Patents by Inventor Shanker Gupta

Shanker Gupta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7476692
    Abstract: The present invention provides stable aqueous solutions consisting essentially of: (a) a sphingolipid; (b) lactic acid; and (c) optionally a stabilizing agent; wherein the solution has a molar ratio of lactic acid to sphingolipid of 1:1 to 10:1. The present invention further provides an emulsion formulation consisting essentially of: (a) lactic acid; (b) a sphingolipid, wherein the sphingolipid is present in an amount of about 0.1 to about 30 mg/ml of emulsion; (b) optionally an isotonic agent; and (c) a phospholipid present in an amount of about 0.2 to about 200 mg/ml of emulsion. Methods of making and using the compositions are also provided.
    Type: Grant
    Filed: February 19, 2004
    Date of Patent: January 13, 2009
    Assignee: Childrens Hospital Los Angeles
    Inventors: Shanker Gupta, C. Patrick Reynolds, Barry J. Maurer, B. Rao Vishnuvajjala
  • Patent number: 7169819
    Abstract: A pharmaceutical composition for parenteral delivery, comprising a retinide such as fenretinide in combination with a solvent capable of dispersing or solubilizing the retinide. The solvent comprises an alcohol, such as ethanol, in combination with an alkoxylated castor oil, such as CREMOPHORĀ® EL, or comprising a retinide, such as fenretinide, in an emulsion composed of a lipoid dispersed in an aqueous phase, a stabilizing amount of a non-ionic surfactant, optionally a solvent, and optionally an isotonic agent. In addition, a method of use in the treatment of hyperproliferative disorders, such as cancers is described.
    Type: Grant
    Filed: December 5, 2001
    Date of Patent: January 30, 2007
    Assignee: Childrens Hospital Los Angeles
    Inventors: Shanker Gupta, Barry J. Maurer, C. Patrick Reynolds, B. Rao Vishnuvajjala
  • Publication number: 20050282742
    Abstract: The invention relates to the formulation of pharmaceutical compounds. More particularly, the invention provides stable, pharmaceutically acceptable compositions prepared from boronic acid compounds and methods for preparing the compositions. The invention also provides novel boronate ester compounds. The invention further provides boronic acid anhydride compounds useful in the methods of the invention.
    Type: Application
    Filed: July 19, 2005
    Publication date: December 22, 2005
    Applicants: Government of the USA, represented by the Secretary,Dept. of Health and Human Services, Millennium Parmaceuticals, Inc.
    Inventors: Louis Plamondon, Louis Grenier, Julian Adams, Shanker Gupta
  • Publication number: 20050187186
    Abstract: The present invention provides stable aqueous solutions consisting essentially of: (a) a sphingolipid; (b) lactic acid; and (c) optionally a stabilizing agent; wherein the solution has a molar ratio of lactic acid to sphingolipid of 1:1 to 10:1. The present invention further provides an emulsion formulation consisting essentially of: (a) lactic acid; (b) a sphingolipid, wherein the sphingolipid is present in an amount of about 0.1 to about 30 mg/ml of emulsion; (b) optionally an isotonic agent; and (c) a phospholipid present in an amount of about 0.2 to about 200 mg/ml of emulsion. Methods of making and using the compositions are also provided.
    Type: Application
    Filed: February 19, 2004
    Publication date: August 25, 2005
    Inventors: Barry Maurer, Shanker Gupta, C. Reynolds, B. Vishnuvajjala
  • Patent number: 6838090
    Abstract: The present invention provides a drug delivery system comprising a water-insoluble drug, a water-miscible organic solvent for the water-insoluble drug, a surfactant, and water, as well as a process for preparing the same. This invention further provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and such a drug delivery system. In addition, the present invention provides a method of delivering a drug to a host by administering to the host the drug delivery system of the present invention.
    Type: Grant
    Filed: June 5, 2003
    Date of Patent: January 4, 2005
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: S. Esmail Tabibi, Emmanuel I. Ezennia, B. Rao Vishnuvajjala, Shanker Gupta
  • Patent number: 6682758
    Abstract: The present invention provides a drug delivery system comprising a water-insoluble drug, a water-miscible organic solvent for the water-insoluble drug, a surfactant, and water, as well as a process for preparing the same. This invention further provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and such a drug delivery system. In addition, the present invention provides a method of delivering a drug to a host by administering to the host the drug delivery system of the present invention.
    Type: Grant
    Filed: June 21, 2001
    Date of Patent: January 27, 2004
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: S. Esmail Tabibi, Emmanuel I. Ezennia, B. Rao Vishnuvajjala, Shanker Gupta
  • Publication number: 20030211144
    Abstract: The present invention provides a drug delivery system comprising a water-insoluble drug, a water-miscible organic solvent for the water-insoluble drug, a surfactant, and water, as well as a process for preparing the same. This invention further provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and such a drug delivery system. In addition, the present invention provides a method of delivering a drug to a host by administering to the host the drug delivery system of the present invention.
    Type: Application
    Filed: June 5, 2003
    Publication date: November 13, 2003
    Applicant: Government of the U.S.A., represented by the Secretary, Department of Health and Human Services
    Inventors: S. Esmail Tabibi, Emmanuel I. Ezennia, B. Rao Vishnuvajjala, Shanker Gupta
  • Publication number: 20020183394
    Abstract: A pharmaceutical composition for parenteral delivery, comprising a retinide such as fenretinide in combination with a solvent capable of dispersing or solubilizing the retinide. The solvent comprises an alcohol, such as ethanol, in combination with an alkoxylated castor oil, such as CREMOPHOR® EL, or comprising a retinide, such as fenretinide, in an emulsion composed of a lipoid dispersed in an aqueous phase, a stabilizing amount of a non-ionic surfactant, optionally a solvent, and optionally an isotonic agent. In addition, a method of use in the treatment of hyperproliferative disorders, such as cancers is described.
    Type: Application
    Filed: December 5, 2001
    Publication date: December 5, 2002
    Inventors: Shanker Gupta, Barry J. Maurer, C. Patrick Reynolds, B. Rao Vishnuvajjala