Abstract: Embodiments disclosed herein may include systems and methods for determining a patient's respiratory effort and blood oxygen saturation based on data acquired from a pulse oximetry sensor and analyzing the parameters in conjunction with each other. For example, the respiratory effort may be determined based on a photo-plethysmographic waveform generated from light attenuation detected by the sensor, and the blood oxygen saturation may be a pulse-based estimate of arterial blood oxygen saturation determined from the detected attenuation. Analysis of the parameters may enable detection and classification of apnea (e.g., obstructive or central) or another underlying cause for respiratory instability. Furthermore, the measured respiratory effort may be compared to respiratory effort supplied by a ventilator to ensure proper sensor placement before enabling automatic adjustment of ventilator settings.

Abstract: Embodiments disclosed herein may include systems and methods for determining a patient's respiratory effort and blood oxygen saturation based on data acquired from a pulse oximetry sensor and analyzing the parameters in conjunction with each other. For example, the respiratory effort may be determined based on a photo-plethysmographic waveform generated from light attenuation detected by the sensor, and the blood oxygen saturation may be a pulse-based estimate of arterial blood oxygen saturation determined from the detected attenuation. Analysis of the parameters may enable detection and classification of apnea (e.g., obstructive or central) or another underlying cause for respiratory instability. Furthermore, the measured respiratory effort may be compared to respiratory effort supplied by a ventilator to ensure proper sensor placement before enabling automatic adjustment of ventilator settings.

Abstract: The present disclosure describes systems and methods that utilize a multi-lumen tube with an integral visualization apparatus, such as a camera. The multi-lumen tracheal tube system may include a camera apparatus that is positioned to facilitate left or right bronchial intubation. In addition, the camera apparatus may be a unitary assembly that functions to hold and position the camera relative to the tube and provides an acceptable profile for comfortable intubation. The camera apparatus may include additional components, such as integral light sources and flushing or cleaning devices to remove any buildup from the camera or optical components.

Abstract: Embodiments disclosed herein may include systems and methods for determining a patient's respiratory effort and blood oxygen saturation based on data acquired from a pulse oximetry sensor and analyzing the parameters in conjunction with each other. For example, the respiratory effort may be determined based on a photo-plethysmographic waveform generated from light attenuation detected by the sensor, and the blood oxygen saturation may be a pulse-based estimate of arterial blood oxygen saturation determined from the detected attenuation. Analysis of the parameters may enable detection and classification of apnea (e.g., obstructive or central) or another underlying cause for respiratory instability. Furthermore, the measured respiratory effort may be compared to respiratory effort supplied by a ventilator to ensure proper sensor placement before enabling automatic adjustment of ventilator settings.

Abstract: The present disclosure describes systems and methods that utilize a multi-lumen tube with an integral visualization apparatus, such as a camera. The multi-lumen tracheal tube system may include a camera apparatus that is positioned to facilitate left or right bronchial intubation. In addition, the camera apparatus may be a unitary assembly that functions to hold and position the camera relative to the tube and provides an acceptable profile for comfortable intubation. The camera apparatus may include additional components, such as integral light sources and flushing or cleaning devices to remove any buildup from the camera or optical components.

Abstract: Embodiments of the present invention relate to a system and method for monitoring intracranial pressure. Embodiments of the present invention include emitting an electromagnetic wavelength into forehead tissue of a patient and detecting characteristics of the electromagnetic wavelength after the electromagnetic wavelength has been scattered by the tissue. The characteristics may include variations in the electromagnetic wavelength corresponding to a pulse. Further, embodiments of the present invention include analyzing the variations to identify venous pulsations, and determining whether intracranial pressure is elevated in the patient based on a correlation between the venous pulsations and levels of intracranial pressure.

Abstract: According to various embodiments, a system, method, and sensor are provided that is capable of monitoring electrical impedance of oral or nasal mucosal tissue. Such sensors may be appropriate for assessing gut hypoperfusion, gut ischemia, or the onset of shock. The electrical impedance of the oral mucosa or other tissues in the upper respiratory tract may be used to non-invasively assess the clinical state of gastrointestinal tissue.

Abstract: Embodiments of the present invention relate to a system and method for monitoring intracranial pressure. Embodiments of the present invention include emitting an electromagnetic wavelength into forehead tissue of a patient and detecting characteristics of the electromagnetic wavelength after the electromagnetic wavelength has been scattered by the tissue. The characteristics may include variations in the electromagnetic wavelength corresponding to a pulse. Further, embodiments of the present invention include analyzing the variations to identify venous pulsations, and determining whether intracranial pressure is elevated in the patient based on a correlation between the venous pulsations and levels of intracranial pressure.

Abstract: The current techniques provide a system for monitoring a physiological parameter of a patient using microneedles that are coupled to an optical system, allowing spectroscopic measurements to be made immediately below the outer layer of the epidermis. In embodiments of the present invention, the results of the spectroscopic measurements are used to control the administration of a drug through an intravenous tube. In other embodiments, the microneedles may be coated with a drug for administration to the patient. In other embodiments, the microneedles may be mounted in a probe, wherein an actuator is used to move the needles into contact with the skin, and a drug delivery system is used to infuse the drug into the patient. A method for making needles is also provided.

Abstract: A system configured to provide feedback regarding fluid parameters in the skin and/or compartments of an individual to facilitate early diagnosis of skin wounds and compartment syndromes.

Abstract: A method is provided for determining the location of the sensor. The method comprises determining a physiological parameter based on detected light and determining the location of the sensor based on the physiological parameter. In addition, a method is provided for operating a sensor that includes calibrating a sensor based on a patient-specific physiological parameter, in which the patient-specific physiological parameter is skin color, age, gender, pooled blood, venous blood pulsation, or abnormal tissue.

Abstract: The present disclosure describes systems and methods that utilize a multi-lumen tube with an integral visualization apparatus, such as a camera. The multi-lumen tracheal tube system may include a camera apparatus that is positioned to facilitate left or right bronchial intubation. In addition, the camera apparatus may be a unitary assembly that functions to hold and position the camera relative to the tube and provides an acceptable profile for comfortable intubation. The camera apparatus may include additional components, such as integral light sources and flushing or cleaning devices to remove any buildup from the camera or optical components.

Abstract: Systems and methods are disclosed herein for calibrating the calculation of physiological parameters. Two or more calibration techniques may be used to determine a relationship between physiological measurements and a desired physiological parameter, such as a relationship between differential pulse transit time (DPTT) and blood pressure. Different calibration techniques may be used in a serial fashion, one after the other, or in a parallel fashion, with different weights accorded to each calibration technique. When physiological or other changes occur, the calibration data may be stored for later use and new calibration data may be generated.

Abstract: A system configured to provide feedback regarding fluid parameters in the skin and/or compartments of an individual to facilitate early diagnosis of skin wounds and compartment syndromes.

Abstract: A system configured to provide feedback regarding fluid parameters in the skin and/or compartments of an individual to facilitate early diagnosis of skin wounds and compartment syndromes.

Abstract: The present disclosure provides a biosensor capable of producing an indicator response upon detection of the presence of certain metabolites in a biological sample. The biosensor includes a hydrogel that is functionalized with affinity molecules specific to markers for one or more pathogens. The biosensor also includes a detection system adapted to detect the binding the pathogen-specific markers with their corresponding affinity molecules.

Abstract: This disclosure describes systems and methods for adjusting a determination of the amount of breathing assistance a patient requires while on a ventilator. In general, in determining the amount of breathing assistance required, the ventilator takes into account an airflow resistance attributable to the tube used to deliver ventilation to the patient's lungs. A tube compensation factor is calculated using a tube compensation algorithm, or similar equation. In particular, the tube compensation factor represents the resistance to airflow attributable to the breathing tube itself based on, inter alia, frictional drag, turbulence, and an internal diameter of the tube. Changes in the tube during ventilation impact the calculation of the breathing assistance required by the patient and are accounted for when compensating for the breathing tube.

Abstract: A method and apparatus is provided for measuring a sterol, such as cholesterol, deposited in the skin. Light of two or more wavelengths is emitted toward or into a skin sample and the light is differentially absorbed by the sterol in the skin sample. The differentially absorbed light is detected and the amount of sterol in the skin sample is determined based on the differential absorption.

Abstract: In embodiments, methods and systems are provided for the calculation of one or more indices representing variability in the timing of events in a signal representing a physiological parameter. In embodiments, the method and system may utilize an infinite impulse response formulation for the calculation of the indices to minimize memory and computational overhead, while additionally making the indices more responsive to newer measurements.

Abstract: The present disclosure provides a biosensor capable of producing an indicator response upon detection of the presence of certain metabolites in a biological sample. The biosensor includes a hydrogel that is functionalized with affinity molecules specific to markers for one or more pathogens. The biosensor also includes a detection system adapted to detect the binding the pathogen-specific markers with their corresponding affinity molecules.