Patents by Inventor Shane Climie

Shane Climie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20030166007
    Abstract: The invention relates to methods and reagents for identifying/isolating protein targets of chemical compounds (for example, drug candidates) using mass spectrometry. The invention provides a method for capturing and identifying proteins using tethered small-molecule probes. This technology also allows the market expansion of known drugs by finding new therapeutic targets; identification of the mechanism of toxicity of drug candidates or drugs which failed in the clinic; identification of new chemical tools for chemically-driven target validation; identification of new drug leads; and identification of the mechanism of action of drugs and drug candidates. A key advantage of the technology is that a single experiment can identify the numerous proteins which interact with a probe (or “bait”).
    Type: Application
    Filed: February 3, 2003
    Publication date: September 4, 2003
    Applicant: MDS Proteomics Inc.
    Inventors: Shane Climie, Leroi Victor Desouza, Henry Duewel, Christopher Mark Hosfield, Linda Chiou-Lin Liao, Linda D. B. McBroom, Irving Sucholeiki, Leticia M. Toledo-Sherman
  • Publication number: 20030162221
    Abstract: Methods and reagents for high throughput analysis of protein-protein interaction networks using mass spectrometry.
    Type: Application
    Filed: September 23, 2002
    Publication date: August 28, 2003
    Inventors: Gary Bader, Shane Climie, Daniel Durocher, Joseph Michael Daniel Figeys, Albrecht Gruhler, Adrian Mark Heilbut, Yuen Ho, Lynda A. Moore, Michael Moran, Brenda Muskat, Michael Tyers, Cheryl Deanna Wolting
  • Publication number: 20030157575
    Abstract: The invention relates to methods and reagents for identifying/isolating protein targets of chemical compounds (for example, drug candidates) using mass spectrometry. The invention provides a method for capturing and identifying proteins using tethered small-molecule probes. This technology also allows the market expansion of known drugs by finding new therapeutic targets; identification of the mechanism of toxicity of drug candidates or drugs which failed in the clinic; identification of new chemical tools for chemically-driven target validation; identification of new drug leads; and identification of the mechanism of action of drugs and drug candidates. A key advantage of the technology is that a single experiment can identify the numerous proteins which interact with a probe (or “bait”).
    Type: Application
    Filed: January 28, 2003
    Publication date: August 21, 2003
    Inventors: Shane Climie, Leroi Victor DeSouza, Henry S. Duewel, Christopher Mark Hosfield, Linda Chiou-Lin Liao, Linda D. B. McBroom, Irving Sucholeiki, Leticia M. Toledo-Sherman
  • Patent number: 5495006
    Abstract: The herpes simplex virus encodes ICP4, a DNA binding protein. ICP4-binding duplexed structures having significantly enhanced stability under physiological conditions are described. The structures are provided in the form of polynucleotide conjugates capable of adopting a duplexed structure, in which annealable polynucleotide strands are coupled covalently at one or both ends through a chemical linker which establishes a stabilizing bridge between strands. The present polynucleotide conjugates have therapeutic utility against viral infection as the polynucleotide strands thereof define a binding site for a viral regulatory protein, thereby inactivating the protein and preventing viral replication from occurring.
    Type: Grant
    Filed: March 1, 1993
    Date of Patent: February 27, 1996
    Assignee: Allelix Biopharmaceuticals, Inc.
    Inventors: Shane Climie, Michael Ma