Abstract: Gel compositions for use as a barrier for microbial attachment and growth on a surface are provided. The gel compositions can prevent crystal formation, for example, calcium-based stones in biological systems. The gel compositions can enhance function of mucosal barriers against microbial adhesion. Specific compositions for anti-bacterial and anti-viral use are provided.

Abstract: A system and method are provided for deactivation and disposal of a pharmaceutical dosage form. The system and method employ an oxidant and an immobilizing agent placed in a container. The pharmaceutical dosage form is placed into the container, and water is added to the container. A rapid chemical deactivation of the active ingredient or ingredients in the pharmaceutical then occurs by a chemical oxidation process. Upon contact with the water, the immobilizing agent swells or expands in volume to form a gel or slurry, binding the other components in the container within the gel or slurry, where they remain after disposal. The system can be in the form of a kit, or can be scaled up for use by municipalities or institutions.

Abstract: An antimicrobial composition for the treatment of drug-resistant pathogens is provided. The composition includes antimicrobial compounds and chelating agents assemblies that are particularly effective in inhibiting drug-resistant bacteria and biofilm growth. Optionally, the composition may include an efflux pump inhibitor, further enhancing activity against resistant bacteria. Also provided are methods of treating diseases and surfaces of materials treated with the composition.

Abstract: A pharmaceutical composition for the treatment of pathological calculus and plaque formation is provided. The composition includes conjugates of polymers and metal binding agents that are particularly effective in inhibiting crystal nucleation, growth, and aggregation in the body, such as that observed in the formation of kidney stones. The composition is effective at low dosage, thereby avoiding the side effects typically associated with current treatments for kidney stones. The composition is also effective against plaque formation, and may have intrinsic antimicrobial activity. Also provided are methods of treating diseases and surfaces of devices and materials treated with the composition.

Abstract: A system and method are provided for deactivation and disposal of a pharmaceutical dosage form. The system and method employ an oxidant and an immobilizing agent placed in a container. The pharmaceutical dosage form is placed into the container, and water is added to the container. A rapid chemical deactivation of the active ingredient or ingredients in the pharmaceutical then occurs by a chemical oxidation process. Upon contact with the water, the immobilizing agent swells or expands in volume to form a gel or slurry, binding the other components in the container within the gel or slurry, where they remain after disposal. The system can be in the form of a kit, or can be scaled up for use by municipalities or institutions.

Abstract: An antimicrobial and chemical deactivating composition for use in a liquid medium or for incorporation into a coating, structural plastic materials, thin microporous membranes, textiles and sponges. The composition includes macrosize or submicron particles of silver, platinum with silver and their salts with parabens, oxide, salicylate, acetate, citrate, benzoate and phosphate along with copper and zinc salts of the same.

Abstract: An antimicrobial and chemical deactivating composition for use in a liquid medium or for incorporation into a coating, structural plastic materials, thin microporous membranes, textiles and sponges. The composition includes macrosize or submicron particles of silver, platinum with silver and their salts with parabens, oxide, salicylate, acetate, citrate, benzoate and phosphate along with copper and zinc salts of the same.

Abstract: An antimicrobial and chemical deactivating composition for use in a liquid medium or for incorporation into a coating, structural plastic materials, thin microporous membranes, textiles and sponges. The composition includes macrosize or submicron particles of silver, platinum with silver and their salts with parabens, oxide, salicylate, acetate, citrate, benzoate and phosphate along with copper and zinc salts of the same.

Abstract: An antimicrobial composition is formed from about 5 to about 25 wt % of an antimicrobial formulation and about 75 to about 95 wt % of a silicone resin. The antimicrobial formulation is formed from about 60 to about 95 wt % of an antimicrobial material, about 1 to about 30 wt % calcium chelator, about 0.001 to about 0.25 wt % pigment, and about 0.5 to about 3.5 wt % lubricant. The silicone resin may be a dispersion of about 40 to about 60 w/v % of an RTV silicone resin in a solvent, a liquid silicone resin, or a solid silicone resin. An antimicrobial coating may be formed on the surface of an article by applying an antimicrobial composition to the article and permitting the solvent to evaporate. It may also be formed by making a mixture of about 5 to about 12 wt % of an antimicrobial formulation and about 88 to about 95 wt % of a liquid or solid silicone resin and molding, overmolding, or extruding the article from the compounded mixture.

Abstract: An antimicrobial composition is formed from about 5 to about 25 wt % of an antimicrobial formulation and about 75 to about 95 wt % of a polyurethane resin or polyurethane hybrids, copolymers, or mixtures with other polymers such as polyesters, nitrites, PVC, and synthetic rubber latexes. The antimicrobial formulation is formed from about 60 to about 90 wt % of an antimicrobial material, about 1 to about 30 wt % calcium chelator, about 0.001 to about 2 wt % color and appearance enhancing pigments, about 0.001 to about 2 wt % of surfactants, and about 0.5 to about 10 wt % lubricant. The polyurethane resin may be a nonaqueous or aqueous latex dispersion or a prepolymer that polymerizes when exposed to moisture. An antimicrobial coating may be formed on the surface of an article by applying an antimicrobial composition to the article; if a polyurethane prepolymer is used, the composition is exposed to moisture and if an aqueous or nonaqueous dispersion is used, the water or solvent is evaporated.

Abstract: An accessory is connected between a leg bag and a urinary catheter to prevent microorganisms migrating from the leg bag up through the catheter. The accessory has a sleeve, connectors to connect the sleeve to the leg bag and to the urinary catheter, a filter positioned within the sleeve that can be coated with an antimicrobial composition, and a valve to prevent fluid from moving from the leg bag to the catheter. The antimicrobial coated sleeve can be used with or with out the filter. The filter is made by compounding a polymeric resin powder with an antimicrobial composition.

Abstract: An antimicrobial composition is formed from about 30 to about 70 wt % of an antimicrobial formulation and about 30 to about 70 wt % of a polyurethane resin or polyurethane hybrids, copolymers, or mixtures with other polymers such as polyesters, nitrites, PVC, and synthetic rubber latexes. The antimicrobial formulation is formed from about 60 to about 95 wt % of an antimicrobial material, about 1 to about 30 wt % calcium chelator, about 0.001 to about 0.25 wt % pigment, and about 0.5 to about 3.5 wt % lubricant. The polyurethane resin may be a prepolymer that polymerizes when exposed to moisture or it may be a latex dispersion in water. An antimicrobial coating may be formed on the surface of an article by applying an antimicrobial composition to the article; if a polyurethane prepolymer is used, the composition is exposed to moisture and if an aqueous dispersion is used, the water is evaporated.

Abstract: An antimicrobial composition is formed from about 5 to about 25 wt % of an antimicrobial formulation and about 75 to about 95 wt % of a silicone resin. The antimicrobial formulation is formed from about 60 to about 95 wt % of an antimicrobial material, about 1 to about 30 wt % calcium chelator, about 0.001 to about 0.25 wt % pigment, and about 0.5 to about 3.5 wt % lubricant. The silicone resin may be a dispersion of about 40 to about 60 w/v % of an RTV silicone resin in a solvent, a liquid silicone resin, or a solid silicone resin. An antimicrobial coating may be formed on the surface of an article by applying an antimicrobial composition to the article and permitting the solvent to evaporate. It may also be formed by making a mixture of about 5 to about 12 wt % of an antimicrobial formulation and about 88 to about 95 wt % of a liquid or solid silicone resin and molding, overmolding, or extruding the article from the compounded mixture.

Abstract: An accessory is connected between a leg bag and a urinary catheter to prevent microorganisms migrating from the leg bag up through the catheter. The accessory has a sleeve, connectors to connect the sleeve to the leg bag and to the urinary catheter, a filter positioned within the sleeve that can be coated with an antimicrobial composition, and a valve to prevent fluid from moving from the leg bag to the catheter. The antimicrobial coated sleeve can be used with or with out the filter. The filter is made by compounding a polymeric resin powder with an antimicrobial composition.

Abstract: A process is described for the removal of mercury present at levels of 1-5000 ppb in waste water discharged from clinical research laboratories, industries and hospitals. The process involves preoxidation of the influent waste water with very small amounts of hypochlorite (16-100 ppm levels)or hydrogen peroxide, in a pretreatment tank. The waste water is then serially filtered through two pre filters and four carbon columns at a flow rate of 5 bedvolumes/hr. The preoxidation, prefiltration, organic removal, heavy metals removal (second column) and polishing stages (third and fourth) are important to achieve very low levels of mercury in the effluent. The last three columns contain activated coconut shell carbon impregnated with mercaptothiazoline . The three columns of the mercaptothiazoline impregnated carbon remove mercury and other heavy metals successively and reduce their levels in the influent to very low levels that is well below the enforced limit of 1 ppb.

Abstract: This invention encompasses porous, nanocrystalline, biomimetic calcium phosphate coatings of the order of 2-30 microns that can be grown on metal implants. The chemical surface treatments and methods for making the calcium phosphate coatings are disclosed. Post treatment with dilute hydrogels such as phema reinforce the inorganic structure and enhance the mechanical strength of the coatings. Methods are also disclosed for adsorbing or covalently attaching growth factor proteins to derivatives of the hydrogel coated calcium phosphate coatings. Such hydrogel reinforced calcium phosphate coatings show equivalent bone tissue growth as the currently used implants and are easily resorbed. This property in combination with the immobilized growth factors is expected to enhance the process of osseointegration of the disclosed coatings.

Abstract: Disclosed are coatings and materials that resist bacterial colonization and encrustation for use in medical devices and urological applications. The coating includes acidic chelating components, reactively bound to a hydrophilic polyurethane prepolymer along with noble metal combinations or antibacterials. The acidic and noble metal combinations can also be incorporated as additives during plastic molding of medical devices. A continuous antibacterial surfaces are provided by such coatings and materials.

Abstract: The invention refers to a fuel cell electrode for oxidation preferably methanol or methanol reformate in a fuel cell with acid electrolytes. The electrode material comprises of a) carbons modified by the chemisorption or covalent attachment of metallocomplexes, over which a noble metal catalyst such as platinum is deposited, b) carbon-noble metal systems mixed with metallocomplexes, and c) mixtures of noble metal blacks and metallocomplexes. An improvement of 100-200 mV is seen over controls using platinum alone in full tests using methanol and oxygen or air. The advantages of using the disclosed promoters is the use of low loaded (20% Pt on carbon) electrodes rather than pure noble metal or alloy blacks.

Abstract: Disclosed is an encrustation and bacterial-resistant coating for use on medical devices and in other medical-related applications. The coating includes a reaction product formed by the covalent linkage of a hydrophilic polyurethane prepolymer and aminopolycarboxylic acid. A urease inhibitor and/or an antibacterial agent may also be added to the coating.