Patents by Inventor Sheila Zipfel

Sheila Zipfel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 4-[2-(2-fluorophenoxymethyl)phenyl]piperidine compounds
    Patent number: 8604058
    Abstract: The invention relates to compounds of formula I: where a, R1, and R3-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: December 10, 2013
    Assignee: Theravance, Inc.
    Inventors: Lori Jean Patterson, Eric L. Stangeland, Sheila Zipfel, Daniel D. Long
  • 1-(2-PHENOXYMETHYLHETEROARYL) PIPERIDINE AND PIPERAZINE COMPOUNDS
    Publication number: 20130324550
    Abstract: The invention relates to compounds of formula I: where X, HAr, a, and R1 through R6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
    Type: Application
    Filed: August 9, 2013
    Publication date: December 5, 2013
    Applicant: THERAVANCE, INC.
    Inventors: Eric L. Stangeland, Lori Jean Patterson, Sheila Zipfel
  • Antiviral compounds
    Patent number: 8575135
    Abstract: The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: March 1, 2013
    Date of Patent: November 5, 2013
    Assignee: Gilead Sciences, Inc.
    Inventors: Elizabeth M. Bacon, Jeromy J. Cottell, Ashley Anne Katana, Darryl Kato, Evan S. Krygowski, John O. Link, James Taylor, Chinh Viet Tran, Teresa Alejandra Trejo Martin, Zheng-Yu Yang, Sheila Zipfel
  • 1-(2-phenoxymethylheteroaryl)piperidine and piperazine compounds
    Patent number: 8530663
    Abstract: The invention relates to compounds of formula I: where X, HAr, a, and R1 through R6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
    Type: Grant
    Filed: March 21, 2011
    Date of Patent: September 10, 2013
    Assignee: Theravance, Inc.
    Inventors: Eric L. Stangeland, Lori Jean Patterson, Sheila Zipfel
  • 4-[2-(2-FLUOROPHENOXYMETHYL)PHENYL]PIPERIDINE COMPOUNDS
    Publication number: 20130030020
    Abstract: The invention relates to compounds of formula I: where a, R1, and R3-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
    Type: Application
    Filed: September 28, 2012
    Publication date: January 31, 2013
    Applicant: THERAVANCE, INC.
    Inventors: Lori Jean Patterson, Eric L. Stangeland, Sheila Zipfel, Daniel D. Long
  • 4-[2-(2-fluorophenoxymethyl)phenyl]piperidine compounds
    Patent number: 8304432
    Abstract: The invention relates to compounds of formula I: where a, R1, and R3-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
    Type: Grant
    Filed: November 13, 2009
    Date of Patent: November 6, 2012
    Assignee: Theravance, Inc.
    Inventors: Lori Jean Patterson, Eric L. Stangeland, Sheila Zipfel, Daniel D. Long
  • 1-(2-PHENOXYMETHYLHETEROARYL)PIPERIDINE AND PIPERAZINE COMPOUNDS
    Publication number: 20110230495
    Abstract: The invention relates to compounds of formula I: where X, HAr, a, and R1 through R6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
    Type: Application
    Filed: March 21, 2011
    Publication date: September 22, 2011
    Inventors: Eric L. Stangeland, Lori Jean Patterson, Sheila Zipfel
  • 4-[2-(2-FLUOROPHENOXYMETHYL)PHENYL]PIPERIDINE COMPOUNDS
    Publication number: 20100125092
    Abstract: The invention relates to compounds of formula I: where a, R1, and R3-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
    Type: Application
    Filed: November 13, 2009
    Publication date: May 20, 2010
    Inventors: Lori Jean Patterson, Eric L. Stangeland, Sheila Zipfel, Daniel D. Long
  • Novel Compounds and Compositions as Cathepsin Inhibitors
    Publication number: 20070232654
    Abstract: The present invention relates to novel selective cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
    Type: Application
    Filed: June 6, 2007
    Publication date: October 4, 2007
    Applicant: Axys Pharmaceuticals, Inc.
    Inventors: John Patterson, Sheila Zipfel
  • Cyanomethyl derivatives as cysteine protease inhibitors
    Publication number: 20060122184
    Abstract: The present invention is directed to cyanomethyl derivatives that are inhibitors of cysteine protease, in particular, cathepsin B, K, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.
    Type: Application
    Filed: November 26, 2003
    Publication date: June 8, 2006
    Applicant: AXYS Pharmaceuticals, Inc.
    Inventors: Michael Graupe, Agnes Lau, John Link, Yang Liu, Craig Mossman, John Patterson, Sheila Zipfel
  • Cysteine protease inhibitors
    Publication number: 20050288336
    Abstract: The present invention is directed to compounds that are inhibitors of cysteine protease, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.
    Type: Application
    Filed: May 14, 2003
    Publication date: December 29, 2005
    Applicant: AXYS PHARMACEUTICALS, INC.
    Inventors: Michael Graupe, Agnes Lau, John Link, Yang Liu, Craig Mossman, John Patterson, Sheila Zipfel
  • Haloalkyl containing compounds as cysteine protease inhibitors
    Publication number: 20050182096
    Abstract: The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.
    Type: Application
    Filed: September 17, 2004
    Publication date: August 18, 2005
    Applicant: AXYS PHARMACEUTICALS, INC.
    Inventors: John Link, Craig Mossman, Soon Woo, Sheila Zipfel
  • Novel compounds and compositions as cathepsin inhibitors
    Publication number: 20040142999
    Abstract: The present invention relates to novel selective cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
    Type: Application
    Filed: November 21, 2003
    Publication date: July 22, 2004
    Applicants: Aventis Pharmaceuticals Inc., Axys Pharmaceuticals, Inc.
    Inventors: Michael Graupe, Jiayao Li, John Link, Sheila Zipfel, Andreas Paul Timm, David John Aldous, Sukathini Thurairatnam
  • Novel compounds and compositions as cathepsin S inhititors
    Publication number: 20040014796
    Abstract: The present invention relates to novel selective cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
    Type: Application
    Filed: September 27, 2002
    Publication date: January 22, 2004
    Applicant: AXYS PHARMACEUTICALS, INC.
    Inventors: Michael Graupe, John O. Link, John W. Patterson, Sheila Zipfel
  • Novel Compounds and compositions as protease inhibitors
    Publication number: 20030232864
    Abstract: The present invention relates to novel alkanoyl-substituted heterocyclic derivatives which are cysteine protease inhibitors; the pharmaceutically acceptable salts and N-oxides thereof; their uses as therapeutic agents and the methods of their making.
    Type: Application
    Filed: January 28, 2003
    Publication date: December 18, 2003
    Applicant: Axys Pharmaceuticals, Inc.
    Inventors: John O. Link, Arnold J. Martelli, Valeri Martichonok, John W. Patterson, Oliver L. Saunders, Sheila Zipfel
  • Compounds and compositions as protease inhibitors
    Patent number: 6576630
    Abstract: The present invention relates to novel alkanoyl-substituted heterocyclic derivatives which are cysteine protease inhibitors; the pharmaceutically acceptable salts and N-oxides thereof; their uses as therapeutic agents and the methods of their making.
    Type: Grant
    Filed: March 15, 2000
    Date of Patent: June 10, 2003
    Assignee: AXYS Pharmaceuticals, Inc.
    Inventors: John O. Link, Arnold J. Martelli, Valeri Martichonok, John W. Patterson, Oliver L. Saunders, Sheila Zipfel
  • Compounds and compositions as cathepsin S inhibitors
    Patent number: 6492362
    Abstract: The present invention relates to novel selective cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
    Type: Grant
    Filed: September 15, 2000
    Date of Patent: December 10, 2002
    Assignee: Axys Pharmaceuticals, Inc.
    Inventors: Michael Graupe, John O. Link, John W. Patterson, Sheila Zipfel