Patents by Inventor Shigeo Matsui
Shigeo Matsui has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 9637451Abstract: [Problem] To provide a compound useful as a MT1 and/or MT2 receptor agonist. [Solution] The present inventors have studied on MT1 and/or MT2 receptor agonists, and have confirmed that indole compounds have the activity. As a result, the present invention is accomplished. That is, a compound represented by formula (I) or a salt thereof according to the present invention has a MT1 and/or MT2 receptor agonistic activity and has a low ability of migrating into central nervous system. Therefore, the compound or a salt thereof can be used as a peripheral MT1 and/or MT2 receptor agonist, and therefore can be used as a therapeutic and/or prophylactic agent for urinary incontinence, particularly stress urinary incontinence and mixed urinary incontinence.Type: GrantFiled: January 13, 2015Date of Patent: May 2, 2017Inventors: Shunichiro Matsumoto, Takafumi Shimizu, Tomoyuki Saito, Takatoshi Kanayama, Hiroaki Tanaka, Chiharu Mori, Kazuhiro Yokoyama, Shigeo Matsui
-
Publication number: 20160332966Abstract: [Problem] To provide a compound useful as a MT1 and/or MT2 receptor agonist. [Solution] The present inventors have studied on MT1 and/or MT2 receptor agonists, and have confirmed that indole compounds have the activity. As a result, the present invention is accomplished. That is, a compound represented by formula (I) or a salt thereof according to the present invention has a MT1 and/or MT2 receptor agonistic activity and has a low ability of migrating into central nervous system. Therefore, the compound or a salt thereof can be used as a peripheral MT1 and/or MT2 receptor agonist, and therefore can be used as a therapeutic and/or prophylactic agent for urinary incontinence, particularly stress urinary incontinence and mixed urinary incontinence.Type: ApplicationFiled: January 13, 2015Publication date: November 17, 2016Applicant: ASTELLAS PHARMA INC.Inventors: Shunichiro MATSUMOTO, Takafumi SHIMIZU, Tomoyuki SAITO, Takatoshi KANAYAMA, Hiroaki TANAKA, Chiharu MORI, Kazuhiro YOKOYAMA, Shigeo MATSUI
-
Patent number: 9376449Abstract: The present invention relates to indole carboxamide compounds of formula (I) or a salt thereof wherein R2, R3, R4, R6, R7, R8, R51 and R52 have the meanings as indicated herein, and are MT1 and/or MT2 receptor agonists useful for treating and/or preventing urological diseases.Type: GrantFiled: July 9, 2013Date of Patent: June 28, 2016Assignee: Astellas Pharma Inc.Inventors: Takatoshi Kanayama, Hideki Kubota, Shunichiro Matsumoto, Tomoyuki Saito, Takafumi Shimizu, Naoto Katoh, Shigeo Matsui
-
Patent number: 9260445Abstract: The present invention relates to indole carboxamide compounds of formula (I) or a salt thereof wherein R2, R3, R4, R6, R7, R8, R51 and R52 have the meanings as indicated herein, and are MT1 and/or MT2 receptor agonists useful for treating and/or preventing urological diseases.Type: GrantFiled: July 9, 2013Date of Patent: February 16, 2016Assignee: Astellas Pharma Inc.Inventors: Takatoshi Kanayama, Hideki Kubota, Shunichiro Matsumoto, Tomoyuki Saito, Takafumi Shimizu, Naoto Katoh, Shigeo Matsui
-
Publication number: 20150203505Abstract: [Problem] To provided a compound which is useful as an MT1 and/or MT2 receptor agonist. [Means for Solution] The present inventors have conducted studies on MT1 and/or MT2 receptor agonists, and have found that an indole carboxamide compound has an MT1 and/or MT2 receptor agonistic action, thereby completing the present invention. The indole carboxamide compound of the present invention has the MT1 and/or MT2 receptor agonistic action as well as a low CNS penetration, and therefore, it can be used as an agent for preventing and/or treating urological diseases; in one embodiment, lower urinary tract symptoms; in another embodiment, urine storage symptom, in another embodiment, urinary incontinence; in a still another embodiment, stress urinary incontinence; and the like.Type: ApplicationFiled: July 9, 2013Publication date: July 23, 2015Applicant: Astellas Pharma Inc.Inventors: Takatoshi Kanayama, Hideki Kubota, Shunichiro Matsumoto, Tomoyuki Saito, Takafumi Shimizu, Naoto Katoh, Shigeo Matsui
-
Patent number: 6837355Abstract: In an electromagnetic clutch having drive and driven side clutch plates in which the drive side clutch plate is provided with a plurality of elongated holes circumferentially arranged at given intervals, a depression is formed by compressing and plastically press deforming each bridge portion positioned circumferentially between adjacent two of the elongated holes on an axial end surface of the drive side clutch plate facing the driven side clutch plate. Though tensile stress caused by belt tension is likely concentrated on the bridge portion, the depression, which causes higher hardness of the bridge portion, effectively serves to restrain occurrence of the fatigue failure.Type: GrantFiled: February 27, 2003Date of Patent: January 4, 2005Assignees: Denso Corporation, Michigan Automotive Compressor, A. J. Rose Mfg. Co.Inventors: Shigeo Matsui, Masao Nakano, Masahito Ooya, Alice Schneider, Peter Alderman, Dean Bremke, Craig A. Wightman, Channing M. Suscha, Daniel T. Pritchard
-
Publication number: 20030164277Abstract: In an electromagnetic clutch having drive and driven side clutch plates in which the drive side clutch plate is provided with a plurality of elongated holes circumferentially arranged at given intervals, a depression is formed by compressing and plastically press deforming each bridge portion positioned circumferentially between adjacent two of the elongated holes on an axial end surface of the drive side clutch plate facing the driven side clutch plate. Though tensile stress caused by belt tension is likely concentrated on the bridge portion, the depression, which causes higher hardness of the bridge portion, effectively serves to restrain occurrence of the fatigue failure.Type: ApplicationFiled: February 27, 2003Publication date: September 4, 2003Inventors: Shigeo Matsui, Masao Nakano, Masahito Ooya, Alice Schneider, Peter Alderman, Dean Bremke, Craig A. Wightman, Channing M. Suscha, Daniel T. Pritchard
-
Patent number: 5865880Abstract: An air cleaning system having a forced negative pressure generating function is provided for defining a space in a room for utilizing the space as a smoking area or the like in which contaminated air such as smoke is prevented from flowing out of the space and is cleaned. The air cleaning system having a forced negative pressure generating function has an air curtain producing unit having a blow-out port for producing air curtains to surround a predetermined space, an air sucking unit having a suction port open to the predetermined space defined by the air curtains for sucking air in the predetermined space, an air exhausting unit having an exhaust port open to the outside of the predetermined space for exhausting air sucked by the air sucking means to the outside of the predetermined space, an air cleaner unit interposed between the exhaust port and the suction port, and an air cleaner body supported by a plurality of stems for accommodating the components.Type: GrantFiled: September 11, 1996Date of Patent: February 2, 1999Assignee: Tornex, Inc.Inventor: Shigeo Matsui
-
Patent number: 5264015Abstract: A space surrounded by screens to provide a stable negative pressure preventing contaminated air from flowing out of the space and cleaning the contaminated air before discharged from the space. Air ports and fans are provided in the screen.Type: GrantFiled: September 8, 1992Date of Patent: November 23, 1993Assignee: Japan Air Curtain Company, Ltd.Inventor: Shigeo Matsui
-
Patent number: 5096467Abstract: An array of parallel pipes, each having ports through which jet-like air streams exit, are arranged so that a peripherally directed air curtain is formed. The posts are shielded at both ends, and one end is provided with a chimney along a central axis of the air by which air or fluid is removed. By giving the air curtain a centrifugal force, a negative pressure is produced along a central core, and a spiral flow is produced, creating an artificial tornado.Type: GrantFiled: December 9, 1988Date of Patent: March 17, 1992Assignee: Japan Air Curtain Company, Ltd.Inventor: Shigeo Matsui
-
Patent number: 4732577Abstract: There is provided an improved process for forming high purity carbon monoxide wherein a product of substantially uniform purity is obtained. A waste gas containing at least CO, CO.sub.2 and N.sub.2 is treated by pressure swing adsorption in two stages to remove CO.sub.2 and CO, respectively. The CO content of at least the feed gas and the second stage product gas are monitored and an amount of second stage product gas is recycled to the feed gas and/or the first stage product gas sufficient to assure substantially uniform CO content in the second stage product gas withdrawn from the system.Type: GrantFiled: April 14, 1987Date of Patent: March 22, 1988Assignees: Osaka Sanso Kogyo Ltd., Kawasaki Steel Corp.Inventors: Susumu Koizumi, Shigeo Matsui, Kyoichi Kawata
-
Patent number: 4539020Abstract: A process for separating carbon monoxide from a feed gas comprising CO.sub.2, CO and less adsorbable component than CO through PSA by using at least two adsorption columns in two stage adsorption operation which comprises a first adsorption stage for removing CO.sub.Type: GrantFiled: June 18, 1984Date of Patent: September 3, 1985Assignees: Kawasaki Steel Corporation, Osaka Sanso Kogyo Ltd.Inventors: Toshikazu Sakuraya, Tetsuya Fujii, Shigeo Matsui, Shigeki Hayashi
-
Patent number: RE32590Abstract: A process for separating carbon monoxide from a feed gas .[.comprising.]. .Iadd.including .Iaddend.CO.sub.2, CO and less adsorbable component than CO through PSA by using at least two adsorption columns in two stage adsorption operation which .[.comprises.]. .Iadd.includes .Iaddend.a first adsorption stage for removing CO.sub.2 from .[.said.]. .Iadd.the .Iaddend.feed gas and a second adsorption stage for separating CO from gaseous mixture withdrawn from the first adsorption stage:(1) the first adsorption stage comprising a pressure swing adsorption repeating adsorption and desorption, and(2) the second adsorption stage comprising:(i) pressurization by the first stage product gas,(ii) adsorption,(iii) depressurization,(iv) purge by product gas,(v) evacuation for recovering product gas, and(vi) pressurization by gas withdrawn in other column, periodically switching the flow between or among .[.said.]. .Iadd.the .Iaddend.Type: GrantFiled: October 23, 1986Date of Patent: February 2, 1988Assignees: Kawasaki Steel Corp., Osaka Sanso Kogyo Ltd.Inventors: Toshikazu Sakuraya, Tetsuya Fujii, Shigeo Matsui, Shigeki Hayashi