Patents by Inventor Shigeharu Ueda
Shigeharu Ueda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 6720409Abstract: [Object] To provide an anti-human influenza virus antibody and an immunogenic artificial polypeptide. [Constitution] An anti-human influenza virus antibody which recognizes the stem regions of haemagglutinin molecules of the H1N1 and H2N2 subtypes and has a neutralization activity but does not recognize the stem region of the H3N2 subtype and has no neutralization activity. An immunogenic artificial polypeptide having an antigenicity substantially same as the stem regions of haemagglutinin molecules. An immunogenic artificial polypeptide having an antigenicity substantially same as the stem regions of haemagglutinin molecule and lacking the globular head region of haemagglutinin molecules. [Effect] This antibody is useful in the diagnosis and treatment of influenza A virus, while these polypeptides are useful as a vaccine.Type: GrantFiled: August 1, 2001Date of Patent: April 13, 2004Assignee: Takara Shuzo Co., Ltd.Inventors: Yoshinobu Okuno, Yuji Isegawa, Fuyoko Sasao, Shigeharu Ueda
-
Patent number: 6605284Abstract: Disclosed is a measles virus mutant gene coding for a measles virus mutant H protein antigen, wherein said gene coding for a measles virus mutant H protein antigen is at least one member selected from the group consisting of the following genes (a) to (c): (a) a gene coding for an amino acid sequence of SEQ ID NO: 10; (b) a gene coding for an amino acid sequence of SEQ ID NO: 3 or SEQ ID NO: 11; and (c) a gene coding for an amino acid sequence of SEQ ID NO: 4 or SEQ ID NO: 12. By the use of the measles virus mutant gene of the present invention, it has become possible to provide efficiently and economically a gene vaccine which is adapted for an epidemic strain of measles virus, and a diagnostic reagent capable of accurately detecting infections with an epidemic strain of measles virus.Type: GrantFiled: June 5, 2001Date of Patent: August 12, 2003Assignee: The Research Foundation for Microbial Diseases of Osaka UniversityInventors: Shigeharu Ueda, Michiko Watanabe, Hitomi Kawanish
-
Publication number: 20020146434Abstract: Disclosed is a measles virus mutant antigen, comprising at least one protein antigen selected from the group consisting of (I) a measles virus mutant H protein antigen and (II) a measles virus mutant F protein antigen,Type: ApplicationFiled: June 5, 2001Publication date: October 10, 2002Applicant: The Research Foundation for Microbial Diseases of Osaka UniversityInventors: Shigeharu Ueda, Michiko Watanabe, Hitomi Kawanish
-
Publication number: 20020054882Abstract: [Object] To provide an anti-human influenza virus antibody and an immunogenic artificial polypeptide.Type: ApplicationFiled: August 1, 2001Publication date: May 9, 2002Inventors: Yoshinobu Okuno, Yuji Isegawa, Fuyoko Sasao, Shigeharu Ueda
-
Patent number: 6337070Abstract: The invention provides an anti-human influenza virus antibody which recognizes the stem regions of haemagglutinin molecules of the H1N1 and H2N2 subtypes and has a neutralization activity but does not recognize the stem region of the H3N2 subtype and has no neutralization activity. Also provided is an immunogenic artificial polypeptide having an antigenicity substantially same as the stem region of haemagglutinin molecules, particularly lacking the globular head region of haemagglutinin molecules. This antibody is useful in the diagnosis and treatment of influenza A virus, while the polypeptides are useful as a vaccine.Type: GrantFiled: January 8, 1998Date of Patent: January 8, 2002Assignee: Takara Shuzo Co., Ltd.Inventors: Yoshinobu Okuno, Yuji Isegawa, Fuyoko Sasao, Shigeharu Ueda
-
Patent number: 6277380Abstract: Disclosed is a measles virus mutant antigen consisting essentially of a measles virus mutant H protein antigen, wherein said measles virus mutant H protein antigen is at least one member selected from the group consisting of the following amino acid sequences (a) to (c): (a) an amino acid sequence of SEQ ID NO: 10; (b) an amino acid sequence of SEQ ID NO: 3 or SEQ ID NO: 11; and (c) an amino acid sequence of SEQ ID NO. 4 or SEQ ID NO: 12 By the use of the measles virus mutant antigen of the present invention, it has become possible to provide efficiently and economically a live attenuated measles vaccine which is adapted for an epidemic strain of measles virus, and a diagnostic reagent capable of accurately detecting infections with an epidemic strain of measles virus.Type: GrantFiled: February 4, 1999Date of Patent: August 21, 2001Assignee: The Research Foundation for Microbial Diseases of Osaka UniversityInventors: Shigeharu Ueda, Michiko Watanabe, Hitomi Kawanish
-
Patent number: 5645846Abstract: An antiviral composition comprising: a thiosulfate salt and at least one of thiosulfate complex salt of a metal and a porous particulate carrier; said metal being at least one selected from the group consisting of silver, copper and zinc: said salts being carried on said porous particulate carrier. It is applicable to a wide range of living environment such as medical instruments and appliances, hygienic implements as well as kitchen utensils, and also demonstrates an antibacterial activity in addition to the antiviral activity. The composition releases its salts slowly to the environment and the antiviral and antibacterial activities of said composition lasts for a long period of time. A method for preparing said composition as well as an antiviral disinfection method and a virucidal disinfection fluid using said composition are also disclosed.Type: GrantFiled: January 4, 1996Date of Patent: July 8, 1997Assignee: Matsushita Electric Industrial Co., Ltd.Inventors: Hiroaki Oka, Toshikazu Tomioka, Katsumi Tomita, Kenji Hoshino, Atsushi Nishino, Shigeharu Ueda
-
Patent number: 5631350Abstract: An anti-human influenza virus antibody is provided having the following characteristics: (a) specifically binds to the stem region of hemagglutinin of human influenza A virus subtype H3N2; (b) does not specifically bind to the stem region of hemagglutinin of human influenza A virus subtypes H1N1 and H2N2; and (c) does not specifically bind to the stem region of hemagglutinin of human influenza B virus. A composition comprising the antibody is also provided.Type: GrantFiled: April 5, 1996Date of Patent: May 20, 1997Assignee: Takara Shuzo Co., Ltd.Inventors: Yoshinobu Okuno, Yuji Isegawa, Fuyoko Sasao, Shigeharu Ueda
-
Patent number: 5589174Abstract: An anti-human influenza virus antibody is provided which recognizes the stem regions of haemagglutinin molecules of the H1N1 and H2N2 subtypes and has a neutralization activity, but does not recognize the stem region of the H3N2 subtype and has no neutralization activity. Also provided is an immunogenic artificial polypeptide having an antigenicity substantially the same as the stem regions of haemagglutinin molecules. Provided further is an immunogenic artificial polypeptide having an antigenicity substantially the same as the stem regions of haemagglutinin molecule and lacking the globular head region of haemagglutinin molecules. The antibody is useful in the diagnosis and treatment of influenza A virus, while the polypeptides are useful as a vaccine.Type: GrantFiled: April 19, 1994Date of Patent: December 31, 1996Assignee: Takara Shuzo Co., Ltd.Inventors: Yoshinobu Okuno, Yuji Isegawa, Fuyoko Sasao, Shigeharu Ueda
-
Patent number: 5516519Abstract: An antiviral composition comprising: a thiosulfate salt and at least one of thiosulfate complex salt of a metal and a porous particulate carrier; said metal being at least one selected from the group consisting of silver, copper and zinc; said salts being carried on said porous particulate carrier. It is applicable to a wide range of living environment such as medical instruments and appliances, hygienic implements as well as kitchen utensils, and also demonstrates an antibacterial activity in addition to the antiviral activity. The composition releases its salts slowly to the environment and the antiviral and antibacterial activities of said composition lasts for a long period of time. A method for preparing said composition as well as an antiviral disinfection method and a virucidal disinfection fluid using said composition are also disclosed.Type: GrantFiled: April 11, 1995Date of Patent: May 14, 1996Assignee: Matsushita Electric Industrial Co., Ltd.Inventors: Hiroaki Oka, Toshikazu Tomioka, Katsumi Tomita, Kenji Hoshino, Atsushi Nishino, Shigeharu Ueda
-
Patent number: 5429819Abstract: An antiviral composition comprising: a thiosulfate salt and at least one of thiosulfate complex salt of a metal and a porous particulate carrier; said metal being at least one selected from the group consisting of silver, copper and zinc; said salts being carried on said porous particulate carrier. It is applicable to a wide range of living environment such as medical instruments and appliances, hygienic implements as well as kitchen utensils, and also demonstrates an antibacterial activity in addition to the antiviral activity. The composition releases its salts slowly to the environment and the antiviral and antibacterial activities of said composition lasts for a long period of time. A method for preparing said composition as well as an antiviral disinfection method and a virucidal disinfection fluid using said composition are also disclosed.Type: GrantFiled: October 8, 1993Date of Patent: July 4, 1995Assignee: Matsushita Electric Industrial Co., Ltd.Inventors: Hiroaki Oka, Toshikazu Tomioka, Katsumi Tomita, Kenji Hoshino, Atsushi Nishino, Shigeharu Ueda
-
Patent number: 4867976Abstract: A method for treatment of acquired immuno-deficiency syndrome (AIDS) which comprises administering a therapeutically effective amount of liposomes containing a toxin which specifically inhibits the protein synthesis in cells to a patient with AIDS.Type: GrantFiled: July 2, 1987Date of Patent: September 19, 1989Assignee: Sumitomo Chemical Company, LimitedInventors: Shigeharu Ueda, Kazuyoshi Ikuta, Shiro Kato, Tsuyoshi Uchida