Patents by Inventor Shigeo Matsui

Shigeo Matsui has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9637451
    Abstract: [Problem] To provide a compound useful as a MT1 and/or MT2 receptor agonist. [Solution] The present inventors have studied on MT1 and/or MT2 receptor agonists, and have confirmed that indole compounds have the activity. As a result, the present invention is accomplished. That is, a compound represented by formula (I) or a salt thereof according to the present invention has a MT1 and/or MT2 receptor agonistic activity and has a low ability of migrating into central nervous system. Therefore, the compound or a salt thereof can be used as a peripheral MT1 and/or MT2 receptor agonist, and therefore can be used as a therapeutic and/or prophylactic agent for urinary incontinence, particularly stress urinary incontinence and mixed urinary incontinence.
    Type: Grant
    Filed: January 13, 2015
    Date of Patent: May 2, 2017
    Inventors: Shunichiro Matsumoto, Takafumi Shimizu, Tomoyuki Saito, Takatoshi Kanayama, Hiroaki Tanaka, Chiharu Mori, Kazuhiro Yokoyama, Shigeo Matsui
  • Publication number: 20160332966
    Abstract: [Problem] To provide a compound useful as a MT1 and/or MT2 receptor agonist. [Solution] The present inventors have studied on MT1 and/or MT2 receptor agonists, and have confirmed that indole compounds have the activity. As a result, the present invention is accomplished. That is, a compound represented by formula (I) or a salt thereof according to the present invention has a MT1 and/or MT2 receptor agonistic activity and has a low ability of migrating into central nervous system. Therefore, the compound or a salt thereof can be used as a peripheral MT1 and/or MT2 receptor agonist, and therefore can be used as a therapeutic and/or prophylactic agent for urinary incontinence, particularly stress urinary incontinence and mixed urinary incontinence.
    Type: Application
    Filed: January 13, 2015
    Publication date: November 17, 2016
    Applicant: ASTELLAS PHARMA INC.
    Inventors: Shunichiro MATSUMOTO, Takafumi SHIMIZU, Tomoyuki SAITO, Takatoshi KANAYAMA, Hiroaki TANAKA, Chiharu MORI, Kazuhiro YOKOYAMA, Shigeo MATSUI
  • Patent number: 9376449
    Abstract: The present invention relates to indole carboxamide compounds of formula (I) or a salt thereof wherein R2, R3, R4, R6, R7, R8, R51 and R52 have the meanings as indicated herein, and are MT1 and/or MT2 receptor agonists useful for treating and/or preventing urological diseases.
    Type: Grant
    Filed: July 9, 2013
    Date of Patent: June 28, 2016
    Assignee: Astellas Pharma Inc.
    Inventors: Takatoshi Kanayama, Hideki Kubota, Shunichiro Matsumoto, Tomoyuki Saito, Takafumi Shimizu, Naoto Katoh, Shigeo Matsui
  • Patent number: 9260445
    Abstract: The present invention relates to indole carboxamide compounds of formula (I) or a salt thereof wherein R2, R3, R4, R6, R7, R8, R51 and R52 have the meanings as indicated herein, and are MT1 and/or MT2 receptor agonists useful for treating and/or preventing urological diseases.
    Type: Grant
    Filed: July 9, 2013
    Date of Patent: February 16, 2016
    Assignee: Astellas Pharma Inc.
    Inventors: Takatoshi Kanayama, Hideki Kubota, Shunichiro Matsumoto, Tomoyuki Saito, Takafumi Shimizu, Naoto Katoh, Shigeo Matsui
  • Publication number: 20150203505
    Abstract: [Problem] To provided a compound which is useful as an MT1 and/or MT2 receptor agonist. [Means for Solution] The present inventors have conducted studies on MT1 and/or MT2 receptor agonists, and have found that an indole carboxamide compound has an MT1 and/or MT2 receptor agonistic action, thereby completing the present invention. The indole carboxamide compound of the present invention has the MT1 and/or MT2 receptor agonistic action as well as a low CNS penetration, and therefore, it can be used as an agent for preventing and/or treating urological diseases; in one embodiment, lower urinary tract symptoms; in another embodiment, urine storage symptom, in another embodiment, urinary incontinence; in a still another embodiment, stress urinary incontinence; and the like.
    Type: Application
    Filed: July 9, 2013
    Publication date: July 23, 2015
    Applicant: Astellas Pharma Inc.
    Inventors: Takatoshi Kanayama, Hideki Kubota, Shunichiro Matsumoto, Tomoyuki Saito, Takafumi Shimizu, Naoto Katoh, Shigeo Matsui
  • Patent number: 6837355
    Abstract: In an electromagnetic clutch having drive and driven side clutch plates in which the drive side clutch plate is provided with a plurality of elongated holes circumferentially arranged at given intervals, a depression is formed by compressing and plastically press deforming each bridge portion positioned circumferentially between adjacent two of the elongated holes on an axial end surface of the drive side clutch plate facing the driven side clutch plate. Though tensile stress caused by belt tension is likely concentrated on the bridge portion, the depression, which causes higher hardness of the bridge portion, effectively serves to restrain occurrence of the fatigue failure.
    Type: Grant
    Filed: February 27, 2003
    Date of Patent: January 4, 2005
    Assignees: Denso Corporation, Michigan Automotive Compressor, A. J. Rose Mfg. Co.
    Inventors: Shigeo Matsui, Masao Nakano, Masahito Ooya, Alice Schneider, Peter Alderman, Dean Bremke, Craig A. Wightman, Channing M. Suscha, Daniel T. Pritchard
  • Publication number: 20030164277
    Abstract: In an electromagnetic clutch having drive and driven side clutch plates in which the drive side clutch plate is provided with a plurality of elongated holes circumferentially arranged at given intervals, a depression is formed by compressing and plastically press deforming each bridge portion positioned circumferentially between adjacent two of the elongated holes on an axial end surface of the drive side clutch plate facing the driven side clutch plate. Though tensile stress caused by belt tension is likely concentrated on the bridge portion, the depression, which causes higher hardness of the bridge portion, effectively serves to restrain occurrence of the fatigue failure.
    Type: Application
    Filed: February 27, 2003
    Publication date: September 4, 2003
    Inventors: Shigeo Matsui, Masao Nakano, Masahito Ooya, Alice Schneider, Peter Alderman, Dean Bremke, Craig A. Wightman, Channing M. Suscha, Daniel T. Pritchard
  • Patent number: 5865880
    Abstract: An air cleaning system having a forced negative pressure generating function is provided for defining a space in a room for utilizing the space as a smoking area or the like in which contaminated air such as smoke is prevented from flowing out of the space and is cleaned. The air cleaning system having a forced negative pressure generating function has an air curtain producing unit having a blow-out port for producing air curtains to surround a predetermined space, an air sucking unit having a suction port open to the predetermined space defined by the air curtains for sucking air in the predetermined space, an air exhausting unit having an exhaust port open to the outside of the predetermined space for exhausting air sucked by the air sucking means to the outside of the predetermined space, an air cleaner unit interposed between the exhaust port and the suction port, and an air cleaner body supported by a plurality of stems for accommodating the components.
    Type: Grant
    Filed: September 11, 1996
    Date of Patent: February 2, 1999
    Assignee: Tornex, Inc.
    Inventor: Shigeo Matsui
  • Patent number: 5264015
    Abstract: A space surrounded by screens to provide a stable negative pressure preventing contaminated air from flowing out of the space and cleaning the contaminated air before discharged from the space. Air ports and fans are provided in the screen.
    Type: Grant
    Filed: September 8, 1992
    Date of Patent: November 23, 1993
    Assignee: Japan Air Curtain Company, Ltd.
    Inventor: Shigeo Matsui
  • Patent number: 5096467
    Abstract: An array of parallel pipes, each having ports through which jet-like air streams exit, are arranged so that a peripherally directed air curtain is formed. The posts are shielded at both ends, and one end is provided with a chimney along a central axis of the air by which air or fluid is removed. By giving the air curtain a centrifugal force, a negative pressure is produced along a central core, and a spiral flow is produced, creating an artificial tornado.
    Type: Grant
    Filed: December 9, 1988
    Date of Patent: March 17, 1992
    Assignee: Japan Air Curtain Company, Ltd.
    Inventor: Shigeo Matsui
  • Patent number: 4732577
    Abstract: There is provided an improved process for forming high purity carbon monoxide wherein a product of substantially uniform purity is obtained. A waste gas containing at least CO, CO.sub.2 and N.sub.2 is treated by pressure swing adsorption in two stages to remove CO.sub.2 and CO, respectively. The CO content of at least the feed gas and the second stage product gas are monitored and an amount of second stage product gas is recycled to the feed gas and/or the first stage product gas sufficient to assure substantially uniform CO content in the second stage product gas withdrawn from the system.
    Type: Grant
    Filed: April 14, 1987
    Date of Patent: March 22, 1988
    Assignees: Osaka Sanso Kogyo Ltd., Kawasaki Steel Corp.
    Inventors: Susumu Koizumi, Shigeo Matsui, Kyoichi Kawata
  • Patent number: 4539020
    Abstract: A process for separating carbon monoxide from a feed gas comprising CO.sub.2, CO and less adsorbable component than CO through PSA by using at least two adsorption columns in two stage adsorption operation which comprises a first adsorption stage for removing CO.sub.
    Type: Grant
    Filed: June 18, 1984
    Date of Patent: September 3, 1985
    Assignees: Kawasaki Steel Corporation, Osaka Sanso Kogyo Ltd.
    Inventors: Toshikazu Sakuraya, Tetsuya Fujii, Shigeo Matsui, Shigeki Hayashi
  • Patent number: RE32590
    Abstract: A process for separating carbon monoxide from a feed gas .[.comprising.]. .Iadd.including .Iaddend.CO.sub.2, CO and less adsorbable component than CO through PSA by using at least two adsorption columns in two stage adsorption operation which .[.comprises.]. .Iadd.includes .Iaddend.a first adsorption stage for removing CO.sub.2 from .[.said.]. .Iadd.the .Iaddend.feed gas and a second adsorption stage for separating CO from gaseous mixture withdrawn from the first adsorption stage:(1) the first adsorption stage comprising a pressure swing adsorption repeating adsorption and desorption, and(2) the second adsorption stage comprising:(i) pressurization by the first stage product gas,(ii) adsorption,(iii) depressurization,(iv) purge by product gas,(v) evacuation for recovering product gas, and(vi) pressurization by gas withdrawn in other column, periodically switching the flow between or among .[.said.]. .Iadd.the .Iaddend.
    Type: Grant
    Filed: October 23, 1986
    Date of Patent: February 2, 1988
    Assignees: Kawasaki Steel Corp., Osaka Sanso Kogyo Ltd.
    Inventors: Toshikazu Sakuraya, Tetsuya Fujii, Shigeo Matsui, Shigeki Hayashi