, or for selecting proteins with the desired glycosylation.
    Type: Application
    Filed: March 16, 2018
    Publication date: June 22, 2023
    Inventors: Shaheer H. KHAN, Jonathan BONES, Csaba VARADI
  • Patent number: 10724094
    Abstract: A method of conjugating a substrate includes exchanging a counter ion associated with a biomolecule with a lipophilic counter ion to form a biomolecule complex, dispersing the biomolecule complex in a nonaqueous solvent, and coupling the biomolecule complex to a substrate in the presence of the nonaqueous solvent.
    Type: Grant
    Filed: April 4, 2018
    Date of Patent: July 28, 2020
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Steven M. Menchen, Alan Blanchard, Luisa Andruzzi, Shaheer H. Khan, Dmitriy Gremyachinskiy, Alfred Lui, Craig Stolarczyk, Tanya Sokolsky, Prasanna Krishnan Thwar
  • Patent number: 10309959
    Abstract: Methods, systems, compositions and kits are described for detecting cleaved glycans from a glycoconjugate. After labeling the glycan with a nucleic acid charged oligomer described herein, the labeled glycans can be separated under the influence of an electric field or based on their detectable tag and identified.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: June 4, 2019
    Assignee: Life Technologies Corporation
    Inventors: James Stray, Shaheer H. Khan
  • Publication number: 20180223359
    Abstract: A method of conjugating a substrate includes exchanging a counter ion associated with a biomolecule with a lipophilic counter ion to form a biomolecule complex, dispersing the biomolecule complex in a nonaqueous solvent, and coupling the biomolecule complex to a substrate in the presence of the nonaqueous solvent.
    Type: Application
    Filed: April 4, 2018
    Publication date: August 9, 2018
    Inventors: Steven M. MENCHEN, Alan BLANCHARD, Luisa ANDRUZZI, Shaheer H. KHAN, Dmitriy GREMYACHINSKIY, Alfred LUI, Craig STOLARCZYK, Tanya SOKOLSKY, Prasanna Krishnan THWAR
  • Patent number: 9938577
    Abstract: A method of conjugating a substrate includes exchanging a counter ion associated with a biomolecule with a lipophilic counter ion to form a biomolecule complex, dispersing the biomolecule complex in a nonaqueous solvent, and coupling the biomolecule complex to a substrate in the presence of the nonaqueous solvent.
    Type: Grant
    Filed: September 16, 2015
    Date of Patent: April 10, 2018
    Assignee: Life Technologies Corporation
    Inventors: Steven M. Menchen, Alan Blanchard, Luisa Andruzzi, Shaheer H. Khan, Dmitriy Gremyachinskiy, Alfred Lui, Craig Stolarczyk, Tanya Sokolsky, Prasanna Krishnan Thwar
  • Publication number: 20160002723
    Abstract: A method of conjugating a substrate includes exchanging a counter ion associated with a biomolecule with a lipophilic counter ion to form a biomolecule complex, dispersing the biomolecule complex in a nonaqueous solvent, and coupling the biomolecule complex to a substrate in the presence of the nonaqueous solvent.
    Type: Application
    Filed: September 16, 2015
    Publication date: January 7, 2016
    Inventors: Steven M. MENCHEN, Alan Blanchard, Luisa Andruzzi, Shaheer H. Khan, Dmitriy Gremyachinskiy, Alfred Lui, Craig Stolarczyk, Tanya Sokolsky, Prasanna Krishnan Thwar
  • Publication number: 20120309953
    Abstract: Disclosed, among other things, are compounds having the structure wherein X comprises a bond or a linker, LABEL comprises at least one detectable label, W1 taken alone is —H or —OH, W2 is —OH or a non-extendable moiety, W3 when taken alone is —H or when taken together with W1 is —CH2—O—, and W4 is OH, monophosphate, diphosphate, or triphosphate. Also disclosed are labeled polynucleotide compounds and methods of use thereof.
    Type: Application
    Filed: May 11, 2012
    Publication date: December 6, 2012
    Applicant: Life Technologies Corporation
    Inventors: Barnett B. ROSENBLUM, Geun-sook Jeon, Shaheer H. Khan
  • Patent number: 7998706
    Abstract: Disclosed, among other things, are compounds having the structure wherein X comprises a bond or a linker, LABEL comprises at least one detectable label, W1 taken alone is —H or —OH, W2 is —OH or a non-extendable moiety, W3 when taken alone is —H or when taken together with W1 is —CH2—O—, and W4 is OH, monophosphate, diphosphate, or triphosphate. Also disclosed are labeled polynucleotide compounds and methods of use thereof.
    Type: Grant
    Filed: December 17, 2004
    Date of Patent: August 16, 2011
    Assignee: Applied Biosystems, LLC
    Inventors: Barnett B. Rosenblum, Geun-sook Jeon, Shaheer H. Khan
  • Publication number: 20100304381
    Abstract: Provided are nucleotide-dye conjugates and related compounds in which a dye is linked to a nucleobase directly or indirectly by an anionic linker. The anionic character of the linker is provided by one or more anionic moieties which are present in the linker, such as phosphate, phosphonate, sulfonate, and carboxylate groups. When the dye is a provided as a donor/acceptor dye pair, the anionic linker can be located between the donor and the acceptor, or between the nucleobase and either the donor or acceptor, or both. In one embodiment, conjugates of the invention provide enhanced electrophoretic mobility characteristics to sequencing fragments, e.g., for dideoxy sequencing using labeled terminators.
    Type: Application
    Filed: February 5, 2010
    Publication date: December 2, 2010
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Meng Taing, Shaheer H. Khan, Steven M. Menchen, Barnett B. Rosenblum
  • Publication number: 20100292457
    Abstract: The invention provides novel dye-labeled ribonucleotide analogs and methods for synthesizing those analogs. The compounds of the invention are especially useful for DNA sequencing by the polymerase chain reaction.
    Type: Application
    Filed: January 25, 2010
    Publication date: November 18, 2010
    Applicant: Applied Biosystems, LLC
    Inventors: Peter Virgil Fisher, Paolo Vatta, Shaheer H. Khan
  • Publication number: 20100184074
    Abstract: The invention includes methods and kits for making and analyzing primer extension products incorporating one or more universal bases, including methods and kits for nucleic acid sequencing and microsatellite analysis.
    Type: Application
    Filed: February 8, 2010
    Publication date: July 22, 2010
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Barnett B. ROSENBLUM, Geun-Sook Jeon, Shaheer H. Khan
  • Publication number: 20100113759
    Abstract: The present teachings relate to nucleobase, nucleoside and nucleotide compounds, methods of synthesis, and uses thereof. The present teachings provide compounds, such as nucleobase, nucleoside and/or nucleotide compounds including a propargyl linker, and methods for making or using such compounds.
    Type: Application
    Filed: December 29, 2009
    Publication date: May 6, 2010
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Barnett B. ROSENBLUM, Geun-sook Jeon, Shaheer H. Khan
  • Patent number: 7687236
    Abstract: Provided are nucleotide-dye conjugates and related compounds in which a dye is linked to a nucleobase directly or indirectly by an anionic linker. The anionic character of the linker is provided by one or more anionic moieties which are present in the linker, such as phosphate, phosphonate, sulfonate, and carboxylate groups. When the dye is a provided as a donor/acceptor dye pair, the anionic linker can be located between the donor and the acceptor, or between the nucleobase and either the donor or acceptor, or both. In one embodiment, conjugates of the invention provide enhanced electrophoretic mobility characteristics to sequencing fragments, e.g., for dideoxy sequencing using labeled terminators.
    Type: Grant
    Filed: September 29, 2008
    Date of Patent: March 30, 2010
    Assignee: Applied Biosystems, LLC
    Inventors: Meng C. Taing, Shaheer H. Khan, Steven M. Menchen, Barnett B. Rosenblum
  • Patent number: 7678892
    Abstract: The invention provides novel dye-labeled ribonucleotide analogs and methods for synthesizing those analogs. The compounds of the invention are especially useful for DNA sequencing by the polymerase chain reaction.
    Type: Grant
    Filed: May 4, 2007
    Date of Patent: March 16, 2010
    Assignee: Applied Biosystems, LLC
    Inventors: Peter Virgil Fisher, Paolo Vatta, Shaheer H. Khan
  • Patent number: 7575902
    Abstract: Compounds, methods and kits for making and analyzing primer extension products incorporating one or more universal bases are described, including methods and kits for nucleic acid sequencing and microsatellite analysis.
    Type: Grant
    Filed: April 27, 2007
    Date of Patent: August 18, 2009
    Assignee: Applied Biosystems, LLC
    Inventors: Geun-Sook Jeon, Shaheer H. Khan, Barnett B. Rosenbaum
  • Publication number: 20090092986
    Abstract: Provided are nucleotide-dye conjugates and related compounds in which a dye is linked to a nucleobase directly or indirectly by an anionic linker. The anionic character of the linker is provided by one or more anionic moieties which are present in the linker, such as phosphate, phosphonate, sulfonate, and carboxylate groups. When the dye is a provided as a donor/acceptor dye pair, the anionic linker can be located between the donor and the acceptor, or between the nucleobase and either the donor or acceptor, or both. In one embodiment, conjugates of the invention provide enhanced electrophoretic mobility characteristics to sequencing fragments, e.g., for dideoxy sequencing using labeled terminators.
    Type: Application
    Filed: September 29, 2008
    Publication date: April 9, 2009
    Applicant: APPLIED BIOSYSTEMS INC.
    Inventors: Meng TAING, Shaheer H. KHAN, Steven M. MENCHEN, Barnett B. ROSENBLUM
  • Patent number: 7429651
    Abstract: Provided are nucleotide-dye conjugates and related compounds in which a dye is linked to a nucleobase directly or indirectly by an anionic linker. The anionic character of the linker is provided by one or more anionic moieties which are present in the linker, such as phosphate, phosphonate, sulfonate, and carboxylate groups. When the dye is a provided as a donor/acceptor dye pair, the anionic linker can be located between the donor and the acceptor, or between the nucleobase and either the donor or acceptor, or both. In one embodiment, conjugates of the invention provide enhanced electrophoretic mobility characteristics to sequencing fragments, e.g., for dideoxy sequencing using labeled terminators.
    Type: Grant
    Filed: October 28, 2004
    Date of Patent: September 30, 2008
    Assignee: Applera Corporation
    Inventors: Meng Taing, Shaheer H. Khan, Steven M. Menchen, Barnett B. Rosenblum
  • Patent number: 7262029
    Abstract: The invention provides novel dye-labeled ribonucleotide analogs and methods for synthesizing those analogs. The compounds of the invention are especially useful for DNA sequencing by the polymerase chain reaction.
    Type: Grant
    Filed: December 8, 2004
    Date of Patent: August 28, 2007
    Assignee: Applera Corporation
    Inventors: Peter Virgil Fisher, Paolo Vatta, Shaheer H. Khan
  • Patent number: 7169557
    Abstract: The invention includes methods and kits for making and analyzing primer extension products incorporating one or more universal bases, including methods and kits for nucleic acid sequencing and microsatellite analysis.
    Type: Grant
    Filed: November 7, 2002
    Date of Patent: January 30, 2007
    Assignee: Applera Corporation
    Inventors: Barnett B. Rosenblum, Geun-Sook Jeon, Shaheer H. Khan
  • Patent number: 7018431
    Abstract: Sulfonated diarylrhodamine compounds are useful as fluorescent labels of nucleosides, nucleotides, polynucleotides, and polypeptides. The compounds find particular application in the area of fluorescent nucleic acid analysis, e.g., automated DNA sequencing and fragment analysis, detection of probe hybridization in hybridization arrays, detection of nucleic acid amplification products, and the like.
    Type: Grant
    Filed: June 24, 2003
    Date of Patent: March 28, 2006
    Assignee: Applera Corporation
    Inventors: Steven M. Menchen, Scott C. Benson, Joe Y. L. Lam, Weiguo Zhen, Daqing Sun, Barnett B. Rosenblum, Shaheer H. Khan, Meng Taing