Patents by Inventor ShangHong Chen

ShangHong Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for preparing sugammadex sodium
    Patent number: 10385142
    Abstract: A process for preparing sugammadex sodium comprising: reacting a ?-cyclodextrin of formula I with a halogenating agent in the presence of N-methyl-2-pyrrolidone to provide a compound of formula II; and reacting the compound of formula II with 3-mercapto propionic acid in the presence of a sodium base and an organic solvent to provide sugammadex sodium formula III: wherein X in formula II is halo.
    Type: Grant
    Filed: January 17, 2018
    Date of Patent: August 20, 2019
    Assignee: SCINOPHARM TAIWAN, LTD.
    Inventors: ChiaYing Lee, ShangHong Chen
  • METHOD FOR PREPARING SUGAMMADEX SODIUM
    Publication number: 20180312612
    Abstract: A process for preparing sugammadex sodium comprising: reacting a ?-cyclodextrin of formula I with triphosgene in the presence of N-methyl-2-pyrrolidone to provide a compound of formula II; and reacting the compound of formula II with 3-mercapto propionic acid in the presence of a sodium base and an organic solvent to provide sugammadex sodium formula III: wherein X in formula II is chloro.
    Type: Application
    Filed: July 10, 2018
    Publication date: November 1, 2018
    Inventors: ChiaYing Lee, ShangHong Chen, LungHuang Kuo
  • METHOD FOR PREPARING SUGAMMADEX SODIUM
    Publication number: 20180208683
    Abstract: A process for preparing sugammadex sodium comprising: reacting a ?-cyclodextrin of formula I with a halogenating agent in the presence of N-methyl-2-pyrrolidone to provide a compound of formula II; and reacting the compound of formula II with 3-mercapto propionic acid in the presence of a sodium base and an organic solvent to provide sugammadex sodium formula III:
    Type: Application
    Filed: January 17, 2018
    Publication date: July 26, 2018
    Inventors: ChiaYing Lee, ShangHong Chen
  • Process for the production of a pemetrexed salt
    Patent number: 9051322
    Abstract: A process of making a pemetrexed salt comprising: a) reacting a compound of formula II or an acid salt thereof, wherein each of R1 and R2 is independently a C1-C6 alkyl group, with an aqueous basic solution at a temperature of no more than 10° C. to obtain a first mixture comprising the pemetrexed salt; b) isolating the pemetrexed salt from the first mixture.
    Type: Grant
    Filed: March 23, 2011
    Date of Patent: June 9, 2015
    Assignee: SCINOPHARM TAIWAN, LTD.
    Inventors: ShangHong Chen, HuangHsiung Lin
  • Process for the production of a pemetrexed salt
    Publication number: 20120245349
    Abstract: A process of making a pemetrexed salt comprising: a) reacting a compound of formula II or an acid salt thereof, wherein each of R1 and R2 is independently a C1-C6 alkyl group, with an aqueous basic solution at a temperature of no more than 10° C. to obtain a first mixture comprising the pemetrexed salt; b) isolating the pemetrexed salt from the first mixture.
    Type: Application
    Filed: March 23, 2011
    Publication date: September 27, 2012
    Inventors: ShangHong Chen, HuangHsiung Lin