Patents by Inventor Shifeng Pan

Shifeng Pan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20120202782
    Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or dysregulated B cell activities, particularly diseases or disorders that involve aberrant activation of inositol 1,4,5-trisphosphate 3-kinase B (ITPKb).
    Type: Application
    Filed: April 12, 2012
    Publication date: August 9, 2012
    Applicant: IRM LLC
    Inventors: Badry Bursulaya, Dai Cheng, Jiqing Jiang, Donald S. Karanewsky, Yi Liu, Shifeng Pan, Yongqin Wan, Xia Wang, Yun Feng Xie, Yang Yang
  • Publication number: 20120196849
    Abstract: The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.
    Type: Application
    Filed: April 10, 2012
    Publication date: August 2, 2012
    Applicant: IRM LLC
    Inventors: Wenqi Gao, Jiqing Jiang, Yongqin Wan, Dai Cheng, Dong Han, Xu Wu, Shifeng Pan
  • Patent number: 8202876
    Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, ARG, BCR-Abl, BRK, EphB, Fms, Fyn, KDR, c-Kit, LCK, PDGF-R, b-Raf, c-Raf, SAPK2, Src, Tie2 and TrkB kinases.
    Type: Grant
    Filed: September 24, 2007
    Date of Patent: June 19, 2012
    Assignees: IRM LLC, Novartis AG
    Inventors: Pamela Albaugh, Gregory B. Chopiuk, Qiang Ding, Shenlin Huang, Zuosheng Liu, Shifeng Pan, Pingda Ren, Xia Wang, Xing Wang, Yongping Xie, Chengzhi Zhang, Qiong Zhang, Guobao Zhang, Daniel Poon, Paul Renhowe, Martin Sendzik
  • Patent number: 8178563
    Abstract: The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.
    Type: Grant
    Filed: May 4, 2007
    Date of Patent: May 15, 2012
    Assignee: IRM LLC
    Inventors: Wenqi Gao, Jiqing Jiang, Yongqin Wan, Dai Cheng, Dong Han, Xu Wu, Shifeng Pan
  • Patent number: 8178526
    Abstract: The invention provides a novel class of compounds of formula (I), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or dysregulated B cell activities, particularly diseases or disorders that involve aberrant activation of inositol 1,4,5-trisphosphate 3-kinase B (ITPKb).
    Type: Grant
    Filed: June 12, 2008
    Date of Patent: May 15, 2012
    Assignee: IRM LLC
    Inventors: Badry Bursulaya, Dai Cheng, Jiqing Jiang, Donald S. Karanewsky, Yi Liu, Shifeng Pan, Yongqin Wan, Xia Wang, Yun Feng Xie, Yang Yang
  • Publication number: 20110263610
    Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated B cell activities, particularly diseases or disorders that involve aberrant activation of inositol 1,4,5-trisphosphate 3-kinase B (ITPKb).
    Type: Application
    Filed: March 30, 2009
    Publication date: October 27, 2011
    Applicant: IRM LLC
    Inventors: Yongqin Wan, Shifeng Pan, Guobao Zhang, Xia Wang, Yun Feng Xie, Jiqing Jiang, Dean Phillips, Yang Yang
  • Publication number: 20110237573
    Abstract: The present invention relates to compounds of formulae 1 and 2 and methods for modulating the Wnt signaling pathway using these compounds, wherein A1, A2, B, Y and Z all represent rings.
    Type: Application
    Filed: March 1, 2010
    Publication date: September 29, 2011
    Applicant: IRM LLC
    Inventors: Dai Cheng, Guobao Zhang, Dong Han, Wenqi Gao, Shifeng Pan
  • Publication number: 20110183962
    Abstract: The invention provides methods for modulating, e.g., antagonizing, the activity of the Hedgehog signaling pathway, and for treating Hedgehog related disorders such as cancers (e.g., medulloblastoma). In particular, the invention provides methods for inhibiting aberrant growth states resulting from phenotypes such as Ptch loss-of-function, Hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function by administering to a mammal combinations of Smoothened inhibitors (e.g., a compound of Formula I, Formula II, or Formula III, or any of the compounds listed herein or incorporated by reference) and cholesterol biosynthesis pathway inhibitors (e.g., statins), Gli inhibitors, and/or Phosphatidylinositol 3-kinase (PI3K) inhibitors.
    Type: Application
    Filed: September 28, 2009
    Publication date: July 28, 2011
    Applicant: Novartis AG
    Inventors: Marion Dorsch, John E. Monahan, Michael Patrick Morrissey, Shifeng Pan, Juliet Williams
  • Publication number: 20110152282
    Abstract: The invention provides a method, compounds and compositions for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or GIi gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula (I).
    Type: Application
    Filed: August 24, 2009
    Publication date: June 23, 2011
    Applicant: IRM LLC
    Inventors: Dai Cheng, Dong Han, Guobao Zhang, Yongqin Wan, Yun Feng Xie, Jiqing Jiang, Wenqi Gao, Shifeng Pan
  • Patent number: 7939519
    Abstract: The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
    Type: Grant
    Filed: February 1, 2008
    Date of Patent: May 10, 2011
    Assignee: Novartis AG
    Inventors: Shifeng Pan, Wenqi Gao, Nathanael S Gray, Yuan Mi, Yi Fan
  • Patent number: 7928133
    Abstract: The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.
    Type: Grant
    Filed: July 24, 2007
    Date of Patent: April 19, 2011
    Assignee: IRM LLC
    Inventors: Dai Cheng, Dong Han, Wenqi Gao, Jiqing Jiang, Shifeng Pan, Yongqin Wan, Qihui Jin
  • Publication number: 20100184765
    Abstract: The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, and methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of Alk, Abl, Aurora-A, B-Raf, C-Raf, Bcr-Abl, BRK, Blk, Bmx, BTK, C-Kit, CSK, C-Src, EphB1, EphB2, EphB4, FLT1, Fms, Flt3, Fyn, FRK3, JAK2, KDR, Lck, Lyn, PDGFR?, PDGFR?, PKC?, SAPK2?, Src, SIK, Syk, Tie2 and TrkB kinases.
    Type: Application
    Filed: June 10, 2008
    Publication date: July 22, 2010
    Inventors: Shenlin Huang, Zuosheng Liu, Pamela A. Albaugh, Xing Wang, Shifeng Pan, Yongping Xie, Guobao Zhang
  • Publication number: 20100183564
    Abstract: The present invention relates to compounds and compositions for expanding the number of CD34+ cells for transplantation. The invention further relates to a cell population comprising expanded hematopoietic stem cells (HSCs) and its use in autologous or allogeneic transplantation for the treatment of patients with inherited immunodeficient and autoimmune diseases and diverse hematopoietic disorders to reconstitute the hematopoietic cell lineages and immune system defense.
    Type: Application
    Filed: October 29, 2009
    Publication date: July 22, 2010
    Applicant: IRM LLC
    Inventors: Anthony E. Boitano, Michael Cooke, Shifeng Pan, Peter G. Schultz, John Tellew, Yongqin Wan, Xing Wang
  • Publication number: 20100184748
    Abstract: The invention provides a novel class of compounds of formula (I), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or dysregulated B cell activities, particularly diseases or disorders that involve aberrant activation of inositol 1,4,5-trisphosphate 3-kinase B (ITPKb).
    Type: Application
    Filed: June 12, 2008
    Publication date: July 22, 2010
    Applicant: IRM LLC
    Inventors: Badry Bursulaya, Dai Cheng, Jiqing Jiang, Donald S. Karanewsky, Yi Liu, Shifeng Pan, Yongqin Wan, Xia Wang, Yun Feng Xie, Yang Yang
  • Patent number: PP21452
    Abstract: A new Lantana plant named ‘Bani Redda,’ particularly distinguished by the large bold yellow flowers that turn orange-red, excellent floriferousness because of limited seed set, compact and dense mounding habit with dark green foliage.
    Type: Grant
    Filed: October 19, 2009
    Date of Patent: November 9, 2010
    Assignee: Syngenta Crop Protection AG
    Inventor: Shifeng Pan
  • Patent number: PP21590
    Abstract: A new Lantana plant named ‘Ban Whit,’ particularly distinguished by the large sized white flowers with a golden-yellow throat, excellent floriferousness because of limited seed set, compact and dense mounding habit with medium green foliage.
    Type: Grant
    Filed: October 20, 2009
    Date of Patent: December 28, 2010
    Assignee: Syngenta Crop Protection AG
    Inventor: Shifeng Pan
  • Patent number: PP21616
    Abstract: A new Lantana plant named ‘Bani Rossa,’ particularly distinguished by the large sized, bold yellow flowers that turn red-purple, excellent floriferousness, a result of limited seed set, compact and dense mounding habit with dark green foliage.
    Type: Grant
    Filed: October 20, 2009
    Date of Patent: January 11, 2011
    Assignee: Synegenta Crop Protection AG
    Inventor: Shifeng Pan
  • Patent number: PP21617
    Abstract: A new Lantana plant named ‘Bani Yelbic,’ particularly distinguished by the large sized, bright yellow flower color that matures to white, excellent floriferousness because of limited seed set, compact and dense mounding habit with dark green foliage.
    Type: Grant
    Filed: October 22, 2009
    Date of Patent: January 11, 2011
    Assignee: Syngenta Crop Protection AG
    Inventor: Shifeng Pan
  • Patent number: PP23316
    Abstract: A new Lantana plant named ‘LANZ0003’ particularly distinguished by the large sized, two-toned yellow flowers, with good floriferousness as a result of limited seed set, and a relatively compact habit with medium green foliage.
    Type: Grant
    Filed: October 7, 2011
    Date of Patent: January 8, 2013
    Assignee: Syngenta Crop Protection AG
    Inventor: Shifeng Pan
  • Patent number: PP23317
    Abstract: A new Lantana plant named ‘LANZ0002’ particularly distinguished by the large sized, yellow flowers that mature to orange and light red colored flowers, with excellent floriferousness as a result of limited seed set, and a relatively compact and mounding habit that is well branched with medium green foliage.
    Type: Grant
    Filed: October 7, 2011
    Date of Patent: January 8, 2013
    Assignee: Syngenta Crop Protection AG
    Inventor: Shifeng Pan