Patents by Inventor Shekhar Bhansali
Shekhar Bhansali has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11955673Abstract: Systems and methods for real-time continuous monitoring of fuel cell membrane degradation are provided. At least one microsensor can be used as an inline sensor integrated at the cathode exhaust and/or the anode exhaust of a fuel cell, such as a proton exchange membrane fuel cell (PEMFC)). The microsensor can monitor the PEMFC degradation status by sensing the emission of fluoride.Type: GrantFiled: September 1, 2023Date of Patent: April 9, 2024Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEESInventors: Dongmei Dong, Shekhar Bhansali, Tinsley Benhaddouch, Christopher Metler, John Marcial, Justin Fuentes
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Patent number: 11811116Abstract: Systems and methods for real-time continuous monitoring of fuel cell membrane degradation are provided. At least one microsensor can be used as an inline sensor integrated at the cathode exhaust and/or the anode exhaust of a fuel cell, such as a proton exchange membrane fuel cell (PEMFC)). The microsensor can monitor the PEMFC degradation status by sensing the emission of fluoride.Type: GrantFiled: January 11, 2023Date of Patent: November 7, 2023Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEESInventors: Dongmei Dong, Shekhar Bhansali, Tinsley Benhaddouch, Christopher Metler, John Marcial, Justin Fuentes
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Patent number: 11135589Abstract: Large bioreactors based on microfluidic technology, and methods of manufacturing the same, are provided, The big microbioreactor can include a chip or substrate having the microfluidic channels thereon, and the chip can be manufactured by forming a master mold, forming a male mold from a photopolymer plate using replica molding with the Fmold, and transferring features of the male to a polymer material.Type: GrantFiled: December 22, 2020Date of Patent: October 5, 2021Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEESInventors: Shekhar Bhansali, Maximiliano S. Perez, Betiana Lerner, Natalia Bourguignon
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Patent number: 11076786Abstract: The subject invention provides sensor systems that can detect biomarkers related to wound healing (e.g., uric acid, adenosine, arginine and/or xanthine). In one embodiment, the subject invention pertains to materials and methods for monitoring biomarkers non-invasively in a wound and a biofluid (e.g., sweat) in the proximity of the wound, optionally, including other physiological fluids. Skin based, non-invasive enzymatic electrochemical biosensor on a wearable platform (e.g., sweat patch) that can evaluate the healing of wounds through assessment of its biomarker levels are provided. This non-invasive detection from physiologically biofluids can reduce or eliminate occlusion effects.Type: GrantFiled: October 1, 2019Date of Patent: August 3, 2021Assignees: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES, UNIVERSITY OF MIAMIInventors: Sohini Roy Choudhury, Yogeswaran Umasankar, Shekhar Bhansali, Robert S. Kirsner, Hadar A. Lev-Tov
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Patent number: 11065164Abstract: Systems and methods for a low-cost smart textile electronic (tex-tronic) useful for wound healing assessment are provided. Data collection can be accomplished by reflection of the modulated wound-data to an interrogator. The RF modulation of the data can be done by a textile-based voltage-controlled oscillator (VCO) that takes the electric signal provided by electrochemical sensing of the uric acid found in the wound fluid. The low-cost smart textile electronic uses low-cost materials and is easy to manufacture and use by any patient or medical professional.Type: GrantFiled: January 25, 2021Date of Patent: July 20, 2021Assignee: The Florida International University Board of TrusteesInventors: Dieff Vital, Shubhendu Bhardwaj, John L. Volakis, Pulak Bhushan, Shekhar Bhansali
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Publication number: 20210129151Abstract: Large bioreactors based on microfluidic technology, and methods of manufacturing the same, are provided, The big microbioreactor can include a chip or substrate having the microfluidic channels thereon, and the chip can be manufactured by forming a master mold, forming a male mold from a photopolymer plate using replica molding with the Fmold, and transferring features of the male to a polymer material.Type: ApplicationFiled: December 22, 2020Publication date: May 6, 2021Applicant: The Florida International University Board of TrusteesInventors: Shekhar Bhansali, Maximiliano S. Perez, Betiana Lerner, Natalia Bourguignon
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Publication number: 20210078005Abstract: Large bioreactors based on microfluidic technology, and methods of manufacturing the same, are provided, The big microbioreactor can include a chip or substrate having the microfluidic channels thereon, and the chip can be manufactured by forming a master mold, forming a male mold from a photopolymer plate using replica molding with the Fmold, and transferring features of the male to a polymer material.Type: ApplicationFiled: September 17, 2019Publication date: March 18, 2021Applicant: The Florida International University Board of TrusteesInventors: Shekhar Bhansali, Maximiliano S. Perez, Betiana Lerner, Natalia Bourguignon
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Patent number: 10926261Abstract: Large bioreactors based on microfluidic technology, and methods of manufacturing the same, are provided, The big microbioreactor can include a chip or substrate having the microfluidic channels thereon, and the chip can be manufactured by forming a master mold, forming a male mold from a photopolymer plate using replica molding with the Fmold, and transferring features of the male to a polymer material.Type: GrantFiled: September 17, 2019Date of Patent: February 23, 2021Assignee: The Florida International University Board of TrusteesInventors: Shekhar Bhansali, Maximiliano S. Perez, Betiana Lerner, Natalia Bourguignon
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Patent number: 10739305Abstract: Systems and methods for sensing analytes using an extended gate field effect transistor (EGFET) are provided. A biosensing system can utilize a biodetection layer on a substrate, which can be coupled to a field effect transistor (FET). The coupling can be such that the gate of the field effect transistor is connected to the substrate having the biodetection layer thereon. The functionalized substrate can include a well-defined area that can hold a specific, pre-determined volume of fluid on top of it. An external electrode can be dipped in the fluid and can then be connected to a power source supplying a gate voltage. The presence or concentration of the target analyte in the fluid can be determined based on the source-drain characteristics of the FET.Type: GrantFiled: October 31, 2019Date of Patent: August 11, 2020Assignee: The Florida International University Board of TrusteesInventors: Shekhar Bhansali, Syed Khalid Pasha, Mubarak Ajmuddin Mujawar
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Patent number: 10712306Abstract: Continuous monitoring of acetone is a challenge using related art sensing methods. Though real-time detection of acetone from different biofluids is promising, signal interference from other biomarkers remains an issue. A minor fluctuation of the signals in the micro-ampere range can cause substantial overlapping in linear/polynomial calibration fittings. To address the above in non-invasive detection, principal component analysis (PCA) can be used to generate specific patterns for different concentration points of acetone in the subspace. This results in improvement of the problem of overlapping of the signals between two different concentration points of the data sets while eliminating dimensionality and redundancy of data variables. An algorithm following PCA can be incorporated in a microcontroller of a sensor, resulting in a functional wearable acetone sensor. Acetone in the physiological range (0.5 ppm to 4 ppm) can be detected with such a sensor.Type: GrantFiled: September 25, 2019Date of Patent: July 14, 2020Assignee: The Florida International University Broad of TrusteesInventors: Yogeswaran Umasankar, Shekhar Bhansali, Ahmed Hasnain Jalal, Neera Bhansali
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Patent number: 10699893Abstract: Cylindrical ion traps (CITs) that can be used for molecular sample identification, as well as systems and methods using the same, are provided. A CIT can utilize a notched ring electrode having an inner diameter that increases as a first end of the CIT is approached from the center of the CIT or from a second end of the CIT. The first end can be the one positioned closer to the ion detector than is the second end, which can be positioned closer to the ion source than is the first end.Type: GrantFiled: December 20, 2019Date of Patent: June 30, 2020Assignee: The Florida International University Board of TrusteesInventors: Patrick Roman, Shekhar Bhansali
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Patent number: 10667732Abstract: Devices and methods of making and using the device for the non-invasive detection of volatile anesthetics are provided. The devices are capable of measuring the concentration of volatile anesthetics transdermally and in a non-invasive manner. The devices and methods can be applied in detection of volatile anesthetics in samples collected from human skin perspiration.Type: GrantFiled: May 12, 2017Date of Patent: June 2, 2020Assignees: The Florida International University Board of Trustees, University of MiamiInventors: Yogeswaran Umasankar, Shekhar Bhansali, Ernesto A. Pretto, Jr.
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Publication number: 20200103366Abstract: Continuous monitoring of acetone is a challenge using related art sensing methods. Though real-time detection of acetone from different biofluids is promising, signal interference from other biomarkers remains an issue. A minor fluctuation of the signals in the micro-ampere range can cause substantial overlapping in linear/polynomial calibration fittings. To address the above in non-invasive detection, principal component analysis (PCA) can be used to generate specific patterns for different concentration points of acetone in the subspace. This results in improvement of the problem of overlapping of the signals between two different concentration points of the data sets while eliminating dimensionality and redundancy of data variables. An algorithm following PCA can be incorporated in a microcontroller of a sensor, resulting in a functional wearable acetone sensor. Acetone in the physiological range (0.5 ppm to 4 ppm) can be detected with such a sensor.Type: ApplicationFiled: September 25, 2019Publication date: April 2, 2020Applicant: The Florida International University Board of TrusteesInventors: Yogeswaran Umasankar, Shekhar Bhansali, Ahmed Hasnain Jalal, Neera Bhansali
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Publication number: 20200100711Abstract: The subject invention provides sensor systems that can detect biomarkers related to wound healing (e.g., uric acid, adenosine, arginine and/or xanthine). In one embodiment, the subject invention pertains to materials and methods for monitoring biomarkers non-invasively in a wound and a biofluid (e.g., sweat) in the proximity of the wound, optionally, including other physiological fluids. Skin based, non-invasive enzymatic electrochemical biosensor on a wearable platform (e.g., sweat patch) that can evaluate the healing of wounds through assessment of its biomarker levels are provided. This non-invasive detection from physiologically biofluids can reduce or eliminate occlusion effects.Type: ApplicationFiled: October 1, 2019Publication date: April 2, 2020Applicant: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEESInventors: SOHINI ROY CHOUDHURY, YOGESWARAN UMASANKAR, SHEKHAR BHANSALI, ROBERT S. KIRSNER, HADAR A. LEV-TOV
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Patent number: 10517533Abstract: Provided is a Coupled Domain Sensor (CDS) that can be used to, for example, evaluate hydration and occlusion of blood in patients with edema using electrical and optical measurements. Advantageously, the CDS provides a quicker, more effective and accurate way of monitoring this medical condition.Type: GrantFiled: May 16, 2016Date of Patent: December 31, 2019Assignees: The Florida International University Board of Trustees, University of South FloridaInventors: Shekhar Bhansali, Karina Rincon, Jessica Ramella-Roman, Sanjukta Bhanja
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Patent number: 10309921Abstract: The current invention pertains to electrochemical biosensors. The electrochemical biosensor of the current invention comprises: a) a sensing electrode having attached to its surface a binding agent capable of specifically binding to the analyte to form a binding agent-analyte complex and wherein the binding of the analyte to the binding agent alters the electron transfer properties at the sensing electrode surface thereby providing a change in the electrochemical response at the sensing electrode surface proportional to the number of binding agent-analyte complexes, and b) a test equipment capable of measuring the electrochemical response at the sensing electrode surface. The binding agent can be a binding protein, an antibody, or an aptamer, and the analyte can be a biomolecule. Accordingly, the current invention provides a method of detecting the presence or assessing the likelihood of development of a disease associated with an abnormal level of a biomolecule in a subject.Type: GrantFiled: March 3, 2015Date of Patent: June 4, 2019Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEESInventors: Shekhar Bhansali, Abhay Vasudev Mallari
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Patent number: 10180624Abstract: In one embodiment, a method for fabricating thin film tunneling devices using a mask set includes depositing a first layer of material on a substrate, positioning a first photomask over the substrate, exposing the first layer to light that passes through the first photomask, depositing a second layer of material on the substrate, positioning a second photomask over the substrate by aligning a corner marker provided on the second photomask with one of multiple corner markers provided on the first photomask, wherein the corner marker of the first photomask with which the corner marker of the second photomask aligns defines a degree of overlap between a first structure formed using the first photomask and a second structure formed using the second photomask; and exposing the second layer to light that passes through the second photomask.Type: GrantFiled: September 29, 2017Date of Patent: January 15, 2019Assignee: University of South FloridaInventors: Rudraskandan Ratnadurai, Subramanian Krishnan, Shekhar Bhansali
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Publication number: 20180325429Abstract: Devices and methods of making and using the device for the non-invasive detection of volatile anesthetics are provided. The devices are capable of measuring the concentration of volatile anesthetics transdermally and in a non-invasive manner. The devices and methods can be applied in detection of volatile anesthetics in samples collected from human skin perspiration.Type: ApplicationFiled: May 12, 2017Publication date: November 15, 2018Applicant: The Florida International University Board of TrusteesInventors: Yogeswaran UMASANKAR, Shekhar BHANSALI, Ernesto A. PRETTO
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Patent number: 9897572Abstract: Apparatuses and associated methods for manipulating an assembly of glass slides employed in cellular assay processes are provided. Each apparatus can accommodate at least one removable rack of slides to undergo electrophoresis in a comet assay. The slides can remain in the same apparatus while being subjected to a sequence of fluid staining and washing with temperature control, advantageously shortening the amount of time required for processing the slides by keeping them in the same work station for the entire duration of the assay.Type: GrantFiled: December 2, 2016Date of Patent: February 20, 2018Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEESInventors: Marcus S. Cooke, Shekhar Bhansali, Mahsa Karbaschi, Pratikkumar Shah
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Patent number: 9846137Abstract: The subject invention provides materials and methods of fabricating and using an electrochemical biosensor for continuous detection of biological analytes. In a specific embodiment, the biosensor detects a given analyte when the analyte binds with a molecularly imprinted polymer (MIP) matrix immobilized atop a sensing substrate eliminating the need for a redox probing agent commonly found in electrochemical biosensors. Furthermore, the detection sensitivity of the biosensor is enhanced by modifying the electrode surface with a plurality of nanoscopic metallic structures. Advantageously, technologies provided herein can be used in a variety of low-power electronics for wearable applications.Type: GrantFiled: August 19, 2016Date of Patent: December 19, 2017Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTESSInventors: Shekhar Bhansali, Pandiaraj Manickam