Patents by Inventor Shi-Hua Li

Shi-Hua Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6355481
    Abstract: The invention provides compositions and methods for the study, diagnosis, and treatment of Huntington's disease. Compositions comprise stably transfected cell lines that serve as a cellular model for Huntington's disease, sequences corresponding to an antigen associated with Huntington's disease, and monoclonal antibodies that bind specifically to said antigen. The stably transfected cell lines of the invention express truncated mutant huntingtin protein and display cellular defects similar to those observed in cells of patients with Huntington's disease. A method is provided wherein these cell lines are used to screen for therapeutic agents for the treatment of Huntington's disease. The monoclonal antibodies of the invention find use in a diagnostic assay for Huntington's disease.
    Type: Grant
    Filed: June 19, 2000
    Date of Patent: March 12, 2002
    Assignee: Emory University
    Inventors: Xiao-Jiang Li, Shi-Hua Li
  • Patent number: 6093549
    Abstract: Proteins which specifically bind to huntingtin, the product of the Huntington's Disease locus (HD), are used in assays for screening drug candidates. These proteins, termed huntingtin associated proteins, bind to huntingtins of both normal and Huntington's Disease patients. However, the binding is stronger to the huntingtins from the patients. The strength of binding correlates with the number of glutamine repeats in the huntingtin, which itself correlates with the time of disease onset.
    Type: Grant
    Filed: November 9, 1995
    Date of Patent: July 25, 2000
    Assignee: The Johns Hopkins University
    Inventors: Christopher A. Ross, Xiao-Jiang Li, Shi-Hua Li, Alan H. Sharp, Anthony Lanahan, Paul F. Worley, Solomon H. Snyder